FR2137712A1 - Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition - Google Patents

Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition

Info

Publication number
FR2137712A1
FR2137712A1 FR7216685A FR7216685A FR2137712A1 FR 2137712 A1 FR2137712 A1 FR 2137712A1 FR 7216685 A FR7216685 A FR 7216685A FR 7216685 A FR7216685 A FR 7216685A FR 2137712 A1 FR2137712 A1 FR 2137712A1
Authority
FR
France
Prior art keywords
radical
alkyl
prostanoic acid
salt
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7216685A
Other languages
French (fr)
Other versions
FR2137712B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3967272A external-priority patent/GB1348036A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2137712A1 publication Critical patent/FR2137712A1/en
Application granted granted Critical
Publication of FR2137712B1 publication Critical patent/FR2137712B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-

Abstract

A prostanoic acid (I) or its salt, is new. A prostanoic acid of formula (I) or its salt, is new. R 1>hydroxymethyl, carboxy radical or up to 11C alkoxycarbonyl radical; R 2>hydroxy radical or 1-4C alkanoyloxy radical; R 3>H, or may combine with R 2>to form oxo radical; A : ethylene or trans-vinylene radical; X : 1-3C alkylene radical optionally containing 1-3C alkyl; Y' : oxygen, sulfur, sulfinyl (-SO-) or up to 4C alkylimino (-N-alkyl-) radical; and R 4>aryl, benzyl or furfuryl radical (all optionally substituted by halo, hydroxy, nitro or phenyl radical), alkyl, alkenyl, halogenoalkyl, alkoxy, alkenyloxy or up to 4C acylamino radical or dialkylamino radical containing 1-3C alkyl. The compound optionally contains up to 4C alkyl radical on 2, 3 or 4 carbon atom. An independent claim is included for manufacture of the prostanoic acid. [Image] ACTIVITY : Muscular-Gen.; Contraceptive; Hypotensive. No biological data given. MECHANISM OF ACTION : None given.
FR7216685A 1971-05-11 1972-05-10 Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition Granted FR2137712A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1413971 1971-05-11
GB3967272A GB1348036A (en) 1970-05-15 1972-01-05 Transistorized vertical deflection circuit

Publications (2)

Publication Number Publication Date
FR2137712A1 true FR2137712A1 (en) 1972-12-29
FR2137712B1 FR2137712B1 (en) 1976-04-16

Family

ID=26235892

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7216685A Granted FR2137712A1 (en) 1971-05-11 1972-05-10 Novel prostanoic acid or its salt used as pharmaceutical or veterinary composition

Country Status (26)

Country Link
JP (1) JPS5611699B1 (en)
AR (4) AR194952A1 (en)
AT (4) AT328103B (en)
AU (1) AU462755B2 (en)
BE (1) BE783292A (en)
CA (1) CA1077033A (en)
CH (3) CH596166A5 (en)
CS (1) CS192456B2 (en)
DD (1) DD99155A5 (en)
DE (1) DE2223365C3 (en)
DK (1) DK134598B (en)
EG (1) EG10752A (en)
ES (1) ES402627A1 (en)
FI (1) FI63221C (en)
FR (1) FR2137712A1 (en)
HK (1) HK50176A (en)
HU (1) HU166717B (en)
IE (1) IE37602B1 (en)
IL (1) IL39376A (en)
KE (1) KE2634A (en)
NL (1) NL164272C (en)
NO (1) NO139521C (en)
SE (4) SE399705B (en)
SU (1) SU662007A3 (en)
YU (1) YU35876B (en)
ZM (1) ZM8172A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2184007A1 (en) * 1972-05-10 1973-12-21 Upjohn Co
FR2205335A1 (en) * 1972-11-08 1974-05-31 Pfizer
FR2378010A1 (en) * 1977-01-24 1978-08-18 Searle & Co O-ARYLOXY PROSTYNE-13 OIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE, ESPECIALLY AS CONTRACEPTIVES
EP0349658A1 (en) * 1986-12-12 1990-01-10 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu New prostanoids and their use for increasing the birth rate in animal females
EP0362686A2 (en) * 1988-09-28 1990-04-11 SPOLANA a.s. Method for preparing the (+)-isomer of cloprostenol
WO1997030710A1 (en) * 1996-02-22 1997-08-28 Vision Pharmaceuticals L.P. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966795A (en) * 1973-05-21 1976-06-29 The Upjohn Company 5-Oxa-11-deoxyphenyl- and phenoxy-substituted prostaglandin F1.sub.α analogs
US3968144A (en) * 1973-05-21 1976-07-06 The Upjohn Company 5-Oxa-11-deoxy phenyl- and phenoxy-substituted prostalandin E1 analogs
US4387241A (en) * 1974-11-01 1983-06-07 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4191774A (en) * 1978-01-18 1980-03-04 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Novel 17-aza-PGF2α derivatives and pharmaceutical compositions containing the same
US4228296A (en) * 1979-01-24 1980-10-14 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
CS265947B1 (en) * 1987-06-16 1989-11-14 Kral Josef Means for farming animals' ovarian functions control
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
UA99840C2 (en) * 2007-11-09 2012-10-10 Аллерган, Инк. Substituted cyclopentanes having prostaglanding activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2184007A1 (en) * 1972-05-10 1973-12-21 Upjohn Co
FR2205335A1 (en) * 1972-11-08 1974-05-31 Pfizer
FR2378010A1 (en) * 1977-01-24 1978-08-18 Searle & Co O-ARYLOXY PROSTYNE-13 OIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE, ESPECIALLY AS CONTRACEPTIVES
EP0349658A1 (en) * 1986-12-12 1990-01-10 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu New prostanoids and their use for increasing the birth rate in animal females
EP0362686A2 (en) * 1988-09-28 1990-04-11 SPOLANA a.s. Method for preparing the (+)-isomer of cloprostenol
EP0362686A3 (en) * 1988-09-28 1990-08-29 Vysoka Skola Chemicko-Technologicka Method for preparing the (+)-isomer of cloprostenol method for preparing the (+)-isomer of cloprostenol
WO1997030710A1 (en) * 1996-02-22 1997-08-28 Vision Pharmaceuticals L.P. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

Also Published As

Publication number Publication date
IE37602L (en) 1972-11-11
AT328105B (en) 1976-03-10
DE2223365B2 (en) 1980-07-31
IL39376A (en) 1975-07-28
YU35876B (en) 1981-08-31
FI63221C (en) 1983-05-10
YU125072A (en) 1981-02-28
ES402627A1 (en) 1975-11-01
NO139521B (en) 1978-12-18
AT333447B (en) 1976-11-25
SE7504337L (en) 1975-04-15
DK134598B (en) 1976-12-06
NO139521C (en) 1979-03-28
ATA539073A (en) 1975-05-15
BE783292A (en) 1972-11-10
NL164272C (en) 1980-12-15
AT328104B (en) 1976-03-10
SE7504336L (en) 1975-04-15
IL39376A0 (en) 1972-07-26
CH596165A5 (en) 1978-02-28
CH590223A5 (en) 1977-07-29
ATA538973A (en) 1975-05-15
AR197100A1 (en) 1974-03-15
AR194952A1 (en) 1973-08-30
HK50176A (en) 1976-08-13
JPS5611699B1 (en) 1981-03-16
NL164272B (en) 1980-07-15
FR2137712B1 (en) 1976-04-16
ZM8172A1 (en) 1973-01-22
DK134598C (en) 1977-05-16
AU4202472A (en) 1973-11-15
ATA539173A (en) 1975-05-15
EG10752A (en) 1976-05-31
DE2223365C3 (en) 1981-06-04
AR200484A1 (en) 1974-11-15
CA1077033A (en) 1980-05-06
NL7206361A (en) 1972-11-14
DD99155A5 (en) 1973-07-20
CS192456B2 (en) 1979-08-31
SE399705B (en) 1978-02-27
CH596166A5 (en) 1978-02-28
ATA419172A (en) 1976-03-15
SE7504335L (en) 1975-04-15
FI63221B (en) 1983-01-31
AU462755B2 (en) 1975-07-03
SU662007A3 (en) 1979-05-05
AT328103B (en) 1976-03-10
KE2634A (en) 1976-06-11
IE37602B1 (en) 1977-08-31
AR197101A1 (en) 1974-03-15
DE2223365A1 (en) 1972-12-07
HU166717B (en) 1975-05-28

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0180, 920507

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0179, 720510

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0180, 720510

CL Concession to grant licences