DE2223237C2 - Lösung zur pharmazeutischen Verwendung - Google Patents
Lösung zur pharmazeutischen VerwendungInfo
- Publication number
- DE2223237C2 DE2223237C2 DE2223237A DE2223237A DE2223237C2 DE 2223237 C2 DE2223237 C2 DE 2223237C2 DE 2223237 A DE2223237 A DE 2223237A DE 2223237 A DE2223237 A DE 2223237A DE 2223237 C2 DE2223237 C2 DE 2223237C2
- Authority
- DE
- Germany
- Prior art keywords
- solution
- sterile
- preservative
- sodium
- propan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000243 solution Substances 0.000 claims description 38
- 239000003755 preservative agent Substances 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 11
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 15
- 230000002335 preservative effect Effects 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 9
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 8
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 229910021645 metal ion Inorganic materials 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- 229960001484 edetic acid Drugs 0.000 description 4
- 239000003889 eye drop Substances 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- YYTBMAUAEHQTJU-UHFFFAOYSA-M sodium;propan-2-ol;chloride Chemical compound [Na+].[Cl-].CC(C)O YYTBMAUAEHQTJU-UHFFFAOYSA-M 0.000 description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 3
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 229960000686 benzalkonium chloride Drugs 0.000 description 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
- 241001233037 catfish Species 0.000 description 3
- 229940067107 phenylethyl alcohol Drugs 0.000 description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 2
- RSWUWBQTXBNGNB-UHFFFAOYSA-N 5-(2-hydroxypropoxy)-4-oxochromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)C RSWUWBQTXBNGNB-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000007922 nasal spray Substances 0.000 description 2
- 229940097496 nasal spray Drugs 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 229940037001 sodium edetate Drugs 0.000 description 2
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 1
- WEBGLCLLEONJBN-UHFFFAOYSA-N [Na].[Na].CC(C)O Chemical compound [Na].[Na].CC(C)O WEBGLCLLEONJBN-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002242 chlorocresol Drugs 0.000 description 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- 229940096825 phenylmercury Drugs 0.000 description 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical compound [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1452971 | 1971-05-12 | ||
| GB5716971A GB1399834A (en) | 1971-05-12 | 1971-12-09 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2223237A1 DE2223237A1 (de) | 1972-12-14 |
| DE2223237C2 true DE2223237C2 (de) | 1985-01-17 |
Family
ID=26250625
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2223237A Expired DE2223237C2 (de) | 1971-05-12 | 1972-05-12 | Lösung zur pharmazeutischen Verwendung |
| DE19722266025 Pending DE2266025A1 (enExample) | 1971-05-12 | 1972-05-12 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19722266025 Pending DE2266025A1 (enExample) | 1971-05-12 | 1972-05-12 |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5425082B1 (enExample) |
| AU (1) | AU465305B2 (enExample) |
| BE (1) | BE782981A (enExample) |
| CA (1) | CA1000201A (enExample) |
| CY (1) | CY955A (enExample) |
| DE (2) | DE2223237C2 (enExample) |
| DK (1) | DK131324B (enExample) |
| FR (1) | FR2139872B1 (enExample) |
| GB (1) | GB1399834A (enExample) |
| HK (1) | HK69276A (enExample) |
| IE (1) | IE36337B1 (enExample) |
| IL (1) | IL39286A (enExample) |
| MY (1) | MY7700080A (enExample) |
| NL (1) | NL177386B (enExample) |
| SE (1) | SE396011B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19614823A1 (de) * | 1996-04-15 | 1997-10-16 | Mann Gerhard Chem Pharm Fab | Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2230358A2 (en) * | 1973-05-25 | 1974-12-20 | Fisons Ltd | Cromoglycate contg. solns. - contg. a second therapeutically active cpd. e.g. an antihistamine |
| DE2634908A1 (de) * | 1974-11-09 | 1977-04-14 | Fisons Ltd | Mittel zur behandlung chronischer haut- oder augenerkrankungen |
| DE3700379A1 (de) * | 1987-01-08 | 1988-07-21 | Mann Gerhard Chem Pharm Fab | Konservierte augentropfen mit einem gehalt an cromoglicinsaeure |
| FR2649890A1 (fr) * | 1988-03-22 | 1991-01-25 | Fisons Plc | Compositions pharmaceutiques |
| AT410894B (de) * | 1988-03-22 | 2003-08-25 | Fisons Plc | Verwendung einer wässerigen lösung von natriumcromoglycat und chlorbutol |
| GB2216794B (en) * | 1988-03-22 | 1991-11-20 | Fisons Plc | Pharmaceuticals compositions |
| GB8819490D0 (en) * | 1988-08-16 | 1988-09-21 | Fisons Plc | Pharmaceutical devices |
| EP0933084A4 (en) * | 1995-12-27 | 2000-07-12 | Showa Pharm Chem Ind | AQUEOUS AGENTS CONTAINING CROMOGLYN |
| EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
| JP5785353B2 (ja) * | 2004-02-27 | 2015-09-30 | 大正製薬株式会社 | 眼科用剤 |
| JP5992293B2 (ja) * | 2012-10-31 | 2016-09-14 | 大正製薬株式会社 | 眼科用剤 |
| PL426472A1 (pl) * | 2018-07-27 | 2020-02-10 | Kalbarczyk Grzegorz Arkona Laboratorium Farmakologii Stomatologicznej | Zastosowanie medyczne bromku domifenu oraz kompozycja do leczenia stanów zapalnych w obrębie jamy ustnej |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| GB1190194A (en) * | 1966-07-05 | 1970-04-29 | Fisons Pharmaceuticals Ltd | Bis-Phenoxy Compounds and Chromanone and Chromone Derivatives |
-
1971
- 1971-12-09 GB GB5716971A patent/GB1399834A/en not_active Expired
-
1972
- 1972-04-21 CY CY955A patent/CY955A/xx unknown
- 1972-04-24 IL IL39286A patent/IL39286A/xx unknown
- 1972-04-28 IE IE564/72A patent/IE36337B1/xx unknown
- 1972-05-01 CA CA140,981A patent/CA1000201A/en not_active Expired
- 1972-05-03 BE BE782981A patent/BE782981A/xx not_active IP Right Cessation
- 1972-05-09 NL NLAANVRAGE7206251,A patent/NL177386B/xx not_active Application Discontinuation
- 1972-05-09 AU AU42080/72A patent/AU465305B2/en not_active Expired
- 1972-05-09 SE SE7206151A patent/SE396011B/xx unknown
- 1972-05-10 DK DK232472AA patent/DK131324B/da not_active IP Right Cessation
- 1972-05-10 FR FR7216640A patent/FR2139872B1/fr not_active Expired
- 1972-05-12 DE DE2223237A patent/DE2223237C2/de not_active Expired
- 1972-05-12 JP JP4653772A patent/JPS5425082B1/ja active Pending
- 1972-05-12 DE DE19722266025 patent/DE2266025A1/de active Pending
-
1976
- 1976-11-04 HK HK692/76*UA patent/HK69276A/xx unknown
-
1977
- 1977-12-31 MY MY197780A patent/MY7700080A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19614823A1 (de) * | 1996-04-15 | 1997-10-16 | Mann Gerhard Chem Pharm Fab | Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge |
| US6599944B1 (en) | 1996-04-15 | 2003-07-29 | Bausch & Lomb Incorporated | Ophtalmic compound with extended dwell time on the eye |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2223237A1 (de) | 1972-12-14 |
| NL177386B (nl) | 1985-04-16 |
| DE2266025A1 (enExample) | 1985-03-07 |
| AU465305B2 (en) | 1975-09-25 |
| CY955A (en) | 1978-12-22 |
| FR2139872B1 (enExample) | 1975-10-31 |
| CA1000201A (en) | 1976-11-23 |
| IE36337L (en) | 1972-11-12 |
| DK131324B (da) | 1975-06-30 |
| IE36337B1 (en) | 1976-10-13 |
| SE396011B (sv) | 1977-09-05 |
| AU4208072A (en) | 1973-11-15 |
| DK131324C (enExample) | 1975-11-24 |
| NL7206251A (enExample) | 1972-11-14 |
| GB1399834A (en) | 1975-07-02 |
| JPS5425082B1 (enExample) | 1979-08-25 |
| BE782981A (fr) | 1972-11-03 |
| IL39286A (en) | 1975-02-10 |
| FR2139872A1 (enExample) | 1973-01-12 |
| IL39286A0 (en) | 1972-06-28 |
| HK69276A (en) | 1976-11-12 |
| MY7700080A (en) | 1977-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| AG | Has addition no. |
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| D2 | Grant after examination | ||
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