DE2204598A1 - Anwendung eines verfahrens zur gefrierkonzentrierung von waessrigen loesungen von arzneimitteln - Google Patents
Anwendung eines verfahrens zur gefrierkonzentrierung von waessrigen loesungen von arzneimittelnInfo
- Publication number
- DE2204598A1 DE2204598A1 DE2204598A DE2204598A DE2204598A1 DE 2204598 A1 DE2204598 A1 DE 2204598A1 DE 2204598 A DE2204598 A DE 2204598A DE 2204598 A DE2204598 A DE 2204598A DE 2204598 A1 DE2204598 A1 DE 2204598A1
- Authority
- DE
- Germany
- Prior art keywords
- concentrate
- ice
- concentration
- separated
- ice crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 25
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000243 solution Substances 0.000 claims description 34
- 239000012141 concentrate Substances 0.000 claims description 31
- 239000013078 crystal Substances 0.000 claims description 31
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000543 intermediate Substances 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 239000002532 enzyme inhibitor Substances 0.000 claims description 2
- 102000001399 Kallikrein Human genes 0.000 description 18
- 108060005987 Kallikrein Proteins 0.000 description 18
- 101710162629 Trypsin inhibitor Proteins 0.000 description 8
- 229940122618 Trypsin inhibitor Drugs 0.000 description 8
- 239000002753 trypsin inhibitor Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 239000012045 crude solution Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 238000001953 recrystallisation Methods 0.000 description 5
- 239000010409 thin film Substances 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 description 1
- 108010024976 Asparaginase Proteins 0.000 description 1
- 102000015790 Asparaginase Human genes 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229960003272 asparaginase Drugs 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4853—Kallikrein (3.4.21.34 or 3.4.21.35)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/02—Foam dispersion or prevention
- B01D19/04—Foam dispersion or prevention by addition of chemical substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
- B01D9/04—Crystallisation from solutions concentrating solutions by removing frozen solvent therefrom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE794743D BE794743A (fr) | 1972-02-01 | Procede de concentration par congelation de solutions aqueuses de medicaments | |
| DE2204598A DE2204598A1 (de) | 1972-02-01 | 1972-02-01 | Anwendung eines verfahrens zur gefrierkonzentrierung von waessrigen loesungen von arzneimitteln |
| GB49773A GB1410541A (en) | 1972-02-01 | 1973-01-04 | Concentration of solutions of biological heat sensitive substances |
| JP48010381A JPS4884082A (enExample) | 1972-02-01 | 1973-01-26 | |
| US327108A US3897409A (en) | 1972-02-01 | 1973-01-26 | Freeze concentration of aqueous solutions of heat-labile substances |
| NL7301244A NL7301244A (enExample) | 1972-02-01 | 1973-01-29 | |
| AT80473A AT323319B (de) | 1972-02-01 | 1973-01-30 | Verfahren zur gefrierkonzentrierung von wässerigen lösungen niedermolekularer oder höhermolekularer arzneimittel |
| PL1973160494A PL89089B1 (enExample) | 1972-02-01 | 1973-01-31 | |
| FR7303558A FR2170135B1 (enExample) | 1972-02-01 | 1973-02-01 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2204598A DE2204598A1 (de) | 1972-02-01 | 1972-02-01 | Anwendung eines verfahrens zur gefrierkonzentrierung von waessrigen loesungen von arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2204598A1 true DE2204598A1 (de) | 1973-08-09 |
Family
ID=5834656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2204598A Pending DE2204598A1 (de) | 1972-02-01 | 1972-02-01 | Anwendung eines verfahrens zur gefrierkonzentrierung von waessrigen loesungen von arzneimitteln |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3897409A (enExample) |
| JP (1) | JPS4884082A (enExample) |
| AT (1) | AT323319B (enExample) |
| BE (1) | BE794743A (enExample) |
| DE (1) | DE2204598A1 (enExample) |
| FR (1) | FR2170135B1 (enExample) |
| GB (1) | GB1410541A (enExample) |
| NL (1) | NL7301244A (enExample) |
| PL (1) | PL89089B1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8337060B1 (en) | 2011-07-15 | 2012-12-25 | John Kent Frankovich | Bicycle lighting systems and methods |
| US9527540B2 (en) | 2011-07-15 | 2016-12-27 | Revolights, Inc. | Bicycle lighting systems and methods |
| USD685509S1 (en) | 2011-10-12 | 2013-07-02 | Revolights, Inc. | Bicycle lighting system |
| US9227559B2 (en) | 2012-12-31 | 2016-01-05 | Revolights, Inc. | Vehicle lighting control system and method |
| US8956542B1 (en) * | 2013-07-30 | 2015-02-17 | Showa Freezing Plant Co., Ltd. | Method for processing radioactively-contaminated water |
| WO2015030161A1 (ja) * | 2013-08-29 | 2015-03-05 | 株式会社明治 | 凍結濃縮法による濃縮製品の製造方法 |
| US10393365B2 (en) | 2017-04-05 | 2019-08-27 | Revolights, Inc. | Wheelchair lighting systems and methods |
| CN111646923B (zh) * | 2020-06-18 | 2022-11-15 | 山西省科技资源与大型仪器开放共享中心 | 一种冷冻浓缩提纯羟基乙腈的方法 |
-
0
- BE BE794743D patent/BE794743A/xx unknown
-
1972
- 1972-02-01 DE DE2204598A patent/DE2204598A1/de active Pending
-
1973
- 1973-01-04 GB GB49773A patent/GB1410541A/en not_active Expired
- 1973-01-26 US US327108A patent/US3897409A/en not_active Expired - Lifetime
- 1973-01-26 JP JP48010381A patent/JPS4884082A/ja active Pending
- 1973-01-29 NL NL7301244A patent/NL7301244A/xx unknown
- 1973-01-30 AT AT80473A patent/AT323319B/de not_active IP Right Cessation
- 1973-01-31 PL PL1973160494A patent/PL89089B1/pl unknown
- 1973-02-01 FR FR7303558A patent/FR2170135B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1410541A (en) | 1975-10-15 |
| PL89089B1 (enExample) | 1976-10-30 |
| NL7301244A (enExample) | 1973-08-03 |
| US3897409A (en) | 1975-07-29 |
| JPS4884082A (enExample) | 1973-11-08 |
| FR2170135A1 (enExample) | 1973-09-14 |
| BE794743A (fr) | 1973-07-30 |
| AT323319B (de) | 1975-07-10 |
| FR2170135B1 (enExample) | 1977-02-04 |
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