DE2143745A1 - 3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung - Google Patents
3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellungInfo
- Publication number
- DE2143745A1 DE2143745A1 DE2143745A DE2143745A DE2143745A1 DE 2143745 A1 DE2143745 A1 DE 2143745A1 DE 2143745 A DE2143745 A DE 2143745A DE 2143745 A DE2143745 A DE 2143745A DE 2143745 A1 DE2143745 A1 DE 2143745A1
- Authority
- DE
- Germany
- Prior art keywords
- dihydro
- isoquinoline
- phenyl
- thione
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- IRXWBCKPECPALY-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinoline-1-thione Chemical compound C1=CC=C2C(=S)NCCC2=C1 IRXWBCKPECPALY-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- IOYIDSMWPLNHRC-UHFFFAOYSA-N 2h-isoquinoline-1-thione Chemical compound C1=CC=C2C(S)=NC=CC2=C1 IOYIDSMWPLNHRC-UHFFFAOYSA-N 0.000 claims 1
- -1 4,4-Diethyl-6,7-methylenedioxy-3,4-dihydro-2H-isoquinoline-1-thione Chemical compound 0.000 claims 1
- QJKLPACBLDYFMV-UHFFFAOYSA-N C1(=CC=CC=C1)C1CNC(C2=CC=CC=C12)=S Chemical compound C1(=CC=CC=C1)C1CNC(C2=CC=CC=C12)=S QJKLPACBLDYFMV-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2143745A DE2143745A1 (de) | 1971-09-01 | 1971-09-01 | 3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung |
| DD165084A DD102148A5 (enExample) | 1971-09-01 | 1972-08-16 | |
| CA150,238A CA972755A (en) | 1971-09-01 | 1972-08-25 | 3,4-dihydro-2h-isoquinoline-1-thiones and process for preparing them |
| NL7211627A NL7211627A (enExample) | 1971-09-01 | 1972-08-25 | |
| ES406134A ES406134A1 (es) | 1971-09-01 | 1972-08-26 | Procedimiento para la preparacion de 3-dihidro-2h-isoquino-lein-1-tionas. |
| IL40250A IL40250A0 (en) | 1971-09-01 | 1972-08-29 | 3,4-dihydro-2h-isoquinoline-1-thiones and process for preparing them |
| AU46104/72A AU4610472A (en) | 1971-09-01 | 1972-08-30 | 2. 4-dihydro-2h-isoquinoline-1-thiones and process for preparing them |
| FR7230951A FR2151044A1 (en) | 1971-09-01 | 1972-08-31 | 3,4-dihydro- 2h-isoquinoline -1- thiones - antiphlogistics, for lowering of cholesterol and triglyceride levels in serum |
| ZA725997A ZA725997B (en) | 1971-09-01 | 1972-08-31 | 3,4-dihydro 2h-isoquinoline-1-thiones and process for preparing them |
| BE788321D BE788321A (fr) | 1971-09-01 | 1972-09-01 | Isoquinoleine-thiones et medicaments hypolipemiants en contenant |
| JP47087839A JPS4834885A (enExample) | 1971-09-01 | 1972-09-01 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2143745A DE2143745A1 (de) | 1971-09-01 | 1971-09-01 | 3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2143745A1 true DE2143745A1 (de) | 1973-03-08 |
Family
ID=5818354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2143745A Pending DE2143745A1 (de) | 1971-09-01 | 1971-09-01 | 3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4834885A (enExample) |
| AU (1) | AU4610472A (enExample) |
| BE (1) | BE788321A (enExample) |
| CA (1) | CA972755A (enExample) |
| DD (1) | DD102148A5 (enExample) |
| DE (1) | DE2143745A1 (enExample) |
| ES (1) | ES406134A1 (enExample) |
| FR (1) | FR2151044A1 (enExample) |
| IL (1) | IL40250A0 (enExample) |
| NL (1) | NL7211627A (enExample) |
| ZA (1) | ZA725997B (enExample) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0355750A1 (en) * | 1988-08-19 | 1990-02-28 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| EP0339878A3 (en) * | 1988-04-25 | 1990-12-05 | Eli Lilly And Company | Propanamine derivatives |
| US5177075A (en) * | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| WO2002090334A1 (en) * | 2001-05-08 | 2002-11-14 | Kudos Pharmaceuticals Limited | Isoquinolinone derivatives as parp inhibitors |
| US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7407957B2 (en) | 2004-08-26 | 2008-08-05 | Maybridge Limited | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7470688B2 (en) | 2005-10-19 | 2008-12-30 | Maybridge Limited | Phthalazinone derivatives |
| US7750006B2 (en) | 2000-10-30 | 2010-07-06 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7981890B2 (en) | 2007-09-14 | 2011-07-19 | Astrazeneca Ab | Phthalazinone derivatives |
| US8129380B2 (en) | 2008-01-23 | 2012-03-06 | Astrazeneca Ab | Phthalazinone derivatives |
| US8183369B2 (en) | 2007-10-17 | 2012-05-22 | Kudos Pharmaceuticals Limited | 4- [3- (4-cyclopropanecarbonyl-piperazine-I-carbonyl) -4 -fluoro-benzyl] -2H-phthalaz in-1-one |
| US8912187B2 (en) | 2003-03-12 | 2014-12-16 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55157B2 (sr) | 2008-10-07 | 2023-10-31 | Kudos Pharm Ltd | Farmaceutska formulacija 514 |
-
1971
- 1971-09-01 DE DE2143745A patent/DE2143745A1/de active Pending
-
1972
- 1972-08-16 DD DD165084A patent/DD102148A5/xx unknown
- 1972-08-25 NL NL7211627A patent/NL7211627A/xx unknown
- 1972-08-25 CA CA150,238A patent/CA972755A/en not_active Expired
- 1972-08-26 ES ES406134A patent/ES406134A1/es not_active Expired
- 1972-08-29 IL IL40250A patent/IL40250A0/xx unknown
- 1972-08-30 AU AU46104/72A patent/AU4610472A/en not_active Expired
- 1972-08-31 ZA ZA725997A patent/ZA725997B/xx unknown
- 1972-08-31 FR FR7230951A patent/FR2151044A1/fr not_active Withdrawn
- 1972-09-01 JP JP47087839A patent/JPS4834885A/ja active Pending
- 1972-09-01 BE BE788321D patent/BE788321A/xx unknown
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0339878A3 (en) * | 1988-04-25 | 1990-12-05 | Eli Lilly And Company | Propanamine derivatives |
| EP0355750A1 (en) * | 1988-08-19 | 1990-02-28 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| US5177075A (en) * | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| US7750006B2 (en) | 2000-10-30 | 2010-07-06 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| WO2002090334A1 (en) * | 2001-05-08 | 2002-11-14 | Kudos Pharmaceuticals Limited | Isoquinolinone derivatives as parp inhibitors |
| US6664269B2 (en) | 2001-05-08 | 2003-12-16 | Maybridge Plc | Isoquinolinone derivatives |
| US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US10449192B2 (en) | 2003-03-12 | 2019-10-22 | Kudo Pharmaceuticals Limited | Phthalazinone derivatives |
| US9566276B2 (en) | 2003-03-12 | 2017-02-14 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7662818B2 (en) | 2003-03-12 | 2010-02-16 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US8912187B2 (en) | 2003-03-12 | 2014-12-16 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US9169235B2 (en) | 2003-03-12 | 2015-10-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7666870B2 (en) | 2004-08-26 | 2010-02-23 | Maybridge Limited | Phthalazinone derivatives |
| US7407957B2 (en) | 2004-08-26 | 2008-08-05 | Maybridge Limited | Phthalazinone derivatives |
| US7902193B2 (en) | 2005-10-19 | 2011-03-08 | Maybridge Limited | Phthalazinone derivatives |
| US7470688B2 (en) | 2005-10-19 | 2008-12-30 | Maybridge Limited | Phthalazinone derivatives |
| US7981890B2 (en) | 2007-09-14 | 2011-07-19 | Astrazeneca Ab | Phthalazinone derivatives |
| US8183369B2 (en) | 2007-10-17 | 2012-05-22 | Kudos Pharmaceuticals Limited | 4- [3- (4-cyclopropanecarbonyl-piperazine-I-carbonyl) -4 -fluoro-benzyl] -2H-phthalaz in-1-one |
| US8129380B2 (en) | 2008-01-23 | 2012-03-06 | Astrazeneca Ab | Phthalazinone derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| IL40250A0 (en) | 1972-10-29 |
| ES406134A1 (es) | 1975-08-01 |
| BE788321A (fr) | 1973-03-01 |
| ZA725997B (en) | 1973-07-25 |
| CA972755A (en) | 1975-08-12 |
| DD102148A5 (enExample) | 1973-12-05 |
| AU4610472A (en) | 1974-03-07 |
| JPS4834885A (enExample) | 1973-05-22 |
| NL7211627A (enExample) | 1973-03-05 |
| FR2151044A1 (en) | 1973-04-13 |
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