DE2132499C3 - Mittel zur Schwangerschaftsbestimmung und Verfahren zu dessen Herstellung - Google Patents
Mittel zur Schwangerschaftsbestimmung und Verfahren zu dessen HerstellungInfo
- Publication number
- DE2132499C3 DE2132499C3 DE2132499A DE2132499A DE2132499C3 DE 2132499 C3 DE2132499 C3 DE 2132499C3 DE 2132499 A DE2132499 A DE 2132499A DE 2132499 A DE2132499 A DE 2132499A DE 2132499 C3 DE2132499 C3 DE 2132499C3
- Authority
- DE
- Germany
- Prior art keywords
- solution
- cgh
- serum
- glutaraldehyde
- blood cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 19
- 230000035935 pregnancy Effects 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 12
- 210000003743 erythrocyte Anatomy 0.000 claims description 22
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 17
- 229920000159 gelatin Polymers 0.000 claims description 16
- 235000019322 gelatine Nutrition 0.000 claims description 16
- 108010010803 Gelatin Proteins 0.000 claims description 15
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 15
- 239000008273 gelatin Substances 0.000 claims description 15
- 235000011852 gelatine desserts Nutrition 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 12
- 241001494479 Pecora Species 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims description 9
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims description 9
- 239000007822 coupling agent Substances 0.000 claims description 9
- 239000008098 formaldehyde solution Substances 0.000 claims description 7
- 239000007853 buffer solution Substances 0.000 claims description 6
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims description 6
- 239000000872 buffer Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 210000000601 blood cell Anatomy 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims 2
- 210000002966 serum Anatomy 0.000 description 33
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 29
- 210000004027 cell Anatomy 0.000 description 21
- 239000000725 suspension Substances 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 239000008363 phosphate buffer Substances 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 239000008055 phosphate buffer solution Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 229940015047 chorionic gonadotropin Drugs 0.000 description 3
- 239000000032 diagnostic agent Substances 0.000 description 3
- 229940039227 diagnostic agent Drugs 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000009597 pregnancy test Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- YUJSWFZLUCHGFO-UHFFFAOYSA-N 4-(4-azidophenyl)aniline Chemical compound C1=CC(N)=CC=C1C1=CC=C(N=[N+]=[N-])C=C1 YUJSWFZLUCHGFO-UHFFFAOYSA-N 0.000 description 1
- 241000269350 Anura Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000798077 Poelagus marjorita Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL34960A IL34960A (en) | 1970-07-20 | 1970-07-20 | A method for the determination of pregnancy and a serodiagnostic composition therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2132499A1 DE2132499A1 (de) | 1972-01-27 |
| DE2132499B2 DE2132499B2 (de) | 1980-06-19 |
| DE2132499C3 true DE2132499C3 (de) | 1981-06-19 |
Family
ID=11045501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2132499A Expired DE2132499C3 (de) | 1970-07-20 | 1971-06-30 | Mittel zur Schwangerschaftsbestimmung und Verfahren zu dessen Herstellung |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5525380B1 (enExample) |
| AT (1) | AT318818B (enExample) |
| BR (1) | BR7104562D0 (enExample) |
| CA (1) | CA981581A (enExample) |
| DE (1) | DE2132499C3 (enExample) |
| FR (1) | FR2098142A5 (enExample) |
| GB (1) | GB1350295A (enExample) |
| IL (1) | IL34960A (enExample) |
| NL (1) | NL7109948A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2310964A1 (de) * | 1973-03-02 | 1974-09-05 | Schering Ag | Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation |
| TWI722785B (zh) | 2020-01-31 | 2021-03-21 | 台達電子工業股份有限公司 | 光學校正工具 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL271097A (enExample) * | 1960-11-08 | |||
| US3882225A (en) * | 1968-12-09 | 1975-05-06 | Miles Lab | Direct agglutination immunological reagent |
-
1970
- 1970-07-20 IL IL34960A patent/IL34960A/xx unknown
-
1971
- 1971-06-21 GB GB2902371A patent/GB1350295A/en not_active Expired
- 1971-06-25 CA CA116,685A patent/CA981581A/en not_active Expired
- 1971-06-30 FR FR7124007A patent/FR2098142A5/fr not_active Expired
- 1971-06-30 DE DE2132499A patent/DE2132499C3/de not_active Expired
- 1971-07-01 JP JP4773971A patent/JPS5525380B1/ja active Pending
- 1971-07-19 NL NL7109948A patent/NL7109948A/xx not_active Application Discontinuation
- 1971-07-19 BR BR4562/71A patent/BR7104562D0/pt unknown
- 1971-07-20 AT AT631471A patent/AT318818B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR7104562D0 (pt) | 1973-03-08 |
| IL34960A (en) | 1974-11-29 |
| JPS5525380B1 (enExample) | 1980-07-05 |
| DE2132499A1 (de) | 1972-01-27 |
| NL7109948A (enExample) | 1972-01-24 |
| AT318818B (de) | 1974-11-25 |
| DE2132499B2 (de) | 1980-06-19 |
| IL34960A0 (en) | 1970-09-17 |
| FR2098142A5 (enExample) | 1972-03-03 |
| GB1350295A (en) | 1974-04-18 |
| CA981581A (en) | 1976-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |