DE2023450C3 - 1,2 a-Methylen-spiroxenone, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneipräparate - Google Patents

1,2 a-Methylen-spiroxenone, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneipräparate

Info

Publication number
DE2023450C3
DE2023450C3 DE2023450A DE2023450A DE2023450C3 DE 2023450 C3 DE2023450 C3 DE 2023450C3 DE 2023450 A DE2023450 A DE 2023450A DE 2023450 A DE2023450 A DE 2023450A DE 2023450 C3 DE2023450 C3 DE 2023450C3
Authority
DE
Germany
Prior art keywords
spirox
methylene
spiroxa
treated
dien
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2023450A
Other languages
German (de)
English (en)
Other versions
DE2023450A1 (de
DE2023450B2 (de
Inventor
Glen Edward Cranford Arth
Gary Henry Watchung Rasmusson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2023450A1 publication Critical patent/DE2023450A1/de
Publication of DE2023450B2 publication Critical patent/DE2023450B2/de
Application granted granted Critical
Publication of DE2023450C3 publication Critical patent/DE2023450C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2023450A 1969-05-14 1970-05-13 1,2 a-Methylen-spiroxenone, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneipräparate Expired DE2023450C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467269A 1969-05-14 1969-05-14
US2118370A 1970-03-19 1970-03-19

Publications (3)

Publication Number Publication Date
DE2023450A1 DE2023450A1 (de) 1971-01-14
DE2023450B2 DE2023450B2 (de) 1978-10-05
DE2023450C3 true DE2023450C3 (de) 1979-05-31

Family

ID=26694377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2023450A Expired DE2023450C3 (de) 1969-05-14 1970-05-13 1,2 a-Methylen-spiroxenone, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneipräparate

Country Status (17)

Country Link
JP (1) JPS532865B1 (enrdf_load_stackoverflow)
AR (1) AR192305A1 (enrdf_load_stackoverflow)
BE (1) BE750330A (enrdf_load_stackoverflow)
CA (1) CA926385A (enrdf_load_stackoverflow)
CH (2) CH547792A (enrdf_load_stackoverflow)
CS (2) CS151551B2 (enrdf_load_stackoverflow)
DE (1) DE2023450C3 (enrdf_load_stackoverflow)
DK (3) DK126992B (enrdf_load_stackoverflow)
FI (2) FI47355C (enrdf_load_stackoverflow)
FR (1) FR2051526B1 (enrdf_load_stackoverflow)
GB (1) GB1265444A (enrdf_load_stackoverflow)
IE (1) IE34194B1 (enrdf_load_stackoverflow)
IL (1) IL34431A (enrdf_load_stackoverflow)
NL (1) NL168844C (enrdf_load_stackoverflow)
NO (1) NO131131C (enrdf_load_stackoverflow)
SE (2) SE366305B (enrdf_load_stackoverflow)
YU (1) YU34052B (enrdf_load_stackoverflow)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes

Also Published As

Publication number Publication date
CA926385A (en) 1973-05-15
AR192305A1 (es) 1973-02-14
IL34431A (en) 1974-03-14
DK127880C (da) 1974-06-10
GB1265444A (enrdf_load_stackoverflow) 1972-03-01
JPS532865B1 (enrdf_load_stackoverflow) 1978-02-01
DK127505B (da) 1973-11-19
BE750330A (fr) 1970-11-13
CH547785A (de) 1974-04-11
YU34052B (en) 1978-10-31
NL168844B (nl) 1981-12-16
IL34431A0 (en) 1970-07-19
NL168844C (nl) 1982-05-17
FI47355C (fi) 1973-11-12
DK126992B (da) 1973-09-10
DE2023450A1 (de) 1971-01-14
YU117670A (en) 1978-05-15
FI47355B (enrdf_load_stackoverflow) 1973-07-31
NO131131B (enrdf_load_stackoverflow) 1974-12-30
FR2051526B1 (enrdf_load_stackoverflow) 1974-04-12
FI47885B (enrdf_load_stackoverflow) 1974-01-02
SE386904B (sv) 1976-08-23
CH547792A (de) 1974-04-11
FR2051526A1 (enrdf_load_stackoverflow) 1971-04-09
DK127880B (enrdf_load_stackoverflow) 1974-01-28
CS151552B2 (enrdf_load_stackoverflow) 1973-10-19
SE366305B (enrdf_load_stackoverflow) 1974-04-22
DE2023450B2 (de) 1978-10-05
CS151551B2 (enrdf_load_stackoverflow) 1973-10-19
IE34194B1 (en) 1975-03-05
IE34194L (en) 1970-11-14
NO131131C (enrdf_load_stackoverflow) 1975-04-09
NL7006474A (enrdf_load_stackoverflow) 1970-11-17
FI47885C (fi) 1974-04-10

Similar Documents

Publication Publication Date Title
DE2035738A1 (de) Neue Androstandenvate und Verfahren zu ihrer Herstellung
Klass et al. Digitogenin
DE2023450C3 (de) 1,2 a-Methylen-spiroxenone, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneipräparate
DE2711516C2 (de) 17-Spirosultin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2264189C3 (de) 3'-(3-Oxo-17beta-hydroxy-6,7-methylen-androst-4en-bzw.-l,4-dien-17 a-yl) -propionsäureverbindungen, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE1807980C3 (de) Verfahren zur Herstellung neuer Halogenpregnadiene
EP0014966B1 (de) Neue deA-Steroide, ihre Herstellung und deA-Steroide zur Verwendung als Pharmazeutika
DE956954C (de) Verfahren zur Herstellung von in 4-Stellung ungesaettigten Pregnan-16-01-3, 20-dionen
DD160418A1 (de) Verfahren zur herstellung von 17alpha-substituierten gona-4,9-dienen
DE1668658B2 (de) 16alpha-Methylverbindungen der Pregnanreihe sowie Verfahren zu deren Herstellung. Ausscheidung aus: 1418390
DE1241825C2 (de) Verfahren zur herstellung von 6-chlor-4,6-dienverbindungen der pregnan-, androstan- oder cholestanreihe
DE102009031908B4 (de) Verfahren zur Herstellung von Drospirenon aus 15-Hydroxyandrostendion
DE1593348C3 (de) Verfahren zur Herstellung von 19-Fluorsteroidepoxyden und 19-Fluor-11,19epoxysteroide
DE843411C (de) Verfahren zur Gewinnung in 21-Stellung substituierter Pregnanderivate
DE1493162C3 (de) nalpha-Äthinyl-lS-methyl-^nortestosteronäther, Verfahren zu deren Herstellung, sowie diese enthaltende Mittel
DE2137557C3 (de) Verfahren zur Herstellung von Acyloxy Delta 4 androstenen bzw ostrenen
DE1593613C3 (de) 7 (alpha und beta)-Methyl-androstenderivate und Verfahren zu deren Herstellung
DE1094258B (de) Verfahren zur Herstellung von fluorierten 16-Methylsteroiden
DE2019073A1 (de) Verfahren zur Umwandlung einer 3-Hydroxy-5,6-oxidogruppe eines Steroids in eine delta-4-3-Oxogruppe
DE1618511A1 (de) Verfahren zur Herstellung von neuen 9ss 10alpha-Steroiden
DEC0009455MA (enrdf_load_stackoverflow)
DE1643035B2 (de) 15beta,16beta-methylen-5alpha -androst-l-ene, verfahren zu deren herstellung sowie diese enthaltende mittel
DE2028026A1 (de) Neue Steroide der Pregnanreihe
DE2007416B (de) 7alpha Methyl 3,16alpha, 17alpha tnhydroxy Delta 1,3,5(10) oestratnen
DE1443636A1 (de) Verfahren zur Herstellung neuer Methylandrostene

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee