DE2004553B1 - Verfahren zur Herstellung von Leit schienen aus menschlichen oder tierischen Geweben zur Wiederherstellung beschädigter oder zerstörter spezifischer Gewebsteile im menschlichen und tierischen Korper - Google Patents
Verfahren zur Herstellung von Leit schienen aus menschlichen oder tierischen Geweben zur Wiederherstellung beschädigter oder zerstörter spezifischer Gewebsteile im menschlichen und tierischen KorperInfo
- Publication number
- DE2004553B1 DE2004553B1 DE19702004553D DE2004553DA DE2004553B1 DE 2004553 B1 DE2004553 B1 DE 2004553B1 DE 19702004553 D DE19702004553 D DE 19702004553D DE 2004553D A DE2004553D A DE 2004553DA DE 2004553 B1 DE2004553 B1 DE 2004553B1
- Authority
- DE
- Germany
- Prior art keywords
- tissue
- nerve
- preparation
- human
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001465754 Metazoa Species 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 5
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 210000001519 tissue Anatomy 0.000 claims 20
- 210000005036 nerve Anatomy 0.000 claims 14
- 238000002360 preparation method Methods 0.000 claims 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 210000001640 nerve ending Anatomy 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 206010033799 Paralysis Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 210000000944 nerve tissue Anatomy 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010010149 Complicated fracture Diseases 0.000 claims 1
- 241001269524 Dura Species 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 239000012153 distilled water Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003195 fascia Anatomy 0.000 claims 1
- 206010016629 fibroma Diseases 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 230000030214 innervation Effects 0.000 claims 1
- 230000003780 keratinization Effects 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000007830 nerve conduction Effects 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 239000008237 rinsing water Substances 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/124—Disinfecting agents, e.g. antimicrobials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0094—Gaseous substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Botany (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2004553 | 1970-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2004553B1 true DE2004553B1 (de) | 1971-05-19 |
Family
ID=5761154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702004553D Pending DE2004553B1 (de) | 1970-02-02 | 1970-02-02 | Verfahren zur Herstellung von Leit schienen aus menschlichen oder tierischen Geweben zur Wiederherstellung beschädigter oder zerstörter spezifischer Gewebsteile im menschlichen und tierischen Korper |
Country Status (13)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0069156A1 (de) * | 1981-07-02 | 1983-01-12 | Intermedicat GmbH | Verfahren zur Herstellung von Skleroproteintransplantaten mit erhöhter biologischer Stabilität |
| EP0153995A3 (en) * | 1979-11-02 | 1985-12-27 | Karl Prof. Dr. Theurer | Process for the mild sterilization with respect to microorganisms and viruses of biologically active substances, especially organ tissues for therapeutic use |
| EP0334679A3 (en) * | 1988-03-25 | 1990-06-20 | National Research Development Corporation | Improvements in or relating to the inactivation of infectious agents |
| EP0424159A3 (en) * | 1989-10-19 | 1991-11-06 | Osteotech, Inc., | Aseptic processing of allograft bone and tissue |
| DE10217779A1 (de) * | 2002-04-18 | 2003-11-13 | Co Don Ag | Konservierte Gewebematrix eines Hohlorganes, insbesondere eines Blutgefäßes, Verfahren zur Herstellung und Verwendung dieser |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2150811B (en) * | 1983-12-06 | 1987-04-08 | Ethicon Inc | Surgical training aid |
| RU2172104C1 (ru) * | 2000-06-15 | 2001-08-20 | ГУН Центральный научно-исследовательский институт травматологии и ортопедии им. Н.Н. Приорова | Способ изготовления имплантатов из губчатой костной ткани |
| PT2846845T (pt) * | 2012-05-09 | 2017-06-02 | Icrom Spa | Produção de brinzolamida farmacêutica estéril |
-
1970
- 1970-02-02 DE DE19702004553D patent/DE2004553B1/de active Pending
-
1971
- 1971-01-14 AT AT25971A patent/AT298664B/de not_active IP Right Cessation
- 1971-01-26 FI FI207/71A patent/FI54217C/fi active
- 1971-01-28 CH CH125171A patent/CH557167A/xx not_active IP Right Cessation
- 1971-01-28 NL NL717101140A patent/NL148801B/xx not_active IP Right Cessation
- 1971-01-29 BR BR718/71A patent/BR7100718D0/pt unknown
- 1971-01-29 DK DK41971AA patent/DK127663B/da unknown
- 1971-01-30 IT IT19988/71A patent/IT983092B/it active
- 1971-01-30 ES ES387801A patent/ES387801A1/es not_active Expired
- 1971-02-01 SE SE7101222A patent/SE379920B/xx unknown
- 1971-02-01 NO NO00347/71*[A patent/NO129120B/no unknown
- 1971-02-01 FR FR7103224A patent/FR2112171B1/fr not_active Expired
- 1971-04-19 GB GB20725/71A patent/GB1274409A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0153995A3 (en) * | 1979-11-02 | 1985-12-27 | Karl Prof. Dr. Theurer | Process for the mild sterilization with respect to microorganisms and viruses of biologically active substances, especially organ tissues for therapeutic use |
| EP0069156A1 (de) * | 1981-07-02 | 1983-01-12 | Intermedicat GmbH | Verfahren zur Herstellung von Skleroproteintransplantaten mit erhöhter biologischer Stabilität |
| EP0334679A3 (en) * | 1988-03-25 | 1990-06-20 | National Research Development Corporation | Improvements in or relating to the inactivation of infectious agents |
| EP0424159A3 (en) * | 1989-10-19 | 1991-11-06 | Osteotech, Inc., | Aseptic processing of allograft bone and tissue |
| DE10217779A1 (de) * | 2002-04-18 | 2003-11-13 | Co Don Ag | Konservierte Gewebematrix eines Hohlorganes, insbesondere eines Blutgefäßes, Verfahren zur Herstellung und Verwendung dieser |
| US7175979B2 (en) | 2002-04-18 | 2007-02-13 | Co. Don Ag | Preserved tissue matrix of a hollow organ, particularly of a blood vessel, a method of producing same, and the use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ES387801A1 (es) | 1974-01-16 |
| SE379920B (enrdf_load_stackoverflow) | 1975-10-27 |
| NO129120B (enrdf_load_stackoverflow) | 1974-03-04 |
| CH557167A (de) | 1974-12-31 |
| FR2112171A1 (enrdf_load_stackoverflow) | 1972-06-16 |
| IT983092B (it) | 1974-10-31 |
| FI54217C (fi) | 1978-11-10 |
| FI54217B (fi) | 1978-07-31 |
| NL148801B (nl) | 1976-03-15 |
| DK127663B (da) | 1973-12-17 |
| BR7100718D0 (pt) | 1973-04-19 |
| AT298664B (de) | 1972-05-25 |
| GB1274409A (en) | 1972-05-17 |
| NL7101140A (enrdf_load_stackoverflow) | 1971-08-04 |
| FR2112171B1 (enrdf_load_stackoverflow) | 1974-04-12 |
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