DE19924892A1 - Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten - Google Patents

Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten

Info

Publication number
DE19924892A1
DE19924892A1 DE19924892A DE19924892A DE19924892A1 DE 19924892 A1 DE19924892 A1 DE 19924892A1 DE 19924892 A DE19924892 A DE 19924892A DE 19924892 A DE19924892 A DE 19924892A DE 19924892 A1 DE19924892 A1 DE 19924892A1
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
alkoxy
alkylthio
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19924892A
Other languages
German (de)
English (en)
Inventor
Wilhelm Amberg
Georg Kettschau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to DE19924892A priority Critical patent/DE19924892A1/de
Priority to CZ20014312A priority patent/CZ20014312A3/cs
Priority to KR1020017015482A priority patent/KR20020006049A/ko
Priority to MXPA01012284A priority patent/MXPA01012284A/es
Priority to JP2000621342A priority patent/JP2003500476A/ja
Priority to AU53959/00A priority patent/AU765345B2/en
Priority to CA002375666A priority patent/CA2375666A1/en
Priority to PCT/EP2000/004571 priority patent/WO2000073276A2/de
Priority to IL14680000A priority patent/IL146800A0/xx
Priority to EP00938660A priority patent/EP1181281A2/de
Priority to CN00809738A priority patent/CN1359376A/zh
Priority to TR2001/03475T priority patent/TR200103475T2/xx
Priority to BR0011105-8A priority patent/BR0011105A/pt
Priority to HU0201387A priority patent/HUP0201387A3/hu
Priority to PL00355112A priority patent/PL355112A1/xx
Priority to SK1755-2001A priority patent/SK17552001A3/sk
Priority to ARP000102660A priority patent/AR022047A1/es
Publication of DE19924892A1 publication Critical patent/DE19924892A1/de
Priority to NO20015762A priority patent/NO20015762L/no
Priority to BG106154A priority patent/BG106154A/xx
Priority to HK02108677.1A priority patent/HK1047102A1/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/30—Only oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19924892A 1999-06-01 1999-06-01 Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten Withdrawn DE19924892A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE19924892A DE19924892A1 (de) 1999-06-01 1999-06-01 Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
EP00938660A EP1181281A2 (de) 1999-06-01 2000-05-19 Carbonsäurederivate mit arylsubstituierten stickstoffheterocyclen, ihre herstellung und verwendung als endothelin-rezeptor-antagonisten
BR0011105-8A BR0011105A (pt) 1999-06-01 2000-05-19 Derivado de ácido carboxìlico, uso de um derivado combinação, e, preparação farmacêutica para uso oral, parenteral ou intraperitoneal
MXPA01012284A MXPA01012284A (es) 1999-06-01 2000-05-19 Derivados de acido carboxilico novedosos que contienen heterociclicos nitrogenados sustituidos con arilo, su produccion y su uso como antagonistas de los receptores para endotelina.
JP2000621342A JP2003500476A (ja) 1999-06-01 2000-05-19 アリール置換された窒素複素環を有する新規のカルボン酸誘導体、その製造およびエンドセリン受容体アンタゴニストとしてのその使用
AU53959/00A AU765345B2 (en) 1999-06-01 2000-05-19 Novel carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their production and their use as endothelin receptor antagonists
CA002375666A CA2375666A1 (en) 1999-06-01 2000-05-19 Novel carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their production and their use as endothelin receptor antagonists
PCT/EP2000/004571 WO2000073276A2 (de) 1999-06-01 2000-05-19 Carbonsäurederivate mit arylsubstituierten stickstoffheterocyclen, ihre herstellung und verwendung als endothelin-rezeptor-antagonisten
IL14680000A IL146800A0 (en) 1999-06-01 2000-05-19 Novel carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their preparation and use as endothelin receptor antagonists
CZ20014312A CZ20014312A3 (cs) 1999-06-01 2000-05-19 Nové deriváty karboxylových kyselin obsahující dusíkaté heterocyklické kruhy substituované arylovou skupinou, způsob jejich přípravy a použití jako antagonistů receptorů endothelinu
CN00809738A CN1359376A (zh) 1999-06-01 2000-05-19 新的具有芳香基取代的氮杂环的羧酸衍生物、其制备和作为内皮素受体拮抗剂的应用
TR2001/03475T TR200103475T2 (tr) 1999-06-01 2000-05-19 Aril ikameli nitrogen heterosaykıllı yeni karboksilik asit türevleri
KR1020017015482A KR20020006049A (ko) 1999-06-01 2000-05-19 아릴 치환된 질소 헤테로사이클을 포함하는 신규카르복실산 유도체, 그의 제조 방법 및 엔도텔린 수용체길항제로서의 그의 용도
HU0201387A HUP0201387A3 (en) 1999-06-01 2000-05-19 Carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their production and their use as endothelin receptor antagonists and pharmaceutical compositions containing them
PL00355112A PL355112A1 (en) 1999-06-01 2000-05-19 Carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, their production and their use as endothelin receptor antagonists
SK1755-2001A SK17552001A3 (sk) 1999-06-01 2000-05-19 Deriváty karboxylových kyselín s arylsubstituovanými dusíkatými heterocyklami, ich príprava a použitie ako antagonistov endotelínového receptora
ARP000102660A AR022047A1 (es) 1999-06-01 2000-05-30 Nuevos derivados de acidos carboxilicos con heterociclos de nitrogeno aril-sustituidos, su preparacion y utilizacion como antagonistas de los receptores deendotelina
NO20015762A NO20015762L (no) 1999-06-01 2001-11-26 Nye karboksylsyre-derivater med arylsubstituerte nitrogenheterocykler, deres fremstilling og anvendelse
BG106154A BG106154A (en) 1999-06-01 2001-11-27 Carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, methods for their production and their use as endothelin receptor antagonists
HK02108677.1A HK1047102A1 (zh) 1999-06-01 2002-11-29 新的具有芳香基取代的氮雜環的羧酸衍生物、其製備和作為內皮素受體拮抗劑的應用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19924892A DE19924892A1 (de) 1999-06-01 1999-06-01 Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten

Publications (1)

Publication Number Publication Date
DE19924892A1 true DE19924892A1 (de) 2000-12-07

Family

ID=7909761

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19924892A Withdrawn DE19924892A1 (de) 1999-06-01 1999-06-01 Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten

Country Status (20)

Country Link
EP (1) EP1181281A2 (no)
JP (1) JP2003500476A (no)
KR (1) KR20020006049A (no)
CN (1) CN1359376A (no)
AR (1) AR022047A1 (no)
AU (1) AU765345B2 (no)
BG (1) BG106154A (no)
BR (1) BR0011105A (no)
CA (1) CA2375666A1 (no)
CZ (1) CZ20014312A3 (no)
DE (1) DE19924892A1 (no)
HK (1) HK1047102A1 (no)
HU (1) HUP0201387A3 (no)
IL (1) IL146800A0 (no)
MX (1) MXPA01012284A (no)
NO (1) NO20015762L (no)
PL (1) PL355112A1 (no)
SK (1) SK17552001A3 (no)
TR (1) TR200103475T2 (no)
WO (1) WO2000073276A2 (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035196A1 (en) * 2009-04-22 2012-02-09 Kenji Negoro Carboxylic acid compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199901416T2 (xx) * 1996-12-18 1999-08-23 Basf Aktiengesellschaft Heterosiklik karbonikasit t�revleri.
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
BR9811631A (pt) * 1997-09-04 2000-09-26 Basf Ag Derivado de ácido carboxìlico e uso do mesmo
DE19806438A1 (de) * 1998-02-17 1999-08-19 Basf Ag Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
DE19809144A1 (de) * 1998-03-04 1999-09-09 Basf Ag Neue unsymmetrisch substituierte Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶LAMBDA¶/ET¶B¶-Rezeptorantagonisten
DE19836044A1 (de) * 1998-08-10 2000-02-17 Basf Ag Neue Carbonsäurederivate, die Ketoseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten

Also Published As

Publication number Publication date
IL146800A0 (en) 2002-07-25
HK1047102A1 (zh) 2003-02-07
SK17552001A3 (sk) 2002-08-06
AU5395900A (en) 2000-12-18
EP1181281A2 (de) 2002-02-27
BR0011105A (pt) 2002-03-05
CA2375666A1 (en) 2000-12-07
MXPA01012284A (es) 2002-07-30
CN1359376A (zh) 2002-07-17
AR022047A1 (es) 2002-09-04
HUP0201387A3 (en) 2004-12-28
NO20015762L (no) 2001-12-13
CZ20014312A3 (cs) 2003-02-12
WO2000073276A2 (de) 2000-12-07
WO2000073276A3 (de) 2001-05-10
TR200103475T2 (tr) 2002-04-22
JP2003500476A (ja) 2003-01-07
AU765345B2 (en) 2003-09-18
NO20015762D0 (no) 2001-11-26
HUP0201387A2 (en) 2002-08-28
PL355112A1 (en) 2004-04-05
KR20020006049A (ko) 2002-01-18
BG106154A (en) 2002-08-30

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