DE19747261A1 - Osmotisches Arzneimittelfreisetzungssystem - Google Patents
Osmotisches ArzneimittelfreisetzungssystemInfo
- Publication number
- DE19747261A1 DE19747261A1 DE19747261A DE19747261A DE19747261A1 DE 19747261 A1 DE19747261 A1 DE 19747261A1 DE 19747261 A DE19747261 A DE 19747261A DE 19747261 A DE19747261 A DE 19747261A DE 19747261 A1 DE19747261 A1 DE 19747261A1
- Authority
- DE
- Germany
- Prior art keywords
- weight
- core
- drug delivery
- delivery system
- osmotic drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 210000003608 fece Anatomy 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960000227 nisoldipine Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747261A DE19747261A1 (de) | 1997-10-25 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
| PCT/EP1998/006454 WO1999021535A1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| AT98955434T ATE211907T1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| ES98955434T ES2172239T3 (es) | 1997-10-25 | 1998-10-12 | Sistema osmotico de liberacion de farmacos. |
| US09/530,158 US6294201B1 (en) | 1997-10-12 | 1998-10-12 | Osmotic medicament releasing system |
| DE59802670T DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| JP2000517695A JP4295916B2 (ja) | 1997-10-25 | 1998-10-12 | 浸透圧性薬剤放出系 |
| CA002307018A CA2307018C (en) | 1997-10-25 | 1998-10-12 | Osmotic medicament releasing system |
| EP98955434A EP1024793B1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
| AU12278/99A AU1227899A (en) | 1997-10-25 | 1998-10-12 | Osmotic medicament releasing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19747261A DE19747261A1 (de) | 1997-10-25 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19747261A1 true DE19747261A1 (de) | 1999-04-29 |
Family
ID=7846661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19747261A Withdrawn DE19747261A1 (de) | 1997-10-12 | 1997-10-25 | Osmotisches Arzneimittelfreisetzungssystem |
| DE59802670T Expired - Lifetime DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59802670T Expired - Lifetime DE59802670D1 (de) | 1997-10-25 | 1998-10-12 | Osmotisches arzneimittelfreisetzungssystem |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6294201B1 (https=) |
| EP (1) | EP1024793B1 (https=) |
| JP (1) | JP4295916B2 (https=) |
| AT (1) | ATE211907T1 (https=) |
| AU (1) | AU1227899A (https=) |
| CA (1) | CA2307018C (https=) |
| DE (2) | DE19747261A1 (https=) |
| ES (1) | ES2172239T3 (https=) |
| WO (1) | WO1999021535A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002011702A3 (en) * | 2000-08-09 | 2002-11-28 | Pfizer Prod Inc | Hydrogel-driven drug dosage form |
| WO2003086365A1 (en) * | 2002-04-12 | 2003-10-23 | Zentiva, A.S. | Analgesical oral composition with controlled release of an opioid |
| WO2007003330A3 (de) * | 2005-07-06 | 2008-01-10 | Bayer Healthcare Ag | Pharmazeutische darreichungsformen enthaltend eine wirkstoffkombination von nifedipin und/oder nisoldipin und einem angiotensin-ii antagonisten |
| WO2010060564A1 (de) * | 2008-11-27 | 2010-06-03 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische darreichungsform enthaltend nifedipin oder nisoldipin und einen angiotensin-ii antagonisten und/oder ein diuretikum |
| WO2020020790A1 (de) * | 2018-07-24 | 2020-01-30 | Bayer Aktiengesellschaft | Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung |
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| DE19962924A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| DE60223695T2 (de) * | 2001-09-14 | 2008-10-30 | Scolr, Inc., Redmond | Aminosäure-modulierte dosierform mit verlängerter freisetzung |
| JP2005525299A (ja) * | 2001-09-14 | 2005-08-25 | スコラー インコーポレイテッド | アミノ酸調節性の長期放出投薬形態 |
| US6572889B1 (en) | 2002-03-07 | 2003-06-03 | Noveon Ip Holdings Corp. | Controlled release solid dosage carbamazepine formulations |
| WO2003096968A2 (en) * | 2002-05-15 | 2003-11-27 | Sun Pharmaceutical Industries Limited | Oral osmotic controlled drug delivery system |
| US20070077301A1 (en) * | 2002-12-23 | 2007-04-05 | Meyer Glenn A | Venlafaxine osmotic device formulation |
| US8293799B2 (en) * | 2003-12-29 | 2012-10-23 | Osmotica Keresleedelmo és Szolgáltató KFT | Osmotic device containing a venlafaxine salt and a salt having an ion in common |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| AR053986A1 (es) | 2004-12-03 | 2007-05-30 | Osmotica Pharmaceutical Argent | Dispositivo osmotico que contiene amantadina y una sal osmotica |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| JP2008539240A (ja) * | 2005-04-25 | 2008-11-13 | テバ ファーマシュ−ティカルズ ユーエスエー， インコーポレイテッド | 持続放出性処方物 |
| US20070071819A1 (en) * | 2005-05-30 | 2007-03-29 | Kesarwani Amit K | Multiple unit modified release compositions of carbamazepine and process for their preparation |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
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| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| JP5738516B2 (ja) | 2005-12-30 | 2015-06-24 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド | 心機能改善のためのニューレグリンの徐放 |
| DE102006051625A1 (de) * | 2006-11-02 | 2008-05-08 | Bayer Materialscience Ag | Kombinationstherapie substituierter Oxazolidinone |
| US8933197B2 (en) * | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
| CA2748314C (en) | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
| JP5839597B2 (ja) | 2009-06-08 | 2016-01-06 | アムニクス オペレーティング インコーポレイテッド | グルコース調節ポリペプチド並びにその作成及び使用方法 |
| SI2440241T1 (sl) | 2009-06-08 | 2017-11-30 | Amunix Operating Inc. | Polipeptidni rastni hormoni in postopki za njihovo izdelavo in uporabo |
| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
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| CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| CA2872542A1 (en) | 2012-05-07 | 2013-11-14 | Bayer Pharma Aktiengesellschaft | Process for manufacturing a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil |
| UY34856A (es) | 2012-07-03 | 2013-12-31 | Bayer Pharma AG | Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| IL319473A (en) | 2016-12-02 | 2025-05-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| US10905667B2 (en) | 2018-07-24 | 2021-02-02 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
| CA3107169A1 (en) * | 2018-07-24 | 2020-01-30 | Bayer Aktiengesellschaft | Pharmaceutical dosage form which can be administered orally and has modified release |
| JP2023531494A (ja) | 2020-06-25 | 2023-07-24 | アムニクス ファーマシューティカルズ， インコーポレイテッド | Ｈｅｒ－２標的化二重特異性組成物ならびにその作製および使用のための方法 |
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| DE2328409A1 (de) * | 1972-06-05 | 1973-12-20 | Alza Corp | Nach dem osmose-prinzip arbeitender wirkstoff-spender |
| EP0277092A1 (de) * | 1987-01-14 | 1988-08-03 | Ciba-Geigy Ag | Therapeutisches System für schwerlösliche Wirkstoffe |
| DE3833282A1 (de) * | 1987-10-02 | 1989-04-20 | Alza Corp | Osmotische dosierungsform zur verabreichung von isradipin |
| US4892741A (en) * | 1987-06-24 | 1990-01-09 | Bayer Aktiengesellschaft | Press coated DHP tablets |
| US4933186A (en) * | 1987-08-11 | 1990-06-12 | Bayer Aktiengesellschaft | Dihydropyridine depot formulation |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| US5240713A (en) * | 1991-09-27 | 1993-08-31 | Alza Corporation | Dual rate agent delivery device |
| WO1996040080A1 (en) * | 1995-06-07 | 1996-12-19 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
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| US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| DE19515972A1 (de) * | 1995-05-02 | 1996-11-07 | Bayer Ag | Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung |
-
1997
- 1997-10-25 DE DE19747261A patent/DE19747261A1/de not_active Withdrawn
-
1998
- 1998-10-12 DE DE59802670T patent/DE59802670D1/de not_active Expired - Lifetime
- 1998-10-12 CA CA002307018A patent/CA2307018C/en not_active Expired - Lifetime
- 1998-10-12 AU AU12278/99A patent/AU1227899A/en not_active Abandoned
- 1998-10-12 AT AT98955434T patent/ATE211907T1/de not_active IP Right Cessation
- 1998-10-12 EP EP98955434A patent/EP1024793B1/de not_active Expired - Lifetime
- 1998-10-12 US US09/530,158 patent/US6294201B1/en not_active Expired - Lifetime
- 1998-10-12 JP JP2000517695A patent/JP4295916B2/ja not_active Expired - Lifetime
- 1998-10-12 ES ES98955434T patent/ES2172239T3/es not_active Expired - Lifetime
- 1998-10-12 WO PCT/EP1998/006454 patent/WO1999021535A1/de not_active Ceased
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| DE2328409A1 (de) * | 1972-06-05 | 1973-12-20 | Alza Corp | Nach dem osmose-prinzip arbeitender wirkstoff-spender |
| EP0277092A1 (de) * | 1987-01-14 | 1988-08-03 | Ciba-Geigy Ag | Therapeutisches System für schwerlösliche Wirkstoffe |
| US4992278A (en) * | 1987-01-14 | 1991-02-12 | Ciba-Geigy Corporation | Therapeutic system for sparingly soluble active ingredients |
| US4892741A (en) * | 1987-06-24 | 1990-01-09 | Bayer Aktiengesellschaft | Press coated DHP tablets |
| US4933186A (en) * | 1987-08-11 | 1990-06-12 | Bayer Aktiengesellschaft | Dihydropyridine depot formulation |
| DE3833282A1 (de) * | 1987-10-02 | 1989-04-20 | Alza Corp | Osmotische dosierungsform zur verabreichung von isradipin |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| US5240713A (en) * | 1991-09-27 | 1993-08-31 | Alza Corporation | Dual rate agent delivery device |
| WO1996040080A1 (en) * | 1995-06-07 | 1996-12-19 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002011702A3 (en) * | 2000-08-09 | 2002-11-28 | Pfizer Prod Inc | Hydrogel-driven drug dosage form |
| WO2003086365A1 (en) * | 2002-04-12 | 2003-10-23 | Zentiva, A.S. | Analgesical oral composition with controlled release of an opioid |
| WO2007003330A3 (de) * | 2005-07-06 | 2008-01-10 | Bayer Healthcare Ag | Pharmazeutische darreichungsformen enthaltend eine wirkstoffkombination von nifedipin und/oder nisoldipin und einem angiotensin-ii antagonisten |
| US8153160B2 (en) | 2005-07-06 | 2012-04-10 | Bayer Pharma Aktiengesellschaft | Pharmaceutical dosage forms comprising an active ingredient combination of nifedipine and/or nisoldipine and an angiotensin II antagonist |
| WO2010060564A1 (de) * | 2008-11-27 | 2010-06-03 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische darreichungsform enthaltend nifedipin oder nisoldipin und einen angiotensin-ii antagonisten und/oder ein diuretikum |
| EA025485B1 (ru) * | 2008-11-27 | 2016-12-30 | Байер Интеллектуэль Проперти Гмбх | Фармацевтические формы применения, содержащие нифедипин или низолдипин и антагонист ангиотензина-ii и/или диуретик |
| US9993432B2 (en) | 2008-11-27 | 2018-06-12 | Bayer Intellectual Property Gmbh | Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic |
| WO2020020790A1 (de) * | 2018-07-24 | 2020-01-30 | Bayer Aktiengesellschaft | Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung |
Also Published As
| Publication number | Publication date |
|---|---|
| DE59802670D1 (de) | 2002-02-21 |
| EP1024793B1 (de) | 2002-01-16 |
| WO1999021535A1 (de) | 1999-05-06 |
| CA2307018C (en) | 2006-12-12 |
| ES2172239T3 (es) | 2002-09-16 |
| US6294201B1 (en) | 2001-09-25 |
| AU1227899A (en) | 1999-05-17 |
| EP1024793A1 (de) | 2000-08-09 |
| CA2307018A1 (en) | 1999-05-06 |
| JP2001520985A (ja) | 2001-11-06 |
| ATE211907T1 (de) | 2002-02-15 |
| JP4295916B2 (ja) | 2009-07-15 |
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