DE19703816A1 - Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale Anwendung - Google Patents
Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale AnwendungInfo
- Publication number
- DE19703816A1 DE19703816A1 DE19703816A DE19703816A DE19703816A1 DE 19703816 A1 DE19703816 A1 DE 19703816A1 DE 19703816 A DE19703816 A DE 19703816A DE 19703816 A DE19703816 A DE 19703816A DE 19703816 A1 DE19703816 A1 DE 19703816A1
- Authority
- DE
- Germany
- Prior art keywords
- infusion
- concentration
- solutions
- additives
- injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19703816A DE19703816A1 (de) | 1996-01-25 | 1997-01-27 | Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale Anwendung |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19604095 | 1996-01-25 | ||
| DE19703816A DE19703816A1 (de) | 1996-01-25 | 1997-01-27 | Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19703816A1 true DE19703816A1 (de) | 1997-08-07 |
Family
ID=7784538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19703816A Withdrawn DE19703816A1 (de) | 1996-01-25 | 1997-01-27 | Verbesserte konzentrierte Injektions- und Infusionslösungen für die intravasale Anwendung |
| DE59710863T Expired - Fee Related DE59710863D1 (de) | 1996-01-25 | 1997-01-27 | Verbesserte kontrastmittenlösungen für die intravasale anwendung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59710863T Expired - Fee Related DE59710863D1 (de) | 1996-01-25 | 1997-01-27 | Verbesserte kontrastmittenlösungen für die intravasale anwendung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6638913B1 (enExample) |
| EP (1) | EP0876140B1 (enExample) |
| JP (1) | JP2000505789A (enExample) |
| KR (1) | KR100505772B1 (enExample) |
| CN (1) | CN1209751A (enExample) |
| AT (1) | ATE251893T1 (enExample) |
| AU (1) | AU2150497A (enExample) |
| BG (1) | BG62913B1 (enExample) |
| BR (1) | BR9707081A (enExample) |
| CA (1) | CA2244209C (enExample) |
| CZ (1) | CZ234898A3 (enExample) |
| DE (2) | DE19703816A1 (enExample) |
| DK (1) | DK0876140T3 (enExample) |
| ES (1) | ES2208884T3 (enExample) |
| HU (1) | HUP9901355A3 (enExample) |
| IL (1) | IL124676A0 (enExample) |
| NO (1) | NO983438L (enExample) |
| PL (1) | PL328199A1 (enExample) |
| PT (1) | PT876140E (enExample) |
| SK (1) | SK101398A3 (enExample) |
| WO (1) | WO1997026862A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1897535A1 (en) * | 2006-08-30 | 2008-03-12 | Dirinco AG | Substitution fluid for haemofiltration |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| AU1297899A (en) * | 1997-10-31 | 1999-05-24 | Walter Reed Army Institute Of Research | Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules |
| EE04548B1 (et) | 1998-04-01 | 2005-10-17 | Nortran Pharmaceuticals Inc. | Aminotskloheksleeterhendid, nende kompositsioonid ja nende kasutamine |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| ES2332402T5 (es) | 2000-10-12 | 2018-05-14 | Genentech, Inc. | Formulaciones de proteína concentradas de viscosidad reducida |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| US20020169112A1 (en) * | 2001-05-08 | 2002-11-14 | Luc Montagnier | Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections |
| DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
| SI1560812T1 (sl) | 2003-05-02 | 2006-10-31 | Cardiome Pharma Corp | Aminocikloheksil etrske spojine in njihove uporabe |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| EP1729815A2 (en) | 2004-04-01 | 2006-12-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| JP5583325B2 (ja) | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
| US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
| US20090239894A1 (en) * | 2008-03-20 | 2009-09-24 | Bjorn Schurad | Stabilized aqueous solutions of ergoline compounds |
| SG174258A1 (en) | 2009-03-06 | 2011-10-28 | Genentech Inc | Antibody formulation |
| US10634741B2 (en) | 2009-12-04 | 2020-04-28 | Endomagnetics Ltd. | Magnetic probe apparatus |
| US9427186B2 (en) * | 2009-12-04 | 2016-08-30 | Endomagnetics Ltd. | Magnetic probe apparatus |
| AU2011223710B2 (en) | 2010-03-01 | 2016-04-14 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) |
| CN102319258B (zh) * | 2011-08-04 | 2012-10-31 | 山西诺成制药有限公司 | 一种5%葡萄糖置换液及其制备方法 |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| JP6351639B2 (ja) | 2013-03-11 | 2018-07-04 | エンドマグネティクス リミテッド | リンパ節検出のための低浸透圧溶液 |
| US9239314B2 (en) | 2013-03-13 | 2016-01-19 | Endomagnetics Ltd. | Magnetic detector |
| US9234877B2 (en) | 2013-03-13 | 2016-01-12 | Endomagnetics Ltd. | Magnetic detector |
| SG11201507964TA (en) * | 2013-03-27 | 2015-10-29 | Ge Healthcare As | Method and reagent for preparing a diagnostic composition |
| EP3782575A1 (en) | 2015-06-04 | 2021-02-24 | Endomagnetics Ltd. | Marker materials and forms for magnetic marker localization (mml) |
| EP3928765A1 (en) * | 2018-04-16 | 2021-12-29 | Merck Patent GmbH | Viscosity reduction of highly concentrated protein formulations |
| CN110327292A (zh) * | 2019-08-11 | 2019-10-15 | 天津乾丰瑞科技有限公司 | 一种盐酸法舒地尔注射制剂及其制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2039223A1 (de) * | 1969-08-06 | 1971-02-18 | Beecham Group Ltd | Desensibilisierungsmittel gegen Allergien und Verfahren zu seiner Herstellung |
| WO1982003773A1 (en) * | 1981-04-27 | 1982-11-11 | Baxter Travenol Lab | Dialysis solution containing glucose,amino acids & insulin |
| US4663166A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vivo use thereof |
| WO1990011094A1 (en) * | 1989-03-17 | 1990-10-04 | Nycomed As | Contrast media |
| DE4135193C1 (enExample) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| WO1994014478A1 (en) * | 1992-12-24 | 1994-07-07 | Bracco S.P.A. | Aqueous injectable formulations useful for radio-diagnosis comprising iodinated aromatic compounds used as x-ray contrast media |
| WO1995026331A1 (es) * | 1994-03-25 | 1995-10-05 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones farmaceuticas que los contienen |
| DE4446694A1 (de) * | 1994-12-09 | 1996-06-13 | Schering Ag | Verwendung von Zusätzen zu Kontrastmitteln zur Verbesserung der Bildgebung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL183121C (nl) * | 1978-07-04 | 1988-08-01 | Nyegaard & Co As | Werkwijze voor het bereiden van een steriele, injecteerbare, fysiologisch aanvaardbare oplossing van een niet-ionogeen roentgencontrastmiddel. |
| IE60901B1 (en) * | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| JPH0341033A (ja) * | 1989-07-07 | 1991-02-21 | Kyowa Hakko Kogyo Co Ltd | 安定なモチリン類含有製剤 |
| DE59007142D1 (de) | 1990-01-18 | 1994-10-20 | Cereria Amos Sgarbi Spa | Grablicht. |
| GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
-
1997
- 1997-01-27 EP EP97914098A patent/EP0876140B1/de not_active Expired - Lifetime
- 1997-01-27 JP JP9526441A patent/JP2000505789A/ja not_active Ceased
- 1997-01-27 IL IL12467697A patent/IL124676A0/xx unknown
- 1997-01-27 DE DE19703816A patent/DE19703816A1/de not_active Withdrawn
- 1997-01-27 ES ES97914098T patent/ES2208884T3/es not_active Expired - Lifetime
- 1997-01-27 KR KR10-1998-0705697A patent/KR100505772B1/ko not_active Expired - Fee Related
- 1997-01-27 PT PT97914098T patent/PT876140E/pt unknown
- 1997-01-27 DE DE59710863T patent/DE59710863D1/de not_active Expired - Fee Related
- 1997-01-27 CZ CZ982348A patent/CZ234898A3/cs unknown
- 1997-01-27 SK SK1013-98A patent/SK101398A3/sk unknown
- 1997-01-27 BR BR9707081A patent/BR9707081A/pt not_active IP Right Cessation
- 1997-01-27 DK DK97914098T patent/DK0876140T3/da active
- 1997-01-27 AU AU21504/97A patent/AU2150497A/en not_active Abandoned
- 1997-01-27 PL PL97328199A patent/PL328199A1/xx unknown
- 1997-01-27 CN CN97191871A patent/CN1209751A/zh active Pending
- 1997-01-27 AT AT97914098T patent/ATE251893T1/de not_active IP Right Cessation
- 1997-01-27 WO PCT/DE1997/000170 patent/WO1997026862A2/de not_active Ceased
- 1997-01-27 HU HU9901355A patent/HUP9901355A3/hu unknown
- 1997-01-27 CA CA002244209A patent/CA2244209C/en not_active Expired - Fee Related
-
1998
- 1998-07-21 BG BG102644A patent/BG62913B1/bg unknown
- 1998-07-24 NO NO983438A patent/NO983438L/no not_active Application Discontinuation
-
2000
- 2000-02-14 US US09/504,108 patent/US6638913B1/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2039223A1 (de) * | 1969-08-06 | 1971-02-18 | Beecham Group Ltd | Desensibilisierungsmittel gegen Allergien und Verfahren zu seiner Herstellung |
| WO1982003773A1 (en) * | 1981-04-27 | 1982-11-11 | Baxter Travenol Lab | Dialysis solution containing glucose,amino acids & insulin |
| US4663166A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vivo use thereof |
| EP0185759B1 (en) * | 1984-06-22 | 1992-11-19 | VEECH, Richard L. | Electrolyte solutions and (in vivo) use thereof |
| WO1990011094A1 (en) * | 1989-03-17 | 1990-10-04 | Nycomed As | Contrast media |
| DE4135193C1 (enExample) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| WO1994014478A1 (en) * | 1992-12-24 | 1994-07-07 | Bracco S.P.A. | Aqueous injectable formulations useful for radio-diagnosis comprising iodinated aromatic compounds used as x-ray contrast media |
| WO1995026331A1 (es) * | 1994-03-25 | 1995-10-05 | Centro Investigacion Justesa Imagen, S.A. | Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones farmaceuticas que los contienen |
| DE4446694A1 (de) * | 1994-12-09 | 1996-06-13 | Schering Ag | Verwendung von Zusätzen zu Kontrastmitteln zur Verbesserung der Bildgebung |
Non-Patent Citations (3)
| Title |
|---|
| D.L.Miller, Current Patterns of Use, Radiology 172(1989) S.1007-1001 * |
| D.M.A.Jackson and P.Dawson, Clinical Radiology 50 (1995) S.699-704 * |
| S.H.Kim et al., Investigative Radiology 27 (1992) S.45-49 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1897535A1 (en) * | 2006-08-30 | 2008-03-12 | Dirinco AG | Substitution fluid for haemofiltration |
Also Published As
| Publication number | Publication date |
|---|---|
| PT876140E (pt) | 2004-02-27 |
| PL328199A1 (en) | 1999-01-18 |
| JP2000505789A (ja) | 2000-05-16 |
| KR100505772B1 (ko) | 2005-10-25 |
| BG62913B1 (bg) | 2000-11-30 |
| HUP9901355A2 (hu) | 1999-08-30 |
| EP0876140B1 (de) | 2003-10-15 |
| DK0876140T3 (da) | 2003-12-15 |
| ES2208884T3 (es) | 2004-06-16 |
| AU2150497A (en) | 1997-08-20 |
| NO983438L (no) | 1998-09-18 |
| CA2244209C (en) | 2007-10-23 |
| BG102644A (en) | 1999-06-30 |
| ATE251893T1 (de) | 2003-11-15 |
| US6638913B1 (en) | 2003-10-28 |
| KR19990081979A (ko) | 1999-11-15 |
| CA2244209A1 (en) | 1997-07-31 |
| CN1209751A (zh) | 1999-03-03 |
| IL124676A0 (en) | 1998-12-06 |
| DE59710863D1 (de) | 2003-11-20 |
| WO1997026862A3 (de) | 1997-10-23 |
| CZ234898A3 (cs) | 1998-11-11 |
| EP0876140A2 (de) | 1998-11-11 |
| WO1997026862A2 (de) | 1997-07-31 |
| HUP9901355A3 (en) | 2000-06-28 |
| BR9707081A (pt) | 1999-05-25 |
| NO983438D0 (no) | 1998-07-24 |
| SK101398A3 (en) | 1998-12-02 |
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