DE1922702A1 - Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen - Google Patents

Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen

Info

Publication number
DE1922702A1
DE1922702A1 DE19691922702 DE1922702A DE1922702A1 DE 1922702 A1 DE1922702 A1 DE 1922702A1 DE 19691922702 DE19691922702 DE 19691922702 DE 1922702 A DE1922702 A DE 1922702A DE 1922702 A1 DE1922702 A1 DE 1922702A1
Authority
DE
Germany
Prior art keywords
methanol
carbon atoms
dihydro
triazin
glycosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691922702
Other languages
German (de)
English (en)
Inventor
Alois Piskala
Frantisek Sorm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Publication of DE1922702A1 publication Critical patent/DE1922702A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19691922702 1968-05-08 1969-05-03 Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen Pending DE1922702A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS339968 1968-05-08

Publications (1)

Publication Number Publication Date
DE1922702A1 true DE1922702A1 (de) 1969-11-20

Family

ID=5373920

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691922702 Pending DE1922702A1 (de) 1968-05-08 1969-05-03 Verfahren zur Herstellung von 1-Glykosyl-5-azacytosinen

Country Status (12)

Country Link
JP (1) JPS4916435B1 (US08058424-20111115-C00008.png)
AT (1) AT306930B (US08058424-20111115-C00008.png)
BE (1) BE732268A (US08058424-20111115-C00008.png)
BR (1) BR6908600D0 (US08058424-20111115-C00008.png)
CA (1) CA921904A (US08058424-20111115-C00008.png)
CH (1) CH527207A (US08058424-20111115-C00008.png)
DE (1) DE1922702A1 (US08058424-20111115-C00008.png)
ES (1) ES366910A1 (US08058424-20111115-C00008.png)
FR (1) FR2008048A1 (US08058424-20111115-C00008.png)
GB (1) GB1227691A (US08058424-20111115-C00008.png)
IT (1) IT1037009B (US08058424-20111115-C00008.png)
NL (1) NL6906909A (US08058424-20111115-C00008.png)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US7135464B2 (en) 2002-06-05 2006-11-14 Supergen, Inc. Method of administering decitabine
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7276228B2 (en) 2001-04-24 2007-10-02 Supergen, Inc. Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US8212021B2 (en) 2008-08-08 2012-07-03 Scinopharm Taiwan, Ltd. Process for making 5-azacytosine nucleosides and their derivatives
US9381207B2 (en) 2011-08-30 2016-07-05 Astex Pharmaceuticals, Inc. Drug formulations
WO2017090275A1 (ja) 2015-11-27 2017-06-01 大原薬品工業株式会社 ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル
WO2017183217A1 (ja) 2016-04-21 2017-10-26 大原薬品工業株式会社 ５－アザシチジン類の糖部シリルエーテル誘導体
US9901641B2 (en) 2016-04-21 2018-02-27 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine
US10227374B2 (en) 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
US10485764B2 (en) 2015-07-02 2019-11-26 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
US10519190B2 (en) 2017-08-03 2019-12-31 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
SG193206A1 (en) 2008-05-15 2013-09-30 Celgene Corp Oral formulations of cytidine analogs and methods of use thereof

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276228B2 (en) 2001-04-24 2007-10-02 Supergen, Inc. Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
US7135464B2 (en) 2002-06-05 2006-11-14 Supergen, Inc. Method of administering decitabine
US7144873B2 (en) 2002-06-05 2006-12-05 Supergen, Inc. Kit for delivering decitabine in vivo
US8614313B2 (en) 2003-03-17 2013-12-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US7078518B2 (en) 2003-03-17 2006-07-18 Pharmion Corporation Forms of 5-Azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US9192620B2 (en) 2003-03-17 2015-11-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US8975392B2 (en) 2003-03-17 2015-03-10 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7700770B2 (en) 2003-03-17 2010-04-20 Celgene Corporation Methods for isolating crystalline form I of 5-azacytidine
US8779117B2 (en) 2003-03-17 2014-07-15 Pharmion Llc Pharmaceutical compositions comprising 5-azacytidine monohydrate
US7772199B2 (en) 2003-03-17 2010-08-10 Celgene Corporation Forms of 5-azacytidine
US7858774B2 (en) 2003-03-17 2010-12-28 Pharmion Llc Synthesis of 5-azacytidine
US8058424B2 (en) 2003-03-17 2011-11-15 Pharmion Llc Synthesis of 5-azacytidine
US8211862B2 (en) 2003-03-17 2012-07-03 Pharmion Llc Pharmaceutical compositions comprising crystal forms of 5-azacytidine
US8513406B2 (en) 2003-03-17 2013-08-20 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8481715B2 (en) 2003-03-17 2013-07-09 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US8461123B2 (en) 2005-09-29 2013-06-11 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US10933079B2 (en) 2005-09-29 2021-03-02 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9358248B2 (en) 2005-09-29 2016-06-07 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US9480698B2 (en) 2005-09-29 2016-11-01 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US10456415B2 (en) 2005-09-29 2019-10-29 Astex Pharmaceuticals, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8212021B2 (en) 2008-08-08 2012-07-03 Scinopharm Taiwan, Ltd. Process for making 5-azacytosine nucleosides and their derivatives
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine
US10517886B2 (en) 2011-08-30 2019-12-31 Astex Pharmaceuticals, Inc. Drug formulations
US9913856B2 (en) 2011-08-30 2018-03-13 Astex Pharmaceuticals, Inc. Drug formulations
US9381207B2 (en) 2011-08-30 2016-07-05 Astex Pharmaceuticals, Inc. Drug formulations
US10485764B2 (en) 2015-07-02 2019-11-26 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
KR20180088664A (ko) 2015-11-27 2018-08-06 오하라 야꾸힝 고교 가부시키가이샤 5-아자사이티딘 또는 그 2'-데옥시체의 5’-위치 인산 디벤질 에스테르
WO2017090275A1 (ja) 2015-11-27 2017-06-01 大原薬品工業株式会社 ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル
US9670238B1 (en) 2015-11-27 2017-06-06 Ohara Pharmaceutical Co., Ltd. 5′-dibenzyl phosphates of 5-azacytidine or 2′-deoxy-5-azacytidine
US9901641B2 (en) 2016-04-21 2018-02-27 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
WO2017183217A1 (ja) 2016-04-21 2017-10-26 大原薬品工業株式会社 ５－アザシチジン類の糖部シリルエーテル誘導体
US10227374B2 (en) 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
EP3543249A1 (en) 2016-04-21 2019-09-25 Ohara Pharmaceutical Co., Ltd. Sugar moiety silyl ether derivative of 5-azacytidine
US10519190B2 (en) 2017-08-03 2019-12-31 Otsuka Pharmaceutical Co., Ltd. Drug compound and purification methods thereof

Also Published As

Publication number Publication date
GB1227691A (US08058424-20111115-C00008.png) 1971-04-07
IT1037009B (it) 1979-11-10
JPS4916435B1 (US08058424-20111115-C00008.png) 1974-04-22
AT306930B (de) 1973-04-25
NL6906909A (US08058424-20111115-C00008.png) 1969-11-11
BE732268A (US08058424-20111115-C00008.png) 1969-10-01
ES366910A1 (es) 1971-03-16
FR2008048A1 (US08058424-20111115-C00008.png) 1970-01-16
CH527207A (de) 1972-08-31
BR6908600D0 (pt) 1973-02-22
CA921904A (en) 1973-02-27

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