DE1807303A1 - Partiell acylierte L-Asparaginasen - Google Patents
Partiell acylierte L-AsparaginasenInfo
- Publication number
- DE1807303A1 DE1807303A1 DE19681807303 DE1807303A DE1807303A1 DE 1807303 A1 DE1807303 A1 DE 1807303A1 DE 19681807303 DE19681807303 DE 19681807303 DE 1807303 A DE1807303 A DE 1807303A DE 1807303 A1 DE1807303 A1 DE 1807303A1
- Authority
- DE
- Germany
- Prior art keywords
- asparaginases
- partially acylated
- asparaginase
- acylated
- partially
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 title claims description 27
- 108010024976 Asparaginase Proteins 0.000 title claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- VMZCDNSFRSVYKQ-UHFFFAOYSA-N 2-phenylacetyl chloride Chemical compound ClC(=O)CC1=CC=CC=C1 VMZCDNSFRSVYKQ-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000511343 Chondrostoma nasus Species 0.000 description 1
- 241000588698 Erwinia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical class [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- -1 carboxylic acid halides Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002561 ketenes Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681807303 DE1807303A1 (de) | 1968-11-06 | 1968-11-06 | Partiell acylierte L-Asparaginasen |
| IL6933258A IL33258A0 (en) | 1968-11-06 | 1969-10-27 | Partially acylated l-asparaginases and its preparation |
| LU59710D LU59710A1 (enrdf_load_stackoverflow) | 1968-11-06 | 1969-10-28 | |
| AT1018969A AT289689B (de) | 1968-11-06 | 1969-10-29 | Verfahren zur Herstellung neuer, partiell acylierter L-Asparaginasen |
| NL6916609A NL6916609A (enrdf_load_stackoverflow) | 1968-11-06 | 1969-11-04 | |
| GB1264896D GB1264896A (enrdf_load_stackoverflow) | 1968-11-06 | 1969-11-05 | |
| BE741345D BE741345A (enrdf_load_stackoverflow) | 1968-11-06 | 1969-11-06 | |
| FR696938251A FR2024806B1 (enrdf_load_stackoverflow) | 1968-11-06 | 1969-11-06 | |
| ES373232A ES373232A1 (es) | 1968-11-06 | 1969-11-06 | Procedimiento para la preparacion de 1-asparaginasas par- cialmente aciladas. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681807303 DE1807303A1 (de) | 1968-11-06 | 1968-11-06 | Partiell acylierte L-Asparaginasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1807303A1 true DE1807303A1 (de) | 1970-06-04 |
Family
ID=5712520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19681807303 Pending DE1807303A1 (de) | 1968-11-06 | 1968-11-06 | Partiell acylierte L-Asparaginasen |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT289689B (enrdf_load_stackoverflow) |
| BE (1) | BE741345A (enrdf_load_stackoverflow) |
| DE (1) | DE1807303A1 (enrdf_load_stackoverflow) |
| ES (1) | ES373232A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2024806B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1264896A (enrdf_load_stackoverflow) |
| IL (1) | IL33258A0 (enrdf_load_stackoverflow) |
| LU (1) | LU59710A1 (enrdf_load_stackoverflow) |
| NL (1) | NL6916609A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1219706A3 (en) * | 1997-06-09 | 2003-11-19 | Childrens Hospital Of Los Angeles | Production processes for recombinant wolinella succinogenes asparaginase |
| ATE265226T1 (de) * | 1997-06-09 | 2004-05-15 | Los Angeles Childrens Hospital | Verwendung von wolinella succinogenes asparaginase zur behandlung von asparagin- abhängiger krankheiten |
| US6991788B1 (en) | 1997-06-09 | 2006-01-31 | Childrens Hospital Los Angeles | Utilization of wolinella succinogenes asparaginase to treat diseases associated with asparagine dependence |
-
1968
- 1968-11-06 DE DE19681807303 patent/DE1807303A1/de active Pending
-
1969
- 1969-10-27 IL IL6933258A patent/IL33258A0/xx unknown
- 1969-10-28 LU LU59710D patent/LU59710A1/xx unknown
- 1969-10-29 AT AT1018969A patent/AT289689B/de active
- 1969-11-04 NL NL6916609A patent/NL6916609A/xx unknown
- 1969-11-05 GB GB1264896D patent/GB1264896A/en not_active Expired
- 1969-11-06 ES ES373232A patent/ES373232A1/es not_active Expired
- 1969-11-06 FR FR696938251A patent/FR2024806B1/fr not_active Expired
- 1969-11-06 BE BE741345D patent/BE741345A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE741345A (enrdf_load_stackoverflow) | 1970-05-06 |
| IL33258A0 (en) | 1970-03-22 |
| NL6916609A (enrdf_load_stackoverflow) | 1970-05-11 |
| FR2024806B1 (enrdf_load_stackoverflow) | 1973-04-06 |
| GB1264896A (enrdf_load_stackoverflow) | 1972-02-23 |
| ES373232A1 (es) | 1971-12-16 |
| FR2024806A1 (enrdf_load_stackoverflow) | 1970-09-04 |
| AT289689B (de) | 1971-05-10 |
| LU59710A1 (enrdf_load_stackoverflow) | 1970-01-12 |
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