DE1695958A1 - Verfahren zur Herstellung von 1,2-Dihydropyrimidinen - Google Patents

Verfahren zur Herstellung von 1,2-Dihydropyrimidinen

Info

Publication number
DE1695958A1
DE1695958A1 DE19661695958 DE1695958A DE1695958A1 DE 1695958 A1 DE1695958 A1 DE 1695958A1 DE 19661695958 DE19661695958 DE 19661695958 DE 1695958 A DE1695958 A DE 1695958A DE 1695958 A1 DE1695958 A1 DE 1695958A1
Authority
DE
Germany
Prior art keywords
hydrogen
radicals
lower alkyl
radical
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19661695958
Other languages
German (de)
English (en)
Inventor
Anthony William Crawford
Ursprung Joseph John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27414311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE1695958(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE1695958A1 publication Critical patent/DE1695958A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19661695958 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydropyrimidinen Pending DE1695958A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50599365A 1965-11-01 1965-11-01
US505989A US3382247A (en) 1965-11-01 1965-11-01 6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines
US505992A US3382248A (en) 1965-11-01 1965-11-01 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines

Publications (1)

Publication Number Publication Date
DE1695958A1 true DE1695958A1 (de) 1971-05-19

Family

ID=27414311

Family Applications (6)

Application Number Title Priority Date Filing Date
DE19661695939 Pending DE1695939A1 (de) 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydro-1-hydroxypyrimidinen
DE19661795837 Pending DE1795837A1 (de) 1965-11-01 1966-10-28 Verfahren zur herstellung von 1,2-dihydro-1-hydroxy-pyrimidinen
DE1695959A Expired DE1695959C3 (de) 1965-11-01 1966-10-28 6-Amino-1,2-dihydro-1 -hydroxy-2imino-4-phenoxy-pyrimidine
DE19661695940 Pending DE1695940A1 (de) 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydro-1-hydroxy-pyrimidinen
DE19661695958 Pending DE1695958A1 (de) 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydropyrimidinen
DE1620649A Expired DE1620649C3 (de) 1965-11-01 1966-10-28 U-Dmydro-l-hydroxy-2-iinino,4,6diamino-pyrimidine sowie Verfahren zu deren Herstellung

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DE19661695939 Pending DE1695939A1 (de) 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydro-1-hydroxypyrimidinen
DE19661795837 Pending DE1795837A1 (de) 1965-11-01 1966-10-28 Verfahren zur herstellung von 1,2-dihydro-1-hydroxy-pyrimidinen
DE1695959A Expired DE1695959C3 (de) 1965-11-01 1966-10-28 6-Amino-1,2-dihydro-1 -hydroxy-2imino-4-phenoxy-pyrimidine
DE19661695940 Pending DE1695940A1 (de) 1965-11-01 1966-10-28 Verfahren zur Herstellung von 1,2-Dihydro-1-hydroxy-pyrimidinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1620649A Expired DE1620649C3 (de) 1965-11-01 1966-10-28 U-Dmydro-l-hydroxy-2-iinino,4,6diamino-pyrimidine sowie Verfahren zu deren Herstellung

Country Status (7)

Country Link
US (3) US3382247A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH495361A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (6) DE1695939A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (2) FR1510017A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB1167735A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL26686A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL154508B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
CN111065385A (zh) 2017-06-22 2020-04-24 希普拉有限公司 癌症的治疗方法
US10428502B2 (en) 2017-09-26 2019-10-01 Peter M. Parker Flush mechanism for toilets
KR102111321B1 (ko) 2017-11-27 2020-05-18 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 유효성분으로 포함하는 탈모 예방 및 발모 촉진용 약학 조성물
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JP2021521264A (ja) 2018-02-28 2021-08-26 マザーズ ファーマシューティカル カンパニー リミテッド 脱毛治療及び発毛促進用組成物
KR20210119954A (ko) 2018-11-21 2021-10-06 케이스 웨스턴 리저브 유니버시티 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
KR102265431B1 (ko) 2019-08-20 2021-06-15 주식회사 케어젠 발모 촉진 활성을 갖는 펩타이드 및 이의 용도
KR102265433B1 (ko) 2019-08-20 2021-06-15 주식회사 케어젠 발모 촉진 활성을 갖는 펩타이드 및 이의 용도
KR20200056363A (ko) 2020-05-08 2020-05-22 주식회사 파이안바이오테크놀로지 분리된 미토콘드리아를 유효성분으로 포함하는 탈모 예방 및 발모 촉진용 약학 조성물
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NL154508B (nl) 1977-09-15
NL6615385A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1967-05-02
DE1695959B2 (de) 1977-07-14
DE1620649B2 (de) 1978-11-09
US3382247A (en) 1968-05-07
FR1510017A (fr) 1968-01-19
DE1695939A1 (de) 1971-05-13
FR6032M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1968-05-13
GB1167736A (en) 1969-10-22
IL26686A (en) 1971-01-28
DE1620649C3 (de) 1979-07-19
CH495361A (de) 1970-08-31
DE1620649A1 (de) 1970-05-14
DE1695940A1 (de) 1971-05-06
DE1695959C3 (de) 1978-03-09
US3382248A (en) 1968-05-07
DE1695959A1 (de) 1971-05-19
DE1795837A1 (de) 1976-05-13
US3461461A (en) 1969-08-12
GB1167735A (en) 1969-10-22

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