DE1695545C3 - Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Wurmerkrankungen - Google Patents

Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Wurmerkrankungen

Info

Publication number
DE1695545C3
DE1695545C3 DE1695545A DEM0077137A DE1695545C3 DE 1695545 C3 DE1695545 C3 DE 1695545C3 DE 1695545 A DE1695545 A DE 1695545A DE M0077137 A DEM0077137 A DE M0077137A DE 1695545 C3 DE1695545 C3 DE 1695545C3
Authority
DE
Germany
Prior art keywords
benzimidazole
thiazolyl
acid
water
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1695545A
Other languages
German (de)
English (en)
Other versions
DE1695545A1 (de
DE1695545B2 (de
Inventor
H Fisher
D R Hoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1695545A1 publication Critical patent/DE1695545A1/de
Publication of DE1695545B2 publication Critical patent/DE1695545B2/de
Application granted granted Critical
Publication of DE1695545C3 publication Critical patent/DE1695545C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
    • E21D11/00—Lining tunnels, galleries or other underground cavities, e.g. large underground chambers; Linings therefor; Making such linings in situ, e.g. by assembling
    • E21D11/14—Lining predominantly with metal
    • E21D11/28—Longitudinal struts, i.e. longitudinal connections between adjoining arches

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mining & Mineral Resources (AREA)
  • Epidemiology (AREA)
  • Civil Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Architecture (AREA)
  • Animal Behavior & Ethology (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Geology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE1695545A 1967-02-03 1968-02-02 Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Wurmerkrankungen Expired DE1695545C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61374667A 1967-02-03 1967-02-03
US69649668A 1968-01-09 1968-01-09

Publications (3)

Publication Number Publication Date
DE1695545A1 DE1695545A1 (de) 1971-05-06
DE1695545B2 DE1695545B2 (de) 1978-08-31
DE1695545C3 true DE1695545C3 (de) 1979-05-03

Family

ID=27087090

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1695545A Expired DE1695545C3 (de) 1967-02-03 1968-02-02 Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Wurmerkrankungen
DE1795711A Expired DE1795711C3 (de) 1967-02-03 1968-02-02 Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie diese enthaltende anthelminthische Zusammensetzungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1795711A Expired DE1795711C3 (de) 1967-02-03 1968-02-02 Substituierte Benzimidazole, Verfahren zu deren Herstellung sowie diese enthaltende anthelminthische Zusammensetzungen

Country Status (19)

Country Link
AT (5) AT293378B (enExample)
BE (2) BE710081A (enExample)
CH (5) CH509318A (enExample)
CS (1) CS162651B2 (enExample)
CY (1) CY653A (enExample)
DE (2) DE1695545C3 (enExample)
DK (1) DK139940B (enExample)
ES (4) ES350083A1 (enExample)
FI (1) FI52859C (enExample)
FR (1) FR1580153A (enExample)
GB (2) GB1198942A (enExample)
IE (1) IE31812B1 (enExample)
IT (1) IT1044176B (enExample)
NL (1) NL157015B (enExample)
NO (1) NO126484B (enExample)
OA (1) OA04036A (enExample)
SE (1) SE346321B (enExample)
SU (1) SU540569A3 (enExample)
YU (1) YU33831B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711608A (en) * 1971-04-13 1973-01-16 Merck & Co Inc The treatment of pain, fever and inflammation with benzimidazoles
US3985755A (en) * 1972-06-02 1976-10-12 E. R. Squibb & Sons, Inc. Pyridine containing isothiocyanobenzoxazoles
US3983130A (en) * 1972-06-02 1976-09-28 E. R. Squibb & Sons, Inc. Anthelmintic isothiocyanobenzoxazoles
US3853894A (en) * 1972-06-02 1974-12-10 Squibb & Sons Inc Isothiocyanobenzimidazoles
MA19290A1 (fr) * 1980-05-22 1982-04-01 Ciba Geigy Ag Derives du benzole,leur preparaton et leur utilisations therapeutiques .
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
JP2006513159A (ja) * 2002-11-01 2006-04-20 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体
GB0324792D0 (en) 2003-10-23 2003-11-26 Sterix Ltd Compound
CA2540843A1 (en) * 2003-10-23 2005-05-12 Sterix Limited Phenyl carboxamide and sulfonamide derivatives for use as 11-beta-hydroxysteroid dehydrogenase
PT1697343E (pt) * 2003-12-18 2009-09-16 Tibotec Pharm Ltd Aminobenzimidazolos e benzimidazolos como inibidores da replicação do vírus sincicial respiratório
ES2574670T3 (es) * 2005-03-17 2016-06-21 Janssen Sciences Ireland Uc 1,3-Dihidro-bencimidazol-2-ilidenoaminas como inhibidores de replicación del virus sincicial respiratorio

Also Published As

Publication number Publication date
AT289828B (de) 1971-05-10
CH545796A (enExample) 1974-02-15
DE1795711B2 (de) 1978-09-21
DK139940C (enExample) 1979-10-15
CH509318A (de) 1971-06-30
SU540569A3 (ru) 1976-12-25
SE346321B (enExample) 1972-07-03
CH545294A (de) 1974-01-31
IE31812L (en) 1968-08-03
BE735281A (enExample) 1969-12-29
OA04036A (fr) 1979-09-30
YU33831B (en) 1978-06-30
AT289833B (de) 1971-05-10
AT293378B (de) 1971-10-11
NL157015B (nl) 1978-06-15
CH545295A (de) 1974-01-31
CS162651B2 (enExample) 1975-07-15
DE1795711A1 (de) 1974-02-28
ES363760A1 (es) 1970-12-16
ES363762A1 (es) 1970-12-16
CH545293A (de) 1974-01-31
ES350083A1 (es) 1969-11-16
ES363761A1 (es) 1970-12-16
DE1795711C3 (de) 1979-05-17
FR1580153A (enExample) 1969-09-05
YU21268A (en) 1977-12-31
GB1198942A (en) 1970-07-15
DE1695545A1 (de) 1971-05-06
BE710081A (enExample) 1968-07-30
AT301244B (de) 1972-08-25
CY653A (en) 1972-08-31
IT1044176B (it) 1980-03-20
FI52859B (enExample) 1977-08-31
DE1695545B2 (de) 1978-08-31
FI52859C (fi) 1977-12-12
DK139940B (da) 1979-05-21
NO126484B (enExample) 1973-02-12
GB1198941A (en) 1970-07-15
IE31812B1 (en) 1973-01-10
AT289835B (de) 1971-05-10
NL6801482A (enExample) 1968-08-05

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee