DE13731071T1 - Verfahren zur Quantifizierung von Immunzellen in Tumorgewebe und dessen Anwendungen - Google Patents
Verfahren zur Quantifizierung von Immunzellen in Tumorgewebe und dessen Anwendungen Download PDFInfo
- Publication number
- DE13731071T1 DE13731071T1 DE13731071.0T DE13731071T DE13731071T1 DE 13731071 T1 DE13731071 T1 DE 13731071T1 DE 13731071 T DE13731071 T DE 13731071T DE 13731071 T1 DE13731071 T1 DE 13731071T1
- Authority
- DE
- Germany
- Prior art keywords
- stained cells
- cells
- tumor
- stained
- cd45ro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001446 | 2012-06-14 | ||
| WOPCT/IB2012/001446 | 2012-06-14 | ||
| EP13731071.0A EP2861986B1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE13731071T1 true DE13731071T1 (de) | 2016-08-18 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE13731071.0T Pending DE13731071T1 (de) | 2012-06-14 | 2013-06-14 | Verfahren zur Quantifizierung von Immunzellen in Tumorgewebe und dessen Anwendungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10317408B2 (enExample) |
| EP (1) | EP2861986B1 (enExample) |
| JP (1) | JP6449765B2 (enExample) |
| KR (1) | KR102179848B1 (enExample) |
| CN (1) | CN104541167B (enExample) |
| AU (1) | AU2013276470B2 (enExample) |
| BR (1) | BR112014031143B8 (enExample) |
| CA (1) | CA2873278C (enExample) |
| DE (1) | DE13731071T1 (enExample) |
| ES (1) | ES2902879T3 (enExample) |
| IL (1) | IL235738B (enExample) |
| SG (1) | SG11201408107RA (enExample) |
| WO (1) | WO2013186374A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3111221T4 (da) | 2014-02-24 | 2022-04-19 | Ventana Med Syst Inc | Fremgangsmåder, kit og systemer til scoring af immunresponsen mod cancer ved samtidig påvisning af CD3, CD8, CD20 og FOXP3 |
| CA2955156C (en) * | 2014-09-03 | 2024-04-30 | Ventana Medical Systems, Inc. | Systems and methods for generating fields of view |
| WO2016073760A1 (en) * | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block pd1/pdl1 axis |
| US10632151B2 (en) | 2015-01-22 | 2020-04-28 | University Of Massachusetts | Cancer immunotherapy |
| WO2017070585A1 (en) * | 2015-10-23 | 2017-04-27 | Novartis Ag | Method of scoring a sample comprising tumor tissue |
| CN109690314B (zh) * | 2016-05-09 | 2022-08-02 | 法国国家卫生及研究医学协会 | 患有实体癌症的患者的分类方法 |
| US11315240B2 (en) * | 2016-05-18 | 2022-04-26 | Hoffmann-La Roche Inc. | System and method of tumor classification |
| US12158399B2 (en) * | 2016-08-05 | 2024-12-03 | Duke University | CaMKK2 inhibitor compositions and methods of using the same |
| JP7356904B2 (ja) * | 2016-10-27 | 2023-10-05 | コーニンクレッカ フィリップス エヌ ヴェ | １つ又は複数の組織サンプルにおける細胞組成情報を決定する装置 |
| CA3037046A1 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| EP3659110A1 (en) * | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| ES2965647T3 (es) | 2018-01-31 | 2024-04-16 | Ventana Med Syst Inc | Procedimientos y sistemas para la evaluación de infiltrado de células inmunitarias en cáncer colorrectal en estadio III |
| JP7411667B2 (ja) * | 2019-02-05 | 2024-01-11 | ヴェンタナ メディカル システムズ， インク． | ステージｉｖの結腸直腸がんにおける免疫細胞浸潤の評価のための方法及びシステム |
| SG11202112712RA (en) | 2019-06-03 | 2021-12-30 | Inst Nat Sante Rech Med | Methods for modulating a treatment regimen |
| MX2022004501A (es) | 2019-11-07 | 2022-05-06 | Oncxerna Therapeutics Inc | Clasificacion de microambientes tumorales. |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| WO2022002874A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| JP2024530213A (ja) | 2021-08-10 | 2024-08-16 | ルニット・インコーポレイテッド | 病理スライド画像に関する情報を出力する方法及び装置 |
| WO2023175366A1 (en) | 2022-03-17 | 2023-09-21 | Veracyte | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| CN121263449A (zh) | 2023-03-21 | 2026-01-02 | 拜格拉夫55公司 | Cd19/cd38多特异性抗体 |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69627183T2 (de) * | 1995-11-30 | 2004-01-29 | Chromavision Med Sys Inc | Verfahren zur automatischen bildanalyse biologischer proben |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| CA2628317C (en) * | 2005-12-19 | 2015-12-08 | Ventana Medical Systems, Inc. | Automated lean methods in anatomical pathology |
| WO2010033508A1 (en) | 2008-09-16 | 2010-03-25 | Historx, Inc. | Reproducible quantification of biomarker expression |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt not_active IP Right Cessation
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en not_active Ceased
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014031143A2 (pt) | 2017-08-08 |
| EP2861986A1 (en) | 2015-04-22 |
| BR112014031143B8 (pt) | 2022-11-22 |
| AU2013276470A1 (en) | 2014-11-27 |
| CN104541167A (zh) | 2015-04-22 |
| IL235738B (en) | 2019-02-28 |
| US10317408B2 (en) | 2019-06-11 |
| BR112014031143B1 (pt) | 2022-03-03 |
| CA2873278A1 (en) | 2013-12-19 |
| IL235738A0 (en) | 2015-01-29 |
| WO2013186374A1 (en) | 2013-12-19 |
| KR20150023760A (ko) | 2015-03-05 |
| CA2873278C (en) | 2021-10-26 |
| AU2013276470B2 (en) | 2018-06-07 |
| KR102179848B1 (ko) | 2020-11-17 |
| EP2861986B1 (en) | 2021-11-10 |
| ES2902879T3 (es) | 2022-03-30 |
| JP6449765B2 (ja) | 2019-01-09 |
| US20150153349A1 (en) | 2015-06-04 |
| SG11201408107RA (en) | 2015-01-29 |
| JP2015525349A (ja) | 2015-09-03 |
| CN104541167B (zh) | 2018-05-01 |
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