CN104541167B - 用于定量肿瘤组织中的免疫细胞的方法及其应用 - Google Patents
用于定量肿瘤组织中的免疫细胞的方法及其应用 Download PDFInfo
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- CN104541167B CN104541167B CN201380030888.7A CN201380030888A CN104541167B CN 104541167 B CN104541167 B CN 104541167B CN 201380030888 A CN201380030888 A CN 201380030888A CN 104541167 B CN104541167 B CN 104541167B
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001446 | 2012-06-14 | ||
| IBPCT/IB2012/001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104541167A CN104541167A (zh) | 2015-04-22 |
| CN104541167B true CN104541167B (zh) | 2018-05-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201380030888.7A Active CN104541167B (zh) | 2012-06-14 | 2013-06-14 | 用于定量肿瘤组织中的免疫细胞的方法及其应用 |
Country Status (13)
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| EP (1) | EP2861986B1 (enExample) |
| JP (1) | JP6449765B2 (enExample) |
| KR (1) | KR102179848B1 (enExample) |
| CN (1) | CN104541167B (enExample) |
| AU (1) | AU2013276470B2 (enExample) |
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Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2701092T5 (es) | 2014-02-24 | 2022-05-12 | Ventana Med Syst Inc | Procedimientos, kits y sistemas para puntuar la respuesta inmunitaria al cáncer por detección simultánea de CD3, CD8, CD20 y FOXP3 |
| AU2015310886A1 (en) * | 2014-09-03 | 2017-02-02 | Ventana Medical Systems, Inc. | Systems and methods for calculating immune scores |
| WO2016073760A1 (en) * | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block pd1/pdl1 axis |
| US10034901B2 (en) | 2015-01-22 | 2018-07-31 | University Of Massachusetts | Cancer immunotherapy |
| EP3365063B1 (en) * | 2015-10-23 | 2024-04-24 | Novartis AG | Method of scoring a sample comprising tumor tissue |
| CN109690314B (zh) * | 2016-05-09 | 2022-08-02 | 法国国家卫生及研究医学协会 | 患有实体癌症的患者的分类方法 |
| EP3889893B1 (en) * | 2016-05-18 | 2022-03-30 | F. Hoffmann-La Roche AG | Tumor proximity measure |
| US12158399B2 (en) * | 2016-08-05 | 2024-12-03 | Duke University | CaMKK2 inhibitor compositions and methods of using the same |
| US11048911B2 (en) * | 2016-10-27 | 2021-06-29 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| US11459568B2 (en) | 2016-10-31 | 2022-10-04 | University Of Massachusetts | Targeting microRNA-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| EP3659110A1 (en) | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| DK3746790T3 (da) | 2018-01-31 | 2023-12-11 | Ventana Med Syst Inc | Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer |
| WO2020161125A1 (en) * | 2019-02-05 | 2020-08-13 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| WO2020245155A1 (en) | 2019-06-03 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for modulating a treatment regimen |
| IL291748A (en) | 2019-11-07 | 2022-06-01 | Oncxerna Therapeutics Inc | Classification of growth microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| WO2022002873A1 (en) | 2020-06-30 | 2022-01-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| EP4172628A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| WO2023018085A1 (ko) | 2021-08-10 | 2023-02-16 | 주식회사 루닛 | 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치 |
| CA3245129A1 (en) | 2022-03-17 | 2023-09-21 | Univ Paris Cite | METHODS FOR PREDICTING RESPONSE TO IMMUNOTHERAPEUTIC TREATMENT IN A CANCER PATIENT |
| WO2024197157A1 (en) | 2023-03-21 | 2024-09-26 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0864082B1 (en) * | 1995-11-30 | 2003-04-02 | Chromavision Medical Systems, Inc. | Method for automated image analysis of biological specimens |
| US20070141711A1 (en) * | 2005-12-19 | 2007-06-21 | Randy Stephens | Automated lean methods in anatomical pathology |
| EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| EP2335221B8 (en) * | 2008-09-16 | 2016-05-25 | Novartis AG | Reproducible quantification of biomarker expression |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
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2013
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en active Active
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt active IP Right Grant
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
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2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Non-Patent Citations (5)
| Title |
|---|
| Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy;Niels Halama;《Cancer research》;20110901;第17卷;摘要，第5671页右栏第4段，第5672页左栏第2-3段、右栏第4段，第5673页，第5675页左栏第2段，图2-4 * |
| The local immunological microenvironment in colorectal cancer as a prognostic factor for treatment decisions in the clinic;Niels Halama;《OncoImmunology》;20120101;第1卷(第1期);图1、图2，第63页第1栏第36-56行，第63页第2栏第15-27行，第64页第2栏第11-22行，第64页第3栏第3-13行 * |
| 免疫组化技术标准化的探讨;王文勇;《细胞与分子免疫学杂志》;20110831;第27卷(第8期);第928页第6-7节 * |
| 全自动免疫组化仪的应用及影响其染色质量的因素探讨;虞杰;《泰州职业技术学院学报》;20111231;第11卷(第6期);摘要，第70页右栏第1段 * |
| 组织芯片在免疫组化染色阳性对照中的应用;王翠芝 等;《临床与实验病理学杂志》;20060831;第22卷(第4期);第481-第484页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE13731071T1 (de) | 2016-08-18 |
| EP2861986B1 (en) | 2021-11-10 |
| BR112014031143A2 (pt) | 2017-08-08 |
| IL235738A0 (en) | 2015-01-29 |
| KR102179848B1 (ko) | 2020-11-17 |
| ES2902879T3 (es) | 2022-03-30 |
| US20150153349A1 (en) | 2015-06-04 |
| SG11201408107RA (en) | 2015-01-29 |
| BR112014031143B1 (pt) | 2022-03-03 |
| EP2861986A1 (en) | 2015-04-22 |
| KR20150023760A (ko) | 2015-03-05 |
| JP2015525349A (ja) | 2015-09-03 |
| IL235738B (en) | 2019-02-28 |
| CA2873278A1 (en) | 2013-12-19 |
| AU2013276470A1 (en) | 2014-11-27 |
| AU2013276470B2 (en) | 2018-06-07 |
| US10317408B2 (en) | 2019-06-11 |
| CA2873278C (en) | 2021-10-26 |
| JP6449765B2 (ja) | 2019-01-09 |
| BR112014031143B8 (pt) | 2022-11-22 |
| WO2013186374A1 (en) | 2013-12-19 |
| CN104541167A (zh) | 2015-04-22 |
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