BR112014031143B8 - Método para quantificar células imunes em tecidos tumorais e suas aplicações - Google Patents
Método para quantificar células imunes em tecidos tumorais e suas aplicaçõesInfo
- Publication number
- BR112014031143B8 BR112014031143B8 BR112014031143A BR112014031143A BR112014031143B8 BR 112014031143 B8 BR112014031143 B8 BR 112014031143B8 BR 112014031143 A BR112014031143 A BR 112014031143A BR 112014031143 A BR112014031143 A BR 112014031143A BR 112014031143 B8 BR112014031143 B8 BR 112014031143B8
- Authority
- BR
- Brazil
- Prior art keywords
- immune cells
- tumor
- tumor tissues
- applications
- analyzed
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 210000002865 immune cell Anatomy 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012744 immunostaining Methods 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001446 | 2012-06-14 | ||
| IBPCT/IB2012/001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014031143A2 BR112014031143A2 (pt) | 2017-08-08 |
| BR112014031143B1 BR112014031143B1 (pt) | 2022-03-03 |
| BR112014031143B8 true BR112014031143B8 (pt) | 2022-11-22 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014031143A BR112014031143B8 (pt) | 2012-06-14 | 2013-06-14 | Método para quantificar células imunes em tecidos tumorais e suas aplicações |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10317408B2 (enExample) |
| EP (1) | EP2861986B1 (enExample) |
| JP (1) | JP6449765B2 (enExample) |
| KR (1) | KR102179848B1 (enExample) |
| CN (1) | CN104541167B (enExample) |
| AU (1) | AU2013276470B2 (enExample) |
| BR (1) | BR112014031143B8 (enExample) |
| CA (1) | CA2873278C (enExample) |
| DE (1) | DE13731071T1 (enExample) |
| ES (1) | ES2902879T3 (enExample) |
| IL (1) | IL235738B (enExample) |
| SG (1) | SG11201408107RA (enExample) |
| WO (1) | WO2013186374A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6605506B2 (ja) | 2014-02-24 | 2019-11-13 | ヴェンタナ メディカル システムズ， インク． | ＣＤ３、ＣＤ８、ＣＤ２０及びＦｏｘＰ３の同時検出によりがんに対する免疫応答をスコア化するための方法、キット、及びシステム |
| CA2955156C (en) * | 2014-09-03 | 2024-04-30 | Ventana Medical Systems, Inc. | Systems and methods for generating fields of view |
| WO2016073760A1 (en) * | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | Methods for stratifying non-responders to therapies that block pd1/pdl1 axis |
| US10034901B2 (en) | 2015-01-22 | 2018-07-31 | University Of Massachusetts | Cancer immunotherapy |
| EP3365063B1 (en) * | 2015-10-23 | 2024-04-24 | Novartis AG | Method of scoring a sample comprising tumor tissue |
| CN109690314B (zh) * | 2016-05-09 | 2022-08-02 | 法国国家卫生及研究医学协会 | 患有实体癌症的患者的分类方法 |
| US11315240B2 (en) * | 2016-05-18 | 2022-04-26 | Hoffmann-La Roche Inc. | System and method of tumor classification |
| WO2018027223A1 (en) * | 2016-08-05 | 2018-02-08 | Duke University | Camkk2 inhibitor compositions and methods of using the same |
| WO2018078034A1 (en) * | 2016-10-27 | 2018-05-03 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| EP3532638A4 (en) | 2016-10-31 | 2020-07-29 | University of Massachusetts | TARGETING MICROARN-101-3 P IN CARCINOTHERAPY |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| WO2019020556A1 (en) * | 2017-07-24 | 2019-01-31 | Ventana Medical Systems, Inc. | METHODS AND SYSTEMS FOR ASSESSING INFILTRAT OF IMMUNE CELLS IN TUMOR SAMPLES |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| DK3746790T3 (da) | 2018-01-31 | 2023-12-11 | Ventana Med Syst Inc | Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer |
| CN113454458A (zh) * | 2019-02-05 | 2021-09-28 | 文塔纳医疗系统公司 | 用于评估iv期结直肠癌中免疫细胞浸润的方法和系统 |
| AU2020288603A1 (en) | 2019-06-03 | 2021-12-16 | Assistance Publique - Hôpitaux De Paris | Methods for modulating a treatment regimen |
| WO2021092071A1 (en) | 2019-11-07 | 2021-05-14 | Oncxerna Therapeutics, Inc. | Classification of tumor microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| EP4172628A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| US20230235408A1 (en) | 2020-06-30 | 2023-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| WO2023018085A1 (ko) * | 2021-08-10 | 2023-02-16 | 주식회사 루닛 | 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치 |
| AU2022447608A1 (en) | 2022-03-17 | 2024-09-26 | Assistance Publique - Hôpitaux De Paris | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| US12173081B2 (en) | 2023-03-21 | 2024-12-24 | Biograph 55, Inc. | CD19/CD38 multispecific antibodies |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69627183T2 (de) * | 1995-11-30 | 2004-01-29 | Chromavision Med Sys Inc | Verfahren zur automatischen bildanalyse biologischer proben |
| US20070141711A1 (en) * | 2005-12-19 | 2007-06-21 | Randy Stephens | Automated lean methods in anatomical pathology |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| CN102165489B (zh) | 2008-09-16 | 2015-11-25 | 赫斯托克斯公司 | 生物标志物表达的可再现量化 |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en active Active
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt active IP Right Grant
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN104541167A (zh) | 2015-04-22 |
| US20150153349A1 (en) | 2015-06-04 |
| IL235738A0 (en) | 2015-01-29 |
| KR102179848B1 (ko) | 2020-11-17 |
| EP2861986A1 (en) | 2015-04-22 |
| BR112014031143A2 (pt) | 2017-08-08 |
| CA2873278A1 (en) | 2013-12-19 |
| KR20150023760A (ko) | 2015-03-05 |
| DE13731071T1 (de) | 2016-08-18 |
| IL235738B (en) | 2019-02-28 |
| BR112014031143B1 (pt) | 2022-03-03 |
| AU2013276470A1 (en) | 2014-11-27 |
| US10317408B2 (en) | 2019-06-11 |
| CA2873278C (en) | 2021-10-26 |
| ES2902879T3 (es) | 2022-03-30 |
| SG11201408107RA (en) | 2015-01-29 |
| AU2013276470B2 (en) | 2018-06-07 |
| JP2015525349A (ja) | 2015-09-03 |
| EP2861986B1 (en) | 2021-11-10 |
| WO2013186374A1 (en) | 2013-12-19 |
| JP6449765B2 (ja) | 2019-01-09 |
| CN104541167B (zh) | 2018-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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| B25A | Requested transfer of rights approved |
Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) ; ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) ; UNIVERSITE DE PARIS (FR) |
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| B25D | Requested change of name of applicant approved |
Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) ; ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) ; UNIVERSITE PARIS CITE (FR) |