JP6449765B2 - 腫瘍組織における免疫細胞を定量するための方法及びその応用 - Google Patents
腫瘍組織における免疫細胞を定量するための方法及びその応用 Download PDFInfo
- Publication number
- JP6449765B2 JP6449765B2 JP2015516637A JP2015516637A JP6449765B2 JP 6449765 B2 JP6449765 B2 JP 6449765B2 JP 2015516637 A JP2015516637 A JP 2015516637A JP 2015516637 A JP2015516637 A JP 2015516637A JP 6449765 B2 JP6449765 B2 JP 6449765B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- tumor
- stained
- stained cells
- density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G01N33/575—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2012/001446 | 2012-06-14 | ||
| IB2012001446 | 2012-06-14 | ||
| PCT/EP2013/062405 WO2013186374A1 (en) | 2012-06-14 | 2013-06-14 | Method for quantifying immune cells in tumoral tissues and its applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015525349A JP2015525349A (ja) | 2015-09-03 |
| JP2015525349A5 JP2015525349A5 (enExample) | 2016-07-14 |
| JP6449765B2 true JP6449765B2 (ja) | 2019-01-09 |
Family
ID=46881097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516637A Active JP6449765B2 (ja) | 2012-06-14 | 2013-06-14 | 腫瘍組織における免疫細胞を定量するための方法及びその応用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10317408B2 (enExample) |
| EP (1) | EP2861986B1 (enExample) |
| JP (1) | JP6449765B2 (enExample) |
| KR (1) | KR102179848B1 (enExample) |
| CN (1) | CN104541167B (enExample) |
| AU (1) | AU2013276470B2 (enExample) |
| BR (1) | BR112014031143B8 (enExample) |
| CA (1) | CA2873278C (enExample) |
| DE (1) | DE13731071T1 (enExample) |
| ES (1) | ES2902879T3 (enExample) |
| IL (1) | IL235738B (enExample) |
| SG (1) | SG11201408107RA (enExample) |
| WO (1) | WO2013186374A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2701092T5 (es) | 2014-02-24 | 2022-05-12 | Ventana Med Syst Inc | Procedimientos, kits y sistemas para puntuar la respuesta inmunitaria al cáncer por detección simultánea de CD3, CD8, CD20 y FOXP3 |
| EP3195191B1 (en) * | 2014-09-03 | 2020-10-21 | Ventana Medical Systems, Inc. | Systems and methods for calculating immune scores |
| CN107109459A (zh) * | 2014-11-05 | 2017-08-29 | 加利福尼亚大学董事会 | 用于分层对阻断pd1/pdl1轴的疗法的无响应者的方法 |
| CA2973878A1 (en) | 2015-01-22 | 2016-07-28 | University Of Massachusetts | Cancer immunotherapy |
| CN113671186A (zh) * | 2015-10-23 | 2021-11-19 | 诺华股份有限公司 | 对包含肿瘤组织的样品评分的方法 |
| MX393482B (es) * | 2016-05-09 | 2025-03-24 | Inst Nat Sante Rech Med | Metodos para clasificar pacientes con un cancer solido |
| US11315240B2 (en) * | 2016-05-18 | 2022-04-26 | Hoffmann-La Roche Inc. | System and method of tumor classification |
| WO2018027223A1 (en) * | 2016-08-05 | 2018-02-08 | Duke University | Camkk2 inhibitor compositions and methods of using the same |
| EP3532984B1 (en) * | 2016-10-27 | 2024-05-08 | Koninklijke Philips N.V. | Apparatus for determining cellular composition information in one or more tissue samples |
| WO2018081817A2 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| CN106846310A (zh) * | 2017-01-19 | 2017-06-13 | 宁波江丰生物信息技术有限公司 | 一种基于免疫组化技术的病理辅助分析方法 |
| EP3659110A1 (en) * | 2017-07-24 | 2020-06-03 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in tumor samples |
| US11814623B2 (en) | 2018-01-30 | 2023-11-14 | University Of Massachusetts | Methods of treating a wound using epigenetic regulation |
| WO2019149817A1 (en) | 2018-01-31 | 2019-08-08 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iii colorectal cancer |
| EP3921648A1 (en) * | 2019-02-05 | 2021-12-15 | Ventana Medical Systems, Inc. | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer |
| US20220236276A1 (en) | 2019-06-03 | 2022-07-28 | Inserm (Institut National De La Santé Et De La Recherch Médicale | Methods for modulating a treatment regimen |
| AU2020378280A1 (en) | 2019-11-07 | 2022-04-07 | Feng Biosciences, Ltd. | Classification of tumor microenvironments |
| CN111551546B (zh) * | 2020-06-01 | 2023-01-03 | 南京瑟斯检测科技有限公司 | 一种基于光学微腔结构超材料的免疫组化便捷检测方法 |
| EP4172628A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
| CN115997123A (zh) | 2020-06-30 | 2023-04-21 | 国家医疗保健研究所 | 用于预测实体癌患者在术前辅助治疗后复发和/或死亡风险的方法 |
| TWI838687B (zh) * | 2021-01-30 | 2024-04-11 | 奇美醫療財團法人奇美醫院 | 評估腫瘤標本免疫狀態的方法 |
| CN113092202A (zh) * | 2021-03-25 | 2021-07-09 | 上海福君基因生物科技有限公司 | 一种胃癌预后预测装置 |
| CN113515077A (zh) * | 2021-04-23 | 2021-10-19 | 重庆德方信息技术有限公司 | 人体细胞染色过程监控系统及方法 |
| WO2023018085A1 (ko) * | 2021-08-10 | 2023-02-16 | 주식회사 루닛 | 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치 |
| US20250035635A1 (en) | 2022-03-17 | 2025-01-30 | Institut National De La Sante Et De La Recherche Medicale | Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer |
| US12173081B2 (en) | 2023-03-21 | 2024-12-24 | Biograph 55, Inc. | CD19/CD38 multispecific antibodies |
| CN116646088B (zh) * | 2023-07-27 | 2023-12-01 | 广东省人民医院 | 一种预测方法、装置、设备及介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000501184A (ja) * | 1995-11-30 | 2000-02-02 | クロマビジョン メディカル システムズ，インコーポレイテッド | 生体標本の自動画像分析の方法および装置 |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| EP1969338B1 (en) * | 2005-12-19 | 2016-08-24 | Ventana Medical Systems, Inc. | Automated label printing for tissue specimen slides |
| CA2737116C (en) * | 2008-09-16 | 2019-01-15 | Historx, Inc. | Reproducible quantification of biomarker expression |
| FR2964744B1 (fr) * | 2010-09-10 | 2015-04-03 | Univ Versailles St Quentin En Yvelines | Test pronostic de l'evolution d'une tumeur solide par analyse d'images |
-
2013
- 2013-06-14 EP EP13731071.0A patent/EP2861986B1/en active Active
- 2013-06-14 US US14/407,698 patent/US10317408B2/en active Active
- 2013-06-14 KR KR1020157000987A patent/KR102179848B1/ko active Active
- 2013-06-14 JP JP2015516637A patent/JP6449765B2/ja active Active
- 2013-06-14 BR BR112014031143A patent/BR112014031143B8/pt active IP Right Grant
- 2013-06-14 AU AU2013276470A patent/AU2013276470B2/en not_active Ceased
- 2013-06-14 DE DE13731071.0T patent/DE13731071T1/de active Pending
- 2013-06-14 SG SG11201408107RA patent/SG11201408107RA/en unknown
- 2013-06-14 WO PCT/EP2013/062405 patent/WO2013186374A1/en not_active Ceased
- 2013-06-14 CN CN201380030888.7A patent/CN104541167B/zh active Active
- 2013-06-14 ES ES13731071T patent/ES2902879T3/es active Active
- 2013-06-14 CA CA2873278A patent/CA2873278C/en active Active
-
2014
- 2014-11-17 IL IL235738A patent/IL235738B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150023760A (ko) | 2015-03-05 |
| BR112014031143A2 (pt) | 2017-08-08 |
| ES2902879T3 (es) | 2022-03-30 |
| SG11201408107RA (en) | 2015-01-29 |
| BR112014031143B8 (pt) | 2022-11-22 |
| CN104541167B (zh) | 2018-05-01 |
| AU2013276470A1 (en) | 2014-11-27 |
| US20150153349A1 (en) | 2015-06-04 |
| AU2013276470B2 (en) | 2018-06-07 |
| DE13731071T1 (de) | 2016-08-18 |
| US10317408B2 (en) | 2019-06-11 |
| EP2861986A1 (en) | 2015-04-22 |
| JP2015525349A (ja) | 2015-09-03 |
| BR112014031143B1 (pt) | 2022-03-03 |
| KR102179848B1 (ko) | 2020-11-17 |
| CA2873278A1 (en) | 2013-12-19 |
| CA2873278C (en) | 2021-10-26 |
| IL235738B (en) | 2019-02-28 |
| EP2861986B1 (en) | 2021-11-10 |
| CN104541167A (zh) | 2015-04-22 |
| IL235738A0 (en) | 2015-01-29 |
| WO2013186374A1 (en) | 2013-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6449765B2 (ja) | 腫瘍組織における免疫細胞を定量するための方法及びその応用 | |
| US20220051804A1 (en) | Image Analysis for Breast Cancer Prognosis | |
| Fox et al. | Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis | |
| JP5866362B2 (ja) | 画像解析による固形腫瘍進行の予後検査 | |
| EP3117259B1 (en) | Assessment of staining quality | |
| JP2024150478A (ja) | 距離に基づく組織状態の決定 | |
| US20240310379A1 (en) | A method for measuring a prognostic marker in prostate cancer or in breast cancer | |
| JP2019534451A (ja) | １つ又は複数の組織サンプルにおける細胞組成情報を決定する装置 | |
| JP2015525358A (ja) | 組織切片中の単一細胞におけるマーカー定量 | |
| Bae et al. | HER2 status by standardized immunohistochemistry and silver-enhanced in situ hybridization in Korean breast cancer | |
| WO2017171720A1 (en) | Digital image analysis of inflammatory cells and mediators of inflammation | |
| Tobin et al. | Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information | |
| Miller et al. | Objective analysis of cancer stem cell marker expression using immunohistochemistry | |
| CN110534202A (zh) | 一种针对Sox10在三阴性乳腺癌中的表达进行分析的系统 | |
| Stolnicu | Prognostic and predictive factors in breast carcinoma | |
| CN115308418B (zh) | 一种生物标志物及其在肺鳞癌诊断中的应用 | |
| Asogan et al. | Concordance between core needle biopsy and surgical specimen for ER, PgR and Her2neu receptor status in breast cancer and study of difference in reliability between the two groups with the change in ASCO/CAP guidelines | |
| Glajcar et al. | Application of tissue microarrays for receptor immunohistochemistry in breast carcinoma | |
| CN115602313A (zh) | 用于疾病疗效与生存预后预测的生物标志物及其用途 | |
| TWM653792U (zh) | Ai數位病理影像辨識系統 | |
| Pajor | Automated image cytometry for diagnosing bladder cancer by detecting genetically aberrant cells from voided urine via molecular cytogenetics | |
| Müller | Sentinel Lymph |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20150313 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160527 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160527 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170329 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170418 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170707 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171018 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180320 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180620 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20181113 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20181206 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6449765 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313115 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R370 | Written measure of declining of transfer procedure |
Free format text: JAPANESE INTERMEDIATE CODE: R370 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313115 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |