DE131980C - - Google Patents

Info

Publication number

DE131980C

DE131980C DENDAT131980D DE131980DA DE131980C DE 131980 C DE131980 C DE 131980C DE NDAT131980 D DENDAT131980 D DE NDAT131980D DE 131980D A DE131980D A DE 131980DA DE 131980 C DE131980 C DE 131980C

Authority

DE

Germany

Prior art keywords

morphine

sulfonic acid

acid esters

solution

code

Prior art date

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Natural products O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 18
• 229960005181 morphine Drugs 0.000 claims description 9
• 150000003459 sulfonic acid esters Chemical class 0.000 claims description 4
• 239000003513 alkali Substances 0.000 claims 2
• -1 morphine ethers Chemical class 0.000 claims 1
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 238000006243 chemical reaction Methods 0.000 description 3
• 230000007935 neutral effect Effects 0.000 description 3
• 239000000243 solution Substances 0.000 description 3
• RIUIDJADVAUEET-VYKNHSEDSA-N (4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;sodium Chemical compound [Na].O[C@H]([C@@H]1O2)C=C[C@H]3[C@]4([H])N(C)CC[C@]13C1=C2C(O)=CC=C1C4 RIUIDJADVAUEET-VYKNHSEDSA-N 0.000 description 2
• 239000012670 alkaline solution Substances 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 150000007524 organic acids Chemical class 0.000 description 2
• 235000005985 organic acids Nutrition 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 230000001476 alcoholic effect Effects 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 159000000032 aromatic acids Chemical class 0.000 description 1
• 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• XDRMBCMMABGNMM-UHFFFAOYSA-N ethyl benzenesulfonate Chemical compound CCOS(=O)(=O)C1=CC=CC=C1 XDRMBCMMABGNMM-UHFFFAOYSA-N 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• CZXGXYBOQYQXQD-UHFFFAOYSA-N methyl benzenesulfonate Chemical compound COS(=O)(=O)C1=CC=CC=C1 CZXGXYBOQYQXQD-UHFFFAOYSA-N 0.000 description 1
• JNAYDVGAZRZSFK-UHFFFAOYSA-N methyl benzenesulfonate;sodium Chemical compound [Na].COS(=O)(=O)C1=CC=CC=C1 JNAYDVGAZRZSFK-UHFFFAOYSA-N 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 238000010792 warming Methods 0.000 description 1