DE1220556C2 - Verfahren zur Herstellung von peroralen Griseofulvinpraeparaten - Google Patents
Verfahren zur Herstellung von peroralen GriseofulvinpraeparatenInfo
- Publication number
- DE1220556C2 DE1220556C2 DE1961G0032089 DEG0032089A DE1220556C2 DE 1220556 C2 DE1220556 C2 DE 1220556C2 DE 1961G0032089 DE1961G0032089 DE 1961G0032089 DE G0032089 A DEG0032089 A DE G0032089A DE 1220556 C2 DE1220556 C2 DE 1220556C2
- Authority
- DE
- Germany
- Prior art keywords
- griseofulvin
- preparations
- particle size
- production
- surface area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 title claims description 34
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 title claims description 34
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 title claims description 34
- 229960002867 griseofulvin Drugs 0.000 title claims description 34
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 title claims description 34
- 238000002360 preparation method Methods 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000002245 particle Substances 0.000 claims description 18
- 230000036765 blood level Effects 0.000 claims description 9
- 229960000480 griseofulvin microsize Drugs 0.000 claims description 3
- 239000007787 solid Substances 0.000 description 8
- 239000002002 slurry Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 238000003801 milling Methods 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052573 porcelain Inorganic materials 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000031295 Animal disease Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1372560A GB899668A (en) | 1960-04-19 | 1960-04-19 | Improvements in or relating to antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE1220556B DE1220556B (de) | 1966-07-07 |
| DE1220556C2 true DE1220556C2 (de) | 1973-08-30 |
Family
ID=10028253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1961G0032089 Expired DE1220556C2 (de) | 1960-04-19 | 1961-04-19 | Verfahren zur Herstellung von peroralen Griseofulvinpraeparaten |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR6128492D0 (en:Method) |
| DE (1) | DE1220556C2 (en:Method) |
| GB (1) | GB899668A (en:Method) |
| SE (1) | SE323765B (en:Method) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1040187B (de) * | 1956-01-05 | 1958-10-02 | Glaxo Lab Ltd | Verfahren zur Erzeugung von Griseofulvin enthaltenden Trockenprodukten |
-
1960
- 1960-04-19 GB GB1372560A patent/GB899668A/en not_active Expired
-
1961
- 1961-04-18 BR BR12849261A patent/BR6128492D0/pt unknown
- 1961-04-19 DE DE1961G0032089 patent/DE1220556C2/de not_active Expired
- 1961-04-19 SE SE4082/61A patent/SE323765B/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1040187B (de) * | 1956-01-05 | 1958-10-02 | Glaxo Lab Ltd | Verfahren zur Erzeugung von Griseofulvin enthaltenden Trockenprodukten |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1220556B (de) | 1966-07-07 |
| BR6128492D0 (pt) | 1973-06-07 |
| GB899668A (en) | 1962-06-27 |
| SE323765B (en:Method) | 1970-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69635106T2 (de) | Guaninderivat | |
| EP0126379B1 (de) | Zweiphasenformulierung | |
| DE69828886T3 (de) | Neuartige formulierung zur inhalation mit einer bulkdichte zwischen 0.28 und 0.38 g/ml, verfahren zur herstellung der formulierung sowie anwendung derselben | |
| DE60124715T2 (de) | Verwendung von oligosacchariden zur stimulierung der produktion von beta-endorphin | |
| DE69217206T2 (de) | Benzopyranphenolderivate zur verwendung als immunstimulierende mittel | |
| DE69839275T2 (de) | Neue formulierung zur inhalation mit einer bulkdichte zwischen 0,28 und 0,38 g/ml enthaltend budensonide | |
| DE3707909A1 (de) | Niedermolekulare alkalihuminate, verfahren zu ihrer herstellung und verwendung | |
| DE3537656C2 (en:Method) | ||
| DE2348334C2 (de) | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs | |
| DE2200778B2 (de) | Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen | |
| CH642085A5 (de) | Verfahren zur gewinnung der polaren fraktion mit antipsoriatischer wirksamkeit eines extraktes aus farnpflanzen sowie ein gemaess diesem verfahren hergestelltes praeparat. | |
| DE1220556C2 (de) | Verfahren zur Herstellung von peroralen Griseofulvinpraeparaten | |
| DE60202684T2 (de) | Pflanzenpräparat zur Behandlung und Heilung von bronchialen respiratorischen Schwierigkeiten | |
| DE69015890T2 (de) | Aerosole von Pyrido(1,2-a)pyrimidinen. | |
| DE1927015B2 (de) | Verfahren zur herstellung von alpha-hemihydrat-gips | |
| DE68907609T2 (de) | Arzneimittelzusammensetzung. | |
| DE1467750C3 (de) | Verfahren zum Gewinnen von wertvollen Bestandteilen aus Pollen | |
| DE2435226C2 (de) | Backhefepräparat | |
| EP0508330B1 (de) | Verfahren zur Herstellung von Extrakten aus Rhizoma Petasitidis mit Kohlendioxid | |
| EP0285752B1 (de) | Kamillenöle mit hohem Gehalt an natürlichen Polyinen und Verfahren zu deren Herstellung | |
| DE112017006865T5 (de) | Medizinischer Rohstoff aus einem Ginkgo-Extrakt und Verfahren zu dessen Herstellung | |
| DE1931910A1 (de) | Verfahren zur Herstellung von festen Arzneizubereitungen mit gesteuerter Resorption | |
| DE69025272T2 (de) | Therapeutisches Mittel für Erkrankungen des Zentralnervensystems | |
| DE3902323C2 (de) | Verfahren zur Herstellung von Aluminiumoxid mit einer Einkristallgröße unter 1 ¶/¶um | |
| DE1445417A1 (de) | Verfahren zur Herstellung von neuen Hexitestern der Nikotinsaeure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E77 | Valid patent as to the heymanns-index 1977 |