DE122009000018I1 - Behandlung der pompeschen krankheit - Google Patents
Behandlung der pompeschen krankheitInfo
- Publication number
- DE122009000018I1 DE122009000018I1 DE122009000018C DE122009000018C DE122009000018I1 DE 122009000018 I1 DE122009000018 I1 DE 122009000018I1 DE 122009000018 C DE122009000018 C DE 122009000018C DE 122009000018 C DE122009000018 C DE 122009000018C DE 122009000018 I1 DE122009000018 I1 DE 122009000018I1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- pompet
- treatment
- patient
- body weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11129198P | 1998-12-07 | 1998-12-07 | |
PCT/US1999/029042 WO2000034451A1 (en) | 1998-12-07 | 1999-12-06 | Treatment of pompe's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
DE122009000018I1 true DE122009000018I1 (de) | 2009-09-17 |
Family
ID=22337648
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122009000018C Pending DE122009000018I1 (de) | 1998-12-07 | 1999-12-06 | Behandlung der pompeschen krankheit |
DE69939705T Expired - Lifetime DE69939705D1 (de) | 1998-12-07 | 1999-12-06 | Behandlung der pompeschen krankheit |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69939705T Expired - Lifetime DE69939705D1 (de) | 1998-12-07 | 1999-12-06 | Behandlung der pompeschen krankheit |
Country Status (16)
Country | Link |
---|---|
US (7) | US20030007963A1 (de) |
EP (2) | EP2020438B1 (de) |
JP (7) | JP4990434B2 (de) |
KR (1) | KR20010101131A (de) |
AT (1) | ATE410506T1 (de) |
AU (1) | AU3113700A (de) |
BE (1) | BE2018C038I2 (de) |
CA (1) | CA2353522A1 (de) |
CY (2) | CY1121113T1 (de) |
DE (2) | DE122009000018I1 (de) |
DK (2) | DK1137762T3 (de) |
ES (2) | ES2677343T3 (de) |
LU (1) | LU91544I2 (de) |
NL (1) | NL300382I2 (de) |
PT (2) | PT1137762E (de) |
WO (1) | WO2000034451A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1137762E (pt) * | 1998-12-07 | 2009-01-14 | Genzyme Corp | Tratamento da doença de pompe |
ES2328446T5 (es) * | 2000-02-04 | 2014-02-27 | Children's Hospital Research Foundation | Uso de lipasa ácida lisosomal para tratar la aterosclerosis y enfermedades asociadas |
AU2016256663A1 (en) * | 2000-07-18 | 2016-11-24 | Duke University | Treatment of clycogen storage disease type II |
EP1782825B1 (de) * | 2000-07-18 | 2014-09-10 | Duke University | Behandlung der Glykogenspeicherkrankheit typ II |
ES2700865T3 (es) * | 2000-07-18 | 2019-02-19 | Univ Duke | Tratamiento de glucogenosis de tipo II |
US7723296B2 (en) * | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
US7629309B2 (en) * | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
ATE384736T1 (de) * | 2001-04-30 | 2008-02-15 | Zystor Therapeutics Inc | Subzelluläres targeting von therapeutischen proteinen |
US20030072761A1 (en) * | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
US7658916B2 (en) | 2002-04-05 | 2010-02-09 | Genzyme Corporation | Methods of enhancing lysosomal storage disease therapy by modulation of cell surface receptor density |
ES2371913T3 (es) * | 2003-01-22 | 2012-01-11 | Duke University | Constructos mejorados para expresar polipéptidos lisosomales. |
CA2814767C (en) * | 2003-01-31 | 2016-03-15 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
CN1922313B (zh) * | 2004-02-10 | 2011-10-26 | 生物马林医药公司 | 酸性α-糖苷酶及其片段 |
KR100697270B1 (ko) * | 2004-12-10 | 2007-03-21 | 삼성전자주식회사 | 저전력 멀티칩 반도체 메모리 장치 및 그것의 칩 인에이블방법 |
EP3441090A1 (de) | 2005-05-17 | 2019-02-13 | Amicus Therapeutics, Inc. | Verfahren zur behandlung der pompe-krankheit unter verwendung von mit 1-deoxynojirimycin und derivaten |
US20090297496A1 (en) * | 2005-09-08 | 2009-12-03 | Childrens Hospital Medical Center | Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases |
JP2010509344A (ja) * | 2006-11-13 | 2010-03-25 | ザイストール セラピューティクス, インコーポレイテッド | ポンペ病を治療するための方法 |
ES2629853T3 (es) | 2008-05-07 | 2017-08-16 | Biomarin Pharmaceutical Inc. | Péptidos de dirección lisosómica y usos de los mismos |
EP2318037B1 (de) | 2008-07-08 | 2015-01-28 | Duke University | Verfahren zur behandlung einer glykogenspeicherkrankheit |
EP3075386B1 (de) | 2009-06-17 | 2019-10-16 | BioMarin Pharmaceutical Inc. | Formulierungen für lysosomale enzyme |
US8536148B2 (en) | 2009-09-04 | 2013-09-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Disabling autophagy as a treatment for lysosomal storage diseases |
EP3205351B1 (de) | 2010-04-23 | 2023-04-12 | Alexion Pharmaceuticals, Inc. | Enzym für die lysosomale speicherkrankheit |
NZ605865A (en) | 2010-06-25 | 2015-07-31 | Shire Human Genetic Therapies | Cns delivery of therapeutic agents |
DK2585104T3 (da) | 2010-06-25 | 2019-10-14 | Shire Human Genetic Therapies | Fremgangsmåder og sammensætninger tilcns-levering af arylsulfatase a |
NZ702800A (en) | 2010-06-25 | 2017-03-31 | Shire Human Genetic Therapies | Methods and compositions for cns delivery of heparan n-sulfatase |
CA2805449A1 (en) | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc. | Treatment of sanfilippo syndrome type b |
WO2011163647A2 (en) | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc. | Methods and compositions for cns delivery of heparan n-sulfatase |
EP2593131B1 (de) | 2010-06-25 | 2019-08-21 | Shire Human Genetic Therapies, Inc. | Verfahren und zusammensetzungen zur cns-abgabe von iduronat-2-sulfatase |
MX365007B (es) | 2010-09-09 | 2019-05-20 | Alexion Pharmaceuticals Inc Star | Uso de acido lipasa lisosomal para tratar la dificiencia de acido lipasa lisosomal en pacientes. |
KR20140006037A (ko) | 2011-02-15 | 2014-01-15 | 시나게바 바이오파르마, 코포레이션 | 리소좀의 산 리파제 결핍을 치료하는 방법들 |
JP5992902B2 (ja) * | 2011-03-16 | 2016-09-14 | 天野エンザイム株式会社 | 改変型α−グルコシダーゼ及びその用途 |
WO2012145644A1 (en) | 2011-04-22 | 2012-10-26 | Genzyme Corporation | Modified acid alpha glucosidase with accelerated processing |
WO2013096899A2 (en) | 2011-12-23 | 2013-06-27 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
MX349992B (es) | 2012-03-07 | 2017-08-22 | Amicus Therapeutics Inc | Composiciones de alta concentracion de alfa-glucosidasa para el tratamiento de la enfermedad de pompe. |
WO2014130723A1 (en) | 2013-02-20 | 2014-08-28 | Valerion Therapeutics, Llc | Methods and compositions for treatment of pompe disease |
MA40460A (fr) | 2014-08-11 | 2016-02-18 | Shire Human Genetic Therapies | Ciblage lysosomial et utilisation correspondante |
PL3201320T3 (pl) | 2014-09-30 | 2024-03-18 | Amicus Therapeutics, Inc. | Bardzo silnie działająca kwasowa alfa-glukozydaza ze zwiększoną zawartością węglowodanów |
MA41022A (fr) | 2014-11-24 | 2017-10-03 | Shire Human Genetic Therapies | Ciblage lysosomial et utilisations correspondantes |
MA44747A (fr) * | 2015-08-31 | 2019-03-06 | Univ Duke | Méthodes et compositions pour le traitement de troubles associés à une accumulation du glycogène cytoplasmique |
US10940125B2 (en) | 2015-09-18 | 2021-03-09 | Duke University | Methods and compositions for the treatment of steatosis-associated disorders |
BR112018013151A2 (pt) | 2015-12-30 | 2018-12-18 | Amicus Therapeutics Inc | alfa-glicosidase ácida aumentada para o tratamento da doença de pompe |
WO2017173060A1 (en) | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Formulations comprising recombinant acid alpha-glucosidase |
WO2017173059A1 (en) * | 2016-03-30 | 2017-10-05 | Amicus Therapeutics, Inc. | Method for selection of high m6p recombinant proteins |
EP3293260A1 (de) | 2016-09-12 | 2018-03-14 | Genethon | Saure alpha-glucosidase-varianten und verwendungen davon |
PE20191203A1 (es) | 2016-09-12 | 2019-09-10 | Genethon | Variantes de alfa-glucosidasa acida y usos de las mismas |
EP3293203A1 (de) | 2016-09-12 | 2018-03-14 | Genethon | Saure alpha-glucosidase-varianten und verwendungen davon |
US20220331408A1 (en) | 2019-07-09 | 2022-10-20 | Genethon | Treatment of glycogen storage disease (gsd) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0832981A1 (de) * | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten |
WO1993025567A1 (en) | 1992-06-15 | 1993-12-23 | Gene Pharming Europe B.V. | Production of recombinant polypeptides by bovine species and transgenic methods |
DE69027683T2 (de) | 1989-12-01 | 1997-02-13 | Pharming Bv | Herstellung rekombinanter polypeptide durch rinder und transgene methoden |
JPH06506105A (ja) | 1990-08-29 | 1994-07-14 | ファーミング ビーブイ | 哺乳動物細胞における相同性組換え |
US5356804A (en) | 1990-10-24 | 1994-10-18 | Mount Sinai School Of Medicine Of The City Of New York | Cloning and expression of biologically active human α-galactosidase A |
CA2123671C (en) * | 1993-05-17 | 1999-08-03 | Mitsuo Yamada | Oxazolidone ring-containing modified epoxy resins and cathodic electrodeposition paints containing same |
AT1470U1 (de) | 1995-08-01 | 1997-05-26 | Austria Card | Laminierte karte und verfahren zu ihrer herstellung |
US6118045A (en) * | 1995-08-02 | 2000-09-12 | Pharming B.V. | Lysosomal proteins produced in the milk of transgenic animals |
PT1137762E (pt) * | 1998-12-07 | 2009-01-14 | Genzyme Corp | Tratamento da doença de pompe |
-
1999
- 1999-12-06 PT PT99965162T patent/PT1137762E/pt unknown
- 1999-12-06 PT PT81648255T patent/PT2020438T/pt unknown
- 1999-12-06 AU AU31137/00A patent/AU3113700A/en not_active Abandoned
- 1999-12-06 DE DE122009000018C patent/DE122009000018I1/de active Pending
- 1999-12-06 EP EP08164825.5A patent/EP2020438B1/de not_active Expired - Lifetime
- 1999-12-06 ES ES08164825.5T patent/ES2677343T3/es not_active Expired - Lifetime
- 1999-12-06 DE DE69939705T patent/DE69939705D1/de not_active Expired - Lifetime
- 1999-12-06 EP EP99965162A patent/EP1137762B1/de not_active Revoked
- 1999-12-06 DK DK99965162T patent/DK1137762T3/da active
- 1999-12-06 AT AT99965162T patent/ATE410506T1/de active
- 1999-12-06 ES ES99965162T patent/ES2312222T3/es not_active Expired - Lifetime
- 1999-12-06 KR KR1020017007040A patent/KR20010101131A/ko not_active Application Discontinuation
- 1999-12-06 US US09/454,711 patent/US20030007963A1/en not_active Abandoned
- 1999-12-06 CA CA002353522A patent/CA2353522A1/en not_active Abandoned
- 1999-12-06 DK DK08164825.5T patent/DK2020438T3/en active
- 1999-12-06 JP JP2000586885A patent/JP4990434B2/ja not_active Expired - Lifetime
- 1999-12-06 WO PCT/US1999/029042 patent/WO2000034451A1/en not_active Application Discontinuation
-
2003
- 2003-06-30 US US10/611,598 patent/US7351410B2/en not_active Expired - Lifetime
-
2008
- 2008-01-30 US US12/012,003 patent/US7655226B2/en not_active Expired - Fee Related
-
2009
- 2009-03-24 NL NL300382C patent/NL300382I2/nl unknown
- 2009-03-25 LU LU91544C patent/LU91544I2/fr unknown
- 2009-04-20 JP JP2009102515A patent/JP2009161562A/ja not_active Withdrawn
- 2009-12-09 US US12/633,932 patent/US20100092449A1/en not_active Abandoned
-
2011
- 2011-12-21 US US13/333,052 patent/US20130039901A1/en not_active Abandoned
-
2012
- 2012-08-17 JP JP2012181032A patent/JP2012224643A/ja not_active Withdrawn
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2013
- 2013-05-03 US US13/886,573 patent/US20140037611A1/en not_active Abandoned
-
2015
- 2015-05-05 JP JP2015094511A patent/JP2015134836A/ja not_active Withdrawn
- 2015-09-23 US US14/863,333 patent/US20160243203A1/en not_active Abandoned
-
2017
- 2017-01-04 JP JP2017000155A patent/JP2017066160A/ja not_active Withdrawn
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2018
- 2018-03-28 JP JP2018061663A patent/JP2018115200A/ja not_active Withdrawn
- 2018-07-10 CY CY20181100718T patent/CY1121113T1/el unknown
- 2018-07-25 CY CY2018020C patent/CY2018020I2/el unknown
- 2018-09-28 BE BE2018C038C patent/BE2018C038I2/fr unknown
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2019
- 2019-06-05 JP JP2019105319A patent/JP2019172685A/ja active Pending
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