DE122007000008I2 - Reinigung von biologisch aktiven peptiden aus milch - Google Patents

Reinigung von biologisch aktiven peptiden aus milch

Info

Publication number
DE122007000008I2
DE122007000008I2 DE122007000008C DE122007000008C DE122007000008I2 DE 122007000008 I2 DE122007000008 I2 DE 122007000008I2 DE 122007000008 C DE122007000008 C DE 122007000008C DE 122007000008 C DE122007000008 C DE 122007000008C DE 122007000008 I2 DE122007000008 I2 DE 122007000008I2
Authority
DE
Germany
Prior art keywords
milk
purification
biologically active
permeate
active peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE122007000008C
Other languages
German (de)
English (en)
Other versions
DE122007000008I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
rEVO Biologics Inc
Original Assignee
GTC Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GTC Biotherapeutics Inc filed Critical GTC Biotherapeutics Inc
Publication of DE122007000008I1 publication Critical patent/DE122007000008I1/de
Publication of DE122007000008I2 publication Critical patent/DE122007000008I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE122007000008C 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch Active DE122007000008I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/648,235 US6268487B1 (en) 1996-05-13 1996-05-13 Purification of biologically active peptides from milk
PCT/US1997/008044 WO1997042835A1 (en) 1996-05-13 1997-05-13 Purification of biologically active peptides from milk

Publications (2)

Publication Number Publication Date
DE122007000008I1 DE122007000008I1 (de) 2009-05-20
DE122007000008I2 true DE122007000008I2 (de) 2011-01-13

Family

ID=24599969

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122007000008C Active DE122007000008I2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch
DE69715641T Expired - Lifetime DE69715641T2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69715641T Expired - Lifetime DE69715641T2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch

Country Status (14)

Country Link
US (1) US6268487B1 (enExample)
EP (1) EP0923308B1 (enExample)
JP (1) JP4476362B2 (enExample)
AT (1) ATE224145T1 (enExample)
AU (1) AU725993B2 (enExample)
CA (1) CA2254871C (enExample)
DE (2) DE122007000008I2 (enExample)
DK (1) DK0923308T3 (enExample)
ES (1) ES2182074T3 (enExample)
LU (1) LU91305I2 (enExample)
NL (1) NL300256I2 (enExample)
NZ (1) NZ332916A (enExample)
PT (1) PT923308E (enExample)
WO (1) WO1997042835A1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
JP2001520041A (ja) 1997-10-20 2001-10-30 ジェンザイム トランスジェニックス コーポレイション 新規な改変核酸配列並びに細胞システムにおいてｍＲＮＡレベル及び蛋白質発現を増大させる方法
SE9802213D0 (sv) * 1998-06-18 1998-06-18 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
WO2000017239A1 (en) * 1998-09-24 2000-03-30 Ppl Therapeutics (Scotland) Limited Purification of fibrinogen from fluids by precipitation and hydrophobic chromatography
CA2354638C (en) * 1999-01-06 2013-03-19 Atlantic Biopharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
AU5553600A (en) 1999-06-23 2001-01-31 Ppl Therapeutics (Scotland) Ltd Fusion proteins incorporating lysozyme
JP2003532681A (ja) * 2000-05-05 2003-11-05 ジーティーシー バイオセラピューティックス インコーポレイテッド 遺伝子導入により産生されたデコリン
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20040226052A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
BR0210386A (pt) * 2001-06-13 2004-09-14 Taurus Hsa Llc Purificação de albumina de soro humano
US7285631B2 (en) * 2001-08-10 2007-10-23 Serono Genetics Institute S.A. Human cDNAs and proteins and uses thereof
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003090545A1 (en) * 2002-04-24 2003-11-06 Dairy Development Specialists, Inc. Intermediate ingredient for dairy product manufacturing and method of making the same
ATE402955T1 (de) * 2002-05-27 2008-08-15 Nestec Sa Säurelösliche proteine aus casein-micellen
GB0216001D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
JP2006508062A (ja) * 2002-09-17 2006-03-09 ジーティーシー バイオセラピューティックス インコーポレイテッド 重鎖間ジスルフィド結合を欠く免疫グロブリン分子の単離
EP1565564A4 (en) * 2002-11-27 2006-06-07 Gtc Biotherapeutics Inc STILK-STABILIZED ANTIBODIES PRODUCED IN MILK AND METHOD FOR THE MANUFACTURE THEREOF
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
US20040210953A1 (en) * 2003-01-09 2004-10-21 Murray James D. Lysozyme transgenic ungulates
WO2004064750A2 (en) 2003-01-22 2004-08-05 Duke University Improved constructs for expressing lysosomal polypeptides
AU2003261387A1 (en) * 2003-02-24 2004-09-17 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
US20050245444A1 (en) * 2004-04-30 2005-11-03 Yann Echelard Method of using recombinant human antithrombin for neurocognitive disorders
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
WO2006138647A2 (en) * 2005-06-16 2006-12-28 Gtc Biotherapeutics, Inc. Method of making recombinant human antibodies for use in biosensor technology
US20070037192A1 (en) * 2005-07-25 2007-02-15 Gtc Biotherapeutics, Inc. Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile
KR101507027B1 (ko) * 2005-10-21 2015-03-31 엘에프비 유에스에이, 인크. 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
WO2008019036A2 (en) * 2006-08-04 2008-02-14 Pharmathene Inc. Long half-life recombinant butyrylcholinesterase
FR2910786B1 (fr) * 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"
JP5208428B2 (ja) * 2007-01-30 2013-06-12 雪印メグミルク株式会社 美肌剤
FR2912310B1 (fr) 2007-02-13 2009-08-07 Kasan Sarl Nouvelles compositions cosmetiques et/ou pharmaceutiques et leurs applications.
NZ583234A (en) 2007-07-10 2012-06-29 Glanbia Nutritionals Method for removing endotoxin from proteins
TWI346666B (en) * 2007-12-31 2011-08-11 Animal Technology Inst Taiwan Method for seperating casein from casein-contained solution
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
WO2009131052A1 (ja) * 2008-04-21 2009-10-29 不二製油株式会社 脱脂豆乳ペプチドの製造方法
EP2279003A4 (en) * 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF INFLAMMATORY DISEASES
JP5717625B2 (ja) * 2008-05-14 2015-05-13 アグリカルチャー ヴィクトリア サービス ピーティーワイ エルティーディーＡｇｒｉｃｕｌｔｕｒｅ Ｖｉｃｔｏｒｉａ Ｓｅｒｖｉｃｅｓ Ｐｔｙ Ｌｔｄ アンギオゲニン濃縮ミルク分画
SG10201407983VA (en) * 2009-12-18 2015-01-29 Csl Ltd Method of purifying polypeptides
US8729245B2 (en) 2009-12-21 2014-05-20 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
US8861162B2 (en) * 2010-03-09 2014-10-14 Honeywell International Inc. High power solid state power controller (SSPC) solution for primary power distribution applications
CN104922071A (zh) * 2010-04-09 2015-09-23 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
FR2958496A1 (fr) * 2010-04-09 2011-10-14 Bioprotein Technologies Sa Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques.
EP2625262B1 (en) * 2010-10-05 2015-09-23 Novo Nordisk Health Care AG Process for protein production
WO2012090067A1 (en) 2010-12-30 2012-07-05 Lfb Biotechnologies Glycols as pathogen inactivating agents
SG192027A1 (en) 2011-04-01 2013-08-30 Emd Millipore Corp Nanofiber containing composite structures
JP6178311B2 (ja) * 2011-07-07 2017-08-09 エルエフビー ユーエスエー インコーポレイテッドＬｆｂ Ｕｓａ， Ｉｎｃ． タンパク質を安定化する製剤
TW201400499A (zh) 2012-03-12 2014-01-01 Revo Biolog Inc 抗凝血酶用於治療妊娠毒血症之用途
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
WO2014022748A1 (en) 2012-08-03 2014-02-06 Revo Biologics, Inc. The use of antithrombin in extracorporeal membrane oxygenation
US10174110B2 (en) 2013-02-13 2019-01-08 Laboratoire Français Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-α antibodies and uses thereof
WO2014140927A2 (en) 2013-02-13 2014-09-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
KR20160029840A (ko) 2013-07-05 2016-03-15 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 친화성 크로마토그래피 매트릭스
US9661868B2 (en) * 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
EP3149030A2 (en) * 2014-06-02 2017-04-05 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Production of fc fragments
JP6568545B2 (ja) 2014-06-26 2019-08-28 イー・エム・デイー・ミリポア・コーポレイシヨン 増強された汚れ保持容量を有するフィルタ構造
FR3034419B1 (fr) 2015-04-02 2017-12-15 Lab Francais Du Fractionnement Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique
DK3283202T3 (da) * 2015-04-17 2025-12-01 Emd Millipore Corp Fremgangsmåde til rensning af et biologisk materiale af interesse i en prøve gennem brug af ultrafiltreringsmembraner af nanofibre i tangentiel strømningsfiltreringstilstand
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
WO2019016605A1 (en) 2017-07-21 2019-01-24 Merck Millipore Ltd MEMBRANES OF NONWOVEN FIBERS
KR20210016400A (ko) * 2018-05-24 2021-02-15 지앙수 헨그루이 메디슨 컴퍼니 리미티드 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법
FR3082427B1 (fr) 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
WO2022024828A1 (ja) * 2020-07-29 2022-02-03 和弘 原 成分調整物生産装置及び成分調整物生産方法
CN113101737B (zh) * 2021-03-04 2023-09-15 京美生命科技(杭州)有限公司 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459619B1 (fr) 1979-06-26 1983-07-29 Agronomique Inst Nat Rech Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede
FR2487642B2 (fr) 1980-07-31 1985-10-18 Bel Fromageries Procede de preparation de fractions proteiques par ultrafiltration et chromatographie d'exclusion et d'echange d'ions
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
FR2584727B1 (fr) 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
JPS62298536A (ja) 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
DE3743440A1 (de) * 1987-12-21 1989-06-29 Gauri Kailash Kumar Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch
US4897465A (en) 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
WO1993025567A1 (en) 1992-06-15 1993-12-23 Gene Pharming Europe B.V. Production of recombinant polypeptides by bovine species and transgenic methods
AU656720B2 (en) 1989-12-01 1995-02-16 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
NL9001650A (nl) 1990-07-19 1992-02-17 Ver Coop Melkind Werkwijze voor de bereiding van een melkeiwit-isolaat.
US5256294A (en) 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5175013A (en) 1990-12-31 1992-12-29 The Pillsbury Company Frozen dessert compositions and products
US5178894A (en) 1991-09-26 1993-01-12 Silvia P. Rudel High non-fat milk content bread products having improved keeping qualities
US5256437A (en) * 1992-06-19 1993-10-26 Pall Corporation Product and process of making sterile milk through dynamic microfiltration
DK0804070T3 (da) 1993-03-09 2000-08-07 Genzyme Corp Fremgangsmåde til isolering af proteiner fra mælk
FI963197A7 (fi) 1994-02-16 1996-08-15 Pharming Intellectual Property Bv Laktoferriinin eristäminen maidosta
US5597486A (en) * 1995-05-01 1997-01-28 Millipore Investment Holdings Limited Membrane filtration with optimized addition of second liquid to maximize flux

Also Published As

Publication number Publication date
JP2000510701A (ja) 2000-08-22
NL300256I1 (nl) 2007-04-02
EP0923308B1 (en) 2002-09-18
NZ332916A (en) 2000-05-26
US6268487B1 (en) 2001-07-31
NL300256I2 (nl) 2007-09-03
CA2254871C (en) 2008-03-25
DE69715641T2 (de) 2003-08-07
DE69715641D1 (de) 2002-10-24
DK0923308T3 (da) 2002-10-14
LU91305I2 (fr) 2007-03-12
EP0923308A1 (en) 1999-06-23
ATE224145T1 (de) 2002-10-15
ES2182074T3 (es) 2003-03-01
WO1997042835A1 (en) 1997-11-20
JP4476362B2 (ja) 2010-06-09
PT923308E (pt) 2002-11-29
DE122007000008I1 (de) 2009-05-20
EP0923308A4 (enExample) 1999-06-30
AU725993B2 (en) 2000-10-26
CA2254871A1 (en) 1997-11-20
AU2940297A (en) 1997-12-05

Similar Documents

Publication Publication Date Title
ATE224145T1 (de) Reinigung von biologisch aktiven peptiden aus milch
DK0764209T3 (da) Albuminekspression i gær
DK426386D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
ATE346934T1 (de) Modifizierte pflanzenviren als vektore für heterologe peptide
ATE373010T1 (de) Gag-antigen und dessen verwendung zum nachweis von lav-infektion, sowie in immunogenen zusammensetzungen
ATE310017T1 (de) Verfahren zur reinigung und isolierung von wasserlöslichen peptiden und proteinen aus pflanzenquellen
TR199901840T2 (xx) DNA'nın cross-flow-filtrasyonu ile temizlenmesi.
DK0527760T3 (da) Fremgangsmåder og præparater til vaccination mod HIV
ATE146657T1 (de) Verfahren zur herstellung eines molkeprotein- hydrolysates
ATE204019T1 (de) Steigerung der transplantattoleranz durch schwein cytokine
DE69633563D1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
NZ333074A (en) Milk proteins obtained from a bacteria and fat depleted product such as skim milk or whey
DE3789309D1 (de) Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
DK0580829T3 (da) Ekstrakt af bakterielle proteiner, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende den.
DE3786708D1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
ATE311175T1 (de) Verfahren zur verkapselung von proteinen oder peptiden in liposomen
NO971474L (no) Anti-inflammatorisk faktor, fremgangsmåte for isolering, og anvendelse
DK100888D0 (da) Fremgangsmaade til at rense rekombinant pres-1/s-2/s hepatitis b antigen fra gaer
FR2601020B1 (fr) Sorbine purifiee, nouveaux peptides ayant des sequences peptidiques en commun avec la sorbine et compositions pharmaceutiques les contenant
NO149454C (no) Proteinkonsentrat for tilsetning til dyrefor, fremstilling av konsentratet fra gress og andre plantevekster og anvendelse av konsentratet i dyrefor