DE69715641D1 - Reinigung von biologisch aktiven peptiden aus milch - Google Patents

Reinigung von biologisch aktiven peptiden aus milch

Info

Publication number
DE69715641D1
DE69715641D1 DE69715641T DE69715641T DE69715641D1 DE 69715641 D1 DE69715641 D1 DE 69715641D1 DE 69715641 T DE69715641 T DE 69715641T DE 69715641 T DE69715641 T DE 69715641T DE 69715641 D1 DE69715641 D1 DE 69715641D1
Authority
DE
Germany
Prior art keywords
milk
purification
biologically active
permeate
active peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715641T
Other languages
English (en)
Other versions
DE69715641T2 (de
Inventor
P Kutzko
L Hayes
T Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
rEVO Biologics Inc
Original Assignee
Genzyme Transgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Transgenics Corp filed Critical Genzyme Transgenics Corp
Application granted granted Critical
Publication of DE69715641D1 publication Critical patent/DE69715641D1/de
Publication of DE69715641T2 publication Critical patent/DE69715641T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/832Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69715641T 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch Expired - Lifetime DE69715641T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/648,235 US6268487B1 (en) 1996-05-13 1996-05-13 Purification of biologically active peptides from milk
PCT/US1997/008044 WO1997042835A1 (en) 1996-05-13 1997-05-13 Purification of biologically active peptides from milk

Publications (2)

Publication Number Publication Date
DE69715641D1 true DE69715641D1 (de) 2002-10-24
DE69715641T2 DE69715641T2 (de) 2003-08-07

Family

ID=24599969

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69715641T Expired - Lifetime DE69715641T2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch
DE122007000008C Active DE122007000008I2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122007000008C Active DE122007000008I2 (de) 1996-05-13 1997-05-13 Reinigung von biologisch aktiven peptiden aus milch

Country Status (14)

Country Link
US (1) US6268487B1 (de)
EP (1) EP0923308B1 (de)
JP (1) JP4476362B2 (de)
AT (1) ATE224145T1 (de)
AU (1) AU725993B2 (de)
CA (1) CA2254871C (de)
DE (2) DE69715641T2 (de)
DK (1) DK0923308T3 (de)
ES (1) ES2182074T3 (de)
LU (1) LU91305I2 (de)
NL (1) NL300256I2 (de)
NZ (1) NZ332916A (de)
PT (1) PT923308E (de)
WO (1) WO1997042835A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
OA11520A (en) 1997-10-20 2004-02-09 Genzyme Transgenics Corp Novel modified MSP-1 nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
SE9802213D0 (sv) * 1998-06-18 1998-06-18 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
DE69931645T2 (de) * 1998-09-24 2007-05-16 Pharming Intellectual Property Bv Reinigung von fibrinogen aus flüssigkeiten mittels ausfällung und hydrophobischer-interaktion-chromatographie
DE60037397T2 (de) * 1999-01-06 2008-06-05 Merrimack Pharmaceuticals, Inc., Cambridge Expression von ausgeschiedenem, menschlichem alpha-fetoprotein in transgenen tieren
EP1194570A1 (de) 1999-06-23 2002-04-10 PPL Therapeutics (Scotland) Limited Lysozym- enthaltende fusionsproteine
CA2408124A1 (en) * 2000-05-05 2001-11-15 Harry M. Meade Transgenically produced decorin
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20040226053A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
EP1401857A4 (de) * 2001-06-13 2004-07-21 Taurus Hsa Llc Aufreinigung von humanem serumalbumin
EP1414852A2 (de) * 2001-08-10 2004-05-06 Genset S.A. Humanische sekretierte proteine, die dafür kodierenden polynukleotide, und ihre verwendungen
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003090545A1 (en) * 2002-04-24 2003-11-06 Dairy Development Specialists, Inc. Intermediate ingredient for dairy product manufacturing and method of making the same
ATE402955T1 (de) * 2002-05-27 2008-08-15 Nestec Sa Säurelösliche proteine aus casein-micellen
GB0216001D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
WO2004026427A2 (en) * 2002-09-17 2004-04-01 Gtc Biotherapeutics, Inc. Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
WO2004050847A2 (en) * 2002-11-27 2004-06-17 Gtc Biotherapeutics, Inc. Modified antibodies stably produced in milk and methods of producing same
US20040210953A1 (en) * 2003-01-09 2004-10-21 Murray James D. Lysozyme transgenic ungulates
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
JP5433133B2 (ja) 2003-01-22 2014-03-05 デューク・ユニヴァーシティ リソソームポリペプチドを発現するための改善された構築物
AU2003261387A1 (en) * 2003-02-24 2004-09-17 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
US7125963B2 (en) * 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
US20050245444A1 (en) * 2004-04-30 2005-11-03 Yann Echelard Method of using recombinant human antithrombin for neurocognitive disorders
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
WO2006138647A2 (en) * 2005-06-16 2006-12-28 Gtc Biotherapeutics, Inc. Method of making recombinant human antibodies for use in biosensor technology
WO2007014244A2 (en) * 2005-07-25 2007-02-01 Gtc Biotherapeutics, Inc. Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile
EP2388273B1 (de) * 2005-10-21 2017-07-05 LFB USA, Inc. Antikörper mit verbesserter antikörperabhängiger Zelltoxizitätsaktivität sowie Herstellungs- und Verwendungsverfahren dafür
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
FR2901707B1 (fr) * 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
US20090208480A1 (en) * 2006-08-04 2009-08-20 Yue Huang Long half-life recombinant butyrylcholinesterase
FR2910786B1 (fr) * 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"
JP5208428B2 (ja) * 2007-01-30 2013-06-12 雪印メグミルク株式会社 美肌剤
FR2912310B1 (fr) 2007-02-13 2009-08-07 Kasan Sarl Nouvelles compositions cosmetiques et/ou pharmaceutiques et leurs applications.
EP2650302B1 (de) 2007-07-10 2014-10-08 Glanbia Nutritionals (Ireland) Limited Methode zur Entfernung von Endotoxinen von Proteinen
TWI346666B (en) * 2007-12-31 2011-08-11 Animal Technology Inst Taiwan Method for seperating casein from casein-contained solution
EP2077273B1 (de) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Verfahren zur Trennung von Casein aus löslichen Proteinen in einer Zusammensetzung
EP2269471A4 (de) * 2008-04-21 2012-12-26 Fuji Oil Co Ltd Verfahren zur herstellung von entfetteten sojamilchpeptiden
WO2009134389A2 (en) * 2008-05-01 2009-11-05 Gtc Biotherapeutics, Inc. An anti-cd137 antibody as an agent in the treatment of inflammatory conditions
US9247766B2 (en) * 2008-05-14 2016-02-02 Murray Goulburn Co-Operative Co., Limited Angiogenin-enriched milk fractions
EP3715356B1 (de) * 2009-12-18 2023-10-11 CSL Limited Verfahren zur aufreinigung von polypeptiden
EP2516664B1 (de) 2009-12-21 2015-07-22 Pharmathene Inc. Rekombinante butyrylcholinesterase und verkürzungen davon
US8861162B2 (en) * 2010-03-09 2014-10-14 Honeywell International Inc. High power solid state power controller (SSPC) solution for primary power distribution applications
FR2958496A1 (fr) * 2010-04-09 2011-10-14 Bioprotein Technologies Sa Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques.
US20110250264A1 (en) 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
CN103154233A (zh) * 2010-10-05 2013-06-12 诺沃—诺迪斯克保健股份有限公司 生产蛋白质的方法
CN112076330B (zh) 2010-12-30 2023-06-02 法国化学与生物科技实验室 作为病原体灭活剂的二元醇
EP2694196B1 (de) 2011-04-01 2021-07-21 EMD Millipore Corporation Nanofaser mit verbundstrukturen
CA2840876A1 (en) * 2011-07-07 2013-01-10 Revo Biologics, Inc. Formulations that stabilize proteins
TW201400499A (zh) 2012-03-12 2014-01-01 Revo Biolog Inc 抗凝血酶用於治療妊娠毒血症之用途
EP2687595B1 (de) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Verfahren zur Reinigung eines transgenen Faktor VII
AU2013296240B2 (en) 2012-08-03 2018-05-17 Lfb Usa, Inc. The use of antithrombin in extracorporeal membrane oxygenation
CN105263319A (zh) 2013-02-13 2016-01-20 法国化学与生物科技实验室 具有经修饰的糖基化的蛋白及其生产方法
BR112015019341A2 (pt) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal
CA2916566A1 (fr) 2013-07-05 2015-01-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Matrice de chromatographie d'affinite
US9661868B2 (en) * 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
JP2017520531A (ja) * 2014-06-02 2017-07-27 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies Fc断片の産生
KR20160134792A (ko) 2014-06-26 2016-11-23 이엠디 밀리포어 코포레이션 개선된 먼지 포집 능력을 갖는 필터 구조
FR3034419B1 (fr) 2015-04-02 2017-12-15 Lab Francais Du Fractionnement Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique
CN107530639B (zh) 2015-04-17 2021-02-09 Emd密理博公司 使用以切向流过滤模式操作的纳米纤维超滤膜纯化样品中目标生物材料的方法
KR20210016400A (ko) * 2018-05-24 2021-02-15 지앙수 헨그루이 메디슨 컴퍼니 리미티드 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법
FR3082427B1 (fr) 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
JP7478333B2 (ja) * 2020-07-29 2024-05-07 和弘 原 成分調整物生産装置及び成分調整物生産方法
CN113101737B (zh) * 2021-03-04 2023-09-15 京美生命科技(杭州)有限公司 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459619B1 (fr) 1979-06-26 1983-07-29 Agronomique Inst Nat Rech Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede
FR2487642B2 (fr) 1980-07-31 1985-10-18 Bel Fromageries Procede de preparation de fractions proteiques par ultrafiltration et chromatographie d'exclusion et d'echange d'ions
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
FR2584727B1 (fr) 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
JPS62298536A (ja) 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
DE3743440A1 (de) * 1987-12-21 1989-06-29 Gauri Kailash Kumar Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch
US4897465A (en) 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
EP0502976B1 (de) 1989-12-01 1996-07-03 Pharming B.V. Herstellung rekombinanter polypeptide durch rinder und transgene methoden
NL9001650A (nl) 1990-07-19 1992-02-17 Ver Coop Melkind Werkwijze voor de bereiding van een melkeiwit-isolaat.
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5175013A (en) 1990-12-31 1992-12-29 The Pillsbury Company Frozen dessert compositions and products
US5178894A (en) 1991-09-26 1993-01-12 Silvia P. Rudel High non-fat milk content bread products having improved keeping qualities
AU4537393A (en) 1992-06-15 1994-01-04 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
US5256437A (en) * 1992-06-19 1993-10-26 Pall Corporation Product and process of making sterile milk through dynamic microfiltration
JP3801196B2 (ja) 1993-03-09 2006-07-26 ジェンザイム・コーポレイション 乳からの対象化合物の単離
US5861491A (en) 1994-02-16 1999-01-19 Pharming B.V. Isolation of lactoferrin from milk
US5597486A (en) * 1995-05-01 1997-01-28 Millipore Investment Holdings Limited Membrane filtration with optimized addition of second liquid to maximize flux

Also Published As

Publication number Publication date
EP0923308B1 (de) 2002-09-18
ES2182074T3 (es) 2003-03-01
PT923308E (pt) 2002-11-29
LU91305I2 (fr) 2007-03-12
US6268487B1 (en) 2001-07-31
DE69715641T2 (de) 2003-08-07
WO1997042835A1 (en) 1997-11-20
JP4476362B2 (ja) 2010-06-09
EP0923308A4 (de) 1999-06-30
CA2254871A1 (en) 1997-11-20
DE122007000008I2 (de) 2011-01-13
ATE224145T1 (de) 2002-10-15
NL300256I2 (nl) 2007-09-03
EP0923308A1 (de) 1999-06-23
AU2940297A (en) 1997-12-05
DK0923308T3 (da) 2002-10-14
AU725993B2 (en) 2000-10-26
DE122007000008I1 (de) 2009-05-20
JP2000510701A (ja) 2000-08-22
CA2254871C (en) 2008-03-25
NZ332916A (en) 2000-05-26
NL300256I1 (nl) 2007-04-02

Similar Documents

Publication Publication Date Title
DE69715641D1 (de) Reinigung von biologisch aktiven peptiden aus milch
DK426386D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
ATE346934T1 (de) Modifizierte pflanzenviren als vektore für heterologe peptide
DK0764209T3 (da) Albuminekspression i gær
ATE373010T1 (de) Gag-antigen und dessen verwendung zum nachweis von lav-infektion, sowie in immunogenen zusammensetzungen
ATE310017T1 (de) Verfahren zur reinigung und isolierung von wasserlöslichen peptiden und proteinen aus pflanzenquellen
TR199901840T2 (xx) DNA'nın cross-flow-filtrasyonu ile temizlenmesi.
ATE146657T1 (de) Verfahren zur herstellung eines molkeprotein- hydrolysates
FI914911A0 (fi) Ternimaitofraktio, menetelmä sen valmistamiseksi ja sen käyttö kasvualustojen täydennysaineena
DE69633563D1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
NZ333074A (en) Milk proteins obtained from a bacteria and fat depleted product such as skim milk or whey
DE3789309D1 (de) Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
DK0580829T3 (da) Ekstrakt af bakterielle proteiner, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende den.
DE3786708D1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
NO951750L (no) Renset "nontypable" Haemophilus influenzae P5 protein som en vaksine for "nontypable" Haemophilus influenzae stamme
ATE311175T1 (de) Verfahren zur verkapselung von proteinen oder peptiden in liposomen
ATE82471T1 (de) Verfahren zur abtrennung bestimmter proteine aus molke.
ATE91304T1 (de) Verfahren zur herstellung des pres 1/s2/shepatitis-b-antigens aus hefe.
DK628188A (da) Protein og fremgangsmaade til fremstilling deraf
DE3861648D1 (de) Modifizierte anorganische filtermembran zur proteintrennung.
ATE60247T1 (de) Modifizierte anorganische filtermembran zur proteintrennung.