DE69715641D1 - Reinigung von biologisch aktiven peptiden aus milch - Google Patents
Reinigung von biologisch aktiven peptiden aus milchInfo
- Publication number
- DE69715641D1 DE69715641D1 DE69715641T DE69715641T DE69715641D1 DE 69715641 D1 DE69715641 D1 DE 69715641D1 DE 69715641 T DE69715641 T DE 69715641T DE 69715641 T DE69715641 T DE 69715641T DE 69715641 D1 DE69715641 D1 DE 69715641D1
- Authority
- DE
- Germany
- Prior art keywords
- milk
- purification
- biologically active
- permeate
- active peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/832—Milk; colostrum
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/648,235 US6268487B1 (en) | 1996-05-13 | 1996-05-13 | Purification of biologically active peptides from milk |
PCT/US1997/008044 WO1997042835A1 (en) | 1996-05-13 | 1997-05-13 | Purification of biologically active peptides from milk |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69715641D1 true DE69715641D1 (de) | 2002-10-24 |
DE69715641T2 DE69715641T2 (de) | 2003-08-07 |
Family
ID=24599969
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69715641T Expired - Lifetime DE69715641T2 (de) | 1996-05-13 | 1997-05-13 | Reinigung von biologisch aktiven peptiden aus milch |
DE122007000008C Active DE122007000008I2 (de) | 1996-05-13 | 1997-05-13 | Reinigung von biologisch aktiven peptiden aus milch |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122007000008C Active DE122007000008I2 (de) | 1996-05-13 | 1997-05-13 | Reinigung von biologisch aktiven peptiden aus milch |
Country Status (14)
Country | Link |
---|---|
US (1) | US6268487B1 (de) |
EP (1) | EP0923308B1 (de) |
JP (1) | JP4476362B2 (de) |
AT (1) | ATE224145T1 (de) |
AU (1) | AU725993B2 (de) |
CA (1) | CA2254871C (de) |
DE (2) | DE69715641T2 (de) |
DK (1) | DK0923308T3 (de) |
ES (1) | ES2182074T3 (de) |
LU (1) | LU91305I2 (de) |
NL (1) | NL300256I2 (de) |
NZ (1) | NZ332916A (de) |
PT (1) | PT923308E (de) |
WO (1) | WO1997042835A1 (de) |
Families Citing this family (69)
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DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
OA11520A (en) | 1997-10-20 | 2004-02-09 | Genzyme Transgenics Corp | Novel modified MSP-1 nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems. |
SE9802213D0 (sv) * | 1998-06-18 | 1998-06-18 | Amersham Pharm Biotech Ab | A method for the removal/purification of serum albumins and means for use in the method |
US20030005468A1 (en) * | 1998-06-19 | 2003-01-02 | Meade Harry M. | Methods and vectors for improving nucleic acid expression |
DE69931645T2 (de) * | 1998-09-24 | 2007-05-16 | Pharming Intellectual Property Bv | Reinigung von fibrinogen aus flüssigkeiten mittels ausfällung und hydrophobischer-interaktion-chromatographie |
DE60037397T2 (de) * | 1999-01-06 | 2008-06-05 | Merrimack Pharmaceuticals, Inc., Cambridge | Expression von ausgeschiedenem, menschlichem alpha-fetoprotein in transgenen tieren |
EP1194570A1 (de) | 1999-06-23 | 2002-04-10 | PPL Therapeutics (Scotland) Limited | Lysozym- enthaltende fusionsproteine |
CA2408124A1 (en) * | 2000-05-05 | 2001-11-15 | Harry M. Meade | Transgenically produced decorin |
US20020077775A1 (en) * | 2000-05-25 | 2002-06-20 | Schork Nicholas J. | Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof |
US20030195707A1 (en) * | 2000-05-25 | 2003-10-16 | Schork Nicholas J | Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof |
US20040226053A1 (en) * | 2000-10-13 | 2004-11-11 | Meade Harry M. | Methods of producing a target molecule in a transgenic animal and purification of the target molecule |
EP1401857A4 (de) * | 2001-06-13 | 2004-07-21 | Taurus Hsa Llc | Aufreinigung von humanem serumalbumin |
EP1414852A2 (de) * | 2001-08-10 | 2004-05-06 | Genset S.A. | Humanische sekretierte proteine, die dafür kodierenden polynukleotide, und ihre verwendungen |
US6875459B2 (en) * | 2001-09-10 | 2005-04-05 | Henry B. Kopf | Method and apparatus for separation of milk, colostrum, and whey |
US20060253913A1 (en) * | 2001-12-21 | 2006-11-09 | Yue-Jin Huang | Production of hSA-linked butyrylcholinesterases in transgenic mammals |
WO2003090545A1 (en) * | 2002-04-24 | 2003-11-06 | Dairy Development Specialists, Inc. | Intermediate ingredient for dairy product manufacturing and method of making the same |
ATE402955T1 (de) * | 2002-05-27 | 2008-08-15 | Nestec Sa | Säurelösliche proteine aus casein-micellen |
GB0216001D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
WO2004026427A2 (en) * | 2002-09-17 | 2004-04-01 | Gtc Biotherapeutics, Inc. | Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds |
WO2004050847A2 (en) * | 2002-11-27 | 2004-06-17 | Gtc Biotherapeutics, Inc. | Modified antibodies stably produced in milk and methods of producing same |
US20040210953A1 (en) * | 2003-01-09 | 2004-10-21 | Murray James D. | Lysozyme transgenic ungulates |
US20040231010A1 (en) * | 2003-01-09 | 2004-11-18 | Murray James D. | Lysozyme transgenic ungulates |
JP5433133B2 (ja) | 2003-01-22 | 2014-03-05 | デューク・ユニヴァーシティ | リソソームポリペプチドを発現するための改善された構築物 |
AU2003261387A1 (en) * | 2003-02-24 | 2004-09-17 | Gtc Biotherapeutics, Inc. | Methods of tangential flow filtration and an apparatus therefore |
US7125963B2 (en) * | 2004-03-03 | 2006-10-24 | En N Tech Inc | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions |
US20050197496A1 (en) * | 2004-03-04 | 2005-09-08 | Gtc Biotherapeutics, Inc. | Methods of protein fractionation using high performance tangential flow filtration |
US20050245444A1 (en) * | 2004-04-30 | 2005-11-03 | Yann Echelard | Method of using recombinant human antithrombin for neurocognitive disorders |
US20060121004A1 (en) * | 2004-12-07 | 2006-06-08 | Yann Echelard | Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin |
US20060130159A1 (en) * | 2004-12-09 | 2006-06-15 | Nick Masiello | Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum |
US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
WO2006138647A2 (en) * | 2005-06-16 | 2006-12-28 | Gtc Biotherapeutics, Inc. | Method of making recombinant human antibodies for use in biosensor technology |
WO2007014244A2 (en) * | 2005-07-25 | 2007-02-01 | Gtc Biotherapeutics, Inc. | Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile |
EP2388273B1 (de) * | 2005-10-21 | 2017-07-05 | LFB USA, Inc. | Antikörper mit verbesserter antikörperabhängiger Zelltoxizitätsaktivität sowie Herstellungs- und Verwendungsverfahren dafür |
US7531632B2 (en) * | 2006-02-16 | 2009-05-12 | Gtc Biotherapeutics, Inc. | Clarification of transgenic milk using depth filtration |
FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
US20090208480A1 (en) * | 2006-08-04 | 2009-08-20 | Yue Huang | Long half-life recombinant butyrylcholinesterase |
FR2910786B1 (fr) * | 2006-12-29 | 2017-08-11 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) | "procede d'extraction d'une proteine presente dans du lait" |
JP5208428B2 (ja) * | 2007-01-30 | 2013-06-12 | 雪印メグミルク株式会社 | 美肌剤 |
FR2912310B1 (fr) | 2007-02-13 | 2009-08-07 | Kasan Sarl | Nouvelles compositions cosmetiques et/ou pharmaceutiques et leurs applications. |
EP2650302B1 (de) | 2007-07-10 | 2014-10-08 | Glanbia Nutritionals (Ireland) Limited | Methode zur Entfernung von Endotoxinen von Proteinen |
TWI346666B (en) * | 2007-12-31 | 2011-08-11 | Animal Technology Inst Taiwan | Method for seperating casein from casein-contained solution |
EP2077273B1 (de) | 2007-12-31 | 2011-09-14 | Animal Technology Institute Taiwan | Verfahren zur Trennung von Casein aus löslichen Proteinen in einer Zusammensetzung |
EP2269471A4 (de) * | 2008-04-21 | 2012-12-26 | Fuji Oil Co Ltd | Verfahren zur herstellung von entfetteten sojamilchpeptiden |
WO2009134389A2 (en) * | 2008-05-01 | 2009-11-05 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatment of inflammatory conditions |
US9247766B2 (en) * | 2008-05-14 | 2016-02-02 | Murray Goulburn Co-Operative Co., Limited | Angiogenin-enriched milk fractions |
EP3715356B1 (de) * | 2009-12-18 | 2023-10-11 | CSL Limited | Verfahren zur aufreinigung von polypeptiden |
EP2516664B1 (de) | 2009-12-21 | 2015-07-22 | Pharmathene Inc. | Rekombinante butyrylcholinesterase und verkürzungen davon |
US8861162B2 (en) * | 2010-03-09 | 2014-10-14 | Honeywell International Inc. | High power solid state power controller (SSPC) solution for primary power distribution applications |
FR2958496A1 (fr) * | 2010-04-09 | 2011-10-14 | Bioprotein Technologies Sa | Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques. |
US20110250264A1 (en) | 2010-04-09 | 2011-10-13 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
CN103154233A (zh) * | 2010-10-05 | 2013-06-12 | 诺沃—诺迪斯克保健股份有限公司 | 生产蛋白质的方法 |
CN112076330B (zh) | 2010-12-30 | 2023-06-02 | 法国化学与生物科技实验室 | 作为病原体灭活剂的二元醇 |
EP2694196B1 (de) | 2011-04-01 | 2021-07-21 | EMD Millipore Corporation | Nanofaser mit verbundstrukturen |
CA2840876A1 (en) * | 2011-07-07 | 2013-01-10 | Revo Biologics, Inc. | Formulations that stabilize proteins |
TW201400499A (zh) | 2012-03-12 | 2014-01-01 | Revo Biolog Inc | 抗凝血酶用於治療妊娠毒血症之用途 |
EP2687595B1 (de) | 2012-07-19 | 2018-05-30 | Laboratoire Français du Fractionnement et des Biotechnologies | Verfahren zur Reinigung eines transgenen Faktor VII |
AU2013296240B2 (en) | 2012-08-03 | 2018-05-17 | Lfb Usa, Inc. | The use of antithrombin in extracorporeal membrane oxygenation |
CN105263319A (zh) | 2013-02-13 | 2016-01-20 | 法国化学与生物科技实验室 | 具有经修饰的糖基化的蛋白及其生产方法 |
BR112015019341A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal |
CA2916566A1 (fr) | 2013-07-05 | 2015-01-08 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Matrice de chromatographie d'affinite |
US9661868B2 (en) * | 2013-07-16 | 2017-05-30 | Mead Johnson Nutrition Company | Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin |
JP2017520531A (ja) * | 2014-06-02 | 2017-07-27 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | Fc断片の産生 |
KR20160134792A (ko) | 2014-06-26 | 2016-11-23 | 이엠디 밀리포어 코포레이션 | 개선된 먼지 포집 능력을 갖는 필터 구조 |
FR3034419B1 (fr) | 2015-04-02 | 2017-12-15 | Lab Francais Du Fractionnement | Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique |
CN107530639B (zh) | 2015-04-17 | 2021-02-09 | Emd密理博公司 | 使用以切向流过滤模式操作的纳米纤维超滤膜纯化样品中目标生物材料的方法 |
KR20210016400A (ko) * | 2018-05-24 | 2021-02-15 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 재조합 인간 인슐린 또는 그 유사체의 전구체를 제조하는 방법 |
FR3082427B1 (fr) | 2018-06-14 | 2020-09-25 | Lab Francais Du Fractionnement | Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x |
JP7478333B2 (ja) * | 2020-07-29 | 2024-05-07 | 和弘 原 | 成分調整物生産装置及び成分調整物生産方法 |
CN113101737B (zh) * | 2021-03-04 | 2023-09-15 | 京美生命科技(杭州)有限公司 | 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2459619B1 (fr) | 1979-06-26 | 1983-07-29 | Agronomique Inst Nat Rech | Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede |
FR2487642B2 (fr) | 1980-07-31 | 1985-10-18 | Bel Fromageries | Procede de preparation de fractions proteiques par ultrafiltration et chromatographie d'exclusion et d'echange d'ions |
DE3432718C1 (de) | 1984-09-06 | 1986-05-22 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen |
FR2584727B1 (fr) | 1985-07-11 | 1988-06-17 | Roussel Uclaf | Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques |
JPS62298536A (ja) | 1986-06-17 | 1987-12-25 | Green Cross Corp:The | 生理活性物質の自動精製方法および自動精製装置 |
DE3743440A1 (de) * | 1987-12-21 | 1989-06-29 | Gauri Kailash Kumar | Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch |
US4897465A (en) | 1988-10-12 | 1990-01-30 | Abbott Laboratories | Enrichment and concentration of proteins by ultrafiltration |
EP0502976B1 (de) | 1989-12-01 | 1996-07-03 | Pharming B.V. | Herstellung rekombinanter polypeptide durch rinder und transgene methoden |
NL9001650A (nl) | 1990-07-19 | 1992-02-17 | Ver Coop Melkind | Werkwijze voor de bereiding van een melkeiwit-isolaat. |
US5256294A (en) * | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
US5175013A (en) | 1990-12-31 | 1992-12-29 | The Pillsbury Company | Frozen dessert compositions and products |
US5178894A (en) | 1991-09-26 | 1993-01-12 | Silvia P. Rudel | High non-fat milk content bread products having improved keeping qualities |
AU4537393A (en) | 1992-06-15 | 1994-01-04 | Gene Pharming Europe Bv | Production of recombinant polypeptides by bovine species and transgenic methods |
US5256437A (en) * | 1992-06-19 | 1993-10-26 | Pall Corporation | Product and process of making sterile milk through dynamic microfiltration |
JP3801196B2 (ja) | 1993-03-09 | 2006-07-26 | ジェンザイム・コーポレイション | 乳からの対象化合物の単離 |
US5861491A (en) | 1994-02-16 | 1999-01-19 | Pharming B.V. | Isolation of lactoferrin from milk |
US5597486A (en) * | 1995-05-01 | 1997-01-28 | Millipore Investment Holdings Limited | Membrane filtration with optimized addition of second liquid to maximize flux |
-
1996
- 1996-05-13 US US08/648,235 patent/US6268487B1/en not_active Expired - Lifetime
-
1997
- 1997-05-13 DE DE69715641T patent/DE69715641T2/de not_active Expired - Lifetime
- 1997-05-13 AT AT97923643T patent/ATE224145T1/de active
- 1997-05-13 CA CA002254871A patent/CA2254871C/en not_active Expired - Lifetime
- 1997-05-13 NZ NZ332916A patent/NZ332916A/xx not_active IP Right Cessation
- 1997-05-13 WO PCT/US1997/008044 patent/WO1997042835A1/en active IP Right Grant
- 1997-05-13 DE DE122007000008C patent/DE122007000008I2/de active Active
- 1997-05-13 DK DK97923643T patent/DK0923308T3/da active
- 1997-05-13 AU AU29402/97A patent/AU725993B2/en not_active Expired
- 1997-05-13 EP EP97923643A patent/EP0923308B1/de not_active Expired - Lifetime
- 1997-05-13 PT PT97923643T patent/PT923308E/pt unknown
- 1997-05-13 ES ES97923643T patent/ES2182074T3/es not_active Expired - Lifetime
- 1997-05-13 JP JP54103697A patent/JP4476362B2/ja not_active Expired - Lifetime
-
2007
- 2007-01-12 LU LU91305C patent/LU91305I2/fr unknown
- 2007-01-19 NL NL300256C patent/NL300256I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0923308B1 (de) | 2002-09-18 |
ES2182074T3 (es) | 2003-03-01 |
PT923308E (pt) | 2002-11-29 |
LU91305I2 (fr) | 2007-03-12 |
US6268487B1 (en) | 2001-07-31 |
DE69715641T2 (de) | 2003-08-07 |
WO1997042835A1 (en) | 1997-11-20 |
JP4476362B2 (ja) | 2010-06-09 |
EP0923308A4 (de) | 1999-06-30 |
CA2254871A1 (en) | 1997-11-20 |
DE122007000008I2 (de) | 2011-01-13 |
ATE224145T1 (de) | 2002-10-15 |
NL300256I2 (nl) | 2007-09-03 |
EP0923308A1 (de) | 1999-06-23 |
AU2940297A (en) | 1997-12-05 |
DK0923308T3 (da) | 2002-10-14 |
AU725993B2 (en) | 2000-10-26 |
DE122007000008I1 (de) | 2009-05-20 |
JP2000510701A (ja) | 2000-08-22 |
CA2254871C (en) | 2008-03-25 |
NZ332916A (en) | 2000-05-26 |
NL300256I1 (nl) | 2007-04-02 |
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