JP2000510701A - 生物学的に活性なペプチドのミルクからの精製 - Google Patents
生物学的に活性なペプチドのミルクからの精製Info
- Publication number
- JP2000510701A JP2000510701A JP09541036A JP54103697A JP2000510701A JP 2000510701 A JP2000510701 A JP 2000510701A JP 09541036 A JP09541036 A JP 09541036A JP 54103697 A JP54103697 A JP 54103697A JP 2000510701 A JP2000510701 A JP 2000510701A
- Authority
- JP
- Japan
- Prior art keywords
- milk
- soluble
- protein
- capture device
- permeate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/832—Milk; colostrum
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.可溶性乳成分をミルク又はミルク画分から分離する方法であって、下記を含 む当該方法: a) ミルク又はミルク画分を、保持物と可溶性乳成分を含む透過物とを形成 するのに十分な多孔度の膜を横切る接線流濾過にかけ; b) この透過物を捕獲用デバイスにかけて、実質的にその可溶性乳成分を取 り出し; c) ステップb)におけるこの捕獲用デバイスからの流出物を元のミルク試 料と合わせ;そして d) ステップa)からc)を、可溶性乳成分が実質的に回収されるまで繰り 返す。 2.ミルク又はミルク画分を、ミルクの凝集を減じて、濾過膜の通過を改善する のに十分な量のキレート化剤と合わせる、請求項1に記載の方法。 3.成分がペプチド又は蛋白質である、請求項1に記載の方法。 4.蛋白質を、糖蛋白質、免疫グロブリン、ペプチド、ホルモン、酵素、血清蛋 白質、乳蛋白質、細胞性蛋白質、可溶性レセプター及び産業用酵素よりなる群か ら選択する、請求項3に記載の方法。 5.蛋白質を、エリスロポエチン、アルファ−1プロテイナーゼインヒビター、 アルカリホスファターゼ、アンギオゲニン、抗トロンビンIII、キチナーゼ、細 胞外スーパーオキシドジスムターゼ、因子VIII、因子IX、因子X、フィブリノー ゲン、グルコセレブロシダーゼ、グルタメートデカルボキシラーゼ、ヒト血清ア ルブミン、インシュリン、ミエリン塩基性蛋白質、ラクトフェリン、ラクトグロ ブリン、リゾチーム、ラクタルブミン、プロインシュリン、可溶性CD4、可溶 性CD4の成分及び複合体、組織プラスミノーゲンアクチベーター並びにこれら の変化物よりなる群から選択する、請求項4に記載の方法。 6.接線流フィルターが、実質的にすべての脂肪、カゼインミセル、体細胞及び 粒状物を保持物中に保持するのに十分な多孔度を有する、請求項1に記載の方法 。 7.接線流フィルターが0.1〜1,000ナノメートルの範囲の細孔寸法を有 する、請求項1に記載の方法。 8.生乳中に存在する細菌、マイコプラズマ、ウイルス、プリオン粒子及び他の 汚染微生物が実質的に除去される、請求項1に記載の方法。 9.キレート化剤を、EDTA、EGTA及びシトレートよりなる群から選択す る、請求項2に記載の方法。 10.キレート化剤を、1〜500ミリモルの終濃度範囲で加える、請求項9に 記載の方法。 11.キレート化剤がEDTAである、請求項9に記載の方法。 12.EDTAを、約25ミリモルの終濃度で加える、請求項11に記載の方法 。 13.捕獲用デバイスがクロマトグラフィー捕獲用デバイスである、請求項1に 記載の方法。 14.クロマトグラフィー捕獲用デバイスがアフィニティークロマトグラフィー 捕獲用デバイスである、請求項13に記載の方法。 15.アフィニティークロマトグラフィー捕獲用デバイスを、ヘパリンカラム、 プロテインAカラム又はプロテインGカラムよりなる群から選択する、請求項1 4に記載の方法。 16.クロマトグラフィー捕獲用デバイスが、イオン交換クロマトグラフィー捕 獲用デバイスである、請求項13に記載の方法。 17.ミルクを、トランスジェニック哺乳動物及びトランソミック哺乳動物より なる群から選択する泌乳性非ヒト哺乳動物から得る、請求項1に記載の方法。 18.ミルクを、トランスジェニックウシ、ヤギ、ブタ、ウサギ、マウス、ラッ ト又はヒツジから得る、請求項17に記載の方法。 19.可溶性乳成分を、閉ループ式連続抽出システムにおいてミルク又はミルク 画分から分離する方法であって、下記を含む当該方法: a) ミルク又はミルク画分を、保持物と可溶性乳成分を含む透過物とを形成 するのに十分な多孔度の膜を横切る接線流濾過にかけ; b) この透過物をクロマトグラフィー捕獲用デバイスにかけて、実質的に、 可溶性乳成分を取り出し; c) ステップb)における捕獲手順からの流出液を元のミルク試料と合わせ ;そして d) ステップa)からc)を、可溶性乳成分が、実質的に、回収される間で 繰り返す。 20.クロマトグラフィー捕獲用デバイスがアフィニティークロマトグラフィー 捕獲用デバイスである、請求項19に記載の方法。 21.クロマトグラフィー捕獲用デバイスがイオン交換クロマトグラフィー捕獲 用デバイスである、請求項19に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/648,235 US6268487B1 (en) | 1996-05-13 | 1996-05-13 | Purification of biologically active peptides from milk |
US08/648,235 | 1996-05-13 | ||
PCT/US1997/008044 WO1997042835A1 (en) | 1996-05-13 | 1997-05-13 | Purification of biologically active peptides from milk |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000510701A true JP2000510701A (ja) | 2000-08-22 |
JP2000510701A5 JP2000510701A5 (ja) | 2005-01-13 |
JP4476362B2 JP4476362B2 (ja) | 2010-06-09 |
Family
ID=24599969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54103697A Expired - Lifetime JP4476362B2 (ja) | 1996-05-13 | 1997-05-13 | 生物学的に活性なペプチドのミルクからの精製 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6268487B1 (ja) |
EP (1) | EP0923308B1 (ja) |
JP (1) | JP4476362B2 (ja) |
AT (1) | ATE224145T1 (ja) |
AU (1) | AU725993B2 (ja) |
CA (1) | CA2254871C (ja) |
DE (2) | DE69715641T2 (ja) |
DK (1) | DK0923308T3 (ja) |
ES (1) | ES2182074T3 (ja) |
LU (1) | LU91305I2 (ja) |
NL (1) | NL300256I2 (ja) |
NZ (1) | NZ332916A (ja) |
PT (1) | PT923308E (ja) |
WO (1) | WO1997042835A1 (ja) |
Cited By (7)
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JP2010514746A (ja) * | 2006-12-29 | 2010-05-06 | エルエフビー バイオテクノロジーズ | ミルクからのタンパク質の抽出方法 |
JP2011519962A (ja) * | 2008-05-14 | 2011-07-14 | アグリカルチャー ヴィクトリア サービス ピーティーワイ エルティーディー | アンギオゲニン濃縮ミルク分画 |
JP2013524786A (ja) * | 2010-04-09 | 2013-06-20 | バイオプロテイン テクノロジーズ エスエー | トランスジェニック動物の乳からの組換えヒト血漿リン脂質転送タンパク質(pltp)の製造 |
JP2013538588A (ja) * | 2010-10-05 | 2013-10-17 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | タンパク質を生産するための方法 |
JP2014520820A (ja) * | 2011-07-07 | 2014-08-25 | エルエフビー ユーエスエー インコーポレイテッド | タンパク質を安定化する製剤 |
JP2017520531A (ja) * | 2014-06-02 | 2017-07-27 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | Fc断片の産生 |
JP2018513008A (ja) * | 2015-04-17 | 2018-05-24 | イー・エム・デイー・ミリポア・コーポレイシヨン | 接線流濾過モードで作動するナノファイバー限外濾過膜を用いた、試料中の目的の生物学的物質を精製する方法 |
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JP3670003B2 (ja) | 1992-06-15 | 2005-07-13 | ファーミング ビー.ブイ. | ウシ種による組み換えポリペプチドの製造及びトランスジェニック法 |
US5256437A (en) * | 1992-06-19 | 1993-10-26 | Pall Corporation | Product and process of making sterile milk through dynamic microfiltration |
PT804070E (pt) | 1993-03-09 | 2000-11-30 | Genzyme Corp | Isolamento de componentes de interesse a partir do leite. |
CA2183459A1 (en) | 1994-02-16 | 1995-08-24 | Jan H. Nuijens | Isolation of lactoferrin from milk |
US5597486A (en) * | 1995-05-01 | 1997-01-28 | Millipore Investment Holdings Limited | Membrane filtration with optimized addition of second liquid to maximize flux |
-
1996
- 1996-05-13 US US08/648,235 patent/US6268487B1/en not_active Expired - Lifetime
-
1997
- 1997-05-13 PT PT97923643T patent/PT923308E/pt unknown
- 1997-05-13 AU AU29402/97A patent/AU725993B2/en not_active Expired
- 1997-05-13 CA CA002254871A patent/CA2254871C/en not_active Expired - Lifetime
- 1997-05-13 WO PCT/US1997/008044 patent/WO1997042835A1/en active IP Right Grant
- 1997-05-13 JP JP54103697A patent/JP4476362B2/ja not_active Expired - Lifetime
- 1997-05-13 AT AT97923643T patent/ATE224145T1/de active
- 1997-05-13 NZ NZ332916A patent/NZ332916A/xx not_active IP Right Cessation
- 1997-05-13 EP EP97923643A patent/EP0923308B1/en not_active Expired - Lifetime
- 1997-05-13 DK DK97923643T patent/DK0923308T3/da active
- 1997-05-13 DE DE69715641T patent/DE69715641T2/de not_active Expired - Lifetime
- 1997-05-13 DE DE122007000008C patent/DE122007000008I2/de active Active
- 1997-05-13 ES ES97923643T patent/ES2182074T3/es not_active Expired - Lifetime
-
2007
- 2007-01-12 LU LU91305C patent/LU91305I2/fr unknown
- 2007-01-19 NL NL300256C patent/NL300256I2/nl unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2010514746A (ja) * | 2006-12-29 | 2010-05-06 | エルエフビー バイオテクノロジーズ | ミルクからのタンパク質の抽出方法 |
JP2011519962A (ja) * | 2008-05-14 | 2011-07-14 | アグリカルチャー ヴィクトリア サービス ピーティーワイ エルティーディー | アンギオゲニン濃縮ミルク分画 |
JP2013524786A (ja) * | 2010-04-09 | 2013-06-20 | バイオプロテイン テクノロジーズ エスエー | トランスジェニック動物の乳からの組換えヒト血漿リン脂質転送タンパク質(pltp)の製造 |
JP2013538588A (ja) * | 2010-10-05 | 2013-10-17 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | タンパク質を生産するための方法 |
US10138290B2 (en) | 2010-10-05 | 2018-11-27 | Novo Nordisk Healthcare Ag | Process for protein production |
JP2014520820A (ja) * | 2011-07-07 | 2014-08-25 | エルエフビー ユーエスエー インコーポレイテッド | タンパク質を安定化する製剤 |
JP2017520531A (ja) * | 2014-06-02 | 2017-07-27 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | Fc断片の産生 |
JP2018513008A (ja) * | 2015-04-17 | 2018-05-24 | イー・エム・デイー・ミリポア・コーポレイシヨン | 接線流濾過モードで作動するナノファイバー限外濾過膜を用いた、試料中の目的の生物学的物質を精製する方法 |
Also Published As
Publication number | Publication date |
---|---|
ATE224145T1 (de) | 2002-10-15 |
DE122007000008I2 (de) | 2011-01-13 |
NZ332916A (en) | 2000-05-26 |
DE122007000008I1 (de) | 2009-05-20 |
ES2182074T3 (es) | 2003-03-01 |
DE69715641D1 (de) | 2002-10-24 |
PT923308E (pt) | 2002-11-29 |
CA2254871C (en) | 2008-03-25 |
EP0923308A4 (ja) | 1999-06-30 |
EP0923308A1 (en) | 1999-06-23 |
US6268487B1 (en) | 2001-07-31 |
LU91305I2 (fr) | 2007-03-12 |
WO1997042835A1 (en) | 1997-11-20 |
JP4476362B2 (ja) | 2010-06-09 |
NL300256I2 (nl) | 2007-09-03 |
AU2940297A (en) | 1997-12-05 |
DE69715641T2 (de) | 2003-08-07 |
CA2254871A1 (en) | 1997-11-20 |
NL300256I1 (nl) | 2007-04-02 |
AU725993B2 (en) | 2000-10-26 |
EP0923308B1 (en) | 2002-09-18 |
DK0923308T3 (da) | 2002-10-14 |
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