ATE204019T1 - Steigerung der transplantattoleranz durch schwein cytokine - Google Patents
Steigerung der transplantattoleranz durch schwein cytokineInfo
- Publication number
- ATE204019T1 ATE204019T1 AT93925071T AT93925071T ATE204019T1 AT E204019 T1 ATE204019 T1 AT E204019T1 AT 93925071 T AT93925071 T AT 93925071T AT 93925071 T AT93925071 T AT 93925071T AT E204019 T1 ATE204019 T1 AT E204019T1
- Authority
- AT
- Austria
- Prior art keywords
- porcine
- bone marrow
- marrow cells
- increase
- cytokine
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 4
- 108090000695 Cytokines Proteins 0.000 title abstract 4
- 210000002798 bone marrow cell Anatomy 0.000 abstract 4
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96718892A | 1992-10-27 | 1992-10-27 | |
US08/133,979 US5589582A (en) | 1992-10-27 | 1993-10-08 | Polynucleotides en coding porcine cytokines |
PCT/US1993/010295 WO1994009803A1 (en) | 1992-10-27 | 1993-10-26 | Enhancement of xenograft tolerance and porcine cytokines therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE204019T1 true ATE204019T1 (de) | 2001-08-15 |
Family
ID=26831859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93925071T ATE204019T1 (de) | 1992-10-27 | 1993-10-26 | Steigerung der transplantattoleranz durch schwein cytokine |
Country Status (8)
Country | Link |
---|---|
US (3) | US5589582A (de) |
EP (1) | EP0669829B1 (de) |
JP (1) | JP3784063B2 (de) |
AT (1) | ATE204019T1 (de) |
AU (2) | AU5452194A (de) |
CA (1) | CA2147989C (de) |
DE (1) | DE69330566T2 (de) |
WO (1) | WO1994009803A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
GB9515839D0 (en) * | 1995-08-02 | 1995-10-04 | Q One Biotech Ltd | Feline stem cell factor |
US6011197A (en) | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
US6428782B1 (en) | 1997-05-23 | 2002-08-06 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
US6447767B1 (en) | 1997-05-23 | 2002-09-10 | Hadasit Medical Research Services And Development Ltd. | Non-myeloablative tolerogenic treatment |
AU8828898A (en) * | 1997-08-13 | 1999-03-08 | Biotransplant Incorporated | Porcine stem cell factor varients and recombinant cells expressing such polypeptides |
WO1999009141A1 (en) * | 1997-08-14 | 1999-02-25 | Biotransplant, Inc. | Porcine totipotent cells and method for long-term culture |
US6248587B1 (en) * | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
US6703209B1 (en) * | 1998-08-13 | 2004-03-09 | Biotransplant, Inc. | Porcine totipotent cells and method for long-term culture |
US6700037B2 (en) | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
US6258998B1 (en) | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
US6538028B1 (en) | 2000-02-01 | 2003-03-25 | Vanderbilt University | Method for inhibiting complement activation |
EP1335972A2 (de) * | 2000-11-22 | 2003-08-20 | Geron Corporation | Toleranz-induzierende allotransplantate aus pluripotenten stammzellen |
AU2002338660B2 (en) * | 2001-03-28 | 2006-06-15 | Mayo Foundation For Medical Education And Research | Elimination of endogenous porcine retrovirus |
US20020152490A1 (en) * | 2001-04-12 | 2002-10-17 | Philip Lake | Tolerance-inducing thy-marrow composite tissue construct and organ |
AU2002363322A1 (en) * | 2001-10-26 | 2003-05-19 | Large Scale Biology Corporation | Endothelial cell derived hemotopoietic growth factor |
DE60330468D1 (de) | 2002-08-21 | 2010-01-21 | Revivicor Inc | Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferase |
US8106251B2 (en) | 2002-08-21 | 2012-01-31 | Revivicor, Inc. | Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
CA2548080A1 (en) | 2003-11-05 | 2005-05-26 | University Of Pittsburgh | Porcine isogloboside 3 synthase protein, cdna, genomic organization, and regulatory region |
US7489849B2 (en) * | 2004-11-03 | 2009-02-10 | Adc Telecommunications, Inc. | Fiber drop terminal |
EP2476437B1 (de) | 2006-08-11 | 2018-11-28 | Life Sciences Research Partners VZW | Immunogene Peptide und deren Verwendung bei Immunerkrankungen |
EP2623125A1 (de) | 2008-02-14 | 2013-08-07 | Life Sciences Research Partners VZW | Beseitigung von Immunantworten an virale Vektoren |
EP2244733B1 (de) | 2008-02-14 | 2015-06-17 | Life Sciences Research Partners VZW | Auf intrazelluläre pathogene abzielende immuntherapie |
AU2009214039B2 (en) * | 2008-02-14 | 2013-09-19 | Katholieke Universiteit Leuven | Immunogenic control of tumours and tumour cells |
EP2249855B1 (de) * | 2008-02-14 | 2017-03-22 | Life Sciences Research Partners VZW | Immunogene peptide und ihre verwendung bei transplantationen |
EP2249864B1 (de) * | 2008-02-14 | 2016-05-04 | Life Sciences Research Partners VZW | Strategien zur Prävention und/oder Behandlung von Immunantworten auf lösliche Allofaktoren |
WO2009101207A1 (en) | 2008-02-14 | 2009-08-20 | Life Sciences Research Partners Vzw | Cd4+ t-cells with cytolytic properties |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
ES2924027T3 (es) | 2010-11-25 | 2022-10-04 | Imcyse Sa | Péptidos inmunogénicos para su uso en la prevención y/o tratamiento de enfermedades infecciosas, enfermedades autoinmunitarias, respuestas inmunitarias a alofactores, enfermedades alérgicas, tumores, rechazo de injerto y respuestas inmunitarias contra vectores virales usados para terapia génica o vacunación génica |
BR112013017585A2 (pt) * | 2011-01-10 | 2020-11-24 | The Regents Of The University Of Michigan | inibidor do fator de células-tronco |
GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
WO2017050966A1 (en) | 2015-09-25 | 2017-03-30 | Imcyse Sa | Improved methods and compounds for eliminating immune responses to therapeutic agents |
RU2018136760A (ru) | 2016-04-19 | 2020-05-19 | Имсис Са | НОВЫЕ ИММУНОГЕННЫЕ CD1d-СВЯЗЫВАЮЩИЕ ПЕПТИДЫ |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106733A (en) * | 1987-06-25 | 1992-04-21 | Immunex Corporation | Bovine granulocyte-macrophage colony stimulating factor |
EP0453453B1 (de) * | 1989-01-10 | 1996-09-11 | Amrad Corporation Limited | Leukämiehemmender faktor aus vieharten und seine verwendung zur verbesserung der implantation und der entwicklung von embryonalen zellen |
CA2114416C (en) * | 1991-08-07 | 1998-07-07 | W. French Anderson | Retroviral vectors containing internal ribosome entry sites |
-
1993
- 1993-10-08 US US08/133,979 patent/US5589582A/en not_active Expired - Lifetime
- 1993-10-26 EP EP93925071A patent/EP0669829B1/de not_active Expired - Lifetime
- 1993-10-26 WO PCT/US1993/010295 patent/WO1994009803A1/en active IP Right Grant
- 1993-10-26 AT AT93925071T patent/ATE204019T1/de not_active IP Right Cessation
- 1993-10-26 JP JP51043494A patent/JP3784063B2/ja not_active Expired - Fee Related
- 1993-10-26 CA CA002147989A patent/CA2147989C/en not_active Expired - Fee Related
- 1993-10-26 AU AU54521/94A patent/AU5452194A/en not_active Abandoned
- 1993-10-26 DE DE69330566T patent/DE69330566T2/de not_active Expired - Fee Related
-
1995
- 1995-05-08 US US08/436,890 patent/US5858963A/en not_active Expired - Lifetime
- 1995-05-26 US US08/451,213 patent/US5863528A/en not_active Expired - Lifetime
-
1998
- 1998-01-02 AU AU50359/98A patent/AU703371B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU5452194A (en) | 1994-05-24 |
CA2147989A1 (en) | 1994-05-11 |
US5589582A (en) | 1996-12-31 |
JPH08502650A (ja) | 1996-03-26 |
AU703371B2 (en) | 1999-03-25 |
EP0669829A1 (de) | 1995-09-06 |
EP0669829A4 (de) | 1997-05-07 |
DE69330566D1 (de) | 2001-09-13 |
US5863528A (en) | 1999-01-26 |
DE69330566T2 (de) | 2002-06-27 |
EP0669829B1 (de) | 2001-08-08 |
CA2147989C (en) | 2002-10-22 |
JP3784063B2 (ja) | 2006-06-07 |
WO1994009803A1 (en) | 1994-05-11 |
US5858963A (en) | 1999-01-12 |
AU5035998A (en) | 1998-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |