AU2001234730A1 - Method for inhibiting complement activation - Google Patents

Method for inhibiting complement activation

Info

Publication number
AU2001234730A1
AU2001234730A1 AU2001234730A AU3473001A AU2001234730A1 AU 2001234730 A1 AU2001234730 A1 AU 2001234730A1 AU 2001234730 A AU2001234730 A AU 2001234730A AU 3473001 A AU3473001 A AU 3473001A AU 2001234730 A1 AU2001234730 A1 AU 2001234730A1
Authority
AU
Australia
Prior art keywords
complement activation
inhibiting complement
inhibiting
activation
complement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234730A
Inventor
Agnes M. Azimzadeh
Todd D. Giorgio
Richard N. Pierson
Simon Robson
George L. Zorn Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Vanderbilt University
Original Assignee
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association, Vanderbilt University filed Critical Beth Israel Deaconess Medical Center Inc
Publication of AU2001234730A1 publication Critical patent/AU2001234730A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
AU2001234730A 2000-02-01 2001-02-01 Method for inhibiting complement activation Abandoned AU2001234730A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17954300P 2000-02-01 2000-02-01
US60179543 2000-02-01
PCT/US2001/003296 WO2001057184A2 (en) 2000-02-01 2001-02-01 Use of platelet activity modulators for inhibiting complement activation

Publications (1)

Publication Number Publication Date
AU2001234730A1 true AU2001234730A1 (en) 2001-08-14

Family

ID=22657027

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001234730A Abandoned AU2001234730A1 (en) 2000-02-01 2001-02-01 Method for inhibiting complement activation

Country Status (3)

Country Link
US (2) US6538028B1 (en)
AU (1) AU2001234730A1 (en)
WO (1) WO2001057184A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538028B1 (en) * 2000-02-01 2003-03-25 Vanderbilt University Method for inhibiting complement activation
US6716962B2 (en) * 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
US20040244062A1 (en) * 2003-06-02 2004-12-02 Crittenden Jill R. Use of protein inhibitors as antithrombotic agents
US7141544B2 (en) * 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
PL1755674T3 (en) * 2004-05-14 2015-05-29 Alexion Pharma Inc Prolongation of survival of an allograft by inhibiting complement activity
US20070196367A1 (en) * 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
CN101437501B (en) * 2006-03-02 2012-09-05 阿莱克申药物公司 Prolongation of survival of an allograft by inhibiting complement activity
ES2475199T3 (en) 2008-09-16 2014-07-10 Imuneks Farma Ila� Sanayi Ve Ticaret A.S. Use of opioid antagonists for the preparation of a medicine in the treatment of degenerative diseases of the retina
WO2011040894A1 (en) * 2009-10-01 2011-04-07 Mustafa Nevzat Ilaç Sanayii A.Ş. Topical compositions of opioid antagonists and methods for treating skin conditions therewith
TR201002473A2 (en) 2010-03-31 2011-09-21 Mustafa Nevzat �La� Sanay�� A.�. A method of treating herpes zoster disease using an opiate receptor antagonist.
US10588879B2 (en) 2011-08-01 2020-03-17 Aurin Biotech Inc. Treatment of age-related macular degeneration
US10966945B2 (en) 2011-08-01 2021-04-06 Aurin Biotech Inc. Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic synthetic complex
CN104661660A (en) * 2012-07-13 2015-05-27 奥林生物技术股份有限公司 Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex
US8877808B2 (en) * 2012-12-06 2014-11-04 Aurin Biotech Inc. Protection against skin diseases by aurin tricarboxylic acid and its derivatives
US10004707B2 (en) 2014-04-15 2018-06-26 Aurin Biotech Inc. Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex
US11013750B2 (en) 2017-01-20 2021-05-25 Aurin Biotech Inc. Methods for treating and preventing nociceptive pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007270A (en) 1975-11-18 1977-02-08 American Cyanamid Company Complement inhibitors
IL79254A0 (en) 1986-06-26 1986-09-30 Hadassah Med Org Compositions for preventing graft rejection
US4880788A (en) 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
US5573940A (en) 1989-06-12 1996-11-12 Oklahoma Medical Research Foundation Cells expressing high levels of CD59
US5135916A (en) 1989-06-12 1992-08-04 Oklahoma Medical Research Foundation Inhibition of complement mediated inflammatory response
US5589582A (en) 1992-10-27 1996-12-31 Biotransplant, Inc. Polynucleotides en coding porcine cytokines
US5434185A (en) 1993-05-17 1995-07-18 The University Of Kentucky Research Foundation Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts
DE4338793A1 (en) 1993-11-12 1995-05-18 Froelich Juergen C L-arginine and analogues as platelet aggregation inhibitors
JP3110931B2 (en) 1993-12-28 2000-11-20 第一製薬株式会社 Argatroban preparation with smooth muscle cell growth inhibitory action
US5891645A (en) 1994-06-01 1999-04-06 Alexion Pharmaceuticals, Inc. Porcine E-selectin
US5679345A (en) * 1994-06-02 1997-10-21 The Johns Hopkins University Method for preventing complement-dependent rejection of organ or tissue transplants
US6538028B1 (en) * 2000-02-01 2003-03-25 Vanderbilt University Method for inhibiting complement activation

Also Published As

Publication number Publication date
US6538028B1 (en) 2003-03-25
US20030144358A1 (en) 2003-07-31
WO2001057184A3 (en) 2002-04-25
WO2001057184A2 (en) 2001-08-09

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