AU5452194A - Enhancement of xenograft tolerance and porcine cytokines therefor - Google Patents

Enhancement of xenograft tolerance and porcine cytokines therefor

Info

Publication number
AU5452194A
AU5452194A AU54521/94A AU5452194A AU5452194A AU 5452194 A AU5452194 A AU 5452194A AU 54521/94 A AU54521/94 A AU 54521/94A AU 5452194 A AU5452194 A AU 5452194A AU 5452194 A AU5452194 A AU 5452194A
Authority
AU
Australia
Prior art keywords
porcine
bone marrow
marrow cells
enhancement
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU54521/94A
Inventor
Robert J Hawley
Rodney L Monroy
Paul D. Ponath
Margaret D. Rosa
Bernice Z Schacter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotransplant Inc
Original Assignee
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotransplant Inc filed Critical Biotransplant Inc
Publication of AU5452194A publication Critical patent/AU5452194A/en
Priority to AU50359/98A priority Critical patent/AU703371B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.
AU54521/94A 1992-10-27 1993-10-26 Enhancement of xenograft tolerance and porcine cytokines therefor Abandoned AU5452194A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50359/98A AU703371B2 (en) 1992-10-27 1998-01-02 Enhancement of xenograft tolerance and porcine cytokines therefor

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96718892A 1992-10-27 1992-10-27
US967188 1992-10-27
US08/133,979 US5589582A (en) 1992-10-27 1993-10-08 Polynucleotides en coding porcine cytokines
US133979 1993-10-08
PCT/US1993/010295 WO1994009803A1 (en) 1992-10-27 1993-10-26 Enhancement of xenograft tolerance and porcine cytokines therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU50359/98A Division AU703371B2 (en) 1992-10-27 1998-01-02 Enhancement of xenograft tolerance and porcine cytokines therefor

Publications (1)

Publication Number Publication Date
AU5452194A true AU5452194A (en) 1994-05-24

Family

ID=26831859

Family Applications (2)

Application Number Title Priority Date Filing Date
AU54521/94A Abandoned AU5452194A (en) 1992-10-27 1993-10-26 Enhancement of xenograft tolerance and porcine cytokines therefor
AU50359/98A Ceased AU703371B2 (en) 1992-10-27 1998-01-02 Enhancement of xenograft tolerance and porcine cytokines therefor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU50359/98A Ceased AU703371B2 (en) 1992-10-27 1998-01-02 Enhancement of xenograft tolerance and porcine cytokines therefor

Country Status (8)

Country Link
US (3) US5589582A (en)
EP (1) EP0669829B1 (en)
JP (1) JP3784063B2 (en)
AT (1) ATE204019T1 (en)
AU (2) AU5452194A (en)
CA (1) CA2147989C (en)
DE (1) DE69330566T2 (en)
WO (1) WO1994009803A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9515839D0 (en) * 1995-08-02 1995-10-04 Q One Biotech Ltd Feline stem cell factor
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
US6447767B1 (en) 1997-05-23 2002-09-10 Hadasit Medical Research Services And Development Ltd. Non-myeloablative tolerogenic treatment
US6428782B1 (en) 1997-05-23 2002-08-06 Hadasit Medical Research Services And Development Ltd. Non-myeloablative tolerogenic treatment
WO1999009163A1 (en) * 1997-08-13 1999-02-25 Biotransplant, Inc. Porcine stem cell factor varients and recombinant cells expressing such polypeptides
AU8827998A (en) * 1997-08-14 1999-03-08 Biotransplant Incorporated Porcine totipotent cells and method for long-term culture
US6248587B1 (en) * 1997-11-26 2001-06-19 University Of Southern Cailfornia Method for promoting mesenchymal stem and lineage-specific cell proliferation
US6703209B1 (en) * 1998-08-13 2004-03-09 Biotransplant, Inc. Porcine totipotent cells and method for long-term culture
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
US6538028B1 (en) 2000-02-01 2003-03-25 Vanderbilt University Method for inhibiting complement activation
KR20040029311A (en) * 2000-11-22 2004-04-06 제론 코포레이션 Tolerizing allografts of pluripotent stem cells
EP1379701A4 (en) * 2001-03-28 2005-09-14 Nextran Inc Elimination of endogenous porcine retrovirus
US20020152490A1 (en) * 2001-04-12 2002-10-17 Philip Lake Tolerance-inducing thy-marrow composite tissue construct and organ
WO2003039232A2 (en) * 2001-10-26 2003-05-15 Large Scale Biology Corporation Endothelial cell derived hemotopoietic growth factor
US7795493B2 (en) 2002-08-21 2010-09-14 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1, 3 galactosyltransferase
AU2004290006A1 (en) 2003-11-05 2005-05-26 University Of Pittsburgh Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region
EP1734814B1 (en) 2004-03-17 2015-01-21 Revivicor, Inc. Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
US7489849B2 (en) * 2004-11-03 2009-02-10 Adc Telecommunications, Inc. Fiber drop terminal
PT2059256T (en) 2006-08-11 2016-11-08 Life Sciences Res Partners Vzw Immunogenic peptides and their use in immune disorders
WO2009101205A2 (en) * 2008-02-14 2009-08-20 Life Sciences Research Partners Vzw Immunogenic control of tumours and tumour cells
ES2650236T3 (en) 2008-02-14 2018-01-17 Life Sciences Research Partners Vzw CD4 + T lymphocytes with cytolytic properties
AU2009214042B2 (en) 2008-02-14 2014-02-13 Katholieke Universiteit Leuven Immunotherapy targeting intracellular pathogens
ES2545885T3 (en) 2008-02-14 2015-09-16 Life Sciences Research Partners Vzw Elimination of immune responses against viral vectors
PL2249864T3 (en) * 2008-02-14 2016-11-30 Strategies to prevent and/or treat immune responses to soluble allofactors
US9248171B2 (en) * 2008-02-14 2016-02-02 Imcyse Sa Immunogenic peptides and their use in transplantation
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
HUE055070T2 (en) 2010-11-25 2021-10-28 Imnate Sarl Immunogenic peptides for use in the prevention and/or treatment of infectious diseases, autoimmune diseases, immune responses to allofactors, allergic diseases, tumors, graft rejection and immune responses against viral vectors used for gene therapy or gene vaccination
CN103547288B (en) * 2011-01-10 2016-03-16 密执安大学评议会 Stem cell factor inhibitor
GB201201511D0 (en) 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
US10729791B2 (en) 2015-05-18 2020-08-04 Imcyse Sa Animal models for evaluating pharmaceutical compounds
US11787849B2 (en) 2015-09-25 2023-10-17 Imcyse Sa Methods and compounds for eliminating immune responses to therapeutic agents
WO2017182528A1 (en) 2016-04-19 2017-10-26 Imcyse Sa Novel immunogenic cd1d binding peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106733A (en) * 1987-06-25 1992-04-21 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
DE69028514T2 (en) * 1989-01-10 1997-02-20 Amrad Corp Ltd LEAKOMA-INHIBITING FACTOR FROM LIVESTOCK AND ITS USE FOR IMPLANTING AND IMPROVING EMBRYONAL CELLS
DE69232438T2 (en) * 1991-08-07 2002-10-10 W French Anderson INTERNAL RIBOSOM INPUTS INCLUDING RETROVIRAL VECTORS

Also Published As

Publication number Publication date
WO1994009803A1 (en) 1994-05-11
AU5035998A (en) 1998-03-19
US5858963A (en) 1999-01-12
EP0669829B1 (en) 2001-08-08
EP0669829A1 (en) 1995-09-06
ATE204019T1 (en) 2001-08-15
EP0669829A4 (en) 1997-05-07
DE69330566D1 (en) 2001-09-13
US5863528A (en) 1999-01-26
US5589582A (en) 1996-12-31
DE69330566T2 (en) 2002-06-27
CA2147989C (en) 2002-10-22
CA2147989A1 (en) 1994-05-11
AU703371B2 (en) 1999-03-25
JPH08502650A (en) 1996-03-26
JP3784063B2 (en) 2006-06-07

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