DK0923308T3 - Oprensning af biologisk aktive peptider fra mælk - Google Patents

Oprensning af biologisk aktive peptider fra mælk

Info

Publication number
DK0923308T3
DK0923308T3 DK97923643T DK97923643T DK0923308T3 DK 0923308 T3 DK0923308 T3 DK 0923308T3 DK 97923643 T DK97923643 T DK 97923643T DK 97923643 T DK97923643 T DK 97923643T DK 0923308 T3 DK0923308 T3 DK 0923308T3
Authority
DK
Denmark
Prior art keywords
milk
purification
biologically active
permeate
active peptides
Prior art date
Application number
DK97923643T
Other languages
Danish (da)
English (en)
Inventor
Joseph P Kutzko
Michael L Hayes
Lee T Sherman
Original Assignee
Genzyme Transgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Transgenics Corp filed Critical Genzyme Transgenics Corp
Application granted granted Critical
Publication of DK0923308T3 publication Critical patent/DK0923308T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK97923643T 1996-05-13 1997-05-13 Oprensning af biologisk aktive peptider fra mælk DK0923308T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/648,235 US6268487B1 (en) 1996-05-13 1996-05-13 Purification of biologically active peptides from milk
PCT/US1997/008044 WO1997042835A1 (en) 1996-05-13 1997-05-13 Purification of biologically active peptides from milk

Publications (1)

Publication Number Publication Date
DK0923308T3 true DK0923308T3 (da) 2002-10-14

Family

ID=24599969

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97923643T DK0923308T3 (da) 1996-05-13 1997-05-13 Oprensning af biologisk aktive peptider fra mælk

Country Status (14)

Country Link
US (1) US6268487B1 (enExample)
EP (1) EP0923308B1 (enExample)
JP (1) JP4476362B2 (enExample)
AT (1) ATE224145T1 (enExample)
AU (1) AU725993B2 (enExample)
CA (1) CA2254871C (enExample)
DE (2) DE69715641T2 (enExample)
DK (1) DK0923308T3 (enExample)
ES (1) ES2182074T3 (enExample)
LU (1) LU91305I2 (enExample)
NL (1) NL300256I2 (enExample)
NZ (1) NZ332916A (enExample)
PT (1) PT923308E (enExample)
WO (1) WO1997042835A1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
AP1219A (en) 1997-10-20 2003-10-22 Gtc Biotherapeutics Inc Novel modified MSP-1 nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
SE9802213D0 (sv) * 1998-06-18 1998-06-18 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
US20030005468A1 (en) * 1998-06-19 2003-01-02 Meade Harry M. Methods and vectors for improving nucleic acid expression
ATE328007T1 (de) * 1998-09-24 2006-06-15 Pharming Intellectual Pty Bv Reinigung von fibrinogen aus flüssigkeiten mittels ausfällung und hydrophobischer- interaktion-chromatographie
CA2354638C (en) * 1999-01-06 2013-03-19 Atlantic Biopharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
AU5553600A (en) 1999-06-23 2001-01-31 Ppl Therapeutics (Scotland) Ltd Fusion proteins incorporating lysozyme
AU2001259465B2 (en) * 2000-05-05 2006-12-07 Gtc Biotherapeutics, Inc. Transgenically produced decorin
US20020077775A1 (en) * 2000-05-25 2002-06-20 Schork Nicholas J. Methods of DNA marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20030195707A1 (en) * 2000-05-25 2003-10-16 Schork Nicholas J Methods of dna marker-based genetic analysis using estimated haplotype frequencies and uses thereof
US20040226053A1 (en) * 2000-10-13 2004-11-11 Meade Harry M. Methods of producing a target molecule in a transgenic animal and purification of the target molecule
JP2004536081A (ja) * 2001-06-13 2004-12-02 トーラス エイチエスエイ エルエルシー ヒト血清アルブミンの精製
CA2456571A1 (en) * 2001-08-10 2003-02-20 Genset Sa Human secreted proteins, their encoding polynucleotides, and uses thereof
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003090545A1 (en) * 2002-04-24 2003-11-06 Dairy Development Specialists, Inc. Intermediate ingredient for dairy product manufacturing and method of making the same
DE60227922D1 (de) * 2002-05-27 2008-09-11 Nestec Sa Säurelösliche Proteine aus Casein-Micellen
GB0216001D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
CN1856324A (zh) * 2002-09-17 2006-11-01 Gtc生物治疗学公司 缺乏重链间二硫键的免疫球蛋白分子的分离
CA2506629A1 (en) * 2002-11-27 2004-06-17 Gtc Biotherapeutics, Inc. Modified antibodies stably produced in milk and methods of producing same
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
US20040210953A1 (en) * 2003-01-09 2004-10-21 Murray James D. Lysozyme transgenic ungulates
US20040248262A1 (en) 2003-01-22 2004-12-09 Koeberl Dwight D. Constructs for expressing lysomal polypeptides
RU2005129745A (ru) * 2003-02-24 2006-03-20 Джитиси Байотерапьютикс, Инк. (Us) Способы и устройство проточной фильтрации вдоль потока
WO2005085287A1 (en) 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
US20050245444A1 (en) * 2004-04-30 2005-11-03 Yann Echelard Method of using recombinant human antithrombin for neurocognitive disorders
US20060121004A1 (en) * 2004-12-07 2006-06-08 Yann Echelard Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin
US20060130159A1 (en) * 2004-12-09 2006-06-15 Nick Masiello Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum
US20080019905A9 (en) * 2005-02-18 2008-01-24 Strome Scott E Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
WO2006138647A2 (en) * 2005-06-16 2006-12-28 Gtc Biotherapeutics, Inc. Method of making recombinant human antibodies for use in biosensor technology
WO2007014244A2 (en) * 2005-07-25 2007-02-01 Gtc Biotherapeutics, Inc. Method of purifying recombinant human antithrombin to enhance the viral and prion safety profile
ES2642787T3 (es) * 2005-10-21 2017-11-20 Lfb Usa, Inc. Anticuerpos con actividad de citotoxicidad celular dependiente de anticuerpos mejorada, métodos para su producción y uso
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
CA2659809A1 (en) * 2006-08-04 2008-02-14 Pharmathene Inc. Long half-life recombinant butyrylcholinesterase
FR2910786B1 (fr) * 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"
JP5208428B2 (ja) * 2007-01-30 2013-06-12 雪印メグミルク株式会社 美肌剤
FR2912310B1 (fr) 2007-02-13 2009-08-07 Kasan Sarl Nouvelles compositions cosmetiques et/ou pharmaceutiques et leurs applications.
JP2010533201A (ja) 2007-07-10 2010-10-21 グランビア ニュートリショナルズ タンパク質からエンドトキシンを除去するための方法
TWI346666B (en) * 2007-12-31 2011-08-11 Animal Technology Inst Taiwan Method for seperating casein from casein-contained solution
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
EP2269471A4 (en) * 2008-04-21 2012-12-26 Fuji Oil Co Ltd METHOD FOR PRODUCING DEFAMED SOYAMILPEPTIDES
EP2279003A4 (en) * 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF INFLAMMATORY DISEASES
US9247766B2 (en) * 2008-05-14 2016-02-02 Murray Goulburn Co-Operative Co., Limited Angiogenin-enriched milk fractions
KR20120108989A (ko) * 2009-12-18 2012-10-05 시에스엘 리미티드 폴리펩타이드를 정제하는 방법
US8729245B2 (en) 2009-12-21 2014-05-20 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
US8861162B2 (en) * 2010-03-09 2014-10-14 Honeywell International Inc. High power solid state power controller (SSPC) solution for primary power distribution applications
FR2958496A1 (fr) * 2010-04-09 2011-10-14 Bioprotein Technologies Sa Preparation de proteine plasmatique de transfert des phospholipides (pltp) humaine recombinante a partir du lait d'animaux transgeniques.
US20110250264A1 (en) * 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
EP2625262B1 (en) 2010-10-05 2015-09-23 Novo Nordisk Health Care AG Process for protein production
AU2011350895B2 (en) 2010-12-30 2015-05-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Glycols as pathogen inactivating agents
CN103459006B (zh) 2011-04-01 2016-01-06 Emd密理博公司 含有纳米纤维的复合材料结构
AR087094A1 (es) * 2011-07-07 2014-02-12 Gtc Biotherapeutics Inc Formulaciones que estabilizan proteinas
TW201400499A (zh) 2012-03-12 2014-01-01 Revo Biolog Inc 抗凝血酶用於治療妊娠毒血症之用途
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
CN104884080A (zh) 2012-08-03 2015-09-02 Lfb美国股份有限公司 抗凝血酶在体外膜式氧合中的用途
BR112015019348A2 (pt) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária
EP3594230A1 (en) 2013-02-13 2020-01-15 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-tnf-alpha antibodies and uses thereof
MX384222B (es) 2013-07-05 2025-03-14 Lab Francais Du Fractionnement Matriz de cromatografia de afinidad.
US9661868B2 (en) * 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
JP2017520531A (ja) * 2014-06-02 2017-07-27 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ Ｆｃ断片の産生
KR20200058600A (ko) 2014-06-26 2020-05-27 이엠디 밀리포어 코포레이션 개선된 먼지 포집 능력을 갖는 필터 구조
FR3034419B1 (fr) 2015-04-02 2017-12-15 Lab Francais Du Fractionnement Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique
KR102206959B1 (ko) * 2015-04-17 2021-01-25 이엠디 밀리포어 코포레이션 접선방향 유동 여과 모드에서 작동되는 나노섬유 한외여과막을 사용하여 샘플에서 목적하는 생물학적 물질을 정제하는 방법
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
JP7159308B2 (ja) 2017-07-21 2022-10-24 メルク・ミリポア・リミテッド ラテラルフローデバイスおよびこれを用いる試料中の検体を検出する方法
WO2019223752A1 (zh) * 2018-05-24 2019-11-28 江苏恒瑞医药股份有限公司 一种重组人胰岛素或其类似物的前体的制备方法
FR3082427B1 (fr) 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
JP7478333B2 (ja) * 2020-07-29 2024-05-07 和弘 原 成分調整物生産装置及び成分調整物生産方法
CN113101737B (zh) * 2021-03-04 2023-09-15 京美生命科技(杭州)有限公司 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459619B1 (fr) 1979-06-26 1983-07-29 Agronomique Inst Nat Rech Procede pour l'obtention a partir de lactoserum, d'un produit enrichi en alpha-lactalbumine et applications dudit procede
FR2487642B2 (fr) 1980-07-31 1985-10-18 Bel Fromageries Procede de preparation de fractions proteiques par ultrafiltration et chromatographie d'exclusion et d'echange d'ions
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
FR2584727B1 (fr) 1985-07-11 1988-06-17 Roussel Uclaf Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques
JPS62298536A (ja) 1986-06-17 1987-12-25 Green Cross Corp:The 生理活性物質の自動精製方法および自動精製装置
DE3743440A1 (de) * 1987-12-21 1989-06-29 Gauri Kailash Kumar Verfahren zum trennen der geloesten und ungeloesten bestandteile von milch
US4897465A (en) 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
WO1991008216A1 (en) 1989-12-01 1991-06-13 Genpharm International, Inc. Production of recombinant polypeptides by bovine species and transgenic methods
NL9001650A (nl) 1990-07-19 1992-02-17 Ver Coop Melkind Werkwijze voor de bereiding van een melkeiwit-isolaat.
US5256294A (en) 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5175013A (en) 1990-12-31 1992-12-29 The Pillsbury Company Frozen dessert compositions and products
US5178894A (en) 1991-09-26 1993-01-12 Silvia P. Rudel High non-fat milk content bread products having improved keeping qualities
AU4537393A (en) 1992-06-15 1994-01-04 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
US5256437A (en) * 1992-06-19 1993-10-26 Pall Corporation Product and process of making sterile milk through dynamic microfiltration
EP0804070B1 (en) 1993-03-09 2000-05-24 Genzyme Corporation Process of isolation of proteins from milk
AU1809895A (en) 1994-02-16 1995-09-04 Pharming Bv Isolation of lactoferrin from milk
US5597486A (en) * 1995-05-01 1997-01-28 Millipore Investment Holdings Limited Membrane filtration with optimized addition of second liquid to maximize flux

Also Published As

Publication number Publication date
NL300256I2 (nl) 2007-09-03
JP2000510701A (ja) 2000-08-22
WO1997042835A1 (en) 1997-11-20
DE122007000008I1 (de) 2009-05-20
AU725993B2 (en) 2000-10-26
DE122007000008I2 (de) 2011-01-13
ATE224145T1 (de) 2002-10-15
EP0923308B1 (en) 2002-09-18
CA2254871A1 (en) 1997-11-20
PT923308E (pt) 2002-11-29
EP0923308A4 (enExample) 1999-06-30
DE69715641T2 (de) 2003-08-07
NL300256I1 (nl) 2007-04-02
ES2182074T3 (es) 2003-03-01
EP0923308A1 (en) 1999-06-23
JP4476362B2 (ja) 2010-06-09
DE69715641D1 (de) 2002-10-24
AU2940297A (en) 1997-12-05
NZ332916A (en) 2000-05-26
US6268487B1 (en) 2001-07-31
CA2254871C (en) 2008-03-25
LU91305I2 (fr) 2007-03-12

Similar Documents

Publication Publication Date Title
DK0923308T3 (da) Oprensning af biologisk aktive peptider fra mælk
ATE278785T1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
TR199901840T2 (xx) DNA'nın cross-flow-filtrasyonu ile temizlenmesi.
DK0552192T3 (da) Forbedret tangentialstrømningsfiltreringsfremgangsmåde og -apparat
DK426386D0 (da) Fremgangsmaade til rensning og aktivering af proteiner fra uoploeselige inklusionslegemer
RU2007110534A (ru) Способ концентрирования препаратов антител
ATE310017T1 (de) Verfahren zur reinigung und isolierung von wasserlöslichen peptiden und proteinen aus pflanzenquellen
DK1200179T3 (da) Ladede filtreringsmembraner og anvendelser deraf
DE3774323D1 (de) Mikroporoese membran und verfahren zu ihrer herstellung.
DE3588254D1 (de) Gag-Antigen und dessen Verwendung zum Nachweis von LAV-Infektion, sowie in immunogenen Zusammensetzungen
DE69534096D1 (de) Hochpermeable Umkehrosmose-Verbundmembran, Verfahren zu deren Herstellung und Verfahren zu deren Verwendung
DK0751988T3 (da) Højeffektiv fremstilling og isolering af virale partikler
DE3878899D1 (de) Poroese polytetrafluoraethylen-membran, trennvorrichtung unter verwendung dieser membran sowie verfahren zur herstellung.
ATE204019T1 (de) Steigerung der transplantattoleranz durch schwein cytokine
DK0764209T3 (da) Albuminekspression i gær
DK0481257T3 (da) Fremgangsmåde og system til fremstilling af en medicinsk opløsning, for eksempel en dialyseopløsning
ATE279441T1 (de) Verfahren zur herstellung von genetisch veränderten lymphozyten vorläuferzellen von wirbeltieren und deren gebrauch zur produktion von heterologen bindeproteinen
DK1060134T3 (da) Fremgangsmåde og indretning til behandling af vandige strømme i en bioreaktor, en ultrafiltreringsenhed og en membranfiltreringsenhed
DE69815688D1 (de) Verfahren zur hohlfasern filtration
TR200000899T2 (tr) Su arıtma cihazı ve metodu.
SE8902317L (sv) Saett att rena proteiner
IL115293A (en) Method for the purification of an anti-inflammatory factor anti-inflammatory factor obtained by this method and pharmaceutical compositions containing the same
DK100888A (da) Fremgangsmaade til at rense rekombinant pres-1/s-2/s hepatitis b antigen fra gaer
DE4495604T1 (de) Reaktive Membran zur Filtrierung und Reinigung von Gasen zwecks Abtrennung von Verunreinigungen und Verfahren unter Anwendung dieser Membran
RU96122514A (ru) Способ выделения бактериофагов