DE69928961D1 - Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben - Google Patents

Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Info

Publication number
DE69928961D1
DE69928961D1 DE69928961T DE69928961T DE69928961D1 DE 69928961 D1 DE69928961 D1 DE 69928961D1 DE 69928961 T DE69928961 T DE 69928961T DE 69928961 T DE69928961 T DE 69928961T DE 69928961 D1 DE69928961 D1 DE 69928961D1
Authority
DE
Germany
Prior art keywords
thromboplastin
reagents
solution
clotting factors
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69928961T
Other languages
English (en)
Other versions
DE69928961T2 (de
Inventor
Marc Goldford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trinity Biotech Manufacturing Ltd
Original Assignee
Trinity Biotech Manufacturing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trinity Biotech Manufacturing Ltd filed Critical Trinity Biotech Manufacturing Ltd
Publication of DE69928961D1 publication Critical patent/DE69928961D1/de
Application granted granted Critical
Publication of DE69928961T2 publication Critical patent/DE69928961T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69928961T 1998-10-07 1999-10-07 Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben Expired - Fee Related DE69928961T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10341798P 1998-10-07 1998-10-07
US103417P 1998-10-07
PCT/US1999/023369 WO2000020835A2 (en) 1998-10-07 1999-10-07 Thromboplastin reagents and methods for preparing and using such reagents

Publications (2)

Publication Number Publication Date
DE69928961D1 true DE69928961D1 (de) 2006-01-19
DE69928961T2 DE69928961T2 (de) 2006-07-13

Family

ID=22295068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928961T Expired - Fee Related DE69928961T2 (de) 1998-10-07 1999-10-07 Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Country Status (9)

Country Link
US (1) US6391609B1 (de)
EP (1) EP1127259B1 (de)
JP (1) JP2002526557A (de)
AT (1) ATE313068T1 (de)
AU (1) AU1311800A (de)
CA (1) CA2342606A1 (de)
DE (1) DE69928961T2 (de)
ES (1) ES2252986T3 (de)
WO (1) WO2000020835A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1458408B1 (de) 2001-12-21 2009-04-15 Novo Nordisk Health Care AG Flüssige zusammensetzung aus faktor vii polypeptiden
EP1517698B2 (de) 2002-06-21 2017-12-06 Novo Nordisk Health Care AG STABILISIERTE FESTE ZUSAMMENSETZUNGEN VON FAKTOR VIIa POLYPEPTIDEN
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
JP4658041B2 (ja) 2003-06-25 2011-03-23 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドの液体組成物
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
WO2006088741A2 (en) * 2005-02-16 2006-08-24 The Board Of Trustees Of The University Of Illinois Procoagulants based on metal-chelating lipids
EP1869082B1 (de) * 2005-03-04 2011-04-13 The Board Of Trustees Of The University Of Illinois Modulator von coagulationskaskaden und fibrinolytischen kaskaden
WO2006129703A1 (ja) * 2005-05-31 2006-12-07 Kurume University 活性化部分トロンボプラスチン時間の検査方法
JP4897437B2 (ja) * 2006-11-17 2012-03-14 株式会社日立製作所 低分子化合物溶液循環型フローｎｍｒ装置
US20080214795A1 (en) * 2007-02-14 2008-09-04 Amgen Inc. Method of isolating antibodies by precipitation
WO2009046194A2 (en) 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
BRPI0911249A2 (pt) * 2008-04-16 2017-05-23 Biogen Idec Inc método de isolamento de biomacromoléculas usando polialquileno glicol e metais de transição
JP6116231B2 (ja) * 2012-12-25 2017-04-19 株式会社Ｌｓｉメディエンス 組織トロンボプラスチン含有血液凝固能測定試薬及び測定方法
EP3414576B1 (de) 2016-02-12 2024-04-03 Instrumentation Laboratory Company Eine "mischung und verwendung" zwei komponenten flüssige thromboplastin reagenz, herstellungsmethoden und verwendungsverfahren
CN110806374B (zh) * 2019-09-29 2022-05-20 杭州联科生物技术股份有限公司 一种Annexin V凋亡检测的Binding Buffer及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA658579A (en) 1963-02-26 Ortho Pharmaceutical Corporation Factor v from mammalian blood plasma
US2847350A (en) 1954-05-27 1958-08-12 Ortho Pharma Corp Preparation of highly active thromboplastin
US3522148A (en) 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
BE787961A (fr) 1971-08-24 1973-02-26 Behringwerke Ag Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere
US3980432A (en) 1973-04-02 1976-09-14 Behringwerke Aktiengesellschaft Partial thromboplastin, its use as diagnostic agent and process for preparing it
ES431736A1 (es) 1973-11-13 1977-05-16 Behringwerke Ag Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre.
US4361510A (en) 1980-05-27 1982-11-30 Cutter Laboratories, Inc. Blood coagulation promoting product
DE3150596A1 (de) 1981-12-21 1983-06-30 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von gewebsthromboplastin
US4495175A (en) 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4755461A (en) 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5017556A (en) 1986-11-04 1991-05-21 Genentech, Inc. Treatment of bleeding disorders using lipid-free tissue factor protein
EP0396733B1 (de) 1988-11-23 1994-01-05 Baxter Diagnostics Inc. Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien
US5270451A (en) 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
CA2080428C (en) * 1991-10-22 2004-01-27 Ray F. Ebert A method for preparing a thromboplastin reagent from cultured cells that is suitable for use in the prothrombin time test
US5358853A (en) 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography

Also Published As

Publication number Publication date
ATE313068T1 (de) 2005-12-15
WO2000020835A3 (en) 2000-08-03
EP1127259A4 (de) 2003-01-02
US6391609B1 (en) 2002-05-21
EP1127259A2 (de) 2001-08-29
ES2252986T3 (es) 2006-05-16
CA2342606A1 (en) 2000-04-13
AU1311800A (en) 2000-04-26
DE69928961T2 (de) 2006-07-13
WO2000020835A2 (en) 2000-04-13
JP2002526557A (ja) 2002-08-20
EP1127259B1 (de) 2005-12-14

Similar Documents

Publication Publication Date Title
DE69928961D1 (de) Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben
BR0207722A (pt) Material compósito de enxerto de medula óssea, método de preparação do mesmo, e, kit para a preparação do mesmo
DE60131495D1 (de) Verfahren zur Herstellung von Composite-Membranen aus Perfluoropolymeren zur Gastrennung
DE69400874D1 (de) Verfahren zur herstellung von keramischen hohlfasermembranen zur mikorfiltration, ultrafiltration und gastrennung
DE60230672D1 (de) Nukleinsäureanreicherung
ATE127708T1 (de) Verfahren zur herstellung von wässrigen dispersionen.
DE60317561D1 (de) Vorrichtung und verfahren zur herstellung von autologem thrombinserum
DE60031752D1 (de) Verfahren zur Herstellung von Gastrennungsmembranen aus Polyimid
ATE425808T1 (de) Vorrichtung zur effizienten hamodiafiltration
ATE469219T1 (de) Zusammensetzungen, methoden und reagentien zur nukleinsäureisolierung mittels oberflächenaktiven substanzen und proteasen
AT381463B (de) Definierte poren aufweisende membran, verfahren zu ihrer herstellung und verwendung derselben
ATE295372T1 (de) Hydrophobisch-modifizierte hedgehog protein zusammensetzungen und verfahren
BR0105239A (pt) Membrana microporosa seletiva para gás selecionado; e; processo de preparação de uma membrana microporosa seletiva para gás selecionado
DE60016889D1 (de) Zusammengesetzte Umkehrosmosemembranen und Verfahren zu ihrer Herstellung
ATE278785T1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
DE59912857D1 (de) Verfahren zur Herstellung von Farbstoffen und/oder Aufhellerzubereitungen
DE60044087D1 (de) Verfahren und mittels zur manipulierung der expression des uncoupling proteins
DOP2001000159A (es) Purificación de cuerpos de inclusión de proteina por microfiltracion de flujo cruzado
DE69728656D1 (de) Methode zur herstellung einer flüssigen mischung
DE69940338D1 (de) Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein-polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit
DE60231020D1 (de) Membran zur Gastrennung und Verfahren zu ihrer Herstellung
ES2196870T3 (es) Procedimiento para la purificacion o aislamiento de acidos nucleicos virales.
AU5855499A (en) Method for extracting solid substances from solutions
DE3786673D1 (de) Verfahren zur entfernung unerwuenschter zellen aus menschlichen lymphozytenpopulationen, anwendung des verfahrens zur herstellung monoklonaler antikoerper und dafuer geeigneter kit.
DE60127593D1 (de) Verfahren zur Herstellung von Membranen und die damit hergestellten Membranen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee