ATE313068T1 - Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben - Google Patents

Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Info

Publication number
ATE313068T1
ATE313068T1 AT99956522T AT99956522T ATE313068T1 AT E313068 T1 ATE313068 T1 AT E313068T1 AT 99956522 T AT99956522 T AT 99956522T AT 99956522 T AT99956522 T AT 99956522T AT E313068 T1 ATE313068 T1 AT E313068T1
Authority
AT
Austria
Prior art keywords
thromboplastin
reagents
solution
clotting factors
membrane
Prior art date
Application number
AT99956522T
Other languages
English (en)
Inventor
Marc Goldford
Original Assignee
Trinity Biotech Mfg Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trinity Biotech Mfg Ltd filed Critical Trinity Biotech Mfg Ltd
Application granted granted Critical
Publication of ATE313068T1 publication Critical patent/ATE313068T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
AT99956522T 1998-10-07 1999-10-07 Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben ATE313068T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10341798P 1998-10-07 1998-10-07
PCT/US1999/023369 WO2000020835A2 (en) 1998-10-07 1999-10-07 Thromboplastin reagents and methods for preparing and using such reagents

Publications (1)

Publication Number Publication Date
ATE313068T1 true ATE313068T1 (de) 2005-12-15

Family

ID=22295068

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99956522T ATE313068T1 (de) 1998-10-07 1999-10-07 Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben

Country Status (9)

Country Link
US (1) US6391609B1 (de)
EP (1) EP1127259B1 (de)
JP (1) JP2002526557A (de)
AT (1) ATE313068T1 (de)
AU (1) AU1311800A (de)
CA (1) CA2342606A1 (de)
DE (1) DE69928961T2 (de)
ES (1) ES2252986T3 (de)
WO (1) WO2000020835A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2357751C2 (ru) 2001-12-21 2009-06-10 Ново Нордиск Хелт Кэр Аг Жидкая композиция полипептидов фактора vii
EP2283856B1 (de) 2002-06-21 2017-09-20 Novo Nordisk Health Care AG Stabiliserte feste Zusammensetzungen von Faktor VIIa Polypeptiden
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
ES2382157T3 (es) 2003-06-25 2012-06-05 Novo Nordisk Health Care Ag Composición líquida de polipépttidos del factor VII
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
JP2008530208A (ja) * 2005-02-16 2008-08-07 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 万能前凝固薬
JP2008531692A (ja) * 2005-03-04 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 凝固及び線維素溶解カスケードのモジュレーター
WO2006129703A1 (ja) * 2005-05-31 2006-12-07 Kurume University 活性化部分トロンボプラスチン時間の検査方法
JP4897437B2 (ja) * 2006-11-17 2012-03-14 株式会社日立製作所 低分子化合物溶液循環型フローｎｍｒ装置
WO2008100578A2 (en) * 2007-02-14 2008-08-21 Amgen Inc. Method of isolating antibodies by precipitation
WO2009046194A2 (en) 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
CA2720048A1 (en) * 2008-04-16 2009-10-22 Biogen Idec Ma Inc. Method of isolating biomacromolecules using polyalkylene glycol and transition metals
JP6116231B2 (ja) * 2012-12-25 2017-04-19 株式会社Ｌｓｉメディエンス 組織トロンボプラスチン含有血液凝固能測定試薬及び測定方法
JP6709286B2 (ja) * 2016-02-12 2020-06-10 インストゥルメンテーション ラボラトリー カンパニー ２成分「混合および使用」の液体トロンボプラスチン試薬、その作製方法および使用方法
CN110806374B (zh) * 2019-09-29 2022-05-20 杭州联科生物技术股份有限公司 一种Annexin V凋亡检测的Binding Buffer及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA658579A (en) 1963-02-26 Ortho Pharmaceutical Corporation Factor v from mammalian blood plasma
US2847350A (en) 1954-05-27 1958-08-12 Ortho Pharma Corp Preparation of highly active thromboplastin
US3522148A (en) 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
BE787961A (fr) 1971-08-24 1973-02-26 Behringwerke Ag Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere
US3980432A (en) 1973-04-02 1976-09-14 Behringwerke Aktiengesellschaft Partial thromboplastin, its use as diagnostic agent and process for preparing it
ES431736A1 (es) 1973-11-13 1977-05-16 Behringwerke Ag Procedimiento para la preparacion de un agente para diagnos-tico para el proposito de efectuar el control de la capaci- dad de coagulacion de la sangre.
US4361510A (en) 1980-05-27 1982-11-30 Cutter Laboratories, Inc. Blood coagulation promoting product
DE3150596A1 (de) 1981-12-21 1983-06-30 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von gewebsthromboplastin
US4495175A (en) 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4755461A (en) 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5017556A (en) 1986-11-04 1991-05-21 Genentech, Inc. Treatment of bleeding disorders using lipid-free tissue factor protein
EP0396733B1 (de) 1988-11-23 1994-01-05 Baxter Diagnostics Inc. Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien
US5270451A (en) 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
CA2080428C (en) * 1991-10-22 2004-01-27 Ray F. Ebert A method for preparing a thromboplastin reagent from cultured cells that is suitable for use in the prothrombin time test
US5358853A (en) 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography

Also Published As

Publication number Publication date
DE69928961D1 (de) 2006-01-19
EP1127259B1 (de) 2005-12-14
AU1311800A (en) 2000-04-26
CA2342606A1 (en) 2000-04-13
ES2252986T3 (es) 2006-05-16
EP1127259A4 (de) 2003-01-02
WO2000020835A3 (en) 2000-08-03
WO2000020835A2 (en) 2000-04-13
DE69928961T2 (de) 2006-07-13
EP1127259A2 (de) 2001-08-29
US6391609B1 (en) 2002-05-21
JP2002526557A (ja) 2002-08-20

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