ATE421339T1 - Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein- polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit - Google Patents
Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein- polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeitInfo
- Publication number
- ATE421339T1 ATE421339T1 AT99905732T AT99905732T ATE421339T1 AT E421339 T1 ATE421339 T1 AT E421339T1 AT 99905732 T AT99905732 T AT 99905732T AT 99905732 T AT99905732 T AT 99905732T AT E421339 T1 ATE421339 T1 AT E421339T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- vaccines
- polysaccharide
- restricted
- conjugate
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/291—Gel sorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7379098P | 1998-02-05 | 1998-02-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421339T1 true ATE421339T1 (de) | 2009-02-15 |
Family
ID=22115824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99905732T ATE421339T1 (de) | 1998-02-05 | 1999-02-04 | Vereinfachte methode zur entfernung von freiem protein während der herstellung von protein- polysaccharid-konjugaten und impfstoffen unter verwendung von medien mit limitierter durchlässigkeit |
Country Status (8)
Country | Link |
---|---|
US (1) | US6284250B1 (de) |
EP (1) | EP1053021B1 (de) |
JP (1) | JP2002502830A (de) |
AT (1) | ATE421339T1 (de) |
AU (1) | AU763349B2 (de) |
CA (1) | CA2320470A1 (de) |
DE (1) | DE69940338D1 (de) |
WO (1) | WO1999039739A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248334B1 (en) * | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
EP1713508A2 (de) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Verwendung von aminoox-funktionalen gruppen bei der herstellung von vakzine-konjugaten |
GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0713880D0 (en) * | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
US8207298B2 (en) * | 2008-05-01 | 2012-06-26 | Archemix Corp. | Methods of separating biopolymer conjugated molecules from unconjugated molecules |
US8647621B2 (en) | 2009-07-27 | 2014-02-11 | Fina Biosolutions, Llc | Method of producing protein-carbohydrate vaccines reduced in free carbohydrate |
US9044517B2 (en) | 2009-12-17 | 2015-06-02 | Fina Biosolutions, Llc | Activation of polysaccharides via the cyanylating agent, 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), in the preparation of polysaccharide/protein conjugate vaccines |
ES2743156T3 (es) | 2010-04-23 | 2020-02-18 | Serum Institute Of India Pvt Ltd | Método simple para eliminación simultánea de múltiples impurezas a partir de sobrenadantes de cultivo a niveles ultrabajos |
WO2014058570A1 (en) | 2012-09-17 | 2014-04-17 | Alltech Associates, Inc. | Chromatography media and devices |
WO2014188313A1 (en) | 2013-05-20 | 2014-11-27 | Shantha Biotechnics Limited | Purification of polysaccharide protein conjugates |
CN104324708B (zh) * | 2014-11-05 | 2016-08-24 | 华玉叶 | 一种亲水色谱介质的制备方法 |
US10836839B2 (en) * | 2015-04-28 | 2020-11-17 | Biological E Limited | Method for separation of protein and other impurities from microbial capsular polysaccharides |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4923978A (en) | 1987-12-28 | 1990-05-08 | E. I. Du Pont De Nemours & Company | Process for purifying nucleic acids |
US4929560A (en) * | 1988-02-03 | 1990-05-29 | Damon Biotech, Inc. | Recovery of tissue plasminogen activator |
US5277813A (en) * | 1988-06-17 | 1994-01-11 | S.A.C. Corporation | Shielded stationary phases |
US5106966A (en) | 1989-07-10 | 1992-04-21 | University Of Kansas | Use of gel polymer for dna extraction with organic solvents |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
US5278284A (en) * | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
JP4163251B2 (ja) * | 1992-09-24 | 2008-10-08 | ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | グループbストレプトコッカス・タイプ▲ii▼およびタイプ▲v▼多糖−蛋白質接合ワクチン |
US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
EP0720485B1 (de) * | 1993-09-22 | 2003-11-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
EP0814833B1 (de) | 1995-03-22 | 2003-05-28 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden |
HUP9802199A3 (en) * | 1995-06-07 | 1999-07-28 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein and use of |
AUPN694895A0 (en) * | 1995-12-01 | 1996-01-04 | Macquarie Research Limited | Desalting and purification of oligosaccharides and their derivatives |
-
1999
- 1999-02-04 AT AT99905732T patent/ATE421339T1/de not_active IP Right Cessation
- 1999-02-04 US US09/244,178 patent/US6284250B1/en not_active Expired - Lifetime
- 1999-02-04 JP JP2000530236A patent/JP2002502830A/ja not_active Withdrawn
- 1999-02-04 CA CA002320470A patent/CA2320470A1/en not_active Abandoned
- 1999-02-04 EP EP99905732A patent/EP1053021B1/de not_active Expired - Lifetime
- 1999-02-04 WO PCT/US1999/002416 patent/WO1999039739A1/en active IP Right Grant
- 1999-02-04 AU AU25829/99A patent/AU763349B2/en not_active Ceased
- 1999-02-04 DE DE69940338T patent/DE69940338D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2320470A1 (en) | 1999-08-12 |
US6284250B1 (en) | 2001-09-04 |
EP1053021A1 (de) | 2000-11-22 |
JP2002502830A (ja) | 2002-01-29 |
WO1999039739A1 (en) | 1999-08-12 |
EP1053021B1 (de) | 2009-01-21 |
DE69940338D1 (de) | 2009-03-12 |
AU2582999A (en) | 1999-08-23 |
AU763349B2 (en) | 2003-07-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |