DE60118558D1 - Verfahren zur herstellung und sammlung von kristallinen partikeln - Google Patents

Verfahren zur herstellung und sammlung von kristallinen partikeln

Info

Publication number
DE60118558D1
DE60118558D1 DE60118558T DE60118558T DE60118558D1 DE 60118558 D1 DE60118558 D1 DE 60118558D1 DE 60118558 T DE60118558 T DE 60118558T DE 60118558 T DE60118558 T DE 60118558T DE 60118558 D1 DE60118558 D1 DE 60118558D1
Authority
DE
Germany
Prior art keywords
preparing
crystalline particles
collecting crystalline
particles
collecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60118558T
Other languages
English (en)
Other versions
DE60118558T2 (de
Inventor
Robert William Lancaster
Hardev Singh
Andrew Lewis Theopilus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE60118558D1 publication Critical patent/DE60118558D1/de
Application granted granted Critical
Publication of DE60118558T2 publication Critical patent/DE60118558T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60118558T 2000-06-29 2001-06-29 Verfahren zur herstellung und sammlung von kristallinen partikeln Expired - Lifetime DE60118558T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0015981 2000-06-29
GBGB0015981.4A GB0015981D0 (en) 2000-06-29 2000-06-29 Novel process for preparing crystalline particles
PCT/GB2001/002922 WO2002000198A1 (en) 2000-06-29 2001-06-29 Process for preparing and harvesting crystalline particles

Publications (2)

Publication Number Publication Date
DE60118558D1 true DE60118558D1 (de) 2006-05-18
DE60118558T2 DE60118558T2 (de) 2006-08-24

Family

ID=9894682

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60118558T Expired - Lifetime DE60118558T2 (de) 2000-06-29 2001-06-29 Verfahren zur herstellung und sammlung von kristallinen partikeln

Country Status (9)

Country Link
US (1) US20030181432A1 (de)
EP (1) EP1294359B1 (de)
JP (1) JP2004500983A (de)
AT (1) ATE322252T1 (de)
AU (1) AU2001266218A1 (de)
DE (1) DE60118558T2 (de)
ES (1) ES2260236T3 (de)
GB (1) GB0015981D0 (de)
WO (1) WO2002000198A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
WO2002094243A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
WO2002094238A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of anti-migraine compounds through an inhalation route
DE60230502D1 (de) * 2001-05-24 2009-02-05 Alexza Pharmaceuticals Inc Verabreichung von antimigränemitteln durch inhalation
ATE336231T1 (de) * 2001-08-29 2006-09-15 Dow Global Technologies Inc Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung
GB0208608D0 (en) * 2002-04-13 2002-05-22 Glaxo Group Ltd Composition
ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
JP4748584B2 (ja) * 2003-01-31 2011-08-17 水ｉｎｇ株式会社 晶析法による液中イオンの除去方法及び装置
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
CA2526475A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
GB0406069D0 (en) * 2004-03-17 2004-04-21 Thompson James Process
WO2006010078A2 (en) * 2004-07-08 2006-01-26 Dr. Reddy's Laboratories Ltd. Polymorphic form of naratriptan hydrochloride
CA2650395A1 (en) * 2006-04-28 2007-11-08 Schering Corporation Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
US8420122B2 (en) 2006-04-28 2013-04-16 Merck Sharp & Dohme Corp. Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
EP2049086A2 (de) * 2006-08-09 2009-04-22 Glaxo Group Limited Verfahren zur herstellung von lactose
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
SG182485A1 (en) * 2010-01-15 2012-08-30 Lithera Inc Lyophilized cake formulations
JP2014520848A (ja) * 2011-07-08 2014-08-25 ファイザー・リミテッド １型プロピオン酸フルチカゾンの調製のための方法
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
DK3517541T3 (da) 2012-05-08 2020-09-07 Nicox Ophthalmics Inc Polymorf form af fluticasonpropionat
EP2705838A1 (de) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium-Zubereitungen
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
JP2018126699A (ja) * 2017-02-09 2018-08-16 水ｉｎｇ株式会社 晶析方法及び晶析装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3154395A (en) * 1961-01-30 1964-10-27 Universal Oil Prod Co Continuous fractional crystallization process
US3984409A (en) * 1973-08-09 1976-10-05 Pfizer Inc. Cyclic n-substituted derivatives of 1,4-benzene disulphonamide
NL7501406A (en) * 1975-02-06 1976-08-10 Dso Pharmachim Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed
ES2078447T3 (es) * 1990-06-15 1995-12-16 Merck & Co Inc Un procedimiento de cristalizacion para mejorar la estructura y el tamaño de los cristales.
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
JP4157272B2 (ja) * 1997-09-03 2008-10-01 メルク エンド カムパニー インコーポレーテッド ２ｒ−［１−ヒドロキシ−１−トリフルオロメチル−３−シクロプロピルプロピン−２−イル］−４−クロロアニリンの光学純度を高める方法
WO1999033851A1 (en) * 1997-12-29 1999-07-08 Clarion Pharmaceuticals, Inc. N-het-substituted glycerophosphoethanolamines
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
AU755283B2 (en) * 1998-08-31 2002-12-05 Nof Corporation High-purity polysaccharide containing hydrophobic groups and process for producing the same
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
BR0007396A (pt) * 1999-01-29 2001-10-30 Bristol Myers Squibb Co Aparelho e processo de cristalização por jato deimpacto sÈnico

Also Published As

Publication number Publication date
ES2260236T3 (es) 2006-11-01
GB0015981D0 (en) 2000-08-23
EP1294359B1 (de) 2006-04-05
ATE322252T1 (de) 2006-04-15
EP1294359A1 (de) 2003-03-26
JP2004500983A (ja) 2004-01-15
US20030181432A1 (en) 2003-09-25
WO2002000198A1 (en) 2002-01-03
AU2001266218A1 (en) 2002-01-08
DE60118558T2 (de) 2006-08-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition