NL7501406A - Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed - Google Patents

Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed

Info

Publication number
NL7501406A
NL7501406A NL7501406A NL7501406A NL7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A
Authority
NL
Netherlands
Prior art keywords
crystallisation
frequency vibrations
purer
prod
subjecting
Prior art date
Application number
NL7501406A
Other languages
Dutch (nl)
Original Assignee
Dso Pharmachim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dso Pharmachim filed Critical Dso Pharmachim
Priority to NL7501406A priority Critical patent/NL7501406A/en
Publication of NL7501406A publication Critical patent/NL7501406A/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for preparing tetracycline hydrochloride (I) comprises treating a suspension of tetracycline (II) in organic solvent with conc. HCl and irradiating the resulting soln. with high-frequency vibrations, esp. of 10,000-400,000 Hz at flux density 0.5-10.5 W/sq.cm. By this irradiation crystallisation of (I) is 10-13 times quicker, and a purer product is obtained in higher yields. (I) is deposited as small, micronised crystals (particularly suitable for ointments, syrups etc.) and not as conglomerates enclosing solvent and acid. The activity of the mother liquor is 2000-4000 units/ml lower than for a control; that of (I) is higher than for a control and is close to the theoretical. (I) is esp. useful for preparation of tetraolean, and has a reduced toxicity.
NL7501406A 1975-02-06 1975-02-06 Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed NL7501406A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7501406A NL7501406A (en) 1975-02-06 1975-02-06 Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7501406A NL7501406A (en) 1975-02-06 1975-02-06 Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed

Publications (1)

Publication Number Publication Date
NL7501406A true NL7501406A (en) 1976-08-10

Family

ID=19823132

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7501406A NL7501406A (en) 1975-02-06 1975-02-06 Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed

Country Status (1)

Country Link
NL (1) NL7501406A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000200A1 (en) * 2000-06-29 2002-01-03 Glaxo Group Limited Novel process for preparing crystalline particles
WO2002000198A1 (en) * 2000-06-29 2002-01-03 Glaxo Group Limited Process for preparing and harvesting crystalline particles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000200A1 (en) * 2000-06-29 2002-01-03 Glaxo Group Limited Novel process for preparing crystalline particles
WO2002000198A1 (en) * 2000-06-29 2002-01-03 Glaxo Group Limited Process for preparing and harvesting crystalline particles

Similar Documents

Publication Publication Date Title
AT323236B (en) DEVICE FOR PRODUCING SINGLE CRYSTALS FROM CONDUCTIVE COMPOUNDS ACCORDING TO THE CZOCHRALSKI PROCESS
ZA872019B (en) Purification of glycolide
GB1484860A (en) Manufacture of boric acid
FI831105L (en) FOERFARANDE FOER FRAMSTAELLNING AV ISOMALTULOS (6-0- -D-GLUCOPYRANOSIDO-D-FRUKTOS) MED TILLHJAELP AV IMMOBILISERADE BAKTERIECELLER.
NL7501406A (en) Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed
FI901150A0 (en) Process for the preparation of therapeutically useful N-acetylneuraminate trihydrate
ES8705835A1 (en) A process for the resolution of a racemate.
MX9703673A (en) Method for the separation of paraxylene involving at least one high temperature crystallization stage and at least one clay treatment located upstream of the adsorption area.
ES449815A1 (en) Method of continuously crystallizing sodium carbonate peroxide
GB992749A (en) Ferrous glutamate
CA2133644A1 (en) Process for making vancomycin
EP0055921A3 (en) Ammonium sulfate recovery process
GB1382648A (en) Process for concentrating hydrogen peroxide
US3297546A (en) Preparation of 6-aminopenicillanic acid
GB1130306A (en) Improvements in or relating to the oxidation of hydrocarbons
FR2455583A1 (en) PROCESS FOR THE PURIFICATION OF CRUDE CAPROLACTAM CONTAINING PRIMARY AMIDES AND PURIFIED CAPROLACTAM OBTAINED
ES388664A1 (en) Process for the recovery of ammonium sulphate from it aqueous solutions contaminated by organic substances
CA1023736A (en) Process for recovery of cyanuric acid from treated chlorinator mother liquor
GB1022818A (en) Melamine refining procedure
GB1172180A (en) A Process for Improving the Purity of Inorganic or Organic Crystalline Products
JPS54144314A (en) Recovery of lysine
JPS53120698A (en) Purification method of caustic soda obtained from diaphragm method
KR920001139B1 (en) Method for production of 3.4-anhgdro vindlastin
JPS5612339A (en) Purification of trimethoxybenzoic acid
GB1038005A (en) Purification of p-aminophenol

Legal Events

Date Code Title Description
BV The patent application has lapsed