NL7501406A - Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed - Google Patents
Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formedInfo
- Publication number
- NL7501406A NL7501406A NL7501406A NL7501406A NL7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A NL 7501406 A NL7501406 A NL 7501406A
- Authority
- NL
- Netherlands
- Prior art keywords
- crystallisation
- frequency vibrations
- purer
- prod
- subjecting
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Process for preparing tetracycline hydrochloride (I) comprises treating a suspension of tetracycline (II) in organic solvent with conc. HCl and irradiating the resulting soln. with high-frequency vibrations, esp. of 10,000-400,000 Hz at flux density 0.5-10.5 W/sq.cm. By this irradiation crystallisation of (I) is 10-13 times quicker, and a purer product is obtained in higher yields. (I) is deposited as small, micronised crystals (particularly suitable for ointments, syrups etc.) and not as conglomerates enclosing solvent and acid. The activity of the mother liquor is 2000-4000 units/ml lower than for a control; that of (I) is higher than for a control and is close to the theoretical. (I) is esp. useful for preparation of tetraolean, and has a reduced toxicity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7501406A NL7501406A (en) | 1975-02-06 | 1975-02-06 | Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7501406A NL7501406A (en) | 1975-02-06 | 1975-02-06 | Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7501406A true NL7501406A (en) | 1976-08-10 |
Family
ID=19823132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7501406A NL7501406A (en) | 1975-02-06 | 1975-02-06 | Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL7501406A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002000198A1 (en) * | 2000-06-29 | 2002-01-03 | Glaxo Group Limited | Process for preparing and harvesting crystalline particles |
WO2002000200A1 (en) * | 2000-06-29 | 2002-01-03 | Glaxo Group Limited | Novel process for preparing crystalline particles |
-
1975
- 1975-02-06 NL NL7501406A patent/NL7501406A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002000198A1 (en) * | 2000-06-29 | 2002-01-03 | Glaxo Group Limited | Process for preparing and harvesting crystalline particles |
WO2002000200A1 (en) * | 2000-06-29 | 2002-01-03 | Glaxo Group Limited | Novel process for preparing crystalline particles |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |