DE60317561D1 - Vorrichtung und verfahren zur herstellung von autologem thrombinserum - Google Patents
Vorrichtung und verfahren zur herstellung von autologem thrombinserumInfo
- Publication number
- DE60317561D1 DE60317561D1 DE60317561T DE60317561T DE60317561D1 DE 60317561 D1 DE60317561 D1 DE 60317561D1 DE 60317561 T DE60317561 T DE 60317561T DE 60317561 T DE60317561 T DE 60317561T DE 60317561 D1 DE60317561 D1 DE 60317561D1
- Authority
- DE
- Germany
- Prior art keywords
- reaction chamber
- thrombin serum
- autologous thrombin
- producing autologous
- activating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 2
- 229960004072 thrombin Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000002966 serum Anatomy 0.000 title 1
- 230000003213 activating effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940021317 other blood product in atc Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US328419 | 2002-12-23 | ||
US10/328,419 US20040120942A1 (en) | 2002-12-23 | 2002-12-23 | Device and process for the preparation of autologous thrombin serum |
PCT/US2003/040804 WO2004058943A2 (en) | 2002-12-23 | 2003-12-18 | Device and process for the preparation of autologous thrombin serum |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60317561D1 true DE60317561D1 (de) | 2007-12-27 |
DE60317561T2 DE60317561T2 (de) | 2008-09-04 |
Family
ID=32594463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60317561T Expired - Lifetime DE60317561T2 (de) | 2002-12-23 | 2003-12-18 | Vorrichtung und verfahren zur herstellung von autologem thrombinserum |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040120942A1 (de) |
EP (1) | EP1576153B1 (de) |
JP (1) | JP4886194B2 (de) |
AT (1) | ATE378402T1 (de) |
AU (1) | AU2003301200A1 (de) |
DE (1) | DE60317561T2 (de) |
WO (1) | WO2004058943A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000062828A1 (en) * | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
CN101317855A (zh) * | 2003-01-27 | 2008-12-10 | 哈维斯特技术公司 | 从抗凝全血生产的自体或同种促凝剂 |
EP1848473B1 (de) * | 2005-02-07 | 2013-05-22 | Hanuman LLC | Plasmakonzentrationsvorrichtung |
US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US8753690B2 (en) | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
JP5442310B2 (ja) * | 2009-04-23 | 2014-03-12 | 旭化成メディカル株式会社 | トロンビン溶液の調製方法 |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
CN102573790B (zh) | 2009-08-27 | 2017-03-22 | 拜欧米特生物制剂有限责任公司 | 用于产生白介素‑1受体拮抗剂的可植入装置 |
GB201004072D0 (en) * | 2010-03-11 | 2010-04-28 | Turzi Antoine | Process, tube and device for the preparation of wound healant composition |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
KR20140003398A (ko) | 2010-09-03 | 2014-01-09 | 바이오멧 바이오로직스, 엘엘씨 | 인터루킨-1 수용체 길항제를 전달하는 방법 및 조성물 |
US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
US8586324B2 (en) | 2011-08-15 | 2013-11-19 | Biomet Biologics, Llc | Method and apparatus to create autologous clotting serum |
US10849931B2 (en) * | 2011-09-30 | 2020-12-01 | Depuy Synthes Products, Inc | Compositions and methods for platelet enriched fibrin constructs |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
RU2589648C2 (ru) * | 2012-09-25 | 2016-07-10 | Стем Селл Партнерс Ллк | Способ и устройство для получения сыворотки с тромбином от одного донора |
US9149529B2 (en) * | 2012-10-24 | 2015-10-06 | Orthovita, Inc. | Stable compositions containing thrombin and methods for preparation and use thereof |
ITVR20120229A1 (it) * | 2012-11-15 | 2014-05-16 | Bbs Srl | Dispositivo pronto all'uso e metodo per la rimozione di interferenti da campioni da sottoporre ad esame microbiologico |
US9114190B2 (en) * | 2013-02-08 | 2015-08-25 | Laser Spine Institute, Llc | Regeneration of spinal discs |
US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
EP3074507B1 (de) | 2013-11-26 | 2022-01-05 | Biomet Biologics, LLC | Verfahren zur vermittlung von makrophagenphänotypen |
ES2645862T3 (es) * | 2014-03-17 | 2017-12-11 | Al.Chi.Mi.A. S.R.L. | Dispositivo listo para usar y método para eliminar factores interferentes de muestras que se van a someter a examen microbiológico |
US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
US20170274012A1 (en) * | 2014-09-03 | 2017-09-28 | Entegrion, Inc. | Acceleration of Reconstitution of Plasma Powder by Mixing with Small Beads |
US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
CN105181978B (zh) * | 2015-09-23 | 2016-07-20 | 青岛古高生物科技有限公司 | 一种凝血酶时间测定试剂及其制备方法 |
EP3426401B1 (de) | 2016-03-10 | 2021-05-12 | Arthrex, Inc. | Systeme zur herstellung eines thrombinserums |
WO2017156379A2 (en) | 2016-03-10 | 2017-09-14 | Arthrex, Inc. | Systems and methods for preparing protein enhanced serums |
CA3127191A1 (en) | 2019-01-21 | 2020-07-30 | Eclipse Medcorp, Llc | Methods, systems and apparatus for separating components of a biological sample |
PL439627A1 (pl) * | 2021-11-24 | 2023-05-29 | Biovico Spółka Z Ograniczoną Odpowiedzialnością | System zawierający aktywator zwiększający poziom endogennego inhibitora szlaku Wnt |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5165938A (en) * | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
US5733545A (en) * | 1995-03-03 | 1998-03-31 | Quantic Biomedical Partners | Platelet glue wound sealant |
US5643192A (en) * | 1995-04-06 | 1997-07-01 | Hamilton Civic Hospitals Research Development, Inc. | Autologous fibrin glue and methods for its preparation and use |
US5677162A (en) * | 1995-05-01 | 1997-10-14 | New York Blood Center, Inc. | Method for activating prothrombin to thrombin |
US5814022A (en) * | 1996-02-06 | 1998-09-29 | Plasmaseal Llc | Method and apparatus for applying tissue sealant |
WO1997040864A1 (en) * | 1996-04-30 | 1997-11-06 | Medtronic, Inc. | Method for making autologous fibrin sealant |
US6274090B1 (en) * | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
US6472162B1 (en) * | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
EP1381410A2 (de) * | 2001-04-09 | 2004-01-21 | Medtronic, Inc. | Zentrifugationsverfahren zur isolierung der blutbestandteile, und deren verwendungen |
-
2002
- 2002-12-23 US US10/328,419 patent/US20040120942A1/en not_active Abandoned
-
2003
- 2003-12-18 DE DE60317561T patent/DE60317561T2/de not_active Expired - Lifetime
- 2003-12-18 AT AT03814264T patent/ATE378402T1/de not_active IP Right Cessation
- 2003-12-18 WO PCT/US2003/040804 patent/WO2004058943A2/en active IP Right Grant
- 2003-12-18 AU AU2003301200A patent/AU2003301200A1/en not_active Abandoned
- 2003-12-18 JP JP2004563884A patent/JP4886194B2/ja not_active Expired - Fee Related
- 2003-12-18 EP EP03814264A patent/EP1576153B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20040120942A1 (en) | 2004-06-24 |
AU2003301200A1 (en) | 2004-07-22 |
WO2004058943A3 (en) | 2005-02-10 |
AU2003301200A8 (en) | 2004-07-22 |
ATE378402T1 (de) | 2007-11-15 |
JP2006515853A (ja) | 2006-06-08 |
JP4886194B2 (ja) | 2012-02-29 |
EP1576153A4 (de) | 2006-01-18 |
EP1576153A2 (de) | 2005-09-21 |
WO2004058943A2 (en) | 2004-07-15 |
DE60317561T2 (de) | 2008-09-04 |
EP1576153B1 (de) | 2007-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |