ATE378402T1 - Vorrichtung und verfahren zur herstellung von autologem thrombinserum - Google Patents

Vorrichtung und verfahren zur herstellung von autologem thrombinserum

Info

Publication number
ATE378402T1
ATE378402T1 AT03814264T AT03814264T ATE378402T1 AT E378402 T1 ATE378402 T1 AT E378402T1 AT 03814264 T AT03814264 T AT 03814264T AT 03814264 T AT03814264 T AT 03814264T AT E378402 T1 ATE378402 T1 AT E378402T1
Authority
AT
Austria
Prior art keywords
autologue
producing
reaction chamber
thrombin serum
activating agent
Prior art date
Application number
AT03814264T
Other languages
English (en)
Inventor
Daniel Mcginnis
Cherylyn Voorhees
Hubert Smith
Original Assignee
Sorin Group Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorin Group Usa Inc filed Critical Sorin Group Usa Inc
Application granted granted Critical
Publication of ATE378402T1 publication Critical patent/ATE378402T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
AT03814264T 2002-12-23 2003-12-18 Vorrichtung und verfahren zur herstellung von autologem thrombinserum ATE378402T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/328,419 US20040120942A1 (en) 2002-12-23 2002-12-23 Device and process for the preparation of autologous thrombin serum

Publications (1)

Publication Number Publication Date
ATE378402T1 true ATE378402T1 (de) 2007-11-15

Family

ID=32594463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03814264T ATE378402T1 (de) 2002-12-23 2003-12-18 Vorrichtung und verfahren zur herstellung von autologem thrombinserum

Country Status (7)

Country Link
US (1) US20040120942A1 (de)
EP (1) EP1576153B1 (de)
JP (1) JP4886194B2 (de)
AT (1) ATE378402T1 (de)
AU (1) AU2003301200A1 (de)
DE (1) DE60317561T2 (de)
WO (1) WO2004058943A2 (de)

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US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
BRPI0406931A (pt) * 2003-01-27 2006-01-03 Harvest Technologies Inc Método para a produção de um coagulante a partir de sangue total anticoagulado, kit para a preparação de um coagulante a partir de sangue total anticoagulado, e, fração de sangue humano
PL1848473T3 (pl) * 2005-02-07 2013-11-29 Hanuman Llc Urządzenie - koncentrator osocza
US7694828B2 (en) * 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2008127639A1 (en) 2007-04-12 2008-10-23 Biomet Biologics, Llc Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
PL2259774T3 (pl) 2008-02-27 2013-04-30 Biomet Biologics Llc Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1
US8753690B2 (en) 2008-02-27 2014-06-17 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
JP5442310B2 (ja) * 2009-04-23 2014-03-12 旭化成メディカル株式会社 トロンビン溶液の調製方法
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
EP2470162B1 (de) 2009-08-27 2019-03-27 Biomet Biologics, LLC Implantierbare vorrichtung zur herstellung von interleukin-1-rezeptor-antagonisten
GB201004072D0 (en) * 2010-03-11 2010-04-28 Turzi Antoine Process, tube and device for the preparation of wound healant composition
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
KR20140003398A (ko) 2010-09-03 2014-01-09 바이오멧 바이오로직스, 엘엘씨 인터루킨-1 수용체 길항제를 전달하는 방법 및 조성물
US9011846B2 (en) 2011-05-02 2015-04-21 Biomet Biologics, Llc Thrombin isolated from blood and blood fractions
US8586324B2 (en) 2011-08-15 2013-11-19 Biomet Biologics, Llc Method and apparatus to create autologous clotting serum
US10849931B2 (en) * 2011-09-30 2020-12-01 Depuy Synthes Products, Inc Compositions and methods for platelet enriched fibrin constructs
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN104349805B (zh) * 2012-09-25 2017-06-23 干细胞合伙有限责任公司 制备单供体凝血酶血清的方法和装置
US9149529B2 (en) * 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
ITVR20120229A1 (it) * 2012-11-15 2014-05-16 Bbs Srl Dispositivo pronto all'uso e metodo per la rimozione di interferenti da campioni da sottoporre ad esame microbiologico
US9114190B2 (en) * 2013-02-08 2015-08-25 Laser Spine Institute, Llc Regeneration of spinal discs
US9758806B2 (en) 2013-03-15 2017-09-12 Biomet Biologics, Llc Acellular compositions for treating inflammatory disorders
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9878011B2 (en) 2013-03-15 2018-01-30 Biomet Biologics, Llc Treatment of inflammatory respiratory disease using biological solutions
US9833474B2 (en) 2013-11-26 2017-12-05 Biomet Biologies, LLC Methods of mediating macrophage phenotypes
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US9550028B2 (en) 2014-05-06 2017-01-24 Biomet Biologics, LLC. Single step desiccating bead-in-syringe concentrating device
WO2016036807A1 (en) * 2014-09-03 2016-03-10 Entegrion, Inc. Acceleration of reconstitution of plasma powder by mixing with small beads
US10441635B2 (en) 2014-11-10 2019-10-15 Biomet Biologics, Llc Methods of treating pain using protein solutions
US9763800B2 (en) 2015-03-18 2017-09-19 Biomet C. V. Implant configured for hammertoe and small bone fixation
CN105181978B (zh) * 2015-09-23 2016-07-20 青岛古高生物科技有限公司 一种凝血酶时间测定试剂及其制备方法
EP3426400B1 (de) 2016-03-10 2020-09-02 Arthrex Inc System zur herstellung von proteinverstärkten seren
WO2017156375A1 (en) 2016-03-10 2017-09-14 Arthrex, Inc. Systems and methods for preparing a thrombin serum
US12440835B2 (en) 2019-01-21 2025-10-14 Vias Partners, Llc Methods, systems and apparatus for separating components of a biological sample
KR20220091580A (ko) 2019-10-31 2022-06-30 이클립스 메드코프 엘엘씨 샘플의 구성요소들을 분리하기 위한 시스템, 방법 및 장치
PL249129B1 (pl) * 2021-11-24 2026-03-02 Biovico Spółka Z Ograniczoną Odpowiedzialnością Urządzenie do izolacji i separacji frakcji płynów autologicznych pacjenta zawierające aktywator zwiększający poziom endogennego inhibitora szlaku Wnt

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US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5643192A (en) * 1995-04-06 1997-07-01 Hamilton Civic Hospitals Research Development, Inc. Autologous fibrin glue and methods for its preparation and use
US5677162A (en) * 1995-05-01 1997-10-14 New York Blood Center, Inc. Method for activating prothrombin to thrombin
US5814022A (en) * 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
DE29723807U1 (de) * 1996-04-30 1999-11-04 Medtronic, Inc., Minneapolis, Minn. Autologe Fibrin-Blutstillungsmittel
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) * 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
WO2002081007A2 (en) * 2001-04-09 2002-10-17 Medtronic, Inc. Methods of isolating blood components using a centrifuge and uses thereof

Also Published As

Publication number Publication date
WO2004058943A3 (en) 2005-02-10
US20040120942A1 (en) 2004-06-24
DE60317561D1 (de) 2007-12-27
WO2004058943A2 (en) 2004-07-15
EP1576153B1 (de) 2007-11-14
JP4886194B2 (ja) 2012-02-29
JP2006515853A (ja) 2006-06-08
EP1576153A2 (de) 2005-09-21
AU2003301200A8 (en) 2004-07-22
DE60317561T2 (de) 2008-09-04
AU2003301200A1 (en) 2004-07-22
EP1576153A4 (de) 2006-01-18

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