DE1216866B - Verfahren zur Herstellung von Carbonsaeureestern des 4-Aminobutin-(2)-ols-(1) und deren therapeutisch vertraeglichen Salzen - Google Patents

Verfahren zur Herstellung von Carbonsaeureestern des 4-Aminobutin-(2)-ols-(1) und deren therapeutisch vertraeglichen Salzen

Info

Publication number
DE1216866B
DE1216866B DEM49737A DEM0049737A DE1216866B DE 1216866 B DE1216866 B DE 1216866B DE M49737 A DEM49737 A DE M49737A DE M0049737 A DEM0049737 A DE M0049737A DE 1216866 B DE1216866 B DE 1216866B
Authority
DE
Germany
Prior art keywords
radical
ester
general formula
acid
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEM49737A
Other languages
German (de)
English (en)
Inventor
Kenneth N Campbell
Robert F Majewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mead Johnson and Co LLC
Original Assignee
Mead Johnson and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mead Johnson and Co LLC filed Critical Mead Johnson and Co LLC
Publication of DE1216866B publication Critical patent/DE1216866B/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DEM49737A 1960-07-26 1961-07-19 Verfahren zur Herstellung von Carbonsaeureestern des 4-Aminobutin-(2)-ols-(1) und deren therapeutisch vertraeglichen Salzen Pending DE1216866B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4529260A 1960-07-26 1960-07-26
US118261A US3176019A (en) 1960-07-26 1961-06-20 Substituted aminobutynyl acetates

Publications (1)

Publication Number Publication Date
DE1216866B true DE1216866B (de) 1966-05-18

Family

ID=26722613

Family Applications (1)

Application Number Title Priority Date Filing Date
DEM49737A Pending DE1216866B (de) 1960-07-26 1961-07-19 Verfahren zur Herstellung von Carbonsaeureestern des 4-Aminobutin-(2)-ols-(1) und deren therapeutisch vertraeglichen Salzen

Country Status (9)

Country Link
US (1) US3176019A (enExample)
BE (1) BE606560A (enExample)
CH (1) CH421078A (enExample)
DE (1) DE1216866B (enExample)
DK (1) DK113854B (enExample)
ES (1) ES269353A1 (enExample)
FR (1) FR1325M (enExample)
GB (1) GB940540A (enExample)
NL (2) NL124473C (enExample)

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US5036107A (en) * 1986-06-27 1991-07-30 Marion Merrell Dow Inc. 1,7-substituted heptyn-2-ones and use
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IL91377A (en) * 1988-09-14 1996-09-12 Nippon Shinyaku Co Ltd Derivatives of botinylamine glycolate
US5532278A (en) * 1995-01-31 1996-07-02 Sepracor, Inc. Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin
US5677346A (en) * 1995-01-31 1997-10-14 Sepracor, Inc. Treating urinary incontinence using (S)-desethyloxybutynin
AU3799997A (en) * 1996-07-09 1998-02-02 Sepracor, Inc. Dextrorotatory isomers of oxybutynin and desethyloxybutynin in the treatment of gastrointestinal hyperactivity
US6140529A (en) * 1998-10-22 2000-10-31 Sepracor Inc. Synthesis of optically active cyclohexylphenylglycolate esters
US5973182A (en) * 1998-10-22 1999-10-26 Sepracor Inc. Carbonate Intermediates useful in the preparation of optically active cyclohexylphenylglycolate esters
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
DK1280486T3 (da) * 2000-04-26 2011-02-14 Watson Pharmaceuticals Inc Minimering af bivirkning forbundet med oxybutinin-terapi
BR0206207A (pt) 2001-10-26 2003-12-23 Pharmacia & Up John Company Compostos de amÈnio quaternário e seu uso como agentes antimuscarìnicos
US7399779B2 (en) 2002-07-08 2008-07-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
AU2002368152A1 (en) * 2002-07-31 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists
AU2002321711A1 (en) * 2002-08-09 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
ATE423769T1 (de) * 2002-08-23 2009-03-15 Ranbaxy Lab Ltd Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten
TW200412945A (en) 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
EP1572648B1 (en) 2002-12-10 2008-07-09 Ranbaxy Laboratories, Ltd. 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists
DE60225195T2 (de) * 2002-12-23 2009-02-26 Ranbaxy Laboratories, Ltd. Flavaxat-derivate als muscarin-rezeptor antagonisten
US7465751B2 (en) * 2002-12-23 2008-12-16 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7517905B2 (en) * 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7560479B2 (en) 2003-04-10 2009-07-14 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
BR0318242A (pt) * 2003-04-10 2006-04-04 Ranbaxy Lab Ltd derivados de azabiciclo hexano substituìdo como antagonistas de receptores muscarìnicos e processo para sua preparação
US20070021487A1 (en) * 2003-04-11 2007-01-25 Mohammad Salman Azabicyclo derivatives as muscarinic receptor antagonists
ATE419246T1 (de) * 2004-06-16 2009-01-15 Ranbaxy Lab Ltd Als antagonisten des muscarinrezeptors geeignete xanthinderivate
US20080262075A1 (en) * 2004-08-19 2008-10-23 Ranbaxy Laboratories Limited Pyrrolidine Derivatives as Muscarinic Receptor Antagonists
EP1794161A2 (en) * 2004-09-24 2007-06-13 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
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US20100016400A1 (en) * 2004-11-19 2010-01-21 Naresh Kumar Azabicyclic muscarinic receptor antagonists
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US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
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PE20131341A1 (es) 2010-08-03 2013-12-07 Altherx Inc Combinaciones de agonistas del receptor beta-3-adrenergico y antagonistas del receptor muscarinico para tratar vejiga hiperactiva
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
TW201338772A (zh) 2012-02-09 2013-10-01 Altherx Inc 藥學組合物
KR20170086659A (ko) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법
PL3365321T3 (pl) 2015-10-23 2024-03-25 B3Ar Therapeutics, Inc. Jon obojnaczy solabegronu i jego zastosowania
BR112020015316A2 (pt) 2018-01-30 2020-12-08 Apnimed, Inc. (Delaware) Métodos e composições para o tratamento da apneia do sono
CN115667205A (zh) 2020-05-05 2023-01-31 爱普宁公司(特拉华) (r)-盐酸奥昔布宁的多晶形物形式

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE895595C (de) * 1943-09-29 1953-11-05 Basf Ag Verfahren zur Herstellung von Aminoalkinolen
DE1003209B (de) * 1953-03-24 1957-02-28 Basf Ag Verfahren zur Herstellung spasmolytisch wirksamer basischer Carbinole
DE1083254B (de) * 1957-04-01 1960-06-15 Lakeside Lab In Verfahren zur Herstellung von blutdrucksenkenden N-disubstituierten Diaminoalkinen, deren Saeureadditionssalzen oder quaternaeren Ammoniumsalzen
DE1100617B (de) * 1959-10-22 1961-03-02 Basf Ag Verfahren zur Herstellung von 1-Dialkylamino-4-hydroxy-acetylenen-(2)

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US2867619A (en) * 1956-11-05 1959-01-06 Lakeside Lab Inc Aminoalkynyl-n-alkylpiperidine carboxylates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE895595C (de) * 1943-09-29 1953-11-05 Basf Ag Verfahren zur Herstellung von Aminoalkinolen
DE1003209B (de) * 1953-03-24 1957-02-28 Basf Ag Verfahren zur Herstellung spasmolytisch wirksamer basischer Carbinole
DE1083254B (de) * 1957-04-01 1960-06-15 Lakeside Lab In Verfahren zur Herstellung von blutdrucksenkenden N-disubstituierten Diaminoalkinen, deren Saeureadditionssalzen oder quaternaeren Ammoniumsalzen
DE1100617B (de) * 1959-10-22 1961-03-02 Basf Ag Verfahren zur Herstellung von 1-Dialkylamino-4-hydroxy-acetylenen-(2)

Also Published As

Publication number Publication date
CH421078A (de) 1966-09-30
BE606560A (fr) 1962-01-26
NL124473C (enExample)
FR1325M (fr) 1962-05-21
NL267508A (enExample)
ES269353A1 (es) 1961-11-16
DK113854B (da) 1969-05-05
US3176019A (en) 1965-03-30
GB940540A (en) 1963-10-30

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