DE1171434B - Verfahren zur Herstellung eines geschmackfreien Salzes des 3-(5'-Nitrofurfuryliden-amino)-5-(morpholino-methyl)-oxazolidons-(2) - Google Patents
Verfahren zur Herstellung eines geschmackfreien Salzes des 3-(5'-Nitrofurfuryliden-amino)-5-(morpholino-methyl)-oxazolidons-(2)Info
- Publication number
- DE1171434B DE1171434B DEN20129A DEN0020129A DE1171434B DE 1171434 B DE1171434 B DE 1171434B DE N20129 A DEN20129 A DE N20129A DE N0020129 A DEN0020129 A DE N0020129A DE 1171434 B DE1171434 B DE 1171434B
- Authority
- DE
- Germany
- Prior art keywords
- salt
- amino
- morpholino
- methyl
- nitrofurfurylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 title claims description 14
- 125000001064 morpholinomethyl group Chemical group [H]C([H])(*)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 4
- 230000009967 tasteless effect Effects 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title claims description 3
- 239000012442 inert solvent Substances 0.000 claims description 3
- -1 nitrofuran compound Chemical class 0.000 claims description 2
- 229960001907 nitrofurazone Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000005265 Lupinus mutabilis Species 0.000 description 1
- 235000008755 Lupinus mutabilis Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000019095 Sechium edule Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- VNWURUHLRKUPJD-UHFFFAOYSA-O [O-][N+](C1=CC=C(C=NN([CH-]OC2C[NH+]3CCOCC3)C2=O)O1)=O Chemical compound [O-][N+](C1=CC=C(C=NN([CH-]OC2C[NH+]3CCOCC3)C2=O)O1)=O VNWURUHLRKUPJD-UHFFFAOYSA-O 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4220560A | 1960-07-12 | 1960-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1171434B true DE1171434B (de) | 1964-06-04 |
Family
ID=21920621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEN20129A Pending DE1171434B (de) | 1960-07-12 | 1961-06-02 | Verfahren zur Herstellung eines geschmackfreien Salzes des 3-(5'-Nitrofurfuryliden-amino)-5-(morpholino-methyl)-oxazolidons-(2) |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH390254A (enrdf_load_stackoverflow) |
| DE (1) | DE1171434B (enrdf_load_stackoverflow) |
| ES (1) | ES268449A1 (enrdf_load_stackoverflow) |
| FR (2) | FR1590053A (enrdf_load_stackoverflow) |
| NL (1) | NL266216A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06510285A (ja) * | 1991-08-14 | 1994-11-17 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | 抗不整脈及び抗細動剤として有用な環状ウレタン類 |
| DE19633480A1 (de) * | 1996-08-20 | 1998-02-26 | Bayer Ag | Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2802002A (en) * | 1956-07-18 | 1957-08-06 | Norwich Pharma Co | Series of new nu-(5-nitro-2-furyl) alkylidene-3-amino-5-tertiaryamino-methyl-2-oxazolidones and the preparation thereof |
-
0
- NL NL266216D patent/NL266216A/xx unknown
-
1961
- 1961-06-02 DE DEN20129A patent/DE1171434B/de active Pending
- 1961-06-21 ES ES0268449A patent/ES268449A1/es not_active Expired
- 1961-07-11 FR FR1590053D patent/FR1590053A/fr not_active Expired
- 1961-07-11 CH CH808861A patent/CH390254A/de unknown
- 1961-10-09 FR FR875390A patent/FR1452M/fr active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2802002A (en) * | 1956-07-18 | 1957-08-06 | Norwich Pharma Co | Series of new nu-(5-nitro-2-furyl) alkylidene-3-amino-5-tertiaryamino-methyl-2-oxazolidones and the preparation thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1452M (fr) | 1962-08-20 |
| FR1590053A (enrdf_load_stackoverflow) | 1970-04-13 |
| CH390254A (de) | 1965-04-15 |
| ES268449A1 (es) | 1961-12-01 |
| NL266216A (enrdf_load_stackoverflow) |
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