DE10225420A1 - Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon - Google Patents
Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davonInfo
- Publication number
- DE10225420A1 DE10225420A1 DE10225420A DE10225420A DE10225420A1 DE 10225420 A1 DE10225420 A1 DE 10225420A1 DE 10225420 A DE10225420 A DE 10225420A DE 10225420 A DE10225420 A DE 10225420A DE 10225420 A1 DE10225420 A1 DE 10225420A1
- Authority
- DE
- Germany
- Prior art keywords
- preparation according
- strontium
- salt
- mixture
- hpo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000004568 cement Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 229910052712 strontium Inorganic materials 0.000 title claims abstract description 26
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 title claims abstract description 26
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 title claims description 26
- 229910052586 apatite Inorganic materials 0.000 title claims description 24
- 239000000203 mixture Substances 0.000 claims abstract description 43
- 239000000843 powder Substances 0.000 claims abstract description 33
- 239000011575 calcium Substances 0.000 claims abstract description 26
- 239000007864 aqueous solution Substances 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 13
- 150000003863 ammonium salts Chemical class 0.000 claims abstract description 8
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims abstract description 6
- 229910000018 strontium carbonate Inorganic materials 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 30
- 210000000988 bone and bone Anatomy 0.000 claims description 26
- 239000011734 sodium Substances 0.000 claims description 19
- 235000011007 phosphoric acid Nutrition 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000000316 bone substitute Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 229910052700 potassium Inorganic materials 0.000 claims description 10
- 150000001447 alkali salts Chemical class 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 208000001132 Osteoporosis Diseases 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 159000000000 sodium salts Chemical class 0.000 claims description 5
- 229940088623 biologically active substance Drugs 0.000 claims description 4
- 239000007795 chemical reaction product Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- VAWSWDPVUFTPQO-UHFFFAOYSA-N calcium strontium Chemical compound [Ca].[Sr] VAWSWDPVUFTPQO-UHFFFAOYSA-N 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 3
- HKSVWJWYDJQNEV-UHFFFAOYSA-L strontium;hydron;phosphate Chemical compound [Sr+2].OP([O-])([O-])=O HKSVWJWYDJQNEV-UHFFFAOYSA-L 0.000 claims description 3
- JOPDZQBPOWAEHC-UHFFFAOYSA-H tristrontium;diphosphate Chemical compound [Sr+2].[Sr+2].[Sr+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O JOPDZQBPOWAEHC-UHFFFAOYSA-H 0.000 claims description 3
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 2
- 229930182566 Gentamicin Natural products 0.000 claims description 2
- 108010059993 Vancomycin Proteins 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 229920001222 biopolymer Polymers 0.000 claims description 2
- 239000002639 bone cement Substances 0.000 claims description 2
- 229960002227 clindamycin Drugs 0.000 claims description 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 239000000824 cytostatic agent Substances 0.000 claims description 2
- 230000001085 cytostatic effect Effects 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229960002518 gentamicin Drugs 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical class C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 229960000707 tobramycin Drugs 0.000 claims description 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 2
- 229960003165 vancomycin Drugs 0.000 claims description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 235000019858 potassium salts of orthophosphoric acid Nutrition 0.000 claims 1
- 239000011644 potassium salts of orthophosphoric acid Substances 0.000 claims 1
- 235000019857 sodium salts of orthophosphoric acid Nutrition 0.000 claims 1
- 239000011643 sodium salts of orthophosphoric acid Substances 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- 159000000011 group IA salts Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 11
- 239000000463 material Substances 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 9
- 230000007547 defect Effects 0.000 description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 7
- 210000002997 osteoclast Anatomy 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000004097 bone metabolism Effects 0.000 description 5
- 239000001506 calcium phosphate Substances 0.000 description 5
- 235000011010 calcium phosphates Nutrition 0.000 description 5
- 230000001009 osteoporotic effect Effects 0.000 description 5
- 229910001427 strontium ion Inorganic materials 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 230000001195 anabolic effect Effects 0.000 description 3
- 230000010072 bone remodeling Effects 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 239000004068 calcium phosphate ceramic Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 210000000963 osteoblast Anatomy 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 241001474728 Satyrodes eurydice Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- MXZRMHIULZDAKC-UHFFFAOYSA-L ammonium magnesium phosphate Chemical compound [NH4+].[Mg+2].[O-]P([O-])([O-])=O MXZRMHIULZDAKC-UHFFFAOYSA-L 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000001925 catabolic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 229910052567 struvite Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
- C04B12/02—Phosphate cements
- C04B12/025—Phosphates of ammonium or of the alkali or alkaline earth metals
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Structural Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Composite Materials (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Dental Preparations (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10225420A DE10225420A1 (de) | 2002-06-07 | 2002-06-07 | Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon |
| KR1020047019845A KR101061308B1 (ko) | 2002-06-07 | 2003-05-14 | 스트론튬-아파타이트-접합 제제 및 이로부터 형성된접합제 및 이의 용도 |
| PCT/EP2003/005059 WO2003103734A1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
| ES03735389T ES2304515T3 (es) | 2002-06-07 | 2003-05-14 | Preparados de cemento de apatito de estroncio y sus usos. |
| JP2004510853A JP4914005B2 (ja) | 2002-06-07 | 2003-05-14 | ストロンチウム−アパタイト−セメント調合物、およびその利用 |
| DE50309585T DE50309585D1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
| AT03735389T ATE391519T1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
| CNB03813148XA CN1323726C (zh) | 2002-06-07 | 2003-05-14 | 锶磷灰石骨水泥制剂及其应用 |
| AU2003236650A AU2003236650A1 (en) | 2002-06-07 | 2003-05-14 | Strontium-apatite-cement-preparations and the use thereof |
| EP03735389A EP1511521B1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
| US11/006,326 US7273523B2 (en) | 2002-06-07 | 2004-12-06 | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
| US11/851,346 US7501020B2 (en) | 2002-06-07 | 2007-09-06 | Strontium-apatite cement preparations, cements formed therefrom, and uses thereof |
| US12/359,907 US7758693B2 (en) | 2002-06-07 | 2009-01-26 | Strontium-apatite cement preparations, cements formed therefrom, and uses thereof |
| US12/792,526 US8715410B2 (en) | 2002-06-07 | 2010-06-02 | Strontium-apatite cement preparation cements formed therefrom, and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10225420A DE10225420A1 (de) | 2002-06-07 | 2002-06-07 | Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10225420A1 true DE10225420A1 (de) | 2003-12-24 |
Family
ID=29594328
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10225420A Ceased DE10225420A1 (de) | 2002-06-07 | 2002-06-07 | Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon |
| DE50309585T Expired - Lifetime DE50309585D1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50309585T Expired - Lifetime DE50309585D1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1511521B1 (enExample) |
| JP (1) | JP4914005B2 (enExample) |
| KR (1) | KR101061308B1 (enExample) |
| CN (1) | CN1323726C (enExample) |
| AT (1) | ATE391519T1 (enExample) |
| AU (1) | AU2003236650A1 (enExample) |
| DE (2) | DE10225420A1 (enExample) |
| ES (1) | ES2304515T3 (enExample) |
| WO (1) | WO2003103734A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098618A3 (en) * | 2003-05-07 | 2005-03-24 | Osteologix As | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US7595342B2 (en) | 2003-05-07 | 2009-09-29 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| US8609616B2 (en) | 2004-02-26 | 2013-12-17 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
| US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
| CN1292804C (zh) * | 2004-03-08 | 2007-01-03 | 西安交通大学 | 含锶纳米磷酸钙生物活性骨水泥的制备工艺 |
| CA2564687A1 (en) | 2004-04-27 | 2005-11-10 | Kyphon Inc. | Bone substitute compositions and method of use |
| FR2869544B1 (fr) * | 2004-05-03 | 2006-07-21 | Centre Nat Rech Scient Cnrse | Composition pour ciment injectable, utile comme substitut osseux |
| US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
| US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
| US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
| FR2903684B1 (fr) * | 2006-07-12 | 2008-10-17 | Centre Nat Rech Scient | Nouveau compose phospho-calco-strontique et ses utilisations dans des ciments endodontiques. |
| CN101053673B (zh) * | 2007-04-20 | 2010-11-10 | 西安交通大学 | 高强韧可降解磷酸锶钙复合骨水泥及其制备方法 |
| EP2142224B1 (en) * | 2007-04-23 | 2016-03-23 | Baxter International Inc. | Fibrin compositions containing strontium compounds |
| US20080317807A1 (en) * | 2007-06-22 | 2008-12-25 | The University Of Hong Kong | Strontium fortified calcium nano-and microparticle compositions and methods of making and using thereof |
| US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
| CN101623514B (zh) * | 2009-08-07 | 2013-04-10 | 陕西科技大学 | 一种金属离子掺杂纳米羟基磷灰石的制备方法 |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| TWI453174B (zh) * | 2010-10-19 | 2014-09-21 | Univ Nat Cheng Kung | 骨水泥配方及由其製備的生物可吸收的硬化骨水泥複合材料 |
| CN102430147B (zh) * | 2011-09-02 | 2013-11-06 | 浙江大学 | 可生物降解的生物活性掺锶硫酸钙材料、制备方法及应用 |
| WO2013063585A1 (en) * | 2011-10-28 | 2013-05-02 | Baxter International Inc. | Aqueous compositions for bone hemostasis, and methods for their use and manufacture |
| CZ305232B6 (cs) * | 2013-08-28 | 2015-06-24 | Vysoké Učení Technické V Brně | Způsob přípravy a použití stroncium samaritého cementu |
| CN104147639B (zh) * | 2014-08-06 | 2016-01-06 | 山东明德生物医学工程有限公司 | 含锶可注射骨水泥及制备方法 |
| KR20170011455A (ko) | 2015-07-23 | 2017-02-02 | (주)아이디알 | 가습기능을 갖는 무드등 |
| ES2922210T3 (es) * | 2019-08-16 | 2022-09-09 | Univ Heidelberg | Sustitución osteotrópica de hueso |
| CN111848150B (zh) * | 2020-07-09 | 2022-05-24 | 上海交通大学医学院附属第九人民医院 | 一种SrCuSi4O10－Ca3(PO4)2复合生物陶瓷、骨支架及其用途 |
| CN114229813A (zh) * | 2021-12-22 | 2022-03-25 | 中国科学院上海硅酸盐研究所 | 一种羟基磷酸锶超长纳米线及其制备方法和应用 |
| CN116212117B (zh) * | 2022-12-29 | 2025-04-22 | 西安交通大学 | 锶镁缓释磷灰石生物活性骨水泥及其制备工艺 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0511868A2 (en) * | 1991-05-01 | 1992-11-04 | Chichibu Onoda Cement Corporation | Medical or dental hardening compositions |
| WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69123312T2 (de) * | 1990-08-21 | 1997-03-20 | Asahi Glass Co Ltd | Kalziumphosphat Glaskeramik |
| ES2040626B1 (es) * | 1991-11-22 | 1994-05-16 | Boltong Maria G | Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales. |
| FR2772746B1 (fr) * | 1997-12-23 | 2000-01-28 | Commissariat Energie Atomique | Procede de fabrication d'une ceramique apatitique, en particulier pour usage biologique |
| DE19853832A1 (de) * | 1998-11-21 | 2000-05-25 | Merck Patent Gmbh | Polyalkensäuren enthaltende Calcium-Phosphatzemente |
| DE10032220A1 (de) * | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
-
2002
- 2002-06-07 DE DE10225420A patent/DE10225420A1/de not_active Ceased
-
2003
- 2003-05-14 EP EP03735389A patent/EP1511521B1/de not_active Expired - Lifetime
- 2003-05-14 ES ES03735389T patent/ES2304515T3/es not_active Expired - Lifetime
- 2003-05-14 CN CNB03813148XA patent/CN1323726C/zh not_active Expired - Fee Related
- 2003-05-14 WO PCT/EP2003/005059 patent/WO2003103734A1/de not_active Ceased
- 2003-05-14 AU AU2003236650A patent/AU2003236650A1/en not_active Abandoned
- 2003-05-14 KR KR1020047019845A patent/KR101061308B1/ko not_active Expired - Fee Related
- 2003-05-14 JP JP2004510853A patent/JP4914005B2/ja not_active Expired - Fee Related
- 2003-05-14 DE DE50309585T patent/DE50309585D1/de not_active Expired - Lifetime
- 2003-05-14 AT AT03735389T patent/ATE391519T1/de not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0511868A2 (en) * | 1991-05-01 | 1992-11-04 | Chichibu Onoda Cement Corporation | Medical or dental hardening compositions |
| WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098618A3 (en) * | 2003-05-07 | 2005-03-24 | Osteologix As | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US7595342B2 (en) | 2003-05-07 | 2009-09-29 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| US8541471B2 (en) | 2003-05-07 | 2013-09-24 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| US8623422B2 (en) | 2003-05-07 | 2014-01-07 | Osteologix A/S | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions |
| US8609616B2 (en) | 2004-02-26 | 2013-12-17 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1323726C (zh) | 2007-07-04 |
| KR20050016517A (ko) | 2005-02-21 |
| EP1511521B1 (de) | 2008-04-09 |
| ES2304515T3 (es) | 2008-10-16 |
| JP2005531341A (ja) | 2005-10-20 |
| ATE391519T1 (de) | 2008-04-15 |
| CN1658913A (zh) | 2005-08-24 |
| EP1511521A1 (de) | 2005-03-09 |
| JP4914005B2 (ja) | 2012-04-11 |
| WO2003103734A1 (de) | 2003-12-18 |
| KR101061308B1 (ko) | 2011-08-31 |
| DE50309585D1 (de) | 2008-05-21 |
| AU2003236650A1 (en) | 2003-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8131 | Rejection |