JP4914005B2 - ストロンチウム−アパタイト−セメント調合物、およびその利用 - Google Patents
ストロンチウム−アパタイト−セメント調合物、およびその利用 Download PDFInfo
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- JP4914005B2 JP4914005B2 JP2004510853A JP2004510853A JP4914005B2 JP 4914005 B2 JP4914005 B2 JP 4914005B2 JP 2004510853 A JP2004510853 A JP 2004510853A JP 2004510853 A JP2004510853 A JP 2004510853A JP 4914005 B2 JP4914005 B2 JP 4914005B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
- A61L24/0063—Phosphorus containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L31/123—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
- C04B12/02—Phosphate cements
- C04B12/025—Phosphates of ammonium or of the alkali or alkaline earth metals
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Ceramic Engineering (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Structural Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Composite Materials (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Prostheses (AREA)
Description
混合の後、通常、ペーストが形成される。このペーストは1つ型枠に充填され得る。それにより、型枠の該ペーストの硬化後に、続いて定義される型体が母材として製造され得る。ここで、混合物の粘性および堅さは、混合物がペーストとして器具を用いて欠損に提供されるのみでなく、注入もされ得るように、設定される。
P =粉末混合物
L =液体
L/P =ml/g単位での液体/粉末混合物 比率
ti =初期硬化時間(ASTM C266−89に従う)
tf =最終硬化時間(ASTM C266−89に従う)
Cg(xh/yd)=37°Cで0.9%の食塩水溶液内に、x時間/y日置いた後の
Mpa単位での圧縮強度
Mpa =メガパスカル
ストロンチウム−アパタイト−セメント調合物の製造およびそれによって形成されたセメント
以下の実施例1〜7に示されるように、全ての構成成分を測りとった後に、粉末成分Pを、球状挽き器内において均質に挽き、続いて水溶液Lを用いて、示された比率に混合した。所定の硬化時間の経過後、それぞれ、圧縮強度を決定した。
実施例1:
P = 65g Ca3(PO4)2 + 16g Sr3(PO4)2
L = 3.5M (NH4)2HPO4
L/P = 0.40
Cg(48h)= 30 MPa
Cg(10d)= 43.8 MPa
実施例2:
P = 65g Ca3(PO4)2 + 16g Sr3(PO4)2
L = 4% Na2HPO4
L/P = 0.35
ti = 13’30’’(13分30秒)
実施例3:
P= 65g Ca3(PO4)2 + 16g Sr3(PO4)2 + 3g SrCO3
L = 3.5M (NH4)2HPO4
L/P = 0.40
Cg(10d)= 46.4 MPa
実施例4:
P = 60g Ca3(PO4)2 + 10g Sr3(PO4)2 + 10g SrHPO4 + 3g SrCO3
L = 3M K2HPO4/1M KH2PO4
L/P = 0.40
Cg(2h)= 3.8 MPa
Cg(18h)= 26.4 MPa
実施例5:
P = 65g Ca3(PO4)2 + 16g SrHPO4 + 3g SrCO3
L = 3.5M K2HPO4/1M KH2PO4
L/P = 0.30
Cg(5h)= 18.4 MPa
実施例6:
P = 65g Ca3(PO4)2 + 12g Sr3(PO4)2 + 14g SrHPO4 + 3g SrCO3
L = 3.2M (NH4)2HPO4
L/P = 0.35
Cg(5h)= 13.0 MPa
実施例7:
P = 30g Ca3(PO4)2 + 10g Sr3(PO4)2 + 10g SrHPO4 + 5g SrCO3 + 10g K2HPO4
L = 3M K2HPO4/1M KH2PO4
L/P = 0.22
Cg(72h)= 40 MPa
Claims (9)
- a)リン酸カルシウムおよびリン酸ストロンチウムの水と組み合わせ可能である組み合わせ物であって、ここで、リン酸塩に対するカルシウムモル比が、1より大きく1.5以下であり、リン酸塩に対するストロンチウムのモル比が、1.5未満である、水と組み合わせ可能である組み合わせ物;ならびに
b)リン酸の塩
を含む骨セメント組成物であって、
マグネシウムイオンを含まないか、または高々痕跡量のマグネシウムしか含まない、骨セメント組成物。 - 前記リン酸カルシウムおよびリン酸ストロンチウムがオルトリン酸塩である、請求項1に記載の組成物。
- 前記リン酸カルシウムおよびリン酸ストロンチウムが、粉末の混合物中に含まれる、請求項1または2に記載の組成物。
- 前記b)のリン酸が、オルトリン酸である、請求項1〜3のいずれか1項に記載の組成物。
- 前記塩が、アルカリ塩およびアンモニウム塩からなる群より選択される、請求項4に記載の組成物。
- 前記オルトリン酸のアルカリ塩が、ナトリウム塩(Na塩)およびカリウム塩(K)のうちの少なくとも1つを含む、請求項5に記載の組成物。
- 前記オルトリン酸のアルカリ塩が、第一カリウム塩、第二カリウム塩、第一ナトリウム塩、第二ナトリウム塩、ならびに該カリウム塩および該ナトリウム塩の組み合わせ、からなる群より選択される、請求項6に記載の組成物。
- 前記オルトリン酸のアルカリ塩またはアンモニウム塩が、水溶液中に存在している、請求項5に記載の組成物。
- 粉末混合物成分および水性成分を含む、請求項1に記載の組成物であって、ここで、前記粉末混合成分が、
Ca3(PO4)2(TCP)、
SrHPO4および/またはSr3(PO4)2ならびに
SrCO3
を含み、そして、該水性成分が、オルトリン酸のアルカリ塩またはアンモニウム塩を含む、
組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10225420A DE10225420A1 (de) | 2002-06-07 | 2002-06-07 | Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon |
DE10225420.6 | 2002-06-07 | ||
PCT/EP2003/005059 WO2003103734A1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005531341A JP2005531341A (ja) | 2005-10-20 |
JP2005531341A5 JP2005531341A5 (ja) | 2006-06-15 |
JP4914005B2 true JP4914005B2 (ja) | 2012-04-11 |
Family
ID=29594328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004510853A Expired - Fee Related JP4914005B2 (ja) | 2002-06-07 | 2003-05-14 | ストロンチウム−アパタイト−セメント調合物、およびその利用 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1511521B1 (ja) |
JP (1) | JP4914005B2 (ja) |
KR (1) | KR101061308B1 (ja) |
CN (1) | CN1323726C (ja) |
AT (1) | ATE391519T1 (ja) |
AU (1) | AU2003236650A1 (ja) |
DE (2) | DE10225420A1 (ja) |
ES (1) | ES2304515T3 (ja) |
WO (1) | WO2003103734A1 (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
AU2004237438B2 (en) | 2003-05-07 | 2011-01-20 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
ATE342722T1 (de) | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
PL1732575T3 (pl) | 2004-02-26 | 2011-05-31 | Osteologix As | Związki zawierające stron do stosowania w zapobieganiu lub leczeniu stanów nekrotycznych kości |
CN1292804C (zh) * | 2004-03-08 | 2007-01-03 | 西安交通大学 | 含锶纳米磷酸钙生物活性骨水泥的制备工艺 |
EP1742680B1 (en) | 2004-04-27 | 2012-10-24 | Kyphon SÀRL | Bone substitute compositions and method of use |
FR2869544B1 (fr) | 2004-05-03 | 2006-07-21 | Centre Nat Rech Scient Cnrse | Composition pour ciment injectable, utile comme substitut osseux |
US7651701B2 (en) | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
FR2903684B1 (fr) * | 2006-07-12 | 2008-10-17 | Centre Nat Rech Scient | Nouveau compose phospho-calco-strontique et ses utilisations dans des ciments endodontiques. |
CN101053673B (zh) * | 2007-04-20 | 2010-11-10 | 西安交通大学 | 高强韧可降解磷酸锶钙复合骨水泥及其制备方法 |
ES2573327T3 (es) * | 2007-04-23 | 2016-06-07 | Baxter International Inc. | Composiciones de fibrina que contienen compuestos de estroncio |
US20080317807A1 (en) * | 2007-06-22 | 2008-12-25 | The University Of Hong Kong | Strontium fortified calcium nano-and microparticle compositions and methods of making and using thereof |
US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
CN101623514B (zh) * | 2009-08-07 | 2013-04-10 | 陕西科技大学 | 一种金属离子掺杂纳米羟基磷灰石的制备方法 |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
TWI453174B (zh) * | 2010-10-19 | 2014-09-21 | Univ Nat Cheng Kung | 骨水泥配方及由其製備的生物可吸收的硬化骨水泥複合材料 |
CN102430147B (zh) * | 2011-09-02 | 2013-11-06 | 浙江大学 | 可生物降解的生物活性掺锶硫酸钙材料、制备方法及应用 |
ES2877715T3 (es) * | 2011-10-28 | 2021-11-17 | Baxter Int | Composiciones no acuosas para hemostasia ósea, y métodos para su uso y fabricación |
CZ305232B6 (cs) * | 2013-08-28 | 2015-06-24 | Vysoké Učení Technické V Brně | Způsob přípravy a použití stroncium samaritého cementu |
CN104147639B (zh) * | 2014-08-06 | 2016-01-06 | 山东明德生物医学工程有限公司 | 含锶可注射骨水泥及制备方法 |
KR20170011455A (ko) | 2015-07-23 | 2017-02-02 | (주)아이디알 | 가습기능을 갖는 무드등 |
PL3777904T3 (pl) * | 2019-08-16 | 2022-08-22 | Universität Heidelberg | Osteotropowy substytut kości |
CN111848150B (zh) * | 2020-07-09 | 2022-05-24 | 上海交通大学医学院附属第九人民医院 | 一种SrCuSi4O10-Ca3(PO4)2复合生物陶瓷、骨支架及其用途 |
CN114229813A (zh) * | 2021-12-22 | 2022-03-25 | 中国科学院上海硅酸盐研究所 | 一种羟基磷酸锶超长纳米线及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
JP2001527020A (ja) * | 1997-12-23 | 2001-12-25 | コミサリヤ・ア・レネルジ・アトミク | 特に生物用途のアパタイトセラミックスの製造方法 |
WO2002002478A1 (de) * | 2000-07-03 | 2002-01-10 | Sanatis Gmbh | Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0473048B1 (en) * | 1990-08-21 | 1996-11-27 | Asahi Glass Company Ltd. | Calcium phosphate type glass-ceramic |
EP0511868B1 (en) * | 1991-05-01 | 1996-09-25 | Chichibu Onoda Cement Corporation | Medical or dental hardening compositions |
ES2040626B1 (es) * | 1991-11-22 | 1994-05-16 | Boltong Maria G | Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales. |
DE19853832A1 (de) * | 1998-11-21 | 2000-05-25 | Merck Patent Gmbh | Polyalkensäuren enthaltende Calcium-Phosphatzemente |
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2002
- 2002-06-07 DE DE10225420A patent/DE10225420A1/de not_active Ceased
-
2003
- 2003-05-14 AU AU2003236650A patent/AU2003236650A1/en not_active Abandoned
- 2003-05-14 ES ES03735389T patent/ES2304515T3/es not_active Expired - Lifetime
- 2003-05-14 AT AT03735389T patent/ATE391519T1/de not_active IP Right Cessation
- 2003-05-14 JP JP2004510853A patent/JP4914005B2/ja not_active Expired - Fee Related
- 2003-05-14 CN CNB03813148XA patent/CN1323726C/zh not_active Expired - Fee Related
- 2003-05-14 KR KR1020047019845A patent/KR101061308B1/ko not_active IP Right Cessation
- 2003-05-14 EP EP03735389A patent/EP1511521B1/de not_active Expired - Lifetime
- 2003-05-14 DE DE50309585T patent/DE50309585D1/de not_active Expired - Lifetime
- 2003-05-14 WO PCT/EP2003/005059 patent/WO2003103734A1/de active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2001527020A (ja) * | 1997-12-23 | 2001-12-25 | コミサリヤ・ア・レネルジ・アトミク | 特に生物用途のアパタイトセラミックスの製造方法 |
WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
WO2002002478A1 (de) * | 2000-07-03 | 2002-01-10 | Sanatis Gmbh | Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung |
Also Published As
Publication number | Publication date |
---|---|
CN1323726C (zh) | 2007-07-04 |
EP1511521B1 (de) | 2008-04-09 |
EP1511521A1 (de) | 2005-03-09 |
WO2003103734A1 (de) | 2003-12-18 |
ES2304515T3 (es) | 2008-10-16 |
JP2005531341A (ja) | 2005-10-20 |
ATE391519T1 (de) | 2008-04-15 |
AU2003236650A1 (en) | 2003-12-22 |
DE50309585D1 (de) | 2008-05-21 |
KR101061308B1 (ko) | 2011-08-31 |
CN1658913A (zh) | 2005-08-24 |
DE10225420A1 (de) | 2003-12-24 |
KR20050016517A (ko) | 2005-02-21 |
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