JP4914005B2 - ストロンチウム−アパタイト−セメント調合物、およびその利用 - Google Patents
ストロンチウム−アパタイト−セメント調合物、およびその利用 Download PDFInfo
- Publication number
- JP4914005B2 JP4914005B2 JP2004510853A JP2004510853A JP4914005B2 JP 4914005 B2 JP4914005 B2 JP 4914005B2 JP 2004510853 A JP2004510853 A JP 2004510853A JP 2004510853 A JP2004510853 A JP 2004510853A JP 4914005 B2 JP4914005 B2 JP 4914005B2
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- JP
- Japan
- Prior art keywords
- salt
- strontium
- bone
- composition
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 239000004568 cement Substances 0.000 title abstract description 38
- 238000009472 formulation Methods 0.000 title description 20
- 239000011575 calcium Substances 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 9
- 150000003863 ammonium salts Chemical class 0.000 claims abstract description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
- 229910052712 strontium Inorganic materials 0.000 claims abstract description 5
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 25
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 14
- 235000011007 phosphoric acid Nutrition 0.000 claims description 12
- 150000001447 alkali salts Chemical class 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000001506 calcium phosphate Substances 0.000 claims description 8
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 8
- 235000011010 calcium phosphates Nutrition 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 7
- 239000010452 phosphate Substances 0.000 claims description 6
- 159000000000 sodium salts Chemical class 0.000 claims description 6
- JOPDZQBPOWAEHC-UHFFFAOYSA-H tristrontium;diphosphate Chemical compound [Sr+2].[Sr+2].[Sr+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O JOPDZQBPOWAEHC-UHFFFAOYSA-H 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 239000002639 bone cement Substances 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 3
- 229910000018 strontium carbonate Inorganic materials 0.000 abstract description 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- 159000000011 group IA salts Chemical class 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 description 29
- 239000000463 material Substances 0.000 description 14
- 239000011734 sodium Substances 0.000 description 10
- 208000001132 Osteoporosis Diseases 0.000 description 8
- 230000007547 defect Effects 0.000 description 8
- 229910052586 apatite Inorganic materials 0.000 description 7
- 239000000316 bone substitute Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 7
- 210000002997 osteoclast Anatomy 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 229910001427 strontium ion Inorganic materials 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000000963 osteoblast Anatomy 0.000 description 4
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical group [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000004068 calcium phosphate ceramic Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000001195 anabolic effect Effects 0.000 description 2
- 230000004097 bone metabolism Effects 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
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- 239000002245 particle Substances 0.000 description 2
- 239000011644 potassium salts of orthophosphoric acid Substances 0.000 description 2
- 235000019858 potassium salts of orthophosphoric acid Nutrition 0.000 description 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- MXZRMHIULZDAKC-UHFFFAOYSA-L ammonium magnesium phosphate Chemical compound [NH4+].[Mg+2].[O-]P([O-])([O-])=O MXZRMHIULZDAKC-UHFFFAOYSA-L 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000012227 artificial bone substitute Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 125000005340 bisphosphate group Chemical group 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- -1 hydrogen salt Chemical class 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 229910052751 metal Inorganic materials 0.000 description 1
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- 239000002159 nanocrystal Substances 0.000 description 1
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000011643 sodium salts of orthophosphoric acid Substances 0.000 description 1
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- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- HKSVWJWYDJQNEV-UHFFFAOYSA-L strontium;hydron;phosphate Chemical compound [Sr+2].OP([O-])([O-])=O HKSVWJWYDJQNEV-UHFFFAOYSA-L 0.000 description 1
- 229910052567 struvite Inorganic materials 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
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- 230000001629 suppression Effects 0.000 description 1
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical class C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
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- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
Classifications
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B12/00—Cements not provided for in groups C04B7/00 - C04B11/00
- C04B12/02—Phosphate cements
- C04B12/025—Phosphates of ammonium or of the alkali or alkaline earth metals
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Structural Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Composite Materials (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10225420A DE10225420A1 (de) | 2002-06-07 | 2002-06-07 | Strontium-Apatit-Zement-Zubereitungen, die daraus gebildeten Zemente und die Verwendung davon |
| DE10225420.6 | 2002-06-07 | ||
| PCT/EP2003/005059 WO2003103734A1 (de) | 2002-06-07 | 2003-05-14 | Strontium-apatit-zement-zubereitungen und deren verwendungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005531341A JP2005531341A (ja) | 2005-10-20 |
| JP2005531341A5 JP2005531341A5 (enExample) | 2006-06-15 |
| JP4914005B2 true JP4914005B2 (ja) | 2012-04-11 |
Family
ID=29594328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510853A Expired - Fee Related JP4914005B2 (ja) | 2002-06-07 | 2003-05-14 | ストロンチウム−アパタイト−セメント調合物、およびその利用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1511521B1 (enExample) |
| JP (1) | JP4914005B2 (enExample) |
| KR (1) | KR101061308B1 (enExample) |
| CN (1) | CN1323726C (enExample) |
| AT (1) | ATE391519T1 (enExample) |
| AU (1) | AU2003236650A1 (enExample) |
| DE (2) | DE10225420A1 (enExample) |
| ES (1) | ES2304515T3 (enExample) |
| WO (1) | WO2003103734A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
| US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
| PT2266585E (pt) | 2003-05-07 | 2013-07-09 | Osteologix As | Sais de estrôncio hidrossolúveis para uso no tratamento de afeções cartilagíneas e/ou ósseas |
| EP1534305B9 (en) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| PL1732575T3 (pl) | 2004-02-26 | 2011-05-31 | Osteologix As | Związki zawierające stron do stosowania w zapobieganiu lub leczeniu stanów nekrotycznych kości |
| CN1292804C (zh) * | 2004-03-08 | 2007-01-03 | 西安交通大学 | 含锶纳米磷酸钙生物活性骨水泥的制备工艺 |
| CA2564687A1 (en) | 2004-04-27 | 2005-11-10 | Kyphon Inc. | Bone substitute compositions and method of use |
| FR2869544B1 (fr) * | 2004-05-03 | 2006-07-21 | Centre Nat Rech Scient Cnrse | Composition pour ciment injectable, utile comme substitut osseux |
| US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
| US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
| US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
| FR2903684B1 (fr) * | 2006-07-12 | 2008-10-17 | Centre Nat Rech Scient | Nouveau compose phospho-calco-strontique et ses utilisations dans des ciments endodontiques. |
| CN101053673B (zh) * | 2007-04-20 | 2010-11-10 | 西安交通大学 | 高强韧可降解磷酸锶钙复合骨水泥及其制备方法 |
| EP2142224B1 (en) * | 2007-04-23 | 2016-03-23 | Baxter International Inc. | Fibrin compositions containing strontium compounds |
| US20080317807A1 (en) * | 2007-06-22 | 2008-12-25 | The University Of Hong Kong | Strontium fortified calcium nano-and microparticle compositions and methods of making and using thereof |
| US7968616B2 (en) | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
| CN101623514B (zh) * | 2009-08-07 | 2013-04-10 | 陕西科技大学 | 一种金属离子掺杂纳米羟基磷灰石的制备方法 |
| SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
| TWI453174B (zh) * | 2010-10-19 | 2014-09-21 | Univ Nat Cheng Kung | 骨水泥配方及由其製備的生物可吸收的硬化骨水泥複合材料 |
| CN102430147B (zh) * | 2011-09-02 | 2013-11-06 | 浙江大学 | 可生物降解的生物活性掺锶硫酸钙材料、制备方法及应用 |
| WO2013063585A1 (en) * | 2011-10-28 | 2013-05-02 | Baxter International Inc. | Aqueous compositions for bone hemostasis, and methods for their use and manufacture |
| CZ305232B6 (cs) * | 2013-08-28 | 2015-06-24 | Vysoké Učení Technické V Brně | Způsob přípravy a použití stroncium samaritého cementu |
| CN104147639B (zh) * | 2014-08-06 | 2016-01-06 | 山东明德生物医学工程有限公司 | 含锶可注射骨水泥及制备方法 |
| KR20170011455A (ko) | 2015-07-23 | 2017-02-02 | (주)아이디알 | 가습기능을 갖는 무드등 |
| ES2922210T3 (es) * | 2019-08-16 | 2022-09-09 | Univ Heidelberg | Sustitución osteotrópica de hueso |
| CN111848150B (zh) * | 2020-07-09 | 2022-05-24 | 上海交通大学医学院附属第九人民医院 | 一种SrCuSi4O10－Ca3(PO4)2复合生物陶瓷、骨支架及其用途 |
| CN114229813A (zh) * | 2021-12-22 | 2022-03-25 | 中国科学院上海硅酸盐研究所 | 一种羟基磷酸锶超长纳米线及其制备方法和应用 |
| CN116212117B (zh) * | 2022-12-29 | 2025-04-22 | 西安交通大学 | 锶镁缓释磷灰石生物活性骨水泥及其制备工艺 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
| JP2001527020A (ja) * | 1997-12-23 | 2001-12-25 | コミサリヤ・ア・レネルジ・アトミク | 特に生物用途のアパタイトセラミックスの製造方法 |
| WO2002002478A1 (de) * | 2000-07-03 | 2002-01-10 | Sanatis Gmbh | Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69123312T2 (de) * | 1990-08-21 | 1997-03-20 | Asahi Glass Co Ltd | Kalziumphosphat Glaskeramik |
| DE69214005T2 (de) * | 1991-05-01 | 1997-05-15 | Chichibu Onoda Cement Corp | Erhärtende Zusammensetzungen zur Verwendung in der Medizin oder Zahnheilkunde |
| ES2040626B1 (es) * | 1991-11-22 | 1994-05-16 | Boltong Maria G | Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales. |
| DE19853832A1 (de) * | 1998-11-21 | 2000-05-25 | Merck Patent Gmbh | Polyalkensäuren enthaltende Calcium-Phosphatzemente |
-
2002
- 2002-06-07 DE DE10225420A patent/DE10225420A1/de not_active Ceased
-
2003
- 2003-05-14 EP EP03735389A patent/EP1511521B1/de not_active Expired - Lifetime
- 2003-05-14 ES ES03735389T patent/ES2304515T3/es not_active Expired - Lifetime
- 2003-05-14 CN CNB03813148XA patent/CN1323726C/zh not_active Expired - Fee Related
- 2003-05-14 WO PCT/EP2003/005059 patent/WO2003103734A1/de not_active Ceased
- 2003-05-14 AU AU2003236650A patent/AU2003236650A1/en not_active Abandoned
- 2003-05-14 KR KR1020047019845A patent/KR101061308B1/ko not_active Expired - Fee Related
- 2003-05-14 JP JP2004510853A patent/JP4914005B2/ja not_active Expired - Fee Related
- 2003-05-14 DE DE50309585T patent/DE50309585D1/de not_active Expired - Lifetime
- 2003-05-14 AT AT03735389T patent/ATE391519T1/de not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001527020A (ja) * | 1997-12-23 | 2001-12-25 | コミサリヤ・ア・レネルジ・アトミク | 特に生物用途のアパタイトセラミックスの製造方法 |
| WO2001049327A2 (en) * | 2000-01-03 | 2001-07-12 | Hku/Hantak Ortho-Technology Limited | Bioactive and osteoprorotic bone cement |
| WO2002002478A1 (de) * | 2000-07-03 | 2002-01-10 | Sanatis Gmbh | Magnesium-ammonium-phosphat-zemente, deren herstellung und verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1323726C (zh) | 2007-07-04 |
| KR20050016517A (ko) | 2005-02-21 |
| EP1511521B1 (de) | 2008-04-09 |
| ES2304515T3 (es) | 2008-10-16 |
| JP2005531341A (ja) | 2005-10-20 |
| ATE391519T1 (de) | 2008-04-15 |
| DE10225420A1 (de) | 2003-12-24 |
| CN1658913A (zh) | 2005-08-24 |
| EP1511521A1 (de) | 2005-03-09 |
| WO2003103734A1 (de) | 2003-12-18 |
| KR101061308B1 (ko) | 2011-08-31 |
| DE50309585D1 (de) | 2008-05-21 |
| AU2003236650A1 (en) | 2003-12-22 |
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