DE102006031955A1 - Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende - Google Patents

Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende Download PDF

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Publication number
DE102006031955A1
DE102006031955A1 DE102006031955A DE102006031955A DE102006031955A1 DE 102006031955 A1 DE102006031955 A1 DE 102006031955A1 DE 102006031955 A DE102006031955 A DE 102006031955A DE 102006031955 A DE102006031955 A DE 102006031955A DE 102006031955 A1 DE102006031955 A1 DE 102006031955A1
Authority
DE
Germany
Prior art keywords
insulin
amino acid
arg
naturally occurring
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102006031955A
Other languages
German (de)
English (en)
Inventor
Paul Dr. Habermann
Frank Dr. Zocher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to DE102006031955A priority Critical patent/DE102006031955A1/de
Priority to AU2007272057A priority patent/AU2007272057B2/en
Priority to JP2009518756A priority patent/JP5331685B2/ja
Priority to ES07785903T priority patent/ES2423684T3/es
Priority to DK07785903.1T priority patent/DK2041170T3/da
Priority to KR1020097000429A priority patent/KR101439110B1/ko
Priority to MYPI20085343A priority patent/MY148984A/en
Priority to HK09109503.2A priority patent/HK1130815B/xx
Priority to PT77859031T priority patent/PT2041170E/pt
Priority to CN2007800261387A priority patent/CN101490082B/zh
Priority to BRPI0714297-8A priority patent/BRPI0714297A2/pt
Priority to CA2657041A priority patent/CA2657041C/en
Priority to PCT/EP2007/005933 priority patent/WO2008006497A1/de
Priority to MX2009000275A priority patent/MX2009000275A/es
Priority to EP07785903.1A priority patent/EP2041170B1/de
Priority to TW096124845A priority patent/TWI440717B/zh
Priority to ARP070103059A priority patent/AR061865A1/es
Publication of DE102006031955A1 publication Critical patent/DE102006031955A1/de
Priority to IL196360A priority patent/IL196360A/en
Priority to US12/349,854 priority patent/US8410048B2/en
Priority to NO20090663A priority patent/NO20090663L/no
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE102006031955A 2006-07-11 2006-07-11 Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende Withdrawn DE102006031955A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE102006031955A DE102006031955A1 (de) 2006-07-11 2006-07-11 Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
CN2007800261387A CN101490082B (zh) 2006-07-11 2007-07-05 产生具有二碱基b链末端的胰岛素类似物的方法
PCT/EP2007/005933 WO2008006497A1 (de) 2006-07-11 2007-07-05 Verfahren zur herstellung von insulinanaloga mit dibasischem b-kettenende
ES07785903T ES2423684T3 (es) 2006-07-11 2007-07-05 Procedimiento para preparar análogos de insulina con extremo de cadena B dibásico
DK07785903.1T DK2041170T3 (da) 2006-07-11 2007-07-05 Fremgangsmåde til fremstilling af insulinanaloger med dibasisk B-kædeende
KR1020097000429A KR101439110B1 (ko) 2006-07-11 2007-07-05 이염기성 ｂ쇄 말단을 갖는 인슐린 유사체를 제조하는 방법
MYPI20085343A MY148984A (en) 2006-07-11 2007-07-05 Method for producing insulin analogs having a dibasic b chain terminus
HK09109503.2A HK1130815B (en) 2006-07-11 2007-07-05 Method for producing insulin analogs having a dibasic b chain terminus
PT77859031T PT2041170E (pt) 2006-07-11 2007-07-05 Processo para a preparação de análogos de insulina com extremidade de cadeia b dibásica
AU2007272057A AU2007272057B2 (en) 2006-07-11 2007-07-05 Method for producing insulin analogs having a dibasic B chain terminus
BRPI0714297-8A BRPI0714297A2 (pt) 2006-07-11 2007-07-05 processo para produÇço de anÁlogos de insulina com cadeia b-terminal dibÁsica
CA2657041A CA2657041C (en) 2006-07-11 2007-07-05 Method for producing insulin analogs having a dibasic b chain terminus
JP2009518756A JP5331685B2 (ja) 2006-07-11 2007-07-05 二塩基性ｂ鎖末端を有するインスリン類似体の生産方法
MX2009000275A MX2009000275A (es) 2006-07-11 2007-07-05 Metodo para preparar analogos de insulina con extremo de cadena b dibasico.
EP07785903.1A EP2041170B1 (de) 2006-07-11 2007-07-05 Verfahren zur herstellung von insulinanaloga mit dibasischem b-kettenende
TW096124845A TWI440717B (zh) 2006-07-11 2007-07-09 製備具有二元ｂ鏈端的胰島素類似物之方法
ARP070103059A AR061865A1 (es) 2006-07-11 2007-07-10 Metodo para preparar analogos de insulina con extremo de cadena b dibasico
IL196360A IL196360A (en) 2006-07-11 2009-01-05 A method for producing endogenous b-chain insulin analogues with two monovalent groups for transduction
US12/349,854 US8410048B2 (en) 2006-07-11 2009-01-07 Method for producing insulin analogs having a dibasic B chain terminus
NO20090663A NO20090663L (no) 2006-07-11 2009-02-11 Fremgangsmate for fremstilling av insulinanaloger som har en dibasisk B-kjede terminus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006031955A DE102006031955A1 (de) 2006-07-11 2006-07-11 Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende

Publications (1)

Publication Number Publication Date
DE102006031955A1 true DE102006031955A1 (de) 2008-01-17

Family

ID=38468893

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102006031955A Withdrawn DE102006031955A1 (de) 2006-07-11 2006-07-11 Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende

Country Status (19)

Country Link
US (1) US8410048B2 (enExample)
EP (1) EP2041170B1 (enExample)
JP (1) JP5331685B2 (enExample)
KR (1) KR101439110B1 (enExample)
CN (1) CN101490082B (enExample)
AR (1) AR061865A1 (enExample)
AU (1) AU2007272057B2 (enExample)
BR (1) BRPI0714297A2 (enExample)
CA (1) CA2657041C (enExample)
DE (1) DE102006031955A1 (enExample)
DK (1) DK2041170T3 (enExample)
ES (1) ES2423684T3 (enExample)
IL (1) IL196360A (enExample)
MX (1) MX2009000275A (enExample)
MY (1) MY148984A (enExample)
NO (1) NO20090663L (enExample)
PT (1) PT2041170E (enExample)
TW (1) TWI440717B (enExample)
WO (1) WO2008006497A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005046113A1 (de) * 2005-09-27 2007-03-29 Sanofi-Aventis Deutschland Gmbh Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen
ES2612736T3 (es) 2007-11-16 2017-05-18 Novo Nordisk A/S Composiciones farmacéuticas estables que comprenden liraglutida y degludec
RU2495131C2 (ru) * 2008-02-19 2013-10-10 Байокон Лимитид Способ получения рекомбинантного инсулина гларгина
CA2806399A1 (en) * 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
WO2013015697A1 (en) 2011-07-28 2013-01-31 Mabion S.A. A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue
CN102504022A (zh) * 2011-11-30 2012-06-20 苏州元基生物技术有限公司 含有保护赖氨酸的胰岛素原及使用其制备胰岛素的方法
PL233560B1 (pl) 2014-12-05 2019-10-31 Mabion Spolka Akcyjna Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
EP0194864B1 (en) * 1985-03-12 1992-06-17 Novo Nordisk A/S Novel peptides

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JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DE3326473A1 (de) 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3636903A1 (de) 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
GB8618152D0 (en) * 1986-07-25 1986-09-03 Renishaw Plc Co-ordinate measuring
EP0294851A3 (de) * 1987-06-12 1990-05-09 Berlin-Chemie Ag Verfahren zur Herstellung von Humaninsulin und seinen Derivaten
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
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AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
DE10108100A1 (de) 2001-02-20 2002-08-29 Aventis Pharma Gmbh Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse
DE10108212A1 (de) * 2001-02-20 2002-08-22 Aventis Pharma Gmbh Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände
DE10108211A1 (de) 2001-02-20 2002-08-22 Aventis Pharma Gmbh Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen
HU228934B1 (hu) * 2001-11-19 2013-06-28 Novo Nordisk As Eljárás inzulinvegyületek elõállítására
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Publication number Priority date Publication date Assignee Title
EP0194864B1 (en) * 1985-03-12 1992-06-17 Novo Nordisk A/S Novel peptides
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Also Published As

Publication number Publication date
JP5331685B2 (ja) 2013-10-30
NO20090663L (no) 2009-02-11
KR20090038868A (ko) 2009-04-21
MX2009000275A (es) 2009-01-26
WO2008006497A1 (de) 2008-01-17
DK2041170T3 (da) 2013-08-05
HK1130815A1 (en) 2010-01-08
ES2423684T3 (es) 2013-09-23
AU2007272057B2 (en) 2012-06-14
CA2657041C (en) 2016-04-26
EP2041170A1 (de) 2009-04-01
KR101439110B1 (ko) 2014-09-12
JP2009542235A (ja) 2009-12-03
CA2657041A1 (en) 2008-01-17
AU2007272057A1 (en) 2008-01-17
BRPI0714297A2 (pt) 2013-02-26
CN101490082B (zh) 2013-08-14
EP2041170B1 (de) 2013-05-01
MY148984A (en) 2013-06-28
IL196360A0 (en) 2011-08-01
IL196360A (en) 2015-08-31
PT2041170E (pt) 2013-07-18
TW200817511A (en) 2008-04-16
CN101490082A (zh) 2009-07-22
US20090192073A1 (en) 2009-07-30
US8410048B2 (en) 2013-04-02
TWI440717B (zh) 2014-06-11
AR061865A1 (es) 2008-09-24

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
8130 Withdrawal
8165 Publication of following application cancelled