DE3850878T2 - Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination. - Google Patents

Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination.

Info

Publication number
DE3850878T2
DE3850878T2 DE3850878T DE3850878T DE3850878T2 DE 3850878 T2 DE3850878 T2 DE 3850878T2 DE 3850878 T DE3850878 T DE 3850878T DE 3850878 T DE3850878 T DE 3850878T DE 3850878 T2 DE3850878 T2 DE 3850878T2
Authority
DE
Germany
Prior art keywords
cys
pro
lys
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3850878T
Other languages
English (en)
Other versions
DE3850878D1 (de
Inventor
Takashi Sugiyama
Takashi Kamimura
Kenichi Masuda
Masahiro Okada
Eiko Ohtsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3850878D1 publication Critical patent/DE3850878D1/de
Publication of DE3850878T2 publication Critical patent/DE3850878T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
DE3850878T 1987-12-28 1988-12-28 Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination. Expired - Lifetime DE3850878T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33021987 1987-12-28
PCT/JP1988/001342 WO1989006239A1 (en) 1987-12-28 1988-12-28 Elastase inhibiting polypeptides and process for their preparation by genetic recombination

Publications (2)

Publication Number Publication Date
DE3850878D1 DE3850878D1 (de) 1994-09-01
DE3850878T2 true DE3850878T2 (de) 1994-11-10

Family

ID=18230182

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850878T Expired - Lifetime DE3850878T2 (de) 1987-12-28 1988-12-28 Elastase-inhibierungspolypeptide und verfahren zur herstellung durch genetische rekombination.

Country Status (8)

Country Link
EP (1) EP0346500B1 (de)
JP (1) JP2574048B2 (de)
KR (1) KR910007573B1 (de)
AT (1) ATE109156T1 (de)
CA (1) CA1340877C (de)
DE (1) DE3850878T2 (de)
ES (1) ES2015366A6 (de)
WO (1) WO1989006239A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
DE3841873A1 (de) * 1988-12-13 1990-06-21 Gruenenthal Gmbh Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen
WO1991000912A1 (en) * 1989-07-07 1991-01-24 Massachusetts Institute Of Technology Production and use of hybrid protease inhibitors
DE3938971A1 (de) * 1989-11-24 1991-05-29 Biotechnolog Forschung Gmbh Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
JPH06509327A (ja) * 1991-04-18 1994-10-20 ザ　ユー　エー　ビー　リサーチ　ファンデーション エラスターゼ抑制のための組成とその方法
US6869925B1 (en) 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
KR100273620B1 (ko) * 1992-09-09 2000-12-15 스티븐 엠. 오드리 레트로바이러스 감염의 억제방법
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
HUT75660A (en) * 1994-03-23 1997-05-28 Tokyo Tanabe Co Novel remedy for respiratory-tract viral disease
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
CN1305589A (zh) 1998-04-17 2001-07-25 基因创新有限公司 采用还原剂的改进型免疫诊断分析
WO2001064031A2 (en) * 2000-03-01 2001-09-07 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Slpi knockout mice and methods for wound treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS427042Y1 (de) * 1966-11-08 1967-04-03
US4455122A (en) * 1981-12-14 1984-06-19 United Technologies Corporation Blade to blade vibration damper
US4505642A (en) * 1983-10-24 1985-03-19 United Technologies Corporation Rotor blade interplatform seal
US4669959A (en) * 1984-07-23 1987-06-02 United Technologies Corporation Breach lock anti-rotation key
JP2672088B2 (ja) * 1984-12-06 1997-11-05 サイナ−ゲン バイオロジカルズ，インコ−ポレ−テツド セリンプロテアーゼ阻害剤の生産のための遺伝子組み換え法と、同じ目的に有用なｄｎａ塩基配列
DE3600571A1 (de) * 1986-01-10 1987-08-06 Gruenenthal Gmbh Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel

Also Published As

Publication number Publication date
CA1340877C (en) 2000-01-18
ES2015366A6 (es) 1990-08-16
KR900700500A (ko) 1990-08-13
JP2574048B2 (ja) 1997-01-22
WO1989006239A1 (en) 1989-07-13
EP0346500A1 (de) 1989-12-20
KR910007573B1 (ko) 1991-09-28
EP0346500B1 (de) 1994-07-27
EP0346500A4 (en) 1991-05-22
ATE109156T1 (de) 1994-08-15
DE3850878D1 (de) 1994-09-01

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