DE10129265A1 - Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie - Google Patents
Wirkstoff-Kombination zur medikamentösen Sucht- oder RauschmitteltherapieInfo
- Publication number
- DE10129265A1 DE10129265A1 DE10129265A DE10129265A DE10129265A1 DE 10129265 A1 DE10129265 A1 DE 10129265A1 DE 10129265 A DE10129265 A DE 10129265A DE 10129265 A DE10129265 A DE 10129265A DE 10129265 A1 DE10129265 A1 DE 10129265A1
- Authority
- DE
- Germany
- Prior art keywords
- active ingredient
- ingredient combination
- derivatives
- acceptable salts
- single dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000002560 therapeutic procedure Methods 0.000 title claims description 24
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- 239000000126 substance Substances 0.000 claims abstract description 29
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- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 60
- WUFQLZTXIWKION-UHFFFAOYSA-N Deoxypeganine Chemical compound C1C2=CC=CC=C2N=C2N1CCC2 WUFQLZTXIWKION-UHFFFAOYSA-N 0.000 claims description 41
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 31
- 229960003980 galantamine Drugs 0.000 claims description 29
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 claims description 28
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- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 claims description 28
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- 150000003839 salts Chemical class 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 20
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- 230000000694 effects Effects 0.000 claims description 15
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- 230000000144 pharmacologic effect Effects 0.000 claims description 9
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Priority Applications (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129265A DE10129265A1 (de) | 2001-06-18 | 2001-06-18 | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
| ARP020102244A AR034493A1 (es) | 2001-06-18 | 2002-06-14 | Combinacion de principios activos para el tratamiento medico de toxicomanias. |
| BR0211008-3A BR0211008A (pt) | 2001-06-18 | 2002-06-15 | Combinação de ingrediente ativo, uso de uma combinação de ingrediente ativo e método para a terapia farmacológia de uma substância que causa dependência ou que seja intoxicante |
| CA002450787A CA2450787C (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination for pharmacological addictive substance or intoxicant therapy |
| SK1565-2003A SK287180B6 (sk) | 2001-06-18 | 2002-06-15 | Kombinácia účinných látok na medikamentóznu terapiu návykových alebo omamných prostriedkov |
| PCT/EP2002/006630 WO2002102388A2 (de) | 2001-06-18 | 2002-06-15 | Wirkstoffkombination von z.b. galanthamin oder desoxypeganin mit z.b. acamprosat oder memantin gegen sucht wie z.b. alkoholismus |
| CZ20033390A CZ299951B6 (cs) | 2001-06-18 | 2002-06-15 | Kombinace úcinných látek pro medikamentózní terapii návykových nebo omamných prostredku |
| DE50201958T DE50201958D1 (de) | 2001-06-18 | 2002-06-15 | WIRKSTOFF-KOMBINATION (z.B. Galanthamin oder Desoxypeganin mit Acamprosat oder Memantin) ZUR MEDIKAMENTÖSEN SUCHT- ODER RAUSCHMITTELTHERAPIE |
| CNA028110196A CN1527711A (zh) | 2001-06-18 | 2002-06-15 | 用于药物治疗成瘾性物质或麻醉剂成瘾的活性成分组合物 |
| SI200230094T SI1397138T1 (enExample) | 2001-06-18 | 2002-06-15 | |
| PT02754688T PT1397138E (pt) | 2001-06-18 | 2002-06-15 | Combinacao de ingrediente activo (por exemplo galantamina ou desoxipeganina com acamprosato ou memantina) para tratar uma dependencia |
| KR10-2003-7016570A KR20040010744A (ko) | 2001-06-18 | 2002-06-15 | 의약을 사용한 중독성 물질 또는 마약성 물질 의존성치료를 위한 활성 성분 조합 |
| US10/480,287 US20040192683A1 (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination for treating a dependence on addictive substances or narcotics using medicaments |
| DK02754688T DK1397138T3 (da) | 2001-06-18 | 2002-06-15 | Aktivstofkombination (f.eks. galanthamin eller deoxypeganin med acamprosat eller memantin) til medikamentel toksikomani- eller rusmiddelterapi |
| ES02754688T ES2236551T3 (es) | 2001-06-18 | 2002-06-15 | Combinacion de principios activos para el tratamiento medico de toxicomanias. |
| AU2002323873A AU2002323873B2 (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination of E.G. galanthamine or deoxypeganine and E.G. acamprosate or memantine for treating an addiction such as alcoholism |
| EA200400041A EA006647B1 (ru) | 2001-06-18 | 2002-06-15 | Сочетание действующих ингредиентов для медикаментозной терапии зависимостей, вызываемых наркотическими или одурманивающими веществами |
| PL02367207A PL367207A1 (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination (e.g. galanthamine or desoxypeganine with acamprosate or memantine) for treating a dependence on addictive substances or narcotics |
| UA20031211802A UA76753C2 (uk) | 2001-06-18 | 2002-06-15 | Комбінація галантаміну або дезоксипеганіну та протизбуджувального агента, її застосування (варіанти) для лікування наркотичної або токсичної залежності |
| EP02754688A EP1397138B1 (de) | 2001-06-18 | 2002-06-15 | WIRKSTOFF-KOMBINATION (z.B. Galanthamin oder Desoxypeganin mit Acamprosat oder Memantin) ZUR MEDIKAMENTÖSEN SUCHT- ODER RAUSCHMITTELTHERAPIE |
| MXPA03011825A MXPA03011825A (es) | 2001-06-18 | 2002-06-15 | Combinacion de ingrediente activo para tratar una dependencia de sustancias aditivas o narcoticas utilizando medicamentos. |
| AT02754688T ATE286397T1 (de) | 2001-06-18 | 2002-06-15 | Wirkstoff-kombination (z.b. galanthamin oder desoxypeganin mit acamprosat oder memantin) zur medikamentösen sucht- oder rauschmitteltherapie |
| IL15934502A IL159345A0 (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination for pharmacological addictive substances or intoxicant therapy |
| HK04106071.5A HK1063292B (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination (e.g. galanthamine or desoxypeganine with acamprosate or memantine) for treating a dependence on addictive substances or narcotics |
| JP2003504974A JP2005500298A (ja) | 2001-06-18 | 2002-06-15 | 嗜癖物質または麻薬に対する依存症を医薬を用いて処置するための活性成分の組み合わせ |
| HU0400865A HUP0400865A3 (en) | 2001-06-18 | 2002-06-15 | Compositions containing active ingredient combination for treating a dependence on addictive substances or narcotics and process for preparation of the compositions |
| NZ529944A NZ529944A (en) | 2001-06-18 | 2002-06-15 | Active ingredient combination of (e.g. galanthamine or desoxypeganine with acamprosate or memantine) for treating narcotic or alcohol addiction |
| MYPI20022245A MY129726A (en) | 2001-06-18 | 2002-06-17 | Active ingredient combination (e.g. galanthamine or desoxypeganine with acamprosate or memantine) for treating a dependence on addictive substances or narcotics |
| TW091113176A TWI325320B (en) | 2001-06-18 | 2002-06-17 | Active ingredient combination for pharmacological addictive substance or intoxicant therapy |
| ZA200309232A ZA200309232B (en) | 2001-06-18 | 2003-11-27 | Active ingredient combination for treating a dependence on addictive substances or narcotics using medicaments. |
| NO20035458A NO20035458D0 (no) | 2001-06-18 | 2003-12-08 | Virkestoffkombinasjon av for eksempel galantamin eller desoksypeganin og for eksempel acamprosat eller memantin for behandling av enavhengighet slik som alkoholisme |
| IL159345A IL159345A (en) | 2001-06-18 | 2003-12-11 | Combining an active ingredient in pharmacological addictive substances or in the treatment of a toxic substance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129265A DE10129265A1 (de) | 2001-06-18 | 2001-06-18 | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10129265A1 true DE10129265A1 (de) | 2003-01-02 |
Family
ID=7688529
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10129265A Withdrawn DE10129265A1 (de) | 2001-06-18 | 2001-06-18 | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
| DE50201958T Expired - Lifetime DE50201958D1 (de) | 2001-06-18 | 2002-06-15 | WIRKSTOFF-KOMBINATION (z.B. Galanthamin oder Desoxypeganin mit Acamprosat oder Memantin) ZUR MEDIKAMENTÖSEN SUCHT- ODER RAUSCHMITTELTHERAPIE |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50201958T Expired - Lifetime DE50201958D1 (de) | 2001-06-18 | 2002-06-15 | WIRKSTOFF-KOMBINATION (z.B. Galanthamin oder Desoxypeganin mit Acamprosat oder Memantin) ZUR MEDIKAMENTÖSEN SUCHT- ODER RAUSCHMITTELTHERAPIE |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040192683A1 (enExample) |
| EP (1) | EP1397138B1 (enExample) |
| JP (1) | JP2005500298A (enExample) |
| KR (1) | KR20040010744A (enExample) |
| CN (1) | CN1527711A (enExample) |
| AR (1) | AR034493A1 (enExample) |
| AT (1) | ATE286397T1 (enExample) |
| AU (1) | AU2002323873B2 (enExample) |
| BR (1) | BR0211008A (enExample) |
| CA (1) | CA2450787C (enExample) |
| CZ (1) | CZ299951B6 (enExample) |
| DE (2) | DE10129265A1 (enExample) |
| EA (1) | EA006647B1 (enExample) |
| ES (1) | ES2236551T3 (enExample) |
| HU (1) | HUP0400865A3 (enExample) |
| IL (2) | IL159345A0 (enExample) |
| MX (1) | MXPA03011825A (enExample) |
| MY (1) | MY129726A (enExample) |
| NO (1) | NO20035458D0 (enExample) |
| NZ (1) | NZ529944A (enExample) |
| PL (1) | PL367207A1 (enExample) |
| PT (1) | PT1397138E (enExample) |
| SK (1) | SK287180B6 (enExample) |
| TW (1) | TWI325320B (enExample) |
| UA (1) | UA76753C2 (enExample) |
| WO (1) | WO2002102388A2 (enExample) |
| ZA (1) | ZA200309232B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10318714B4 (de) * | 2003-04-25 | 2006-03-23 | Hf Arzneimittelforschung Gmbh | Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches |
| DE102004048927A1 (de) * | 2004-10-06 | 2006-04-20 | Lts Lohmann Therapie-Systeme Ag | Pharmazeutische Kombination enthaltend Desoxypeganin und Cyp2D6 Inhibitoren |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10134038A1 (de) * | 2001-07-12 | 2003-02-06 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit |
| DE10354894A1 (de) * | 2003-11-24 | 2005-07-07 | Hf Arzneimittelforschung Gmbh | Orale Formulierungen des Desoxypeganins und deren Anwendungen |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| BRPI0607017B8 (pt) | 2005-04-06 | 2021-05-25 | Adamas Pharmaceuticals Inc | composição farmacêutica compreendendo memantina e donezepil, e seu uso para o tratamento de condições relacionadas ao snc |
| PT1895994E (pt) * | 2005-05-13 | 2010-12-03 | Alza Corp | Sistema de administração de medicamentos de camada múltipla com barreira contra o fluxo de material do reservatório |
| WO2007026841A1 (ja) | 2005-09-01 | 2007-03-08 | Mitsubishi Chemical Corporation | ポリエステル粒子の熱処理装置及びポリエステル粒子の多段固相重縮合方法 |
| US20070104771A1 (en) * | 2005-09-23 | 2007-05-10 | Jay Audett | Transdermal galantamine delivery system |
| US9463172B2 (en) | 2009-02-12 | 2016-10-11 | Indiana University Research & Technology Corporation | Material and methods for treating developmental disorders including comorbid and idiopathic autism |
| CN106389381A (zh) | 2009-12-02 | 2017-02-15 | 阿达玛斯医药公司 | 金刚烷胺组合物及其使用方法 |
| CA2850468C (en) | 2010-09-28 | 2019-08-13 | Depomed, Inc. | Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract |
| PL3884947T3 (pl) * | 2010-12-03 | 2024-05-06 | Nalpropion Pharmaceuticals Llc | Wzrost biodostępności leku w terapii naltreksonem |
| WO2013160728A1 (en) | 2012-04-26 | 2013-10-31 | Alma Mater Studiorum - Universita' Di Bologna | Dual targeting compounds for the treatment of alzheimer's disease |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| CN108210486B (zh) * | 2016-12-14 | 2020-05-19 | 陆汝斌 | 组合物用于制备治疗酒瘾或酒精滥用的药物的用途 |
| AU2018320946B2 (en) | 2017-08-24 | 2024-05-02 | Adamas Pharma, Llc | Amantadine compositions, preparations thereof, and methods of use |
| BG67408B1 (bg) * | 2019-04-12 | 2022-01-17 | Софарма Ад | Перорален лекарствен състав с растителен алкалоид, за лечение на зависимости |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| DE3315272C2 (de) * | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
| DE3843239C1 (enExample) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| EP0424179A3 (en) * | 1989-10-20 | 1991-12-27 | John William Olney | Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration |
| DE4010079A1 (de) * | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
| US5519017A (en) * | 1990-03-29 | 1996-05-21 | Lts Lohmann Therapie-Systeme Gmbh + Co. Kg | Pharmaceutic formulation for the treatment of alcoholism |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| PL184590B1 (pl) * | 1994-10-21 | 2002-11-29 | Sanochemia Pharmazeutika Ag | Sposób wytwarzania pochodnych a heksahydro H benzofuro[ a ef][ ] benzoazepiny sposób odbromowania tych pochodnych sposób wytwarzania związków typu N demetylobromo i epibromo galantaminy oraz nowe związki z określonego zbioru |
| DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
| GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| EP0945133A1 (en) * | 1998-03-26 | 1999-09-29 | Lipha | Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a NMDA receptor complex modulator |
| WO1999054280A1 (en) * | 1998-04-17 | 1999-10-28 | Kenneth Curry | Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation |
| DE19906974C2 (de) * | 1999-02-19 | 2003-10-09 | Lohmann Therapie Syst Lts | Verwendung von Desoxypeganin zur Behandlung des Alkoholismus |
| DE19906978B4 (de) * | 1999-02-19 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Pharmazeutische Zusammensetzung enthaltend Desoxypeganin zur Behandlung der Drogenabhängigkeit |
| DE19906979B4 (de) * | 1999-02-19 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit |
-
2001
- 2001-06-18 DE DE10129265A patent/DE10129265A1/de not_active Withdrawn
-
2002
- 2002-06-14 AR ARP020102244A patent/AR034493A1/es unknown
- 2002-06-15 BR BR0211008-3A patent/BR0211008A/pt not_active Application Discontinuation
- 2002-06-15 AU AU2002323873A patent/AU2002323873B2/en not_active Ceased
- 2002-06-15 DE DE50201958T patent/DE50201958D1/de not_active Expired - Lifetime
- 2002-06-15 PT PT02754688T patent/PT1397138E/pt unknown
- 2002-06-15 AT AT02754688T patent/ATE286397T1/de not_active IP Right Cessation
- 2002-06-15 KR KR10-2003-7016570A patent/KR20040010744A/ko not_active Ceased
- 2002-06-15 CZ CZ20033390A patent/CZ299951B6/cs not_active IP Right Cessation
- 2002-06-15 MX MXPA03011825A patent/MXPA03011825A/es active IP Right Grant
- 2002-06-15 US US10/480,287 patent/US20040192683A1/en not_active Abandoned
- 2002-06-15 UA UA20031211802A patent/UA76753C2/uk unknown
- 2002-06-15 JP JP2003504974A patent/JP2005500298A/ja active Pending
- 2002-06-15 HU HU0400865A patent/HUP0400865A3/hu unknown
- 2002-06-15 CA CA002450787A patent/CA2450787C/en not_active Expired - Fee Related
- 2002-06-15 CN CNA028110196A patent/CN1527711A/zh active Pending
- 2002-06-15 SK SK1565-2003A patent/SK287180B6/sk not_active IP Right Cessation
- 2002-06-15 WO PCT/EP2002/006630 patent/WO2002102388A2/de not_active Ceased
- 2002-06-15 NZ NZ529944A patent/NZ529944A/en unknown
- 2002-06-15 ES ES02754688T patent/ES2236551T3/es not_active Expired - Lifetime
- 2002-06-15 EA EA200400041A patent/EA006647B1/ru not_active IP Right Cessation
- 2002-06-15 EP EP02754688A patent/EP1397138B1/de not_active Expired - Lifetime
- 2002-06-15 PL PL02367207A patent/PL367207A1/xx unknown
- 2002-06-15 IL IL15934502A patent/IL159345A0/xx active IP Right Grant
- 2002-06-17 MY MYPI20022245A patent/MY129726A/en unknown
- 2002-06-17 TW TW091113176A patent/TWI325320B/zh not_active IP Right Cessation
-
2003
- 2003-11-27 ZA ZA200309232A patent/ZA200309232B/xx unknown
- 2003-12-08 NO NO20035458A patent/NO20035458D0/no not_active Application Discontinuation
- 2003-12-11 IL IL159345A patent/IL159345A/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Life Sci. 66 (12), 1079-1083 (2000) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10318714B4 (de) * | 2003-04-25 | 2006-03-23 | Hf Arzneimittelforschung Gmbh | Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches |
| DE102004048927A1 (de) * | 2004-10-06 | 2006-04-20 | Lts Lohmann Therapie-Systeme Ag | Pharmazeutische Kombination enthaltend Desoxypeganin und Cyp2D6 Inhibitoren |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |
Effective date: 20120103 |