DD290580A5 - Verfahren zur herstellung eines transdermalen therapeutischen systems mit physostigmin als wirksamem bestandteil - Google Patents

Verfahren zur herstellung eines transdermalen therapeutischen systems mit physostigmin als wirksamem bestandteil Download PDF

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Publication number
DD290580A5
DD290580A5 DD89336083A DD33608389A DD290580A5 DD 290580 A5 DD290580 A5 DD 290580A5 DD 89336083 A DD89336083 A DD 89336083A DD 33608389 A DD33608389 A DD 33608389A DD 290580 A5 DD290580 A5 DD 290580A5
Authority
DD
German Democratic Republic
Prior art keywords
layer
physostigmine
polymer material
reservoir layer
plasticizer
Prior art date
Application number
DD89336083A
Other languages
German (de)
English (en)
Inventor
Thomas Dr Hille
Hans-Rainer Dr Hoffmann
Hans-Joachim Dr Huber
Axel Dr Knoch
Gerhard Dr Schneider
Fritz Dr Stanislaus
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ���@�������@��������`�������@����@�K@��K@��k��, ���@����������@��k�� filed Critical ���@�������@��������`�������@����@�K@��K@��k��
Publication of DD290580A5 publication Critical patent/DD290580A5/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DD89336083A 1988-12-22 1989-12-21 Verfahren zur herstellung eines transdermalen therapeutischen systems mit physostigmin als wirksamem bestandteil DD290580A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3843239A DE3843239C1 (sh) 1988-12-22 1988-12-22

Publications (1)

Publication Number Publication Date
DD290580A5 true DD290580A5 (de) 1991-06-06

Family

ID=6369855

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89336083A DD290580A5 (de) 1988-12-22 1989-12-21 Verfahren zur herstellung eines transdermalen therapeutischen systems mit physostigmin als wirksamem bestandteil

Country Status (29)

Country Link
US (1) US5089267A (sh)
EP (1) EP0376067B1 (sh)
JP (1) JPH0784379B2 (sh)
KR (1) KR950015058B1 (sh)
CN (1) CN1045355A (sh)
AT (1) ATE105488T1 (sh)
AU (1) AU614209B2 (sh)
CA (1) CA2006404C (sh)
CS (1) CS277066B6 (sh)
DD (1) DD290580A5 (sh)
DE (2) DE3843239C1 (sh)
DK (1) DK651289A (sh)
ES (1) ES2056185T3 (sh)
FI (1) FI95775C (sh)
GE (1) GEP19960440B (sh)
HU (1) HU205252B (sh)
IE (1) IE64200B1 (sh)
IL (1) IL92680A (sh)
LT (1) LT3785B (sh)
MY (1) MY104491A (sh)
NO (1) NO180072C (sh)
NZ (1) NZ231907A (sh)
PH (1) PH25853A (sh)
PL (1) PL162690B1 (sh)
PT (1) PT92652B (sh)
RU (1) RU2011384C1 (sh)
UA (1) UA18868A (sh)
YU (1) YU47077B (sh)
ZA (1) ZA899878B (sh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019201430A1 (de) 2019-02-05 2020-08-06 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit Transportmedium
DE102019201431A1 (de) 2019-02-05 2020-08-06 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit Feststoffreservoir

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DE3843238C1 (sh) * 1988-12-22 1990-02-22 Lohmann Therapie Syst Lts
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
NZ237241A (en) * 1990-03-02 1993-11-25 Pharmetrix Corp Method for increasing the storage stability of physostigmine
DE4010079A1 (de) * 1990-03-29 1991-10-02 Lohmann Therapie Syst Lts Pharmazeutische formulierung zur behandlung des alkoholismus
WO1991015176A1 (en) * 1990-04-06 1991-10-17 Pharmetrix Corporation Device and method for enhanced administration of physostigmine
DE4020144A1 (de) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen
DE4238223C1 (de) * 1992-11-12 1994-05-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung
US5409948A (en) * 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
DE4301782C1 (de) * 1993-01-23 1994-08-25 Lohmann Therapie Syst Lts Verwendung von Galanthamin zur Behandlung der Nicotinabhängigkeit
DE4301783C1 (de) * 1993-01-23 1994-02-03 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Galanthamin als wirksamem Bestandteil
DE4342174C1 (de) 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
CZ126797A3 (cs) 1994-10-28 1998-01-14 Kimberly-Clark Worldwide, Inc. Absorbční předmět
TW304167B (sh) * 1995-01-30 1997-05-01 Lilly Co Eli
US5810960A (en) * 1995-03-08 1998-09-22 Nitto Denko Corporation Paint film-protective sheet
DE19706824C1 (de) * 1997-02-21 1998-03-26 Lohmann Therapie Syst Lts Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften
DE19906979B4 (de) 1999-02-19 2004-07-08 Lts Lohmann Therapie-Systeme Ag Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit
DE10119863A1 (de) * 2001-04-24 2002-11-07 Hf Arzneimittelforsch Gmbh Verwendung von Desoxypeganin zur Behandlung von psychiatrischen oder zerebralen Krankheitserscheinungen
DE10119862A1 (de) 2001-04-24 2002-11-07 Hf Arzneimittelforsch Gmbh Verwendung von Galanthamin zur Behandlung von Krankheitserscheinungen des zentralen Nervensystems aufgrund von Intoxikationen mit psychotropen Substanzen
DE10129265A1 (de) * 2001-06-18 2003-01-02 Hf Arzneimittelforsch Gmbh Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie
DE10134038A1 (de) * 2001-07-12 2003-02-06 Hf Arzneimittelforsch Gmbh Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit
DE10159745A1 (de) 2001-12-05 2003-07-03 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort
US20040043171A1 (en) * 2002-08-30 2004-03-04 Audett Jay Douglas Multilaminate backing construction
DE10318714B4 (de) * 2003-04-25 2006-03-23 Hf Arzneimittelforschung Gmbh Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches
US20050182044A1 (en) * 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
CA2508585A1 (en) * 2004-06-01 2005-12-01 Axonyx, Inc. Transdermal delivery system for treatment of cognitive disorders
EP1604686A1 (en) * 2004-06-08 2005-12-14 Axonyx, Inc. Use of phenserine and a HMG CoA reductase inhibitor for delaying Alzheimer's disease progression
CN1320009C (zh) * 2005-03-24 2007-06-06 上海交通大学 包含酯基部分带羟基基团的丙烯酸酯的组合物
CN1320005C (zh) * 2005-03-24 2007-06-06 上海交通大学 包含酯基部分带烷烃基的丙烯酸酯的组合物
CN1326894C (zh) * 2005-03-24 2007-07-18 上海交通大学 包含酯基部分带烷氧基的丙烯酸酯的组合物
CN1320006C (zh) * 2005-03-24 2007-06-06 上海交通大学 包含酯基部分带酯基基团的丙烯酸酯的组合物
CN1320008C (zh) * 2005-03-24 2007-06-06 上海交通大学 包含酯基部分带羧基基团的丙烯酸酯的组合物
CN1994290B (zh) * 2006-01-04 2011-03-16 上海医药工业研究院 卡巴拉汀透皮贴剂及其制备方法
GB0809905D0 (en) * 2008-06-02 2008-07-09 Secr Defence A Transdermal drug delivery device
KR101317158B1 (ko) * 2011-02-18 2013-10-15 조선대학교산학협력단 갈란타민 또는 그의 염을 함유하는 경피흡수제제

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019201430A1 (de) 2019-02-05 2020-08-06 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit Transportmedium
DE102019201431A1 (de) 2019-02-05 2020-08-06 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit Feststoffreservoir

Also Published As

Publication number Publication date
MY104491A (en) 1994-04-30
DE58907647D1 (de) 1994-06-16
PT92652A (pt) 1990-06-29
AU614209B2 (en) 1991-08-22
NO895171L (no) 1990-06-25
HU205252B (en) 1992-04-28
IL92680A0 (en) 1990-09-17
ES2056185T3 (es) 1994-10-01
EP0376067A2 (de) 1990-07-04
CN1045355A (zh) 1990-09-19
ZA899878B (en) 1990-09-26
PH25853A (en) 1991-12-02
HU896713D0 (en) 1990-02-28
EP0376067A3 (en) 1990-12-27
CS277066B6 (en) 1992-11-18
ATE105488T1 (de) 1994-05-15
CS719189A3 (en) 1992-06-17
FI896099A0 (fi) 1989-12-19
CA2006404A1 (en) 1990-06-22
UA18868A (uk) 1997-12-25
FI95775B (fi) 1995-12-15
IE64200B1 (en) 1995-07-12
LT3785B (en) 1996-03-25
GEP19960440B (en) 1996-08-30
NO895171D0 (no) 1989-12-21
DE3843239C1 (sh) 1990-02-22
PL162690B1 (pl) 1993-12-31
NO180072C (no) 1997-02-12
KR950015058B1 (ko) 1995-12-21
US5089267A (en) 1992-02-18
YU47077B (sh) 1994-12-28
PT92652B (pt) 1995-09-12
FI95775C (fi) 1996-03-25
RU2011384C1 (ru) 1994-04-30
LTIP1842A (en) 1995-08-25
CA2006404C (en) 1995-10-24
IE894079L (en) 1990-06-22
KR900009065A (ko) 1990-07-02
EP0376067B1 (de) 1994-05-11
NZ231907A (en) 1991-10-25
DK651289A (da) 1990-06-23
HUT54889A (en) 1991-04-29
IL92680A (en) 1993-06-10
AU4684589A (en) 1990-06-28
NO180072B (no) 1996-11-04
JPH0315477A (ja) 1991-01-23
YU240789A (en) 1991-04-30
DK651289D0 (da) 1989-12-20
JPH0784379B2 (ja) 1995-09-13

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