DD207718A5 - Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen - Google Patents
Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen Download PDFInfo
- Publication number
- DD207718A5 DD207718A5 DD81248820A DD24882081A DD207718A5 DD 207718 A5 DD207718 A5 DD 207718A5 DD 81248820 A DD81248820 A DD 81248820A DD 24882081 A DD24882081 A DD 24882081A DD 207718 A5 DD207718 A5 DD 207718A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- pharmaceutically acceptable
- formula
- compounds
- methyl
- mmol
- Prior art date
Links
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- 239000010452 phosphate Substances 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19623180A | 1980-10-14 | 1980-10-14 | |
| US06/293,574 US4374843A (en) | 1980-10-14 | 1981-08-20 | 2-Guanidino-4-heteroarylthiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD207718A5 true DD207718A5 (de) | 1984-03-14 |
Family
ID=26891753
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD81248820A DD207718A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
| DD81248821A DD207719A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
| DD81234080A DD202293A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
| DD81248822A DD207913A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD81248821A DD207719A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
| DD81234080A DD202293A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
| DD81248822A DD207913A5 (de) | 1980-10-14 | 1981-10-14 | Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen |
Country Status (28)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4482723A (en) * | 1983-04-11 | 1984-11-13 | Pfizer Inc. | Process for preparation of 4-acetyl-2-substituted-imidazoles |
| US4435396A (en) * | 1982-05-10 | 1984-03-06 | Pfizer Inc. | Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor |
| AU542287B2 (en) * | 1982-06-17 | 1985-02-14 | Toyama Chemical Co. Ltd. | Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative, it:s salt and intermediates therefor |
| EP0156644A1 (en) * | 1984-04-02 | 1985-10-02 | Pfizer Inc. | Process and intermediates for 4-acetylimidazoles |
| US4560690A (en) * | 1984-04-30 | 1985-12-24 | Pfizer Inc. | 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents |
| US4632993A (en) * | 1984-10-11 | 1986-12-30 | Pfizer Inc. | Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide |
| US4591595A (en) * | 1984-10-11 | 1986-05-27 | Pfizer Inc. | 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis |
| US4567179A (en) * | 1984-10-11 | 1986-01-28 | Pfizer, Inc. | Antiinflammatory salts of piroxicam |
| WO1986003203A1 (fr) * | 1984-11-22 | 1986-06-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Derives de thienylthiazole |
| US4814341A (en) * | 1986-08-26 | 1989-03-21 | Reiter Lawrence A | 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents |
| ES2031514T3 (es) * | 1986-08-29 | 1992-12-16 | Pfizer Inc. | 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas. |
| ATE106884T1 (de) * | 1986-10-29 | 1994-06-15 | Pfizer | Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat. |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| JPH06505724A (ja) * | 1991-03-13 | 1994-06-30 | 藤沢薬品工業株式会社 | チアゾール誘導体 |
| SI0928793T1 (en) * | 1998-01-02 | 2002-10-31 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| BRPI0615186A2 (pt) * | 2005-08-23 | 2016-09-13 | Ube Industries | processo para preparar um composto de 5-acil-imidazol 1-substituído |
| EP2832731A4 (en) | 2012-03-27 | 2015-08-19 | Shionogi & Co | AROMATIC HETEROCYCLIC CHAIN 5-CORE DERIVED DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY |
| CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
| WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1516777A (fr) * | 1966-08-02 | 1968-02-05 | Innothera Lab Sa | Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation |
| US3519637A (en) * | 1966-12-06 | 1970-07-07 | Hoffmann La Roche | 1-(4-thiazolylmethyl)nitroimidazole derivatives |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| US3950353A (en) * | 1971-03-09 | 1976-04-13 | Smith Kline & French Laboratories Limited | Pharmacologically active thiourea and urea compounds |
| HU168776B (cg-RX-API-DMAC10.html) * | 1973-11-09 | 1976-07-28 | ||
| DE2614189A1 (de) * | 1976-04-02 | 1977-10-20 | Hoechst Ag | Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung |
| GR62452B (en) * | 1977-04-20 | 1979-04-12 | Ici Ltd | Preparation process of guanidine derivatives |
| DE2961923D1 (en) * | 1978-01-18 | 1982-03-11 | Ici Plc | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| EP0014057B1 (en) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4220654A (en) * | 1979-06-04 | 1980-09-02 | Merck & Co., Inc. | Cyclic imidazole cyanoguanidines |
| AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
-
1981
- 1981-08-20 US US06/293,574 patent/US4374843A/en not_active Expired - Fee Related
- 1981-10-12 AT AT81304724T patent/ATE11048T1/de not_active IP Right Cessation
- 1981-10-12 EP EP81304724A patent/EP0050458B1/en not_active Expired
- 1981-10-12 IE IE2384/81A patent/IE51642B1/en unknown
- 1981-10-12 DE DE8181304724T patent/DE3168067D1/de not_active Expired
- 1981-10-12 IL IL64035A patent/IL64035A/xx unknown
- 1981-10-13 NO NO813442A patent/NO159654C/no unknown
- 1981-10-13 FI FI813177A patent/FI75821C/fi not_active IP Right Cessation
- 1981-10-13 PH PH26341A patent/PH17562A/en unknown
- 1981-10-13 YU YU2464/81A patent/YU42434B/xx unknown
- 1981-10-13 SU SU813344744A patent/SU1153829A3/ru active
- 1981-10-13 AU AU76287/81A patent/AU530589B2/en not_active Ceased
- 1981-10-13 CA CA000387744A patent/CA1156239A/en not_active Expired
- 1981-10-13 CS CS817500A patent/CS231182B2/cs unknown
- 1981-10-13 ES ES506216A patent/ES8301978A1/es not_active Expired
- 1981-10-13 DK DK453181A patent/DK453181A/da not_active Application Discontinuation
- 1981-10-13 HU HU833918A patent/HU191895B/hu not_active IP Right Cessation
- 1981-10-13 KR KR1019810003857A patent/KR850001858B1/ko not_active Expired
- 1981-10-13 GR GR66268A patent/GR75098B/el unknown
- 1981-10-13 HU HU812951A patent/HU186788B/hu not_active IP Right Cessation
- 1981-10-13 NZ NZ198629A patent/NZ198629A/en unknown
- 1981-10-14 PL PL1981233430A patent/PL134491B1/pl unknown
- 1981-10-14 PL PL1981241643A patent/PL133712B1/pl unknown
- 1981-10-14 DD DD81248820A patent/DD207718A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248821A patent/DD207719A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81234080A patent/DD202293A5/de not_active IP Right Cessation
- 1981-10-14 PT PT73817A patent/PT73817B/pt unknown
- 1981-10-14 DD DD81248822A patent/DD207913A5/de not_active IP Right Cessation
- 1981-10-14 PL PL1981241644A patent/PL135331B1/pl unknown
-
1982
- 1982-08-20 ES ES515159A patent/ES8306751A1/es not_active Expired
- 1982-08-20 ES ES515158A patent/ES8306750A1/es not_active Expired
- 1982-08-20 ES ES515157A patent/ES8306749A1/es not_active Expired
- 1982-08-27 AR AR290462A patent/AR228674A1/es active
- 1982-08-27 AR AR290461A patent/AR229703A1/es active
- 1982-08-27 AR AR290463A patent/AR228675A1/es active
-
1983
- 1983-04-06 PH PH28740A patent/PH18467A/en unknown
- 1983-04-06 PH PH28741A patent/PH17856A/en unknown
- 1983-05-12 YU YU1053/83A patent/YU42078B/xx unknown
- 1983-05-12 YU YU1051/83A patent/YU42076B/xx unknown
- 1983-05-12 YU YU1052/83A patent/YU42077B/xx unknown
-
1984
- 1984-08-17 AU AU32062/84A patent/AU548992B2/en not_active Ceased
-
1987
- 1987-03-09 SG SG234/87A patent/SG23487G/en unknown
- 1987-03-20 KE KE3707A patent/KE3707A/xx unknown
- 1987-07-09 HK HK523/87A patent/HK52387A/xx unknown
- 1987-12-30 MY MY512/87A patent/MY8700512A/xx unknown
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