DD155989A5 - Verfahren zur herstellung von 6(r)-[2-(8'-acyloxy-2'-methyl-6'-methyl-(oder wasserstoff)-polyhydronaphtyl-1')-aethyl]-4-(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-onen und von derivaten dieser verbindungen - Google Patents

Verfahren zur herstellung von 6(r)-[2-(8'-acyloxy-2'-methyl-6'-methyl-(oder wasserstoff)-polyhydronaphtyl-1')-aethyl]-4-(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-onen und von derivaten dieser verbindungen Download PDF

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Publication number
DD155989A5
DD155989A5 DD81227405A DD22740581A DD155989A5 DD 155989 A5 DD155989 A5 DD 155989A5 DD 81227405 A DD81227405 A DD 81227405A DD 22740581 A DD22740581 A DD 22740581A DD 155989 A5 DD155989 A5 DD 155989A5
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DD
German Democratic Republic
Prior art keywords
alkyl
compounds
item
formula
compound
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Application number
DD81227405A
Other languages
German (de)
English (en)
Inventor
Alvin K Willard
Robert L Smith
William F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD155989(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DD155989A5 publication Critical patent/DD155989A5/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
DD81227405A 1980-02-04 1981-02-03 Verfahren zur herstellung von 6(r)-[2-(8'-acyloxy-2'-methyl-6'-methyl-(oder wasserstoff)-polyhydronaphtyl-1')-aethyl]-4-(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-onen und von derivaten dieser verbindungen DD155989A5 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11804980A 1980-02-04 1980-02-04
US11805180A 1980-02-04 1980-02-04
US17546080A 1980-08-05 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (1)

Publication Number Publication Date
DD155989A5 true DD155989A5 (de) 1982-07-21

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81227405A DD155989A5 (de) 1980-02-04 1981-02-03 Verfahren zur herstellung von 6(r)-[2-(8'-acyloxy-2'-methyl-6'-methyl-(oder wasserstoff)-polyhydronaphtyl-1')-aethyl]-4-(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-onen und von derivaten dieser verbindungen

Country Status (22)

Country Link
EP (1) EP0033538B1 (fr)
AU (1) AU548996B2 (fr)
CA (1) CA1199322A (fr)
CY (1) CY1404A (fr)
DD (1) DD155989A5 (fr)
DE (1) DE3173042D1 (fr)
DK (1) DK157292C (fr)
ES (1) ES499079A0 (fr)
FI (1) FI78082C (fr)
GR (1) GR74798B (fr)
HK (1) HK16488A (fr)
IE (1) IE51478B1 (fr)
IL (1) IL62044A (fr)
MA (1) MA19054A1 (fr)
MY (1) MY8700745A (fr)
NL (1) NL930009I2 (fr)
NO (2) NO154229C (fr)
NZ (1) NZ196172A (fr)
PT (1) PT72441B (fr)
RO (1) RO82367B (fr)
SG (1) SG61087G (fr)
YU (1) YU28181A (fr)

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AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
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JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
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ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (fr) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Composition pharmaceutique comprenant ézétimide et simvastatine
WO2010069593A1 (fr) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Utilisation de composés amphiphiles pour la cristallisation régulée de statines et d'intermédiaires de statines
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
EP2216016A1 (fr) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Procédé pour la préparation d'une composition pharmaceutique comprenant de l'ézétimibe
EP2241561A1 (fr) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Composé neuroprotecteur, hypocholestérolémiant et antiépileptique
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Also Published As

Publication number Publication date
AU548996B2 (en) 1986-01-09
IE51478B1 (en) 1987-01-07
MY8700745A (en) 1987-12-31
EP0033538A3 (en) 1982-02-24
DK157292C (da) 1990-05-07
IL62044A0 (en) 1981-03-31
NO154229C (no) 1986-08-13
NO810358L (no) 1981-08-05
DK157292B (da) 1989-12-04
DK46181A (da) 1981-08-05
IL62044A (en) 1987-03-31
FI810287L (fi) 1981-08-05
ES8609296A1 (es) 1985-10-16
CA1199322A (fr) 1986-01-14
NL930009I2 (nl) 1993-09-16
SG61087G (en) 1987-10-23
DE3173042D1 (en) 1986-01-09
PT72441B (pt) 1984-08-01
NL930009I1 (nl) 1993-04-01
RO82367B (ro) 1984-02-28
HK16488A (en) 1988-03-11
NO154229B (no) 1986-05-05
FI78082C (fi) 1989-06-12
EP0033538B1 (fr) 1985-11-27
PT72441A (pt) 1981-03-01
GR74798B (fr) 1984-07-12
EP0033538A2 (fr) 1981-08-12
AU6657381A (en) 1981-08-13
IE810204L (en) 1981-08-04
RO82367A (fr) 1984-02-21
NZ196172A (en) 1985-01-31
FI78082B (fi) 1989-02-28
ES499079A0 (es) 1985-10-16
YU28181A (en) 1983-10-31
CY1404A (en) 1988-04-22
NO1994001I1 (no) 1994-07-01
MA19054A1 (fr) 1981-10-01

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