MY8700745A - 6(r)-(2-8-acyloxy-2'-methyl-6'methyl(or hydrogen)-polyhydronapthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-24-pyran-2-ones, the hydroxy acid from of said pyranones, the parmaceutically acceptable satls of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a parmaceutical antihypercholesterolemic composition containing the same. - Google Patents

6(r)-(2-8-acyloxy-2'-methyl-6'methyl(or hydrogen)-polyhydronapthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-24-pyran-2-ones, the hydroxy acid from of said pyranones, the parmaceutically acceptable satls of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a parmaceutical antihypercholesterolemic composition containing the same.

Info

Publication number
MY8700745A
MY8700745A MY745/87A MY8700745A MY8700745A MY 8700745 A MY8700745 A MY 8700745A MY 745/87 A MY745/87 A MY 745/87A MY 8700745 A MY8700745 A MY 8700745A MY 8700745 A MY8700745 A MY 8700745A
Authority
MY
Malaysia
Prior art keywords
hydroxy
methyl
lower alkyl
same
hydroxy acid
Prior art date
Application number
MY745/87A
Other languages
English (en)
Inventor
Alvin K William
Robert L Smith
William F Hoffmann
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY8700745(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MY8700745A publication Critical patent/MY8700745A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
MY745/87A 1980-02-04 1987-12-30 6(r)-(2-8-acyloxy-2'-methyl-6'methyl(or hydrogen)-polyhydronapthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-24-pyran-2-ones, the hydroxy acid from of said pyranones, the parmaceutically acceptable satls of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a parmaceutical antihypercholesterolemic composition containing the same. MY8700745A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11804980A 1980-02-04 1980-02-04
US11805180A 1980-02-04 1980-02-04
US17546080A 1980-08-05 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (1)

Publication Number Publication Date
MY8700745A true MY8700745A (en) 1987-12-31

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
MY745/87A MY8700745A (en) 1980-02-04 1987-12-30 6(r)-(2-8-acyloxy-2'-methyl-6'methyl(or hydrogen)-polyhydronapthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-24-pyran-2-ones, the hydroxy acid from of said pyranones, the parmaceutically acceptable satls of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a parmaceutical antihypercholesterolemic composition containing the same.

Country Status (22)

Country Link
EP (1) EP0033538B1 (xx)
AU (1) AU548996B2 (xx)
CA (1) CA1199322A (xx)
CY (1) CY1404A (xx)
DD (1) DD155989A5 (xx)
DE (1) DE3173042D1 (xx)
DK (1) DK157292C (xx)
ES (1) ES499079A0 (xx)
FI (1) FI78082C (xx)
GR (1) GR74798B (xx)
HK (1) HK16488A (xx)
IE (1) IE51478B1 (xx)
IL (1) IL62044A (xx)
MA (1) MA19054A1 (xx)
MY (1) MY8700745A (xx)
NL (1) NL930009I2 (xx)
NO (2) NO154229C (xx)
NZ (1) NZ196172A (xx)
PT (1) PT72441B (xx)
RO (1) RO82367B (xx)
SG (1) SG61087G (xx)
YU (1) YU28181A (xx)

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US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
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CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
DE69907960T2 (de) 1998-12-23 2004-02-26 G.D. Searle Llc, Chicago Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
DE69908644T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
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US6562860B1 (en) 1998-12-23 2003-05-13 G. D. Searle & Co. Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
EP1323701B1 (en) * 2000-09-07 2009-07-15 Kaneka Corporation Methods for crystallization of hydroxycarboxylic acids
MXPA04003524A (es) 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
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KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
RS53084B (en) 2006-07-05 2014-06-30 Takeda Gmbh COMBINATION OF HMG-COA ROSUVASTATIN REDUCTASE INHIBITOR WITH PHOSPHODIESTERASE 4 INHIBITOR, WHICH IS ROFLUMILAST, ROFLUMILAST-N-OXIDE FOR THE TREATMENT OF INFLAMMATORY LUNG DISEASES
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (en) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising ezetimibe and simvastatin
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
EP2241561A1 (en) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Neuroprotective, hypocholesterolemic and antiepileptic compound
WO2011002424A2 (en) 2009-07-02 2011-01-06 Bilgic Mahmut Solubility and stability enchancing pharmaceutical formulation
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EP2368543A1 (en) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
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US20150010630A1 (en) 2011-12-29 2015-01-08 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
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Also Published As

Publication number Publication date
AU548996B2 (en) 1986-01-09
IE51478B1 (en) 1987-01-07
EP0033538A3 (en) 1982-02-24
DK157292C (da) 1990-05-07
IL62044A0 (en) 1981-03-31
NO154229C (no) 1986-08-13
NO810358L (no) 1981-08-05
DK157292B (da) 1989-12-04
DK46181A (da) 1981-08-05
IL62044A (en) 1987-03-31
FI810287L (fi) 1981-08-05
ES8609296A1 (es) 1985-10-16
CA1199322A (en) 1986-01-14
NL930009I2 (nl) 1993-09-16
SG61087G (en) 1987-10-23
DE3173042D1 (en) 1986-01-09
PT72441B (pt) 1984-08-01
NL930009I1 (nl) 1993-04-01
RO82367B (ro) 1984-02-28
HK16488A (en) 1988-03-11
NO154229B (no) 1986-05-05
FI78082C (fi) 1989-06-12
EP0033538B1 (en) 1985-11-27
PT72441A (pt) 1981-03-01
GR74798B (xx) 1984-07-12
EP0033538A2 (en) 1981-08-12
AU6657381A (en) 1981-08-13
IE810204L (en) 1981-08-04
RO82367A (ro) 1984-02-21
DD155989A5 (de) 1982-07-21
NZ196172A (en) 1985-01-31
FI78082B (fi) 1989-02-28
ES499079A0 (es) 1985-10-16
YU28181A (en) 1983-10-31
CY1404A (en) 1988-04-22
NO1994001I1 (no) 1994-07-01
MA19054A1 (fr) 1981-10-01

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