FI810287L - Nya antihyperkolesterolemiska foereningar - Google Patents

Nya antihyperkolesterolemiska foereningar

Info

Publication number
FI810287L
FI810287L FI810287A FI810287A FI810287L FI 810287 L FI810287 L FI 810287L FI 810287 A FI810287 A FI 810287A FI 810287 A FI810287 A FI 810287A FI 810287 L FI810287 L FI 810287L
Authority
FI
Finland
Prior art keywords
antihypercolesterolemiska
foereningar
nya
nya antihypercolesterolemiska
antihypercolesterolemiska foereningar
Prior art date
Application number
FI810287A
Other languages
English (en)
Other versions
FI78082C (fi
FI78082B (fi
Inventor
Alvin K Willard
Robert L Smith
William F Hoffmann
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI810287(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI810287L publication Critical patent/FI810287L/fi
Application granted granted Critical
Publication of FI78082B publication Critical patent/FI78082B/fi
Publication of FI78082C publication Critical patent/FI78082C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
FI810287A 1980-02-04 1981-02-02 Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror. FI78082C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11804980A 1980-02-04 1980-02-04
US11805180A 1980-02-04 1980-02-04
US11805180 1980-02-04
US11804980 1980-02-04
US17546080A 1980-08-05 1980-08-05
US17523280 1980-08-05
US17546080 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (3)

Publication Number Publication Date
FI810287L true FI810287L (fi) 1981-08-05
FI78082B FI78082B (fi) 1989-02-28
FI78082C FI78082C (fi) 1989-06-12

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810287A FI78082C (fi) 1980-02-04 1981-02-02 Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror.

Country Status (22)

Country Link
EP (1) EP0033538B1 (fi)
AU (1) AU548996B2 (fi)
CA (1) CA1199322A (fi)
CY (1) CY1404A (fi)
DD (1) DD155989A5 (fi)
DE (1) DE3173042D1 (fi)
DK (1) DK157292C (fi)
ES (1) ES499079A0 (fi)
FI (1) FI78082C (fi)
GR (1) GR74798B (fi)
HK (1) HK16488A (fi)
IE (1) IE51478B1 (fi)
IL (1) IL62044A (fi)
MA (1) MA19054A1 (fi)
MY (1) MY8700745A (fi)
NL (1) NL930009I2 (fi)
NO (2) NO154229C (fi)
NZ (1) NZ196172A (fi)
PT (1) PT72441B (fi)
RO (1) RO82367B (fi)
SG (1) SG61087G (fi)
YU (1) YU28181A (fi)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
EP0094443A1 (en) * 1982-05-17 1983-11-23 Merck & Co. Inc. 6(R)-(2-(8(S) (2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one, process for preparing and pharmaceutical composition containing the same
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
CA1268473A (en) * 1983-01-24 1990-05-01 Paul L. Anderson Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
EP0137445B1 (en) * 1983-10-11 1990-01-03 Merck & Co. Inc. Process for c-methylation of 2-methylbutyrates
EP0137444B1 (en) * 1983-10-11 1990-01-31 Merck & Co. Inc. Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-Decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
GB9100174D0 (en) * 1991-01-04 1991-02-20 British Bio Technology Compounds
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
NO318765B1 (no) * 1995-07-03 2005-05-02 Sankyo Co Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner.
WO1997020834A1 (en) * 1995-12-06 1997-06-12 Antibiotic Co. Method of production of lovastatin
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) * 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
ATE242008T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
WO2000038724A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
WO2000038728A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications
ATE242007T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
ATE240120T1 (de) 1998-12-23 2003-05-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
EA005815B1 (ru) 1998-12-23 2005-06-30 Джи.Ди.Сирл Ллс Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
EP1286984A2 (en) 2000-03-10 2003-03-05 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
IL154718A0 (en) 2000-09-07 2003-10-31 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
BR0213501A (pt) 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
WO2003061604A2 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
ATE535244T1 (de) 2006-07-05 2011-12-15 Nycomed Gmbh Kombination aus atorvastatin mit einem phosphodiesterase-4-hemmer zur behandlung von entzündlichen lungenerkrankungen
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (en) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising ezetimibe and simvastatin
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
EP2241561A1 (en) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Neuroprotective, hypocholesterolemic and antiepileptic compound
WO2011002424A2 (en) 2009-07-02 2011-01-06 Bilgic Mahmut Solubility and stability enchancing pharmaceutical formulation
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EP2368543A1 (en) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
ES2380473B1 (es) * 2010-10-13 2013-02-19 Neuron Biopharma, S.A. Compuesto neuroprotector, hipocolesterolémico, antiinflamatorio y antiepiléptico.
US20150010630A1 (en) 2011-12-29 2015-01-08 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
EP2861624A1 (en) 2012-06-15 2015-04-22 F. Hoffmann-La Roche AG Anti-pcsk9 antibodies, formulations, dosing, and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (fi) * 1974-06-07 1981-03-18
DE2748825C2 (de) 1976-11-02 1986-11-27 Sankyo Co., Ltd., Tokio/Tokyo Substituierte 3,5-Dihydroxyheptansäurederivate und diese enthaltende Arzneimittel gegen Hyperlipämie
JPS6026094B2 (ja) 1978-07-04 1985-06-21 三共株式会社 テトラヒドロｍｌ↓−２３６ｂおよびその誘導体並びにそれを有効成分とする高脂血症治療剤
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
PT72394B (en) 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics

Also Published As

Publication number Publication date
DK157292C (da) 1990-05-07
YU28181A (en) 1983-10-31
PT72441A (pt) 1981-03-01
ES8609296A1 (es) 1985-10-16
AU6657381A (en) 1981-08-13
CA1199322A (en) 1986-01-14
DE3173042D1 (en) 1986-01-09
IE51478B1 (en) 1987-01-07
NO1994001I1 (no) 1994-07-01
SG61087G (en) 1987-10-23
EP0033538A2 (en) 1981-08-12
IE810204L (en) 1981-08-04
DK157292B (da) 1989-12-04
RO82367B (ro) 1984-02-28
IL62044A0 (en) 1981-03-31
AU548996B2 (en) 1986-01-09
NL930009I1 (nl) 1993-04-01
GR74798B (fi) 1984-07-12
MY8700745A (en) 1987-12-31
DD155989A5 (de) 1982-07-21
NO154229B (no) 1986-05-05
IL62044A (en) 1987-03-31
NO810358L (no) 1981-08-05
NL930009I2 (nl) 1993-09-16
RO82367A (ro) 1984-02-21
PT72441B (pt) 1984-08-01
HK16488A (en) 1988-03-11
MA19054A1 (fr) 1981-10-01
ES499079A0 (es) 1985-10-16
CY1404A (en) 1988-04-22
NO154229C (no) 1986-08-13
DK46181A (da) 1981-08-05
NZ196172A (en) 1985-01-31
EP0033538B1 (en) 1985-11-27
FI78082C (fi) 1989-06-12
EP0033538A3 (en) 1982-02-24
FI78082B (fi) 1989-02-28

Similar Documents

Publication Publication Date Title
FI810287L (fi) Nya antihyperkolesterolemiska foereningar
FI812875L (fi) Nya n-arylbenzamidderivat
FI822173A0 (fi) Nya orala dipyridamolformer
FI822243L (fi) Nya n-aryl-piperazinalkanamider
FI833568L (fi) Nya topiskt applicerbara farmaceutiska kompositioner
FI820042L (fi) Framstaellningsfoerfarande foer nya i 11beta-staellning substituerade steroidderivat
FI810058L (fi) Nya dipyridamol-retardationsformer och foerfarande foer deras framstaellning
FI833859A0 (fi) Nya azolfoereningar
FI832844A7 (fi) Nya fenyletanolaminer
FI813971L (fi) Nya pyrimidoner deras framstaellning och deras anvaendning saosom laekemedel
BR8104796A (pt) Fiadeira
FI811504L (fi) Nya triazolokinoxalin-4-oner
FI813934L (fi) Nya fenylalkylaminer deras framstaellning och deras anvaendning saosom laekemedel
FI811059L (fi) Foerfarande foer framstaellning av nya tricykliska etrar
FI811703L (fi) Nya kinoxalin-2-yl-etenylketoner och foerfarande foer deras framstaellning
FI822803A0 (fi) Nya karbostyrilderivat
FI832556A0 (fi) Nya 19-tio-androstanderivat
FI813946L (fi) Nya estrar
FI831253L (fi) Foerfarande foer framstaellning av nya oxazolderivat
FI812303L (fi) Nya imidazokinazolinderivat
FI813561L (fi) Nya indolinoner deras framstaellning och deras anvaendning saosom laekemedel
FI833480A0 (fi) Nya antracyklinglykosider
FI813879L (fi) Nya foerbaettrade glasfibermattor foerdelaktiga vid hopsaettbara takmellanskikt och -system
FI810120L (fi) Nya tioler och foerfarande foer deras framstaellning
FI811448L (fi) Nya antiallergiska medel

Legal Events

Date Code Title Description
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L14

Extension date: 20030406

MA Patent expired

Owner name: MERCK & CO., INC.