IL62044A - Polyhydronaphthylethyl tetrahydro-2h-pyran-2-one derivatives and hydroxy acids and esters thereof,their preparation and pharmaceutical compositions containing them - Google Patents

Polyhydronaphthylethyl tetrahydro-2h-pyran-2-one derivatives and hydroxy acids and esters thereof,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL62044A
IL62044A IL62044A IL6204481A IL62044A IL 62044 A IL62044 A IL 62044A IL 62044 A IL62044 A IL 62044A IL 6204481 A IL6204481 A IL 6204481A IL 62044 A IL62044 A IL 62044A
Authority
IL
Israel
Prior art keywords
polyhydronaphthylethyl
pyran
tetrahydro
esters
derivatives
Prior art date
Application number
IL62044A
Other languages
English (en)
Other versions
IL62044A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL62044(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL62044A0 publication Critical patent/IL62044A0/xx
Priority to IL65769A priority Critical patent/IL65769A0/xx
Publication of IL62044A publication Critical patent/IL62044A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
IL62044A 1980-02-04 1981-02-02 Polyhydronaphthylethyl tetrahydro-2h-pyran-2-one derivatives and hydroxy acids and esters thereof,their preparation and pharmaceutical compositions containing them IL62044A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL65769A IL65769A0 (en) 1980-02-04 1982-05-13 Tetrahydro-2h-pyran-2-one derivative and salts and esters thereof,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US17546080A 1980-08-05 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (2)

Publication Number Publication Date
IL62044A0 IL62044A0 (en) 1981-03-31
IL62044A true IL62044A (en) 1987-03-31

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62044A IL62044A (en) 1980-02-04 1981-02-02 Polyhydronaphthylethyl tetrahydro-2h-pyran-2-one derivatives and hydroxy acids and esters thereof,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0033538B1 (fr)
AU (1) AU548996B2 (fr)
CA (1) CA1199322A (fr)
CY (1) CY1404A (fr)
DD (1) DD155989A5 (fr)
DE (1) DE3173042D1 (fr)
DK (1) DK157292C (fr)
ES (1) ES8609296A1 (fr)
FI (1) FI78082C (fr)
GR (1) GR74798B (fr)
HK (1) HK16488A (fr)
IE (1) IE51478B1 (fr)
IL (1) IL62044A (fr)
MA (1) MA19054A1 (fr)
MY (1) MY8700745A (fr)
NL (1) NL930009I2 (fr)
NO (2) NO154229C (fr)
NZ (1) NZ196172A (fr)
PT (1) PT72441B (fr)
RO (1) RO82367B (fr)
SG (1) SG61087G (fr)
YU (1) YU28181A (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
EP0094443A1 (fr) * 1982-05-17 1983-11-23 Merck & Co. Inc. 6(R)-(2-(8(S)(2,2-diméthylbutyryloxy)-2(S),6(S)-diméthyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-décahydronaphtyl-1(S))éthyl)-4(R)-hydroxy-3,4,5,6-tétrahydro-2H-pyranne-2-one, procédé de préparation et composition pharmaceutique le contenant
US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0117228B1 (fr) * 1983-01-24 1986-11-05 Sandoz Ag Analogues de mévalonolactone et leur dérivés, leur procédé de production, compositions pharmaceutiques les contenant ainsi que leur utilisation comme médicaments
EP0137444B1 (fr) * 1983-10-11 1990-01-31 Merck & Co. Inc. Procédés pour la préparation de 6(R)-(2-(8(S)(2,2-diméthylbutyryloxy)-2(S),6(S)-diméthyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-décahydronaphtyl-1(S))éthyl)-4(R)-hydroxy-3,4,5,6-tétrahydro-2H-pyran-2-one
EP0137445B1 (fr) * 1983-10-11 1990-01-03 Merck & Co. Inc. Procédé de C-méthylation de 2-méthylbutyrates
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
GB8915280D0 (en) * 1989-07-04 1989-08-23 British Bio Technology Compounds
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
GB9100174D0 (en) * 1991-01-04 1991-02-20 British Bio Technology Compounds
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5798375A (en) * 1995-07-03 1998-08-25 Sankyo Company, Limited Treatment of arteriosclerosis and xanthoma
CA2243592C (fr) * 1995-12-06 2001-12-25 Antibiotic Co. Procede de production de lovastatine
CA2185961A1 (fr) 1996-09-19 1998-03-20 K.S. Keshava Murthy Methode de preparation de simvastatine
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (fr) 1998-06-18 1999-12-18 Yong Tao Processus de fabrication de simvastatine et de produits intermediaires
WO2000038721A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert du cholesteryle-ester et de derives de l'acide nicotinique utilisees dans le cadre de troubles cardio-vasculaires
ES2200587T3 (es) 1998-12-23 2004-03-01 G.D. Searle Llc Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares.
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
DE69907960T2 (de) 1998-12-23 2004-02-26 G.D. Searle Llc, Chicago Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
US6569905B1 (en) 1998-12-23 2003-05-27 G.D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
JP2002533414A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ
EA009466B1 (ru) 1998-12-23 2007-12-28 Джи.Ди. Сирл Ллс Ингибитор белка, переносящего эфир холестерила
EP1286984A2 (fr) 2000-03-10 2003-03-05 Pharmacia Corporation Procede de preparation de tetrahydrobenzothiepines
IL154718A0 (en) 2000-09-07 2003-10-31 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
US6740663B2 (en) 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (fr) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Composition pharmaceutique comprenant la simvastatin et l'ezetimibe
PL2363130T3 (pl) 2006-07-05 2014-09-30 Astrazeneca Ab Kombinacja inhibitorów reduktazy HMG-CoA atorwastatyny i symwastatyny z inhibitorem fosfodiesterazy, takim jak roflumilast do leczenia zapalnych chorób płuc
WO2009013764A2 (fr) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Procédé de production du 6(r)-[2-(8'(s)-2',2'-diméthylbutyryloxy-2'(s),6'(r)-diméthyl-1,2,6,7',8',8a'(r)-hexahydronaphtyl-l'(s))éthyl]-4(r)-hydroxy-3,4,5,6-tétrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
ES2343049B1 (es) 2008-10-15 2011-06-10 Neuron Biopharma, S.A. Biosintesis de derivados de monacolina j.
EP2204170A1 (fr) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Composition pharmaceutique comprenant ézétimide et simvastatine
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
EP2216016A1 (fr) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Procédé pour la préparation d'une composition pharmaceutique comprenant de l'ézétimibe
EP2241561A1 (fr) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Composé neuroprotecteur, hypocholestérolémiant et antiépileptique
WO2011002424A2 (fr) 2009-07-02 2011-01-06 Bilgic Mahmut Préparation pharmaceutique améliorant la solubilité et la stabilité
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
EP2368543A1 (fr) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Procédé de préparation de composition pharmaceutique granulée comprenant de la simvastatine et/ou ézétimibe
ES2380473B1 (es) * 2010-10-13 2013-02-19 Neuron Biopharma, S.A. Compuesto neuroprotector, hipocolesterolémico, antiinflamatorio y antiepiléptico.
WO2013102193A1 (fr) 2011-12-29 2013-07-04 Trustees Of Tufts College Fonctionnalisation de biomatériaux pour commander la régénération et des réponses à une inflammation
MX2014014830A (es) 2012-06-15 2015-05-11 Genentech Inc Anticuerpos anti-pcsk9, formulaciones, dosificacion y metodos de uso.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (fr) 1974-06-07 1981-03-18
US4137322A (en) 1976-11-02 1979-01-30 Sankyo Company Limited ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
JPS6026094B2 (ja) 1978-07-04 1985-06-21 三共株式会社 テトラヒドロｍｌ↓−２３６ｂおよびその誘導体並びにそれを有効成分とする高脂血症治療剤
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
PT72394B (en) 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics

Also Published As

Publication number Publication date
GR74798B (fr) 1984-07-12
HK16488A (en) 1988-03-11
NO1994001I1 (no) 1994-07-01
FI810287L (fi) 1981-08-05
DK157292C (da) 1990-05-07
IE51478B1 (en) 1987-01-07
ES499079A0 (es) 1985-10-16
IL62044A0 (en) 1981-03-31
EP0033538A3 (en) 1982-02-24
YU28181A (en) 1983-10-31
NO810358L (no) 1981-08-05
DE3173042D1 (en) 1986-01-09
PT72441A (pt) 1981-03-01
NO154229B (no) 1986-05-05
AU548996B2 (en) 1986-01-09
NZ196172A (en) 1985-01-31
AU6657381A (en) 1981-08-13
RO82367A (fr) 1984-02-21
IE810204L (en) 1981-08-04
EP0033538A2 (fr) 1981-08-12
FI78082B (fi) 1989-02-28
CA1199322A (fr) 1986-01-14
DK46181A (da) 1981-08-05
EP0033538B1 (fr) 1985-11-27
SG61087G (en) 1987-10-23
NL930009I2 (nl) 1993-09-16
ES8609296A1 (es) 1985-10-16
MA19054A1 (fr) 1981-10-01
FI78082C (fi) 1989-06-12
PT72441B (pt) 1984-08-01
NL930009I1 (nl) 1993-04-01
MY8700745A (en) 1987-12-31
DK157292B (da) 1989-12-04
NO154229C (no) 1986-08-13
DD155989A5 (de) 1982-07-21
RO82367B (ro) 1984-02-28
CY1404A (en) 1988-04-22

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