DD140701A5 - Verfahren zur isolierung und reinigung von immunologisch wirksamen polyribosylribitolphosphat - Google Patents

Verfahren zur isolierung und reinigung von immunologisch wirksamen polyribosylribitolphosphat Download PDF

Info

Publication number
DD140701A5
DD140701A5 DD78208715A DD20871578A DD140701A5 DD 140701 A5 DD140701 A5 DD 140701A5 DD 78208715 A DD78208715 A DD 78208715A DD 20871578 A DD20871578 A DD 20871578A DD 140701 A5 DD140701 A5 DD 140701A5
Authority
DD
German Democratic Republic
Prior art keywords
prp
isolation
phosphate buffer
pertussis
sodium phosphate
Prior art date
Application number
DD78208715A
Other languages
German (de)
English (en)
Inventor
Joseph S C Kuo
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/846,466 external-priority patent/US4196192A/en
Priority claimed from US05/846,488 external-priority patent/US4220717A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DD140701A5 publication Critical patent/DD140701A5/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD78208715A 1977-10-28 1978-10-27 Verfahren zur isolierung und reinigung von immunologisch wirksamen polyribosylribitolphosphat DD140701A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/846,466 US4196192A (en) 1977-10-28 1977-10-28 Combined Haemophilus influenzae type b and pertussis vaccine
US05/846,488 US4220717A (en) 1977-12-22 1977-12-22 Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.

Publications (1)

Publication Number Publication Date
DD140701A5 true DD140701A5 (de) 1980-03-26

Family

ID=27126641

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78208715A DD140701A5 (de) 1977-10-28 1978-10-27 Verfahren zur isolierung und reinigung von immunologisch wirksamen polyribosylribitolphosphat

Country Status (25)

Country Link
JP (1) JPS5480408A (zh)
AR (1) AR218932A1 (zh)
AU (1) AU520902B2 (zh)
BE (1) BE871586A (zh)
CA (1) CA1117866A (zh)
CH (1) CH649781A5 (zh)
DD (1) DD140701A5 (zh)
DE (1) DE2845745A1 (zh)
DK (1) DK154327C (zh)
ES (1) ES474611A1 (zh)
FI (1) FI63674C (zh)
FR (1) FR2407000B1 (zh)
GB (1) GB2007244B (zh)
GR (1) GR73991B (zh)
HU (1) HU178166B (zh)
IE (1) IE47474B1 (zh)
IL (1) IL55433A (zh)
IT (1) IT1107570B (zh)
NL (1) NL7810753A (zh)
NO (1) NO149611C (zh)
NZ (1) NZ188211A (zh)
PH (1) PH15882A (zh)
PL (1) PL210545A1 (zh)
SE (1) SE430753B (zh)
YU (1) YU250878A (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
CA1209036A (en) * 1982-08-20 1986-08-05 Joseph S.C. Kuo Combined haemophilus influenzae and diphtheria, pertussis, tetanus vaccine
US4744982A (en) * 1982-08-24 1988-05-17 Hunter Kenneth W Human monoclonal antibody reactive with polyribosylribitol phosphate
ATE128628T1 (de) * 1990-08-13 1995-10-15 American Cyanamid Co Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff.
SK18594A3 (en) * 1991-08-16 1994-08-10 Merck & Co Inc Method of production of capsular polysacharide without lipid and endotoxine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395219A (en) * 1964-12-11 1968-07-30 Merck & Co Inc Process for production of pertussis antigen
IL24946A (en) * 1965-01-19 1969-05-28 Merck & Co Inc Process for preparing antibodies in cilus pertussis
US3465078A (en) * 1965-10-21 1969-09-02 Sydney Z Spiesel Method of recovering antigens from bordetella pertussis cells
NL174267B (nl) * 1969-05-20 Roussel Uclaf Verbetering van de werkwijze voor de bereiding van een somatisch antigeen volgens het nederlandse octrooischrift 169754 en werkwijze ter bereiding van een farmaceutisch preparaat.
US3636192A (en) * 1970-01-13 1972-01-18 Us Army Meningococcal polysaccharide vaccines
FR2253499B1 (zh) * 1973-12-10 1977-11-04 Fabre Sa Pierre
DE2461439C3 (de) * 1974-12-24 1980-03-20 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines schützenden Antigens von Bordetella Pertussis sowie jenes enthaltendes Mittel
US3978209A (en) * 1975-03-24 1976-08-31 Merck & Co., Inc. Endotoxin free meningococcus polysaccharides

Also Published As

Publication number Publication date
HU178166B (en) 1982-03-28
DE2845745C2 (zh) 1987-10-01
JPS6231694B2 (zh) 1987-07-09
AU4108178A (en) 1980-05-01
DK479578A (da) 1979-04-29
GB2007244B (en) 1982-03-31
AR218932A1 (es) 1980-07-15
NL7810753A (nl) 1979-05-02
CH649781A5 (de) 1985-06-14
JPS5480408A (en) 1979-06-27
SE430753B (sv) 1983-12-12
FI783269A (fi) 1979-04-29
BE871586A (fr) 1979-04-27
IE47474B1 (en) 1984-03-21
NO149611B (no) 1984-02-13
FI63674B (fi) 1983-04-29
FI63674C (fi) 1983-08-10
GR73991B (zh) 1984-06-06
FR2407000B1 (zh) 1983-01-21
DK154327C (da) 1989-04-03
SE7811192L (sv) 1979-04-29
CA1117866A (en) 1982-02-09
DE2845745A1 (de) 1979-05-10
IE782146L (en) 1979-04-28
YU250878A (en) 1983-12-31
IT1107570B (it) 1985-11-25
PH15882A (en) 1983-04-13
ES474611A1 (es) 1980-01-16
PL210545A1 (zh) 1980-02-25
GB2007244A (en) 1979-05-16
NZ188211A (en) 1984-09-28
NO149611C (no) 1984-05-23
NO783635L (no) 1979-05-02
IL55433A (en) 1982-09-30
AU520902B2 (en) 1982-03-04
DK154327B (da) 1988-11-07
IL55433A0 (en) 1978-10-31
IT7851621A0 (it) 1978-10-24
FR2407000A1 (zh) 1979-05-25

Similar Documents

Publication Publication Date Title
US4220717A (en) Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
DE69736709T2 (de) Vielwertige dtp-polio-impfstoffe
DE69124235T3 (de) Reinigung und verwendung von pertactin, eines bordetella pertussis aussenmembranproteins
US4196192A (en) Combined Haemophilus influenzae type b and pertussis vaccine
EP0220387A2 (de) Konjugatimpfstoffe gegen Infektionen durch gramnegative Bakterien, Verfahren zu deren Herstellung sowie Verwendung derselben
DE2024586C3 (zh)
DE69731891T2 (de) Verfahren zur reinigung von gbs-toxin/cm101
EP0173241A2 (de) Vakzine zur Behandlung der Harnwegsinfektionen
DE3152621C2 (zh)
DE3541044A1 (de) Neues, allgemein anwendbares antigen (psc-a) gegen pseudomonas aeruginosa, das als mittel zum schutz gegen pseudomonas aeruginosa-infektion wirkt
DD202623A5 (de) Verfahren zur herstellung von sporen-polyosiden
DE3877818T2 (de) Verfahren zur beseitigung von pertussisendotoxin, ein pertussistoxoid und seine herstellung.
CH628088A5 (en) Process for obtaining streptococcal metabolic products
DE2845745C2 (zh)
DE3782356T2 (de) Reinigungsverfahren der proteischen antigene von bordetella-bakterien zur gewinnung eines azellularen vakzins.
DE3780843T2 (de) Industrielles verfahren zur herstellung ribosomaler impfstoffe und die so erhaltenen ribosomalen impfstoffe.
US5045456A (en) Process for removing bacterial endotoxin from gram-negative polysaccharides
US5039610A (en) Process for removing bacterial endotoxin from gram-negative polysaccharides
DE1767993A1 (de) Verfahren zur Herstellung von Substanzen,die dem Organismus eine unspezifische Immunitaet verleihen und seine natuerlichen Abwehrkraefte anregen
DE2737060C2 (de) Escherichia coli-Neurotoxin
CH640244A5 (en) Biologically active substance
DE69632066T2 (de) Verfahren zur reinigung der urease aus helicobacter pylori
DE2364317C3 (de) Verfahren zur Isolierung von Choleragen
KR810001317B1 (ko) 혼합백신의 제조방법
Allen An investigation of the anticryptococcal properties of normal serums